Click here to switch to the map view.

The map label for this gene is hisI

Identifier: 221230126

GI number: 221230126

Start: 1508383

End: 1508730

Strand: Direct

Name: hisI

Synonym: MLBr_01264

Alternate gene names: 221230126

Gene position: 1508383-1508730 (Clockwise)

Preceding gene: 221230125

Following gene: 221230127

Centisome position: 46.16

GC content: 59.2

Gene sequence:

>348_bases
ATGACACTCGACCCAGACATTGCTGTACGCCTCAAGCGCAACGCCGAAGGTTTATTCACCGCCGTCGTACAGGAGCGCTC
CAGCGGAGACGTGCTAATGGTCGCTTGGATGGACGACCAAGCACTGGCTCGCACCCTGGAAACCCGTGAGGCGAATTATT
ATTCGCGATCCCGGGCCGAGCAGTGGATCAAGGGATCGACCTCCGGCAACACGCAGCATGTTCACTCGGTGCGCCTGGAT
TGCGACGGCGACACCGTGCTGTTGACGGTCGACCAGGTCGGTGGAGCCTGCCATACCGGCGCTCACAGTTGCTTTGATTC
CGCAATGTTATTAGCCCCTCAGGACTAG

Upstream 100 bases:

>100_bases
CCGGTGCTGATGCGGTTTTGGCGGCCAGTGTCTTTCATTTCCGAGAGCTAACGATCGGGCAGGTGAAAGACGCTATGGCC
GCAGCAGGGATCGCGGTGCG

Downstream 100 bases:

>100_bases
TCGGCGCCTCACCCATGCCTCTAGCAAGGCGCGGTATCTCAATCCGTTGTCCGCGGCTATCGCCGCGTGGGTCCGTTCGT
GTCGGAAAAACGGCTGGCTG

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 115; Mature: 114

Protein sequence:

>115_residues
MTLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAEQWIKGSTSGNTQHVHSVRLD
CDGDTVLLTVDQVGGACHTGAHSCFDSAMLLAPQD

Sequences:

>Translated_115_residues
MTLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAEQWIKGSTSGNTQHVHSVRLD
CDGDTVLLTVDQVGGACHTGAHSCFDSAMLLAPQD
>Mature_114_residues
TLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAEQWIKGSTSGNTQHVHSVRLDC
DGDTVLLTVDQVGGACHTGAHSCFDSAMLLAPQD

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=42.3913043478261, Blast_Score=91, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=98, Percent_Identity=37.7551020408163, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_MYCLB (B8ZRB5)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503542.1
- ProteinModelPortal:   B8ZRB5
- SMR:   B8ZRB5
- EnsemblBacteria:   EBMYCT00000087334
- GeneID:   7324684
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017128
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 12582; Mature: 12451

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAE
CCCCCCEEEEEECCCCHHHEEEECCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHH
QWIKGSTSGNTQHVHSVRLDCDGDTVLLTVDQVGGACHTGAHSCFDSAMLLAPQD
HHHCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHCCEEEEECCC
>Mature Secondary Structure 
TLDPDIAVRLKRNAEGLFTAVVQERSSGDVLMVAWMDDQALARTLETREANYYSRSRAE
CCCCCEEEEEECCCCHHHEEEECCCCCCCEEEEEEECCHHHHHHHHHHCCCHHHHHHHH
QWIKGSTSGNTQHVHSVRLDCDGDTVLLTVDQVGGACHTGAHSCFDSAMLLAPQD
HHHCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA