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The map label for this gene is thrS

Identifier: 220917084

GI number: 220917084

Start: 2235819

End: 2237771

Strand: Direct

Name: thrS

Synonym: A2cp1_1981

Alternate gene names: 220917084

Gene position: 2235819-2237771 (Clockwise)

Preceding gene: 220917083

Following gene: 220917085

Centisome position: 44.46

GC content: 69.28

Gene sequence:

>1953_bases
ATGTCCGACCTCGTGAAGGTGACGCTCCCGGATGGCAGCCAGAAGGAGGCGCCGCGGGGCACCCCGGTGATCGACTTCGT
GAAGGGGCAGATCGGCCCGGGCCTCGCGAAGGCGGCCTACTTCGCCAGGCTGGACGGCGAGCCGGTGGACCTCTCCCGCG
CCATCGAGCGCGACGCGCGGCTGGAGATCGTCACCACGAGGAACCCGGAGGCGCTCGAGGTCGCGCGCCACGACGCGGCG
CACGTGATGGCGAGCGTGGTGCAGAAGCTCTACCCCGGCACCCAGGTCACCATCGGCCCGGCCATCGAGGACGGCTTCTA
CTACGACTTCGCGCGCGAGACCCCGTTCACGCCCGAGGATCTCGAGCGGATCGAGAAGGCGACCAACGAGGCGATCAAGG
CCGACCTGCCGTTCGTCCGCTCCGAGATCTCGATGGAGGCCGCGCTGGCGCTCTTCGAGGGCATGGGCGAGCGCTACAAG
GTCGAGATCGTGAAGGACATCGCCGCGAAGGGCGCGAAGACGCTCACGCTCTACAAGCACGGCGACTGGGTGGACTTCTG
CCTCGGGCCGCACGGGCCGTCCACCGGGCGCATCGGCGTCGTGAAGCTGCTGAACGTGGCCGGCGCGTACTGGCGCGGCG
ACGCGAAGAACGCGATGCTCCAGCGCATCTACGGCACCGCCTTCTTCGACAAGAAGGAGCTGGACGCGCACCTCGCGAAG
CTCGAGGAGGTGAAGAAGCGCGACCACCGCCGCCTCGGCCCGCAGCTCGGGCTGTTCACGTTCCACGAGTTCGCGCCCGG
CGCGCCGTTCTGGCTGCCCGCCGGCACCGTCCTCTACAACGTGCTCGAGGACGCGATGCGCCGCCTGGTGCTGAAGAACG
GCTACCAGGAGGTGAAGACGCCGCTGCTGTTCAACAAGCGGCTGTGGGAGACCTCCGGGCACTGGGGCAAGTACCGGGAG
AACATGTTCCTGGTGGTCGACAGCGAGTCGGATCCGGCGCTCCCGCTGGAGGACCGGTGCAGCTTCTCGCTGAAGCCCAT
GAACTGCCCGTCGCACCACCTCATCTACAGGATGGACAAGCGCTCGTACCGCGAGCTGCCGGTCCGCTACTTCACCACCG
ACGCGCTCCACCGCAACGAGGCGTCCGGCTCGCTGGGTGGCCTCACCCGCGTGCGCCAGTTCGAGCAGGACGACGCGCAC
ATCTACCTGCGCGAGGAGCAGGTCACCGACGAGGTGCTGCGGATCTTCGAGCTGATGAAGGTCGTCTACGGCGCGTTCGG
CCTGGGCTTCGAGGCCACCTTCTCCACCCGGCCCGAGCAGCGCATCGGCGACGACGCGCTCTGGGACCGCGCCGAGGCGC
TGCTGCGGAAGTCGCTCGACGCGACCGGGCTGAAGTGGACGCTCAACGCGGGCGACGGCGCGTTCTACGGCCCGAAGATC
GACATGCTGGTGACGGACTCGCTGGGCCGGAAGTGGCAGACCTGCACCATCCAGCTCGACTACGCCGCGCCCGAGCGCTT
CGACCTCACCTTCGTGGGCGAGGACAACAAGGAGCACCGGCCGGTGGTGATCCACCGCGCCATCTACGGCTCCTTCGAGC
GCTTCGTCGCGATCCTGGTCGAGCACTACGCCGGCGCGTTCCCGGCCTGGCTCGCGCCGGTGCAGGCGCGGGTGGTGACC
GTCTCGGATCGCTTCGAGGCGTGGGCGCGCGAGGCGGGGGAGGCGCTGCAGGCGCGCGGCTGGCGCGTCGAGGTGGACGC
GTCGTCGGACAAGCTCGGCGCGAAGATCCGCAACGCGCAGCTCGCCAAGATCCCGTTCACGCTGGTGGTCGGCGAGAAGG
AGGTCGAGGCGAAGGGCGTCTCGCCGCGCCGGCACGGCGGCGAGGACCTGAAGACGATGCCGCTCGAGACGTTCGCCGAG
CTGATGGCGCGCGAGGCGACGGCGCCCTTCTGA

Upstream 100 bases:

>100_bases
TGGTTCGATCCCAGCCGTGCCCACATCGCGGGCGTCCCCCGCCACCGAGGGCCAGCCGCCAGGCTGGCCTTTTTTTTCGA
CCGCAGATAGGCATACCGAC

Downstream 100 bases:

>100_bases
TCCGACGAGGGCTGCGCCCTCGCCCGCCGAGCGGAGCTCGGTGGGGCCCACTGCTGCTGCGCGGGGCCCGTGACCTCGCG
CGCCCGCGTTCGCGGGCACG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSDLVKVTLPDGSQKEAPRGTPVIDFVKGQIGPGLAKAAYFARLDGEPVDLSRAIERDARLEIVTTRNPEALEVARHDAA
HVMASVVQKLYPGTQVTIGPAIEDGFYYDFARETPFTPEDLERIEKATNEAIKADLPFVRSEISMEAALALFEGMGERYK
VEIVKDIAAKGAKTLTLYKHGDWVDFCLGPHGPSTGRIGVVKLLNVAGAYWRGDAKNAMLQRIYGTAFFDKKELDAHLAK
LEEVKKRDHRRLGPQLGLFTFHEFAPGAPFWLPAGTVLYNVLEDAMRRLVLKNGYQEVKTPLLFNKRLWETSGHWGKYRE
NMFLVVDSESDPALPLEDRCSFSLKPMNCPSHHLIYRMDKRSYRELPVRYFTTDALHRNEASGSLGGLTRVRQFEQDDAH
IYLREEQVTDEVLRIFELMKVVYGAFGLGFEATFSTRPEQRIGDDALWDRAEALLRKSLDATGLKWTLNAGDGAFYGPKI
DMLVTDSLGRKWQTCTIQLDYAAPERFDLTFVGEDNKEHRPVVIHRAIYGSFERFVAILVEHYAGAFPAWLAPVQARVVT
VSDRFEAWAREAGEALQARGWRVEVDASSDKLGAKIRNAQLAKIPFTLVVGEKEVEAKGVSPRRHGGEDLKTMPLETFAE
LMAREATAPF

Sequences:

>Translated_650_residues
MSDLVKVTLPDGSQKEAPRGTPVIDFVKGQIGPGLAKAAYFARLDGEPVDLSRAIERDARLEIVTTRNPEALEVARHDAA
HVMASVVQKLYPGTQVTIGPAIEDGFYYDFARETPFTPEDLERIEKATNEAIKADLPFVRSEISMEAALALFEGMGERYK
VEIVKDIAAKGAKTLTLYKHGDWVDFCLGPHGPSTGRIGVVKLLNVAGAYWRGDAKNAMLQRIYGTAFFDKKELDAHLAK
LEEVKKRDHRRLGPQLGLFTFHEFAPGAPFWLPAGTVLYNVLEDAMRRLVLKNGYQEVKTPLLFNKRLWETSGHWGKYRE
NMFLVVDSESDPALPLEDRCSFSLKPMNCPSHHLIYRMDKRSYRELPVRYFTTDALHRNEASGSLGGLTRVRQFEQDDAH
IYLREEQVTDEVLRIFELMKVVYGAFGLGFEATFSTRPEQRIGDDALWDRAEALLRKSLDATGLKWTLNAGDGAFYGPKI
DMLVTDSLGRKWQTCTIQLDYAAPERFDLTFVGEDNKEHRPVVIHRAIYGSFERFVAILVEHYAGAFPAWLAPVQARVVT
VSDRFEAWAREAGEALQARGWRVEVDASSDKLGAKIRNAQLAKIPFTLVVGEKEVEAKGVSPRRHGGEDLKTMPLETFAE
LMAREATAPF
>Mature_649_residues
SDLVKVTLPDGSQKEAPRGTPVIDFVKGQIGPGLAKAAYFARLDGEPVDLSRAIERDARLEIVTTRNPEALEVARHDAAH
VMASVVQKLYPGTQVTIGPAIEDGFYYDFARETPFTPEDLERIEKATNEAIKADLPFVRSEISMEAALALFEGMGERYKV
EIVKDIAAKGAKTLTLYKHGDWVDFCLGPHGPSTGRIGVVKLLNVAGAYWRGDAKNAMLQRIYGTAFFDKKELDAHLAKL
EEVKKRDHRRLGPQLGLFTFHEFAPGAPFWLPAGTVLYNVLEDAMRRLVLKNGYQEVKTPLLFNKRLWETSGHWGKYREN
MFLVVDSESDPALPLEDRCSFSLKPMNCPSHHLIYRMDKRSYRELPVRYFTTDALHRNEASGSLGGLTRVRQFEQDDAHI
YLREEQVTDEVLRIFELMKVVYGAFGLGFEATFSTRPEQRIGDDALWDRAEALLRKSLDATGLKWTLNAGDGAFYGPKID
MLVTDSLGRKWQTCTIQLDYAAPERFDLTFVGEDNKEHRPVVIHRAIYGSFERFVAILVEHYAGAFPAWLAPVQARVVTV
SDRFEAWAREAGEALQARGWRVEVDASSDKLGAKIRNAQLAKIPFTLVVGEKEVEAKGVSPRRHGGEDLKTMPLETFAEL
MAREATAPF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=646, Percent_Identity=41.9504643962848, Blast_Score=491, Evalue=1e-138,
Organism=Homo sapiens, GI38570111, Length=649, Percent_Identity=40.9861325115562, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI20070344, Length=629, Percent_Identity=40.8585055643879, Blast_Score=443, Evalue=1e-124,
Organism=Escherichia coli, GI1788013, Length=640, Percent_Identity=43.90625, Blast_Score=549, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71984184, Length=628, Percent_Identity=40.7643312101911, Blast_Score=490, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71984192, Length=628, Percent_Identity=40.7643312101911, Blast_Score=490, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322112, Length=640, Percent_Identity=42.1875, Blast_Score=504, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322654, Length=394, Percent_Identity=40.6091370558376, Blast_Score=303, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24583842, Length=621, Percent_Identity=41.0628019323672, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI28574141, Length=621, Percent_Identity=41.0628019323672, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24583839, Length=621, Percent_Identity=41.0628019323672, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_ANAD2 (B8J823)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492388.1
- ProteinModelPortal:   B8J823
- SMR:   B8J823
- GeneID:   7296637
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1981
- HOGENOM:   HBG352811
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73040; Mature: 72909

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLVKVTLPDGSQKEAPRGTPVIDFVKGQIGPGLAKAAYFARLDGEPVDLSRAIERDAR
CCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCE
LEIVTTRNPEALEVARHDAAHVMASVVQKLYPGTQVTIGPAIEDGFYYDFARETPFTPED
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHH
LERIEKATNEAIKADLPFVRSEISMEAALALFEGMGERYKVEIVKDIAAKGAKTLTLYKH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCEEEEEEEC
GDWVDFCLGPHGPSTGRIGVVKLLNVAGAYWRGDAKNAMLQRIYGTAFFDKKELDAHLAK
CCEEEEEECCCCCCCCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
LEEVKKRDHRRLGPQLGLFTFHEFAPGAPFWLPAGTVLYNVLEDAMRRLVLKNGYQEVKT
HHHHHHHHHHHCCCCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCC
PLLFNKRLWETSGHWGKYRENMFLVVDSESDPALPLEDRCSFSLKPMNCPSHHLIYRMDK
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCEEEEECC
RSYRELPVRYFTTDALHRNEASGSLGGLTRVRQFEQDDAHIYLREEQVTDEVLRIFELMK
HHHHHCCEEEEEHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
VVYGAFGLGFEATFSTRPEQRIGDDALWDRAEALLRKSLDATGLKWTLNAGDGAFYGPKI
HHHHHHCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCEE
DMLVTDSLGRKWQTCTIQLDYAAPERFDLTFVGEDNKEHRPVVIHRAIYGSFERFVAILV
EEEEECCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEHHHHCCHHHHHHHHH
EHYAGAFPAWLAPVQARVVTVSDRFEAWAREAGEALQARGWRVEVDASSDKLGAKIRNAQ
HHHCCCCHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCE
LAKIPFTLVVGEKEVEAKGVSPRRHGGEDLKTMPLETFAELMAREATAPF
EEECCEEEEECCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDLVKVTLPDGSQKEAPRGTPVIDFVKGQIGPGLAKAAYFARLDGEPVDLSRAIERDAR
CCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCE
LEIVTTRNPEALEVARHDAAHVMASVVQKLYPGTQVTIGPAIEDGFYYDFARETPFTPED
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCCCCCCHHH
LERIEKATNEAIKADLPFVRSEISMEAALALFEGMGERYKVEIVKDIAAKGAKTLTLYKH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCEEEEEEEC
GDWVDFCLGPHGPSTGRIGVVKLLNVAGAYWRGDAKNAMLQRIYGTAFFDKKELDAHLAK
CCEEEEEECCCCCCCCCCHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
LEEVKKRDHRRLGPQLGLFTFHEFAPGAPFWLPAGTVLYNVLEDAMRRLVLKNGYQEVKT
HHHHHHHHHHHCCCCCCCEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCC
PLLFNKRLWETSGHWGKYRENMFLVVDSESDPALPLEDRCSFSLKPMNCPSHHLIYRMDK
CHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCEEEEECC
RSYRELPVRYFTTDALHRNEASGSLGGLTRVRQFEQDDAHIYLREEQVTDEVLRIFELMK
HHHHHCCEEEEEHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
VVYGAFGLGFEATFSTRPEQRIGDDALWDRAEALLRKSLDATGLKWTLNAGDGAFYGPKI
HHHHHHCCCEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCEE
DMLVTDSLGRKWQTCTIQLDYAAPERFDLTFVGEDNKEHRPVVIHRAIYGSFERFVAILV
EEEEECCCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCEEEEHHHHCCHHHHHHHHH
EHYAGAFPAWLAPVQARVVTVSDRFEAWAREAGEALQARGWRVEVDASSDKLGAKIRNAQ
HHHCCCCHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCE
LAKIPFTLVVGEKEVEAKGVSPRRHGGEDLKTMPLETFAELMAREATAPF
EEECCEEEEECCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA