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The map label for this gene is nqo13 [H]

Identifier: 220916475

GI number: 220916475

Start: 1533815

End: 1535464

Strand: Reverse

Name: nqo13 [H]

Synonym: A2cp1_1369

Alternate gene names: 220916475

Gene position: 1535464-1533815 (Counterclockwise)

Preceding gene: 220916476

Following gene: 220916474

Centisome position: 30.53

GC content: 65.21

Gene sequence:

>1650_bases
ATGTTCACGCCAGGAAACGTCCTCAGCTGGGCCACCTTCTTCCCGGTCATCGGGTCGGCGCTCATCGTCGTCCTGCTGGC
CGCGAAGTTCTTCCTCCGCCTCGACAAGAAGCTCGTCGACGACGGCTCCCGCTGGATCGCGCTCGTGACGAGCGCGCTCT
CCTTCGCGGCGGCCATCGCCGCGTGGCGCATGTACGACCCGTCGGCCACGGGCGTGCAGCTGGTCCAGCACTTCACCTGG
ATCCGCGCGTTCAACATCGAGTTCTACGTCGGGGTCGACGGCATCTCGATCTCGATGGTGCTGCTGTCCGGCCTCATCTC
CTTCATCGCCACCATCGCGTCGATGCCGTGGTGGTCGGGGAAGAAGGACGCCGAGATGGCCGGCATGGTGGACCACGGCC
ATGACGACCCGCACCACCCCAAGCACTTCTCGGTGCGGATGGTGCCGGGCTACATGGCCATGCTGCTGCTGCTGCAGACC
GGCATGATGGGCACGTTCGTCGCCCTCGACATGTTCCTGTTCTACGTGTTCTGGGAGGTCATGCTCCTGCCGATGTACTT
CCTCATCGGCATCTGGGGCGGGCCGCGCAAGGAGTACGCGGCGATCAAGTTCTTCCTCTACACCCTCGCCGGCTCCGTGC
TGATGCTCCTCGCGATCATCGGCATCTACTACAACAGCGCGCCGGCGCAGCTCGCCGACGGCTCGTGGTCGAGCGGCCAC
ACCTTCAACCTGATCGAGCTCGCGAAGCAGGGCGCGGCCGGGCAGTTCCGCAACGCCGCCCCCATCCTCGGCTTCTCGTT
CGCGAAGATCGTCTTCATCGGCCTGTTCATCGGGTTCGCCATCAAGATCCCGATGTTCCCGTTCCACACCTGGTTGCCCG
ACGCGCACGTCGAGGCGCCCACGCCCATCTCCGTCATCCTGGCCGGCGTGCTCCTGAAGATGGGCATCTACGGCATCCTG
CGCTTCAACTACGGGATCCTCCCCGACGCGACCGCCTGGGCGGCCGGCGGGATCGCGGTGTTCGGCGTCATCAACATCAT
CTACGCGGCGTTCGTCTGCCTCGCGCAGAAGGACCTGAAGAAGCTCATCGCGTACTCCTCCGTCTCGCACATGGGCTTCT
CGCTGCTCGGCATGGCGGCCATGACGCCCCAGGGCATCTCCGGCGCGGTGCTGAACCTCTTCACCCACGGCATCATCAGC
CCGATGCTGTTCCTCATCGTGGGCGTGATCTACGACCGCGCCCACCACCGCGAGATCGAGAAGTTCGGCGGCCTGGCCCA
GGAGCTGCCCGAGTACAGCGCCATCATGGGCCTCGCGTTCTTCGCCTCCCTGGGCCTGCCCGGCCTGGCCGGCTTCATCT
CCGAGTTCACGGTGTTCTCGGGCGCGTTCCCGGTGTTCACCACCTACACGATCATCTCGGCCACCAGCGTCGTCCTGACC
GCCGCGTACTACCTGTGGGCGATCCACCGGATGTTCCTGGGCAAGCTGAACCCGGTCTACAAGGGCTACCCGGACCTGAA
CTGGCGCGAGCGCATGTCGCTGTACCCGCTCGCGGTCATCTGCATCTACCTGGGCTTCTACCCGCAGGCGATCCTGGGCG
TCATCAACCCGGCCCTGCACGCCCTCATCCAGAACATCAAGCCGCTGTAG

Upstream 100 bases:

>100_bases
GACCGGCAAGGTCCAGACCTACCTGTACGGCGCGCTCGGGGGCGCGCTGGTGGTGGTCCTGCTCAACTTCCTCATCTCGT
AGCAACCGGGAGAGCGCGTC

Downstream 100 bases:

>100_bases
GCCCGAGGGGCGACGCATGACGGACCTCATCCCACTGGTCGAAGAGAACCTGCGCTCCACCGCGTGGTTCCGCCCCGAGG
CGGCCCTCACGGTGGGCGCG

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 13; NDH-1, chain 13 [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MFTPGNVLSWATFFPVIGSALIVVLLAAKFFLRLDKKLVDDGSRWIALVTSALSFAAAIAAWRMYDPSATGVQLVQHFTW
IRAFNIEFYVGVDGISISMVLLSGLISFIATIASMPWWSGKKDAEMAGMVDHGHDDPHHPKHFSVRMVPGYMAMLLLLQT
GMMGTFVALDMFLFYVFWEVMLLPMYFLIGIWGGPRKEYAAIKFFLYTLAGSVLMLLAIIGIYYNSAPAQLADGSWSSGH
TFNLIELAKQGAAGQFRNAAPILGFSFAKIVFIGLFIGFAIKIPMFPFHTWLPDAHVEAPTPISVILAGVLLKMGIYGIL
RFNYGILPDATAWAAGGIAVFGVINIIYAAFVCLAQKDLKKLIAYSSVSHMGFSLLGMAAMTPQGISGAVLNLFTHGIIS
PMLFLIVGVIYDRAHHREIEKFGGLAQELPEYSAIMGLAFFASLGLPGLAGFISEFTVFSGAFPVFTTYTIISATSVVLT
AAYYLWAIHRMFLGKLNPVYKGYPDLNWRERMSLYPLAVICIYLGFYPQAILGVINPALHALIQNIKPL

Sequences:

>Translated_549_residues
MFTPGNVLSWATFFPVIGSALIVVLLAAKFFLRLDKKLVDDGSRWIALVTSALSFAAAIAAWRMYDPSATGVQLVQHFTW
IRAFNIEFYVGVDGISISMVLLSGLISFIATIASMPWWSGKKDAEMAGMVDHGHDDPHHPKHFSVRMVPGYMAMLLLLQT
GMMGTFVALDMFLFYVFWEVMLLPMYFLIGIWGGPRKEYAAIKFFLYTLAGSVLMLLAIIGIYYNSAPAQLADGSWSSGH
TFNLIELAKQGAAGQFRNAAPILGFSFAKIVFIGLFIGFAIKIPMFPFHTWLPDAHVEAPTPISVILAGVLLKMGIYGIL
RFNYGILPDATAWAAGGIAVFGVINIIYAAFVCLAQKDLKKLIAYSSVSHMGFSLLGMAAMTPQGISGAVLNLFTHGIIS
PMLFLIVGVIYDRAHHREIEKFGGLAQELPEYSAIMGLAFFASLGLPGLAGFISEFTVFSGAFPVFTTYTIISATSVVLT
AAYYLWAIHRMFLGKLNPVYKGYPDLNWRERMSLYPLAVICIYLGFYPQAILGVINPALHALIQNIKPL
>Mature_549_residues
MFTPGNVLSWATFFPVIGSALIVVLLAAKFFLRLDKKLVDDGSRWIALVTSALSFAAAIAAWRMYDPSATGVQLVQHFTW
IRAFNIEFYVGVDGISISMVLLSGLISFIATIASMPWWSGKKDAEMAGMVDHGHDDPHHPKHFSVRMVPGYMAMLLLLQT
GMMGTFVALDMFLFYVFWEVMLLPMYFLIGIWGGPRKEYAAIKFFLYTLAGSVLMLLAIIGIYYNSAPAQLADGSWSSGH
TFNLIELAKQGAAGQFRNAAPILGFSFAKIVFIGLFIGFAIKIPMFPFHTWLPDAHVEAPTPISVILAGVLLKMGIYGIL
RFNYGILPDATAWAAGGIAVFGVINIIYAAFVCLAQKDLKKLIAYSSVSHMGFSLLGMAAMTPQGISGAVLNLFTHGIIS
PMLFLIVGVIYDRAHHREIEKFGGLAQELPEYSAIMGLAFFASLGLPGLAGFISEFTVFSGAFPVFTTYTIISATSVVLT
AAYYLWAIHRMFLGKLNPVYKGYPDLNWRERMSLYPLAVICIYLGFYPQAILGVINPALHALIQNIKPL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=337, Percent_Identity=33.2344213649852, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI251831117, Length=258, Percent_Identity=29.0697674418605, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788613, Length=520, Percent_Identity=36.7307692307692, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1788827, Length=317, Percent_Identity=29.0220820189274, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788831, Length=367, Percent_Identity=28.0653950953678, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788614, Length=436, Percent_Identity=27.5229357798165, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788829, Length=380, Percent_Identity=24.2105263157895, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI145693160, Length=376, Percent_Identity=24.2021276595745, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367154, Length=259, Percent_Identity=25.4826254826255, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 60253; Mature: 60253

