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The map label for this gene is hslU [H]

Identifier: 220917978

GI number: 220917978

Start: 3179776

End: 3181218

Strand: Reverse

Name: hslU [H]

Synonym: A2cp1_2879

Alternate gene names: 220917978

Gene position: 3181218-3179776 (Counterclockwise)

Preceding gene: 220917979

Following gene: 220917977

Centisome position: 63.25

GC content: 72.14

Gene sequence:

>1443_bases
ATGGCGCCGAGCCCGAAGCCGCAGGACCTCACCCCGCGGGAGATCGTGGCGGAGCTGGACCGCTACGTGGTCGGCCAGGC
GCAGGCGAAGCGCGCGGTCGCGATCGCGCTGCGCAACCGCTGGCGCCGGCAGCGCGTCGGGCCCGAGCTGCGCGACGAGA
TCCTGCCCAAGAACATCGTCATGATCGGCCCCACCGGCGTGGGGAAGACCGAGATCGCGCGCCGGCTGGCACGGCTCGCC
GGCGCGCCGTTCGTCAAGGTCGAGGCGTCCAAGTTCACCGAGGTCGGCTACGTGGGCCGCGACGTGGACTCGATGATCCG
CGACCTGGTCGAGGCGGCGGTCAAGCTCGTGAAGGAGGAGGAGATCGCGAAGCTGCGCGAGCGCGCGCGCGAGGCGGCCG
AGGAGAAGGTCCTCGACGCGCTCGGCTTCGGCTCCGGCTTCGGCCTCGGCTTCCGGAACCCGTTCGGCGGCCGCGGCGCG
CAGCCCGACGAGCCGCAGGCCGCGCCCGCCTCGCACCCGGCCGGCTCCGCCGCCGGCGCCCGCGAGAAGGCGCGCGCCCA
GCTCCGCGCCGGCACGCTCGACGACGACCTGGTGGAGGTGGAGCTCTCGGAGCGCGCCATGCCGGTGATGCCGTTCATGG
GGCCGGGCATGGAGGACATGGCGCAGGGCCTCCAGGACATGGTCCAGAACCTGGGCAACAACCCGCTGCTCGGGATGCTG
GGCGGCGGCGGCCGGAAGCGGAAGCGCAAGGTGAACGTGAAGGAGGCGCTCGAGCTGCTCACCGACGAGGAGGCCGCGCG
GATGGTGGACATGGAGCGCGTGACGCGCGAGGCGCTCGACCGCGCGCAGAACGCCGGGATCGTGTTCATCGACGAGATCG
ACAAGATCGCGGGCGGCGACGGCGGCGGCGTGCGCGGGCCCGACGTCTCGCGGGGCGGCGTGCAACGCGATCTCCTGCCC
ATCGTCGAGGGCTCCAACGTCAACACCAAGTACGGCGTGGTGAAGACCGACCACATGCTGTTCGTGGCCGCCGGCGCCTT
CCACGTGGCCAAGGTCTCCGACCTCATCCCGGAGCTGCAGGGGCGCTTCCCCATCCGCGTGGAGCTGGAGCCGCTCACGC
GCGAGGACCTGGTGCGCATCCTCAAGGAGCCGCGCAACAGCCTGGTGCGGCAGTACACCGCGCTGCTCGCGACCGAGGGC
GTGGACGTGCAGATCCGCGACGAGGCCGTGGACGAGATCGCGCGCATCGCCGCCGAGGTGAACGAGCGCATGGAGAACAT
CGGCGCGCGCCGCCTCCACACCGTGATGGAGCGGCTGCTCGACCAGCTCTCGTTCGAGGGCTCGGAGCTGCGCGGGCAGC
GGATCGTGGTGGACGCGGCCTACGTGCGCGACCGCCTCCAGGGCATCGCGCAGGACGAGGACCTGTCGCGCTACATCCTG
TGA

Upstream 100 bases:

>100_bases
ACTCGGCGCTGGACGCCCGCCAGGTGGCCGAGGAGGCCATGAAGCTCGCCGCCGAGATCTGCATCTACACGAATGGCAAC
CTCACCATCGAGGAGCTGTG

Downstream 100 bases:

>100_bases
GGCGCACGCCCGGGCGCGCCCGACCGGGCGCTCGCGGATCTGGAACTCTCCGCCGCCCGGCTGCTATAAGCGCGGAATGA
CACGCAACGAGTCGATCGCC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MAPSPKPQDLTPREIVAELDRYVVGQAQAKRAVAIALRNRWRRQRVGPELRDEILPKNIVMIGPTGVGKTEIARRLARLA
GAPFVKVEASKFTEVGYVGRDVDSMIRDLVEAAVKLVKEEEIAKLRERAREAAEEKVLDALGFGSGFGLGFRNPFGGRGA
QPDEPQAAPASHPAGSAAGAREKARAQLRAGTLDDDLVEVELSERAMPVMPFMGPGMEDMAQGLQDMVQNLGNNPLLGML
GGGGRKRKRKVNVKEALELLTDEEAARMVDMERVTREALDRAQNAGIVFIDEIDKIAGGDGGGVRGPDVSRGGVQRDLLP
IVEGSNVNTKYGVVKTDHMLFVAAGAFHVAKVSDLIPELQGRFPIRVELEPLTREDLVRILKEPRNSLVRQYTALLATEG
VDVQIRDEAVDEIARIAAEVNERMENIGARRLHTVMERLLDQLSFEGSELRGQRIVVDAAYVRDRLQGIAQDEDLSRYIL

