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The map label for this gene is nuoL [H]

Identifier: 220916476

GI number: 220916476

Start: 1535483

End: 1537954

Strand: Reverse

Name: nuoL [H]

Synonym: A2cp1_1370

Alternate gene names: 220916476

Gene position: 1537954-1535483 (Counterclockwise)

Preceding gene: 220916477

Following gene: 220916475

Centisome position: 30.58

GC content: 68.69

Gene sequence:

>2472_bases
ATGCACGAGACCGCTCACGAGCTCGGCCGGATCGCCGTCACGAACGTCGGCTATCTCTGGCTCATCCCGCTGTTCCCGCT
CATCGGCGCGACCATCAACGCGCTGATCGGCTGGAAGCTGCAGCAGCTGTTCGGGAGGAAGATCGTCCACCGCATCGCGG
TGACCGCGATGTTCGCCGCCTTCGGGGTGGCGCTGGTCGCGTTCTCCCAGATGCTGCGGCTCCCCTCCGAGGAGCGCTTC
CTCCAGGACACGCTCTGGAACCTGATGACCGCCGGGCGGCTGACGGTGGACTTCGGGTTCGCGCTCGACCCGCTCTCCAT
GATGATGGTGCTGGTCATCACCGGGATCGGCTCGCTCATCCACGTCTTCTCCATCGGGTACATGCACGACGAGCCGTCGT
ACTGGCGGTTCTTCAGCTACCTGAACCTGTTCGTCTTCGCGATGTTGCTCCTGGTGATGGGCGACAACTTCGCGGTGATG
TTCTTCGGGTGGGAGGGCGTGGGCCTCGCCTCGTACCTGCTCATCAGCTTCTGGTACACGGACCCCGAGAAGGCGAAGGC
CGGCATGAAGGCCTTCGTGGCGAACCGCTTCGGCGACTTCGGCTTCCTGGCCGGCCTGTTCCTCCTGTTCTGGGCCCTGG
GCGGCGCGTGGACGCCGCGGACCGGCAGCGGGCTGCGGAACAACGACTACCAGCCCATCGCCGAGCTGAACGCCACCGCC
GCCGCGGCCACCCCCGCGCAGGCGCACGCGCTCGCCCCGGCCGTCCACGACGTGAAGGTCGGCCCCACCATGAACTTCCG
CGAGCTGCGGGATCAGGTGGTGATCGACTCGACCGGCGTGAAGGAGCACCTGGCCGGCTCGAGCATCTGGGGCGTCTCGC
TCCTGACGCTGGTCTGCATCCTCCTGTTCGTCGGCGCGATGGGCAAGAGCGCCCAGATCCCGCTCTACGTCTGGCTCCCC
GACGCGATGGCCGGCCCGACGCCGGTCTCCGCCCTCATCCACGCCGCCACCATGGTGACCGCGGGCGTGTACATGGTGGC
GCGCCTCAACTTCCTGTTCGCGCTCTCGCCGAGCGCGATGGGCTGGGTGGCGCTCATCGGCGCCGCGACCGCGATCTTCG
CCGCGTCGATCGGCTTCTTCCAGTACGACATCAAGAAGGTCCTCGCCTACTCCACCGTCTCCCAGCTCGGCTTCATGTTC
ATCGGGGTCGGCGTGGGCGCGTACTGGGCCGGCGCGTACCACCTGCTCACCCACGCGTTCTTCAAGGCCACGCTGTTCCT
CGGCTCCGGCTCGGTGATCCTCGGCTGCCACCACGAGCAGGACATGCGGAAGATGGGCGGGCTGAAGAAGCACATGCCCA
TCACGCGCTGGACCTACCTCGCGGCGTGCTGGGCCATCGCCGGCTTCCCGTGGATGAACGGCTTCTACTCGAAGGACGAG
ATCCTCTACAAGGCGTTCACCAGCGGGCACCTGGCGCTGTTCGGCGTGCCCACCCCGTGGCTCGGGCCGGCCATCTTCCT
GGTCGGCATCGTCGCCGCGACCGGCACCAGCTTCTACATGTTCCGGTCGTACTACATGACGTTCACCGGCGAGTACCGCG
GGAACGCCGGGCACCACGACGAGCACAACGAGGATCCGCACGCCGCCGGCGCCGCCGCCATGTCGCACCTCTCGGTCTCG
GTCCACGCGTCCGACGGCGCGGTCCACGCCGACGGCCACGCGCACGGCCACGCCGCCCCGGCCCACGGCCACGCGGTCCA
CGCCCCGGCCGCCGCCGCGGCCACGGCGCACGCGCCGGCGCACGACGACCACGGCCACCACGGCGGCACGCCGCACGAGT
CGCCCTGGACCGTCACCCTGGTCCTCTCGCTGCTCGCGCTCGGCTCCTTCCTCACGCTGTTCCTGGGCATCCCCATGGCC
TGGACCGGCAAGGCGCCCATCCTCGAGCACTGGCTCGCGCCCGCGCTGACCGCGCAGGAGGGCGTGCCGTTCCAGCACCT
GTCGCACTCCACCGAGTACATGTTCCAGGCGATCGGCGTGCTGGCCGGCGCGGTCGGCTGGTTCTTCGCGATGGTGCTGT
TCAAGGACGCGAAGAGCGAGGTCCCGGCGCGGCTGCGCGACAGGTTCCTCGGCGTCTGGACGGTCGTCTACAACAAGTAC
TACGTGGACGAGCTGTACGCGGTCGCCGTCCTGAAGCCCTCGATGAAGGTCGCGCAGGCCGCGTCCTGGTTCGACTCGAA
CGTGATCGACCGCCTGGTGCTGCTGGCCGGCACGGTCACCCGCGTGGTCGCGAATCTCGACGGCGCCATCGACAAGTACC
TCGTCGACGGCGCGGTGAACGCCGTCGCCAGCGTCACGCAGGAGTGCGