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The map label for this gene is uppS [H]

Identifier: 220932284

GI number: 220932284

Start: 1538708

End: 1539352

Strand: Direct

Name: uppS [H]

Synonym: Hore_14480

Alternate gene names: 220932284

Gene position: 1538708-1539352 (Clockwise)

Preceding gene: 220932283

Following gene: 220932293

Centisome position: 59.68

GC content: 41.55

Gene sequence:

>645_bases
ATGAGAATTCCAGACCATATCGGAGTTATACCAGATGGAAACCGACGCTGGGCTTTAAGTCATGGTTTAACCAGGGAAAA
AGGCTATGCCAGTGGCCTTAAACCGGGTCTTGAAGTTTTTAAATTATGTAAAAAAGTGGGGGTTAAAGAATTAACCTTTT
ATGGGTTCACTATGGACAACACCAAAAGACCGTCTACCCAGACAGAGGCCTTCACAAAGGCCTGTATTGATGCTGTCGAA
ATGTTATCCCGGGAAGATGCTTCCTTACTGGTAGTAGGAAATACTGAATCCCCTAAATTCCCCAGAGAATTACTTAAATA
CACAAGAAAACGACATAAATTTGGCAAGGGGGGACTGAAGGTTAACTTCCTTGTCAATTACGGCTGGCACTGGGATCTTT
ATAATCTCAAACAAAAGAAAGTTAAGAAAAGTAAGTTACAGAAATACTTGAATTCCAGTGATATTTCAAGGGTAGATTTA
ATTATTCGCTGGGGTGGCAGGAGAAGGCTGAGCGGTTTTCTGCCGGTCCAGTCCATCTATGCCGACTTCTATGTCATTGA
CGATTACTGGCCCGATTTTAAACCTGAACATTTTTATGAAGCCCTTGCATGGTATGATAAGCAGGATATAACCCTGGGTG
GATAA

Upstream 100 bases:

>100_bases
ATCCCTTGTGTCTCTTCTGGCTTTTATTGTTTACGGTCTTATCGCCTGTTTTACAATAAAAAAATATACCAATGTCATGG
CCTAAAGGGGGGAAAACTTT

Downstream 100 bases:

>100_bases
AAAATCAACTTTTTACAAGACCGGCTTGAAAGAAATCAATTAGTTCCTGACGGGCCTTTTCTTCATCAGGCCCGTCTATT
TTCAGGGTAATTTTGTCACC

Product: Di-trans-poly-cis-decaprenylcistransferase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIPDHIGVIPDGNRRWALSHGLTREKGYASGLKPGLEVFKLCKKVGVKELTFYGFTMDNTKRPSTQTEAFTKACIDAVE
MLSREDASLLVVGNTESPKFPRELLKYTRKRHKFGKGGLKVNFLVNYGWHWDLYNLKQKKVKKSKLQKYLNSSDISRVDL
IIRWGGRRRLSGFLPVQSIYADFYVIDDYWPDFKPEHFYEALAWYDKQDITLGG

Sequences:

>Translated_214_residues
MRIPDHIGVIPDGNRRWALSHGLTREKGYASGLKPGLEVFKLCKKVGVKELTFYGFTMDNTKRPSTQTEAFTKACIDAVE
MLSREDASLLVVGNTESPKFPRELLKYTRKRHKFGKGGLKVNFLVNYGWHWDLYNLKQKKVKKSKLQKYLNSSDISRVDL
IIRWGGRRRLSGFLPVQSIYADFYVIDDYWPDFKPEHFYEALAWYDKQDITLGG
>Mature_214_residues
MRIPDHIGVIPDGNRRWALSHGLTREKGYASGLKPGLEVFKLCKKVGVKELTFYGFTMDNTKRPSTQTEAFTKACIDAVE
MLSREDASLLVVGNTESPKFPRELLKYTRKRHKFGKGGLKVNFLVNYGWHWDLYNLKQKKVKKSKLQKYLNSSDISRVDL
IIRWGGRRRLSGFLPVQSIYADFYVIDDYWPDFKPEHFYEALAWYDKQDITLGG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=220, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI45580738, Length=220, Percent_Identity=25, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=31.140350877193, Blast_Score=118, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=25.4716981132075, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 24818; Mature: 24818

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPDHIGVIPDGNRRWALSHGLTREKGYASGLKPGLEVFKLCKKVGVKELTFYGFTMDN
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECC
TKRPSTQTEAFTKACIDAVEMLSREDASLLVVGNTESPKFPRELLKYTRKRHKFGKGGLK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEE
VNFLVNYGWHWDLYNLKQKKVKKSKLQKYLNSSDISRVDLIIRWGGRRRLSGFLPVQSIY
EEEEEECCCEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHH
ADFYVIDDYWPDFKPEHFYEALAWYDKQDITLGG
HCEEEEECCCCCCCHHHHHHHHHHCCCCCEECCC
>Mature Secondary Structure
MRIPDHIGVIPDGNRRWALSHGLTREKGYASGLKPGLEVFKLCKKVGVKELTFYGFTMDN
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECC
TKRPSTQTEAFTKACIDAVEMLSREDASLLVVGNTESPKFPRELLKYTRKRHKFGKGGLK
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEE
VNFLVNYGWHWDLYNLKQKKVKKSKLQKYLNSSDISRVDLIIRWGGRRRLSGFLPVQSIY
EEEEEECCCEECHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHHHH
ADFYVIDDYWPDFKPEHFYEALAWYDKQDITLGG
HCEEEEECCCCCCCHHHHHHHHHHCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]