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The map label for this gene is chaA [C]

Identifier: 221230127

GI number: 221230127

Start: 1510464

End: 1511558

Strand: Direct

Name: chaA [C]

Synonym: MLBr_01267

Alternate gene names: 221230127

Gene position: 1510464-1511558 (Clockwise)

Preceding gene: 221230126

Following gene: 221230128

Centisome position: 46.22

GC content: 60.27

Gene sequence:

>1095_bases
ATGTTGAAACGGATAGCCTGGACCGCACTGGTACCTCTGTTTGCTCTGGCCGTGCTGGCATTGACCTGGGGAAGAGAGAT
CGGTCCAGTCGTGACCGCGTTACAGGCGGCGTTGCTGACCGGCGCTGTGCTGGCCGCGGTCCATCATGCGGAGGTTGTCG
CGCACCGGGTTGGTGAGCCGTTTGGGTCGCTGGTGCTCGCTGCAGCGGTGACGGTCATCGAGGTGGCTCTCATCGTCACG
CTCATGGCCTCTGGTGAGAACGAATCATGGACCCTGGCCAGGGATACCGCGTTCGCCGCACTAATGATCACCACTAACGG
GATTGCGGGTTTTTCGCTGCTACTGGGTTCCCGACGCTACGGTGTGACGTTGTTTAACGCCCACGGCAGCGGGGCCGCGC
TGGCCACGCTCACCACGTTGGCGACGTTAAGCCTGGTGCTGCCCACTTTCACTACTAGTCACCGTGGCAATGAGTTCTCA
CCTGGCCAGCTGGCCTTCGCTGCCGTCGCTTCGCTAGGACTTTATCTGCTTTTTGTATTCACACAAACTATCCGGCATCG
CGACTTTTTTTTGCCTGTCGCACAGAAGGGCCAAAAAGGCCTGTTCGAAGAGGATGAAAGCCATGCCGATCCGCCCAGCG
CACGGTCTGCGCTGATCAGCCTCGCATTGCTGCTTGTTGCGCTGATCGCGGTGGTGGGTCTGGCCGAACTGCAGTCGTCG
GCAATCGAGCACTTGGTGACAGCAGTTGGCTTCCCCCAGCCATTCGTTGGTGTAGTGATCGCCACGCTGGTGCTGTTACC
AGAAACACTTGCGGCGGTGCGTGCGGCGCGTCGGGGTCGCATCCAGACCAGCCTGAACCTGGCCTACGGCTCGGCTATGG
CCAGCATTGGGCTGACTATTCCGGCCATCGCGCTGGCTTCCATCTGGCTTACCGGACCGTTGATACTCGGCCTGGGCGCG
ACCCAGTTGGTGTTGTTGGCTCTGACCGTCGTAATCAGCGTGCTGACCGTGGTGCCTGGGCGGGCTACTCGCCTCCAGGG
TGAGGTGCATCTAGTATTGCTTGCCGCTTTCGTGTTTTTGGCGATCATCCCGTAA

Upstream 100 bases:

>100_bases
GAGAGCGGCAGGTAATCGCGGTAGAGCGGCGCTGGTCATAGTGGTTCCGTGTTCGCCCCGCTGGGGAGCCGGCAGATGAC
TTTGGTGAGAATGGCGGGCG

Downstream 100 bases:

>100_bases
AAAGGCAGTTACTATCGACGAGTTTGAATAATTAATCGGTCGATCTGGCCCGCAGCGTCTCTAGCGCCTTGTCGGCATGG
GTGTCCATGCTTAATTCGCT

Product: putative antiporter

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MLKRIAWTALVPLFALAVLALTWGREIGPVVTALQAALLTGAVLAAVHHAEVVAHRVGEPFGSLVLAAAVTVIEVALIVT
LMASGENESWTLARDTAFAALMITTNGIAGFSLLLGSRRYGVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNEFS
PGQLAFAAVASLGLYLLFVFTQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSALISLALLLVALIAVVGLAELQSS
AIEHLVTAVGFPQPFVGVVIATLVLLPETLAAVRAARRGRIQTSLNLAYGSAMASIGLTIPAIALASIWLTGPLILGLGA
TQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAFVFLAIIP

Sequences:

>Translated_364_residues
MLKRIAWTALVPLFALAVLALTWGREIGPVVTALQAALLTGAVLAAVHHAEVVAHRVGEPFGSLVLAAAVTVIEVALIVT
LMASGENESWTLARDTAFAALMITTNGIAGFSLLLGSRRYGVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNEFS
PGQLAFAAVASLGLYLLFVFTQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSALISLALLLVALIAVVGLAELQSS
AIEHLVTAVGFPQPFVGVVIATLVLLPETLAAVRAARRGRIQTSLNLAYGSAMASIGLTIPAIALASIWLTGPLILGLGA
TQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAFVFLAIIP
>Mature_364_residues
MLKRIAWTALVPLFALAVLALTWGREIGPVVTALQAALLTGAVLAAVHHAEVVAHRVGEPFGSLVLAAAVTVIEVALIVT
LMASGENESWTLARDTAFAALMITTNGIAGFSLLLGSRRYGVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNEFS
PGQLAFAAVASLGLYLLFVFTQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSALISLALLLVALIAVVGLAELQSS
AIEHLVTAVGFPQPFVGVVIATLVLLPETLAAVRAARRGRIQTSLNLAYGSAMASIGLTIPAIALASIWLTGPLILGLGA
TQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAFVFLAIIP

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=351, Percent_Identity=36.1823361823362, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 37899; Mature: 37899

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRIAWTALVPLFALAVLALTWGREIGPVVTALQAALLTGAVLAAVHHAEVVAHRVGEP
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
FGSLVLAAAVTVIEVALIVTLMASGENESWTLARDTAFAALMITTNGIAGFSLLLGSRRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHEEEEEEECCCHHHHHHHCCCCC
GVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNEFSPGQLAFAAVASLGLYLLFVF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSALISLALLLVALIAVVGLAELQSS
HHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEHLVTAVGFPQPFVGVVIATLVLLPETLAAVRAARRGRIQTSLNLAYGSAMASIGLTI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
PAIALASIWLTGPLILGLGATQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAFVFL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHH
AIIP
HCCC
>Mature Secondary Structure
MLKRIAWTALVPLFALAVLALTWGREIGPVVTALQAALLTGAVLAAVHHAEVVAHRVGEP
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
FGSLVLAAAVTVIEVALIVTLMASGENESWTLARDTAFAALMITTNGIAGFSLLLGSRRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHEEEEEEECCCHHHHHHHCCCCC
GVTLFNAHGSGAALATLTTLATLSLVLPTFTTSHRGNEFSPGQLAFAAVASLGLYLLFVF
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TQTIRHRDFFLPVAQKGQKGLFEEDESHADPPSARSALISLALLLVALIAVVGLAELQSS
HHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIEHLVTAVGFPQPFVGVVIATLVLLPETLAAVRAARRGRIQTSLNLAYGSAMASIGLTI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
PAIALASIWLTGPLILGLGATQLVLLALTVVISVLTVVPGRATRLQGEVHLVLLAAFVFL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHH
AIIP
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]