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The map label for this gene is citS [H]

Identifier: 220932296

GI number: 220932296

Start: 1555179

End: 1556516

Strand: Direct

Name: citS [H]

Synonym: Hore_14600

Alternate gene names: 220932296

Gene position: 1555179-1556516 (Clockwise)

Preceding gene: 220932293

Following gene: 220932297

Centisome position: 60.32

GC content: 33.41

Gene sequence:

>1338_bases
ATGACAATTTCTTTCCCTAATTTTTATTTATACTATGTAATAACTGAACTAACGGTCTTTACACTGGTTTTAAAAATCCT
TAAAACAACCAGAAACAATTTATATTTTATTATACCCTTTATCCATACTGCTTTTTTATACATATTTAGATCCCATCTCC
ACCCGGTTTTTTCCCTGACCTTTTCTATAATCCTGGGGGGTATACTTATTCATTATATCCTGAGGTTTAATATAATCCAG
AGCCTGATAATTACCCTGATTACATTTTCTATTTATATACCCCTGGAGAATATGGTCTTTGCCCTCTTCTTTTATTTTTC
ATCAGAAGACTATTACACTACTCTAAATTCTATAACATATACAGGCACCATTTTACTCATATTTTTATTAATCATCTTTG
GTTTTACCCTTCTACTCAAGTGCCTGAACTCAAAGAATAACCTTAACAGTGAAAAGTTTAATTACATTAACTGGGAGAAT
ATAGAATTAAGCTCTGTAATTATCTTCATTTTTATTGAAAACATTGCCTTTTCATACTATTTCACTCATCTTCTGGTCCT
TAGACCCGGTGGTAGTAATAAAGAAATTCTCCTTTTTTCCACAGCCTTATTAATCTTGATCATTGTCTCTTTATTAATGG
TTAGATTTATTAAACTTATTAATAAAAAAATAGACCTGGCAGCAGCCGAGGAAAAAATAAACTCCCTTTCCAACCTTAAC
TTTGCTTTAAAACGGCAACTACATGATTTTAAACATCATCTCCAGCTCCTGACCTTTTTAATCCAGATGAAGAAATATGA
CAGGGCCCTTGAATATATGAAAAGTGTAACCACTGAACTAAATGAACTGGGTAAAATTAGTAGTACCGGAATACCTGCCC
TCAACGGACTTCTCCAGTATAAAATGGCCCTGGCTAAAAAAGAAGATATCAAACTCCAGGTGGAAGCCCTGGCCAAACTG
GAAAATCTACCCCTGAACCCTAGCAAGATTTGTCGGGTTATCGGAAACCTTATTGATAATGCCATCGAATACTTAAAAGA
TAAAAAGGACCTTGAAAAATATATACAGTTAATTATAACCGATACCAGACATGAATACCACATAAACCTGTCCAACCCTG
TAACCCCGAAAGACCATTTAAACGAAAACATGTTATCTAAATTTTTACAACCCGGTTTTTCCACCAAGGGAAAAAACCGG
GGATTAGGTCTTGCCATTGTTAATGAAATTATAAAAGAAAGTGGTGGGAAATTTTTACCTCAACTCGATGAAGAAGAAGG
AATTTTGTCATTTCAAATAATAATACCAAAAAGCAACAGTAATGATAAACCATTTTAA

Upstream 100 bases:

>100_bases
TAATATAATTTATAATATTAATGTATAACATATAGTAAGATCTATACAGAGGATATCGGTAAACCAGATTTAAGTGCAAT
TTTTAAGGGAGGTGATTGAG

Downstream 100 bases:

>100_bases
AGAATATTTAAAACAGACATGGGGATGCTATAACAAAAGGATAAAAGGAGGCAAAACATGAGGCGATACCCTCTGGAAAG
GCATCCCTTTAGTGAAGTTA

Product: signal transduction histidine kinase regulating citrate/malate metabolism

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTISFPNFYLYYVITELTVFTLVLKILKTTRNNLYFIIPFIHTAFLYIFRSHLHPVFSLTFSIILGGILIHYILRFNIIQ
SLIITLITFSIYIPLENMVFALFFYFSSEDYYTTLNSITYTGTILLIFLLIIFGFTLLLKCLNSKNNLNSEKFNYINWEN
IELSSVIIFIFIENIAFSYYFTHLLVLRPGGSNKEILLFSTALLILIIVSLLMVRFIKLINKKIDLAAAEEKINSLSNLN
FALKRQLHDFKHHLQLLTFLIQMKKYDRALEYMKSVTTELNELGKISSTGIPALNGLLQYKMALAKKEDIKLQVEALAKL
ENLPLNPSKICRVIGNLIDNAIEYLKDKKDLEKYIQLIITDTRHEYHINLSNPVTPKDHLNENMLSKFLQPGFSTKGKNR
GLGLAIVNEIIKESGGKFLPQLDEEEGILSFQIIIPKSNSNDKPF

Sequences:

>Translated_445_residues
MTISFPNFYLYYVITELTVFTLVLKILKTTRNNLYFIIPFIHTAFLYIFRSHLHPVFSLTFSIILGGILIHYILRFNIIQ
SLIITLITFSIYIPLENMVFALFFYFSSEDYYTTLNSITYTGTILLIFLLIIFGFTLLLKCLNSKNNLNSEKFNYINWEN
IELSSVIIFIFIENIAFSYYFTHLLVLRPGGSNKEILLFSTALLILIIVSLLMVRFIKLINKKIDLAAAEEKINSLSNLN
FALKRQLHDFKHHLQLLTFLIQMKKYDRALEYMKSVTTELNELGKISSTGIPALNGLLQYKMALAKKEDIKLQVEALAKL
ENLPLNPSKICRVIGNLIDNAIEYLKDKKDLEKYIQLIITDTRHEYHINLSNPVTPKDHLNENMLSKFLQPGFSTKGKNR
GLGLAIVNEIIKESGGKFLPQLDEEEGILSFQIIIPKSNSNDKPF
>Mature_444_residues
TISFPNFYLYYVITELTVFTLVLKILKTTRNNLYFIIPFIHTAFLYIFRSHLHPVFSLTFSIILGGILIHYILRFNIIQS
LIITLITFSIYIPLENMVFALFFYFSSEDYYTTLNSITYTGTILLIFLLIIFGFTLLLKCLNSKNNLNSEKFNYINWENI
ELSSVIIFIFIENIAFSYYFTHLLVLRPGGSNKEILLFSTALLILIIVSLLMVRFIKLINKKIDLAAAEEKINSLSNLNF
ALKRQLHDFKHHLQLLTFLIQMKKYDRALEYMKSVTTELNELGKISSTGIPALNGLLQYKMALAKKEDIKLQVEALAKLE
NLPLNPSKICRVIGNLIDNAIEYLKDKKDLEKYIQLIITDTRHEYHINLSNPVTPKDHLNENMLSKFLQPGFSTKGKNRG
LGLAIVNEIIKESGGKFLPQLDEEEGILSFQIIIPKSNSNDKPF

Specific function: Member of the two-component regulatory system CitT/CitS. Regulates the expression of the citM-yflN operon. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex [

COG id: COG3290

COG function: function code T; Signal transduction histidine kinase regulating citrate/malate metabolism

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51340; Mature: 51209

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISFPNFYLYYVITELTVFTLVLKILKTTRNNLYFIIPFIHTAFLYIFRSHLHPVFSLT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
FSIILGGILIHYILRFNIIQSLIITLITFSIYIPLENMVFALFFYFSSEDYYTTLNSITY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TGTILLIFLLIIFGFTLLLKCLNSKNNLNSEKFNYINWENIELSSVIIFIFIENIAFSYY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FTHLLVLRPGGSNKEILLFSTALLILIIVSLLMVRFIKLINKKIDLAAAEEKINSLSNLN
HHHHHEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FALKRQLHDFKHHLQLLTFLIQMKKYDRALEYMKSVTTELNELGKISSTGIPALNGLLQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
KMALAKKEDIKLQVEALAKLENLPLNPSKICRVIGNLIDNAIEYLKDKKDLEKYIQLIIT
HHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
DTRHEYHINLSNPVTPKDHLNENMLSKFLQPGFSTKGKNRGLGLAIVNEIIKESGGKFLP
CCCCEEEEECCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
QLDEEEGILSFQIIIPKSNSNDKPF
CCCCCCCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TISFPNFYLYYVITELTVFTLVLKILKTTRNNLYFIIPFIHTAFLYIFRSHLHPVFSLT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
FSIILGGILIHYILRFNIIQSLIITLITFSIYIPLENMVFALFFYFSSEDYYTTLNSITY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TGTILLIFLLIIFGFTLLLKCLNSKNNLNSEKFNYINWENIELSSVIIFIFIENIAFSYY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FTHLLVLRPGGSNKEILLFSTALLILIIVSLLMVRFIKLINKKIDLAAAEEKINSLSNLN
HHHHHEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FALKRQLHDFKHHLQLLTFLIQMKKYDRALEYMKSVTTELNELGKISSTGIPALNGLLQY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
KMALAKKEDIKLQVEALAKLENLPLNPSKICRVIGNLIDNAIEYLKDKKDLEKYIQLIIT
HHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHC
DTRHEYHINLSNPVTPKDHLNENMLSKFLQPGFSTKGKNRGLGLAIVNEIIKESGGKFLP
CCCCEEEEECCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
QLDEEEGILSFQIIIPKSNSNDKPF
CCCCCCCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9272861; 9384377; 10972810 [H]