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The map label for this gene is menA [H]

Identifier: 220932293

GI number: 220932293

Start: 1550224

End: 1551120

Strand: Direct

Name: menA [H]

Synonym: Hore_14570

Alternate gene names: 220932293

Gene position: 1550224-1551120 (Clockwise)

Preceding gene: 220932284

Following gene: 220932296

Centisome position: 60.13

GC content: 39.8

Gene sequence:

>897_bases
TTGCTGAATACAATTAAGAAATGGTTAATTGCTATTAGACCATTTGGCTTTGCAACAACTCTGGTCTCAACAACCCTGGG
AGCATCCCTGGCCTTCTATCATGGTAGTTTTAACCCAGGGCTCTATTTTATGACAATGGCTCCTCTACTTTTGATCCATA
CTGGAACAAATCTGATCAATGATTATTATGATTATAAATTCGGCCTTGACGGTGAACAGAGTCTATCCTCAAGTGGCCTC
AACAGAGTTAATGGTCAAATTAAATTAAATCAAATATATACTGTAGCCATTGCCTGTTTTCTGGCCAGTATCCCCTTTGG
GGCATATTTAACCCTGTTAAGGGGACCTATTATCTTTATTCTGGGAACACTGGGGGCGCTGGCAGGGTATTTTTATACAG
CATCTCCCATCAGTTATAAATACTATGGTCTTGGTGGCCCCTCCATATTTATTTTTATGGGGGTTATGATGGTCTGGGGA
ATGTTTTATATTCAGACAGGAATTAATAGCTGGTATCCGGTACTGGTGGGCCTTCCTGTTAGCTTTTTAATTACAGGAAT
GCAGCATTCCAATGAATTGAGGGATTATGAAAATGATATGAAAAATGGTATAAAAACAGCCCCGGTAATAATGGGGTTTG
AAAGAGCCAGGTATTATTATTATTTTCTTATCATCTCTGCCTATATATCCCTGGTCTTGCTTATTACCTATAACCTGCTA
CCCCTCTGGACCACCCTGGCCTTTATAACTATACCCCTGGCCTATTTACCAGTAAAAAAAGTAGCAACAGCCACGTCTCA
GAATGACCTTAAAGGTATTGACTATCAGATGGCCCGGTTAAACATTCAATTCGGCATTTTCCTGTCCGGGGCCATTATTA
TCAGTAAATATATGTAA

Upstream 100 bases:

>100_bases
TCTCATAATTGATACCCAGGATATTAAATAATACTCCAGAATACTGCTGTTTTTACTGTCGTAACCCCATGGTCCAATAC
TCATAAAGGAGGTTAAAAAC

Downstream 100 bases:

>100_bases
AATATTTAGACCTTTTTTAATTCCGCTAACCCATGGATTAAGACTGTACAAATGGATTCCAGGCTGTCTTTTATTTCTCC
TGGTTTTCCAGGTAAATTAA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLNTIKKWLIAIRPFGFATTLVSTTLGASLAFYHGSFNPGLYFMTMAPLLLIHTGTNLINDYYDYKFGLDGEQSLSSSGL
NRVNGQIKLNQIYTVAIACFLASIPFGAYLTLLRGPIIFILGTLGALAGYFYTASPISYKYYGLGGPSIFIFMGVMMVWG
MFYIQTGINSWYPVLVGLPVSFLITGMQHSNELRDYENDMKNGIKTAPVIMGFERARYYYYFLIISAYISLVLLITYNLL
PLWTTLAFITIPLAYLPVKKVATATSQNDLKGIDYQMARLNIQFGIFLSGAIIISKYM

Sequences:

>Translated_298_residues
MLNTIKKWLIAIRPFGFATTLVSTTLGASLAFYHGSFNPGLYFMTMAPLLLIHTGTNLINDYYDYKFGLDGEQSLSSSGL
NRVNGQIKLNQIYTVAIACFLASIPFGAYLTLLRGPIIFILGTLGALAGYFYTASPISYKYYGLGGPSIFIFMGVMMVWG
MFYIQTGINSWYPVLVGLPVSFLITGMQHSNELRDYENDMKNGIKTAPVIMGFERARYYYYFLIISAYISLVLLITYNLL
PLWTTLAFITIPLAYLPVKKVATATSQNDLKGIDYQMARLNIQFGIFLSGAIIISKYM
>Mature_298_residues
MLNTIKKWLIAIRPFGFATTLVSTTLGASLAFYHGSFNPGLYFMTMAPLLLIHTGTNLINDYYDYKFGLDGEQSLSSSGL
NRVNGQIKLNQIYTVAIACFLASIPFGAYLTLLRGPIIFILGTLGALAGYFYTASPISYKYYGLGGPSIFIFMGVMMVWG
MFYIQTGINSWYPVLVGLPVSFLITGMQHSNELRDYENDMKNGIKTAPVIMGFERARYYYYFLIISAYISLVLLITYNLL
PLWTTLAFITIPLAYLPVKKVATATSQNDLKGIDYQMARLNIQFGIFLSGAIIISKYM

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=298, Percent_Identity=27.1812080536913, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1790365, Length=261, Percent_Identity=29.1187739463602, Blast_Score=96, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737429, Length=288, Percent_Identity=25.3472222222222, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33310; Mature: 33310

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTIKKWLIAIRPFGFATTLVSTTLGASLAFYHGSFNPGLYFMTMAPLLLIHTGTNLIN
CCHHHHHHHHHHCCCCHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHCCCHHHHH
DYYDYKFGLDGEQSLSSSGLNRVNGQIKLNQIYTVAIACFLASIPFGAYLTLLRGPIIFI
HHHCCCCCCCCHHHHHHCCHHHCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGTLGALAGYFYTASPISYKYYGLGGPSIFIFMGVMMVWGMFYIQTGINSWYPVLVGLPV
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCH
SFLITGMQHSNELRDYENDMKNGIKTAPVIMGFERARYYYYFLIISAYISLVLLITYNLL
HHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLWTTLAFITIPLAYLPVKKVATATSQNDLKGIDYQMARLNIQFGIFLSGAIIISKYM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHEEHHHHHHEECC
>Mature Secondary Structure
MLNTIKKWLIAIRPFGFATTLVSTTLGASLAFYHGSFNPGLYFMTMAPLLLIHTGTNLIN
CCHHHHHHHHHHCCCCHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHCCCHHHHH
DYYDYKFGLDGEQSLSSSGLNRVNGQIKLNQIYTVAIACFLASIPFGAYLTLLRGPIIFI
HHHCCCCCCCCHHHHHHCCHHHCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LGTLGALAGYFYTASPISYKYYGLGGPSIFIFMGVMMVWGMFYIQTGINSWYPVLVGLPV
HHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCH
SFLITGMQHSNELRDYENDMKNGIKTAPVIMGFERARYYYYFLIISAYISLVLLITYNLL
HHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLWTTLAFITIPLAYLPVKKVATATSQNDLKGIDYQMARLNIQFGIFLSGAIIISKYM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHEEHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]