Sequences:

>Translated_480_residues
MAPSPKPQDLTPREIVAELDRYVVGQAQAKRAVAIALRNRWRRQRVGPELRDEILPKNIVMIGPTGVGKTEIARRLARLA
GAPFVKVEASKFTEVGYVGRDVDSMIRDLVEAAVKLVKEEEIAKLRERAREAAEEKVLDALGFGSGFGLGFRNPFGGRGA
QPDEPQAAPASHPAGSAAGAREKARAQLRAGTLDDDLVEVELSERAMPVMPFMGPGMEDMAQGLQDMVQNLGNNPLLGML
GGGGRKRKRKVNVKEALELLTDEEAARMVDMERVTREALDRAQNAGIVFIDEIDKIAGGDGGGVRGPDVSRGGVQRDLLP
IVEGSNVNTKYGVVKTDHMLFVAAGAFHVAKVSDLIPELQGRFPIRVELEPLTREDLVRILKEPRNSLVRQYTALLATEG
VDVQIRDEAVDEIARIAAEVNERMENIGARRLHTVMERLLDQLSFEGSELRGQRIVVDAAYVRDRLQGIAQDEDLSRYIL
>Mature_479_residues
APSPKPQDLTPREIVAELDRYVVGQAQAKRAVAIALRNRWRRQRVGPELRDEILPKNIVMIGPTGVGKTEIARRLARLAG
APFVKVEASKFTEVGYVGRDVDSMIRDLVEAAVKLVKEEEIAKLRERAREAAEEKVLDALGFGSGFGLGFRNPFGGRGAQ
PDEPQAAPASHPAGSAAGAREKARAQLRAGTLDDDLVEVELSERAMPVMPFMGPGMEDMAQGLQDMVQNLGNNPLLGMLG
GGGRKRKRKVNVKEALELLTDEEAARMVDMERVTREALDRAQNAGIVFIDEIDKIAGGDGGGVRGPDVSRGGVQRDLLPI
VEGSNVNTKYGVVKTDHMLFVAAGAFHVAKVSDLIPELQGRFPIRVELEPLTREDLVRILKEPRNSLVRQYTALLATEGV
DVQIRDEAVDEIARIAAEVNERMENIGARRLHTVMERLLDQLSFEGSELRGQRIVVDAAYVRDRLQGIAQDEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=92, Percent_Identity=40.2173913043478, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790366, Length=472, Percent_Identity=54.6610169491525, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=46.1538461538462, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6319704, Length=128, Percent_Identity=37.5, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648289, Length=111, Percent_Identity=45.045045045045, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648291, Length=111, Percent_Identity=45.045045045045, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52648; Mature: 52517

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSPKPQDLTPREIVAELDRYVVGQAQAKRAVAIALRNRWRRQRVGPELRDEILPKNIV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEE
MIGPTGVGKTEIARRLARLAGAPFVKVEASKFTEVGYVGRDVDSMIRDLVEAAVKLVKEE
EECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EIAKLRERAREAAEEKVLDALGFGSGFGLGFRNPFGGRGAQPDEPQAAPASHPAGSAAGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
REKARAQLRAGTLDDDLVEVELSERAMPVMPFMGPGMEDMAQGLQDMVQNLGNNPLLGML
HHHHHHHHHCCCCCCCCEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEE
GGGGRKRKRKVNVKEALELLTDEEAARMVDMERVTREALDRAQNAGIVFIDEIDKIAGGD
CCCCCCHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHCCCC
GGGVRGPDVSRGGVQRDLLPIVEGSNVNTKYGVVKTDHMLFVAAGAFHVAKVSDLIPELQ
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCEECEEEECCEEEEECCHHHHHHHHHHHHHHC
GRFPIRVELEPLTREDLVRILKEPRNSLVRQYTALLATEGVDVQIRDEAVDEIARIAAEV
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHH
NERMENIGARRLHTVMERLLDQLSFEGSELRGQRIVVDAAYVRDRLQGIAQDEDLSRYIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure 
APSPKPQDLTPREIVAELDRYVVGQAQAKRAVAIALRNRWRRQRVGPELRDEILPKNIV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEE
MIGPTGVGKTEIARRLARLAGAPFVKVEASKFTEVGYVGRDVDSMIRDLVEAAVKLVKEE
EECCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EIAKLRERAREAAEEKVLDALGFGSGFGLGFRNPFGGRGAQPDEPQAAPASHPAGSAAGA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
REKARAQLRAGTLDDDLVEVELSERAMPVMPFMGPGMEDMAQGLQDMVQNLGNNPLLGML
HHHHHHHHHCCCCCCCCEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEE
GGGGRKRKRKVNVKEALELLTDEEAARMVDMERVTREALDRAQNAGIVFIDEIDKIAGGD
CCCCCCHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHCCCC
GGGVRGPDVSRGGVQRDLLPIVEGSNVNTKYGVVKTDHMLFVAAGAFHVAKVSDLIPELQ
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCEECEEEECCEEEEECCHHHHHHHHHHHHHHC
GRFPIRVELEPLTREDLVRILKEPRNSLVRQYTALLATEGVDVQIRDEAVDEIARIAAEV
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHH
NERMENIGARRLHTVMERLLDQLSFEGSELRGQRIVVDAAYVRDRLQGIAQDEDLSRYIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA