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The map label for this gene is pgsA2 [H]

Identifier: 220917083

GI number: 220917083

Start: 2235017

End: 2235631

Strand: Direct

Name: pgsA2 [H]

Synonym: A2cp1_1980

Alternate gene names: 220917083

Gene position: 2235017-2235631 (Clockwise)

Preceding gene: 220917082

Following gene: 220917084

Centisome position: 44.44

GC content: 78.05

Gene sequence:

>615_bases
GTGAGCGTCCCGCCCCCGCGCCCGCTCGACGACGAGCCCCGCCCGGCCGAGGACGAGGGCTCGCCGGTGAACCTCGCGAA
CGCGCTCACCGCGCTGCGCATCGCGCTCGCGCCCGCGTTCCTGGTCCTCTACGTGGGCGGCGACCGGCCCCGCGCGCTGG
CCGCGTTCGCGGCGGCGGCGGCGACCGACGTGCTCGACGGGCTGGTGGCGCGCGCGCTCCGGCAGCGCACCCGGCTCGGC
GCGTTCCTCGATCCCATCGCCGACAAGTTCCTGGCCGCGTGCGCGCTGGTGGCGCTGGCCGCCACCGGCCGGCTGCCGGC
GTGGCTCCCGGCGCTGGTGGTGGCCCGCGACCTGGCGCAGCTCGCCGGCGCGGCGTTCCTGCGCACCGTCCACCGGGTCA
TCCCGGTCGCCCCCACCCGCATCGGCAAGTACGCCACCTTCGCGCTCGCCGCGACCGTGCTCACCGCGCTCGCCGGCGAC
TACGGCGGCTACCCGCGCCGCGCCGTCGAGCCGTACGTGGCCGCCCTGGGGCTGCTGGCGGCGCTGTGCGTGACGGTCTC
GTTCGCGCAGTACTTCCTGTTCTTCCTGCGCGCCGCGCGCGCGCCCGGCCGTTGA

Upstream 100 bases:

>100_bases
GGCCGCCGCGGTGGCGCGCGCCGACCCGGCCGCCGCGGCCGCCGGCCCGGTGCGGCGCTTCGTGGCGCTGCGCGCGCTGC
GCGACCGGGCGTGAGGCGTC

Downstream 100 bases:

>100_bases
CACCGATTCCCGTTCGGCTATAACCGCGCCTCATCGAAGGGCGCGTGGCTCAGTGGTAGAGCACCTGCTTGACACGCAGG
GGGTCGCTGGTTCGATCCCA

Product: CDP-alcohol phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSVPPPRPLDDEPRPAEDEGSPVNLANALTALRIALAPAFLVLYVGGDRPRALAAFAAAAATDVLDGLVARALRQRTRLG
AFLDPIADKFLAACALVALAATGRLPAWLPALVVARDLAQLAGAAFLRTVHRVIPVAPTRIGKYATFALAATVLTALAGD
YGGYPRRAVEPYVAALGLLAALCVTVSFAQYFLFFLRAARAPGR

Sequences:

>Translated_204_residues
MSVPPPRPLDDEPRPAEDEGSPVNLANALTALRIALAPAFLVLYVGGDRPRALAAFAAAAATDVLDGLVARALRQRTRLG
AFLDPIADKFLAACALVALAATGRLPAWLPALVVARDLAQLAGAAFLRTVHRVIPVAPTRIGKYATFALAATVLTALAGD
YGGYPRRAVEPYVAALGLLAALCVTVSFAQYFLFFLRAARAPGR
>Mature_203_residues
SVPPPRPLDDEPRPAEDEGSPVNLANALTALRIALAPAFLVLYVGGDRPRALAAFAAAAATDVLDGLVARALRQRTRLGA
FLDPIADKFLAACALVALAATGRLPAWLPALVVARDLAQLAGAAFLRTVHRVIPVAPTRIGKYATFALAATVLTALAGDY
GGYPRRAVEPYVAALGLLAALCVTVSFAQYFLFFLRAARAPGR

Specific function: This Protein Catalyzes The Committed Step To The Synthesis Of The Acidic Phospholipids. [C]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=125, Percent_Identity=36.8, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI10092647, Length=125, Percent_Identity=36.8, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1788220, Length=185, Percent_Identity=36.7567567567568, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71984838, Length=201, Percent_Identity=26.3681592039801, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71984834, Length=201, Percent_Identity=26.3681592039801, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24650130, Length=118, Percent_Identity=38.9830508474576, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650126, Length=118, Percent_Identity=38.9830508474576, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650128, Length=118, Percent_Identity=38.9830508474576, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21356; Mature: 21225

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPPPRPLDDEPRPAEDEGSPVNLANALTALRIALAPAFLVLYVGGDRPRALAAFAAAA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ATDVLDGLVARALRQRTRLGAFLDPIADKFLAACALVALAATGRLPAWLPALVVARDLAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LAGAAFLRTVHRVIPVAPTRIGKYATFALAATVLTALAGDYGGYPRRAVEPYVAALGLLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALCVTVSFAQYFLFFLRAARAPGR
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVPPPRPLDDEPRPAEDEGSPVNLANALTALRIALAPAFLVLYVGGDRPRALAAFAAAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ATDVLDGLVARALRQRTRLGAFLDPIADKFLAACALVALAATGRLPAWLPALVVARDLAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LAGAAFLRTVHRVIPVAPTRIGKYATFALAATVLTALAGDYGGYPRRAVEPYVAALGLLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALCVTVSFAQYFLFFLRAARAPGR
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036; 10889206 [H]