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The map label for this gene is xerD

Identifier: 221230188

GI number: 221230188

Start: 1626471

End: 1627421

Strand: Direct

Name: xerD

Synonym: MLBr_01365

Alternate gene names: 221230188

Gene position: 1626471-1627421 (Clockwise)

Preceding gene: 221230187

Following gene: 221230189

Centisome position: 49.77

GC content: 61.3

Gene sequence:

>951_bases
GTGACGACGGCCGCGCTTCAGACACAGCTGCAGGGCTACCTCGACTATCTGATCATCGAGCGCAGTATAGCGGCAAACAC
GCTGAGCTCCTATCGCCGTGACCTGATCCGCTACTCCAAGCACTTGTCAGATCGGGGAATTGAGGATCTGGCCAAGGTCG
GTGAGCACGATGTTAGCGAGTTCTTGGTGGCGCTGCGCCGTGGGGATCCCGATTCCGGGGTGGCGGCGCTGTCTGCGGTG
TCGGCGGCGCGAGCGTTGATCGCAGTGCGCGGTTTGCATCGGTTCGCTGTCGCCGAAGGGTTGGTCGACCTGGATGTTGC
GCGAGCTGTCCGTCCGCCTACGCCAGGACGTCGGTTGCCCAAGAGCTTGACAGTTGACGAGGTGCTGGCTTTGCTGGAGA
GTGTGGGCGGCGAAAGTCGGGCCGACGGACCGCTGGTACTACGCAATCGGGCGTTGCTGGAGTTGTTGTACTCTACCGGA
TCCCGGATTTCTGAAGCTGTTGGGCTTGATGTCGACGATGTCGACACCCAGGCCAGGACGGTGTTGTTGCAGGGGAAGGG
CGGCAAGCAGCGGCTAGTACCGGTGGGGCGTCCCGCCGTGCAAGCGCTGGATGCCTATCTGGTGCGTGGACGCTCCGATC
TGGCTCGTCGGGGTCCTGGAATGCTTGCGACGCCAGCCATTTTTCTCAATGCGCGCGGAGGTCGGTTGTCGCGTCAAAGT
GCGTGGCAAGTTCTGCAAGATGCTGCTGAACATGCCGGTATCACTTCGGGTGTGTCGCCGCACATGTTGCGGCATTCCTT
TGCCACCCACTTACTCGAAGGTGGCGCCGACATCCGGGTTGTGCAGGAGTTAATGGGTCATGCCTCGGTCACGACAACGC
AGATCTACACGTTGGTTACTGTCCAGGCGTTACGTGAAGTGTGGGCCGGGGCGCACCCTAGGGCCAAATAG

Upstream 100 bases:

>100_bases
TAGCCGCCCATGCGGTGACCACCGAGTTCGTGCAATCGCGCTCACTAAACAGTCAGTGGATCGATAAGCAAACGGTGCTT
GCGGCCCGAAAGGTCACCCA

Downstream 100 bases:

>100_bases
CTCCGCGTTTCAGCCCAGGTATTTGGAATTCCATCACCAGACTGGGGCGCCAGCGTCTGCTATTTGAAGTGCGTCTTGTG
CTCGATGGTGTTCCATAGCG

Product: site-specific tyrosine recombinase XerD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIEDLAKVGEHDVSEFLVALRRGDPDSGVAALSAV
SAARALIAVRGLHRFAVAEGLVDLDVARAVRPPTPGRRLPKSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTG
SRISEAVGLDVDDVDTQARTVLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQS
AWQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQIYTLVTVQALREVWAGAHPRAK

Sequences:

>Translated_316_residues
MTTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIEDLAKVGEHDVSEFLVALRRGDPDSGVAALSAV
SAARALIAVRGLHRFAVAEGLVDLDVARAVRPPTPGRRLPKSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTG
SRISEAVGLDVDDVDTQARTVLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQS
AWQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQIYTLVTVQALREVWAGAHPRAK
>Mature_315_residues
TTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIEDLAKVGEHDVSEFLVALRRGDPDSGVAALSAVS
AARALIAVRGLHRFAVAEGLVDLDVARAVRPPTPGRRLPKSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTGS
RISEAVGLDVDDVDTQARTVLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQSA
WQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQIYTLVTVQALREVWAGAHPRAK

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerD subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=311, Percent_Identity=39.871382636656, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1790244, Length=311, Percent_Identity=36.9774919614148, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1790768, Length=189, Percent_Identity=32.2751322751323, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790767, Length=195, Percent_Identity=29.2307692307692, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERD_MYCLE (Q49890)

Other databases:

- EMBL:   U00021
- EMBL:   Z95117
- EMBL:   AL583921
- PIR:   G87079
- PIR:   S72959
- RefSeq:   NP_301974.1
- ProteinModelPortal:   Q49890
- SMR:   Q49890
- EnsemblBacteria:   EBMYCT00000028491
- GeneID:   910455
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1365
- NMPDR:   fig|272631.1.peg.846
- Leproma:   ML1365
- GeneTree:   EBGT00050000015380
- HOGENOM:   HBG727654
- OMA:   DTQARSV
- ProtClustDB:   PRK00283
- BioCyc:   MLEP272631:ML1365-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01807
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011932
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02225

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33975; Mature: 33844

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: ACT_SITE 162-162 ACT_SITE 186-186 ACT_SITE 261-261 ACT_SITE 264-264 ACT_SITE 287-287 ACT_SITE 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIEDLAKVGEHDVSE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
FLVALRRGDPDSGVAALSAVSAARALIAVRGLHRFAVAEGLVDLDVARAVRPPTPGRRLP
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTGSRISEAVGLDVDDVDTQART
CCCCHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHE
VLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQS
EEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCEECCEEEEECCCCCCCHHH
AWQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQIYTLVT
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHH
VQALREVWAGAHPRAK
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIEDLAKVGEHDVSE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
FLVALRRGDPDSGVAALSAVSAARALIAVRGLHRFAVAEGLVDLDVARAVRPPTPGRRLP
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTGSRISEAVGLDVDDVDTQART
CCCCHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHE
VLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQS
EEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCCEECCEEEEECCCCCCCHHH
AWQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQIYTLVT
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHH
VQALREVWAGAHPRAK
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002