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTPGNVLSWATFFPVIGSALIVVLLAAKFFLRLDKKLVDDGSRWIALVTSALSFAAAIA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AWRMYDPSATGVQLVQHFTWIRAFNIEFYVGVDGISISMVLLSGLISFIATIASMPWWSG
HHHCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KKDAEMAGMVDHGHDDPHHPKHFSVRMVPGYMAMLLLLQTGMMGTFVALDMFLFYVFWEV
CCCCHHHCCHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
MLLPMYFLIGIWGGPRKEYAAIKFFLYTLAGSVLMLLAIIGIYYNSAPAQLADGSWSSGH
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TFNLIELAKQGAAGQFRNAAPILGFSFAKIVFIGLFIGFAIKIPMFPFHTWLPDAHVEAP
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
TPISVILAGVLLKMGIYGILRFNYGILPDATAWAAGGIAVFGVINIIYAAFVCLAQKDLK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KLIAYSSVSHMGFSLLGMAAMTPQGISGAVLNLFTHGIISPMLFLIVGVIYDRAHHREIE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFGGLAQELPEYSAIMGLAFFASLGLPGLAGFISEFTVFSGAFPVFTTYTIISATSVVLT
HHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AAYYLWAIHRMFLGKLNPVYKGYPDLNWRERMSLYPLAVICIYLGFYPQAILGVINPALH
HHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIQNIKPL
HHHHHCCCC
>Mature Secondary Structure
MFTPGNVLSWATFFPVIGSALIVVLLAAKFFLRLDKKLVDDGSRWIALVTSALSFAAAIA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
AWRMYDPSATGVQLVQHFTWIRAFNIEFYVGVDGISISMVLLSGLISFIATIASMPWWSG
HHHCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCC
KKDAEMAGMVDHGHDDPHHPKHFSVRMVPGYMAMLLLLQTGMMGTFVALDMFLFYVFWEV
CCCCHHHCCHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
MLLPMYFLIGIWGGPRKEYAAIKFFLYTLAGSVLMLLAIIGIYYNSAPAQLADGSWSSGH
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TFNLIELAKQGAAGQFRNAAPILGFSFAKIVFIGLFIGFAIKIPMFPFHTWLPDAHVEAP
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
TPISVILAGVLLKMGIYGILRFNYGILPDATAWAAGGIAVFGVINIIYAAFVCLAQKDLK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
KLIAYSSVSHMGFSLLGMAAMTPQGISGAVLNLFTHGIISPMLFLIVGVIYDRAHHREIE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFGGLAQELPEYSAIMGLAFFASLGLPGLAGFISEFTVFSGAFPVFTTYTIISATSVVLT
HHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AAYYLWAIHRMFLGKLNPVYKGYPDLNWRERMSLYPLAVICIYLGFYPQAILGVINPALH
HHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIQNIKPL
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]