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The map label for this gene is trxA [H]

Identifier: 220916850

GI number: 220916850

Start: 1950498

End: 1950830

Strand: Direct

Name: trxA [H]

Synonym: A2cp1_1746

Alternate gene names: 220916850

Gene position: 1950498-1950830 (Clockwise)

Preceding gene: 220916849

Following gene: 220916851

Centisome position: 38.78

GC content: 76.28

Gene sequence:

>333_bases
ATGGCGAGCGGCGTGATGGACATCGGGGACGCGGAGTTCGAGCGCGAGGTGCTGAGCGCGGCCGAGCCGGTGCTGGTGGA
GTTCACCGCGGCGTGGTGCGCGCCCTGCAGGGCGCTCGCGCCCACGCTGGAGGCGCTCGCGAGCGGCTACCGCGGCCGCG
TGAAGGTCGCGGCGCTCGACGTGGAGCGGCACCCGGCCACCGCCGAGCGGTACGGGATCCGCGCGATGCCCACGCTGCTC
TTCTTCAAGGGCGGCGCGGTGGCCCGGCAGCTCGTCGGCGCGGTGCCGCGCGCGCGCCTCGAGGACGTGGTGCGCGAGCT
GCTGCCGCGGTAG

Upstream 100 bases:

>100_bases
AGCGTTCCGGCGCGGCCGGTCGCCCCGGCGCGCCGCCGCGGGTAGATCCGGTCCGCGCGGCGGCCGGGCACTCCGCCCGG
CGGCGCGGGCGGAGGCGGCC

Downstream 100 bases:

>100_bases
GCGGGCGCACGGCCGGGTGGGAGCCCGAACCACCTCCCGCGCCGGGCGCGGGCCTGCGCGCGCCGGCGCAGGTCGGCGCT
TCCGACGCCGGCGCCCGGAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MASGVMDIGDAEFEREVLSAAEPVLVEFTAAWCAPCRALAPTLEALASGYRGRVKVAALDVERHPATAERYGIRAMPTLL
FFKGGAVARQLVGAVPRARLEDVVRELLPR

Sequences:

>Translated_110_residues
MASGVMDIGDAEFEREVLSAAEPVLVEFTAAWCAPCRALAPTLEALASGYRGRVKVAALDVERHPATAERYGIRAMPTLL
FFKGGAVARQLVGAVPRARLEDVVRELLPR
>Mature_109_residues
ASGVMDIGDAEFEREVLSAAEPVLVEFTAAWCAPCRALAPTLEALASGYRGRVKVAALDVERHPATAERYGIRAMPTLLF
FKGGAVARQLVGAVPRARLEDVVRELLPR

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=35.0515463917526, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=35, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=88, Percent_Identity=37.5, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=41.3461538461538, Blast_Score=105, Evalue=9e-25,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=37.6344086021505, Blast_Score=80, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI212646193, Length=105, Percent_Identity=37.1428571428571, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17510299, Length=104, Percent_Identity=40.3846153846154, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=41.9753086419753, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17549970, Length=82, Percent_Identity=40.2439024390244, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=39.0804597701149, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=85, Percent_Identity=34.1176470588235, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=38.5416666666667, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=37.6623376623377, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=45.0704225352113, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=31.1827956989247, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583090, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=37.8048780487805, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358065, Length=82, Percent_Identity=32.9268292682927, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11864; Mature: 11733

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGVMDIGDAEFEREVLSAAEPVLVEFTAAWCAPCRALAPTLEALASGYRGRVKVAALD
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VERHPATAERYGIRAMPTLLFFKGGAVARQLVGAVPRARLEDVVRELLPR
CCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASGVMDIGDAEFEREVLSAAEPVLVEFTAAWCAPCRALAPTLEALASGYRGRVKVAALD
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEE
VERHPATAERYGIRAMPTLLFFKGGAVARQLVGAVPRARLEDVVRELLPR
CCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9795152; 10671452; 12000953 [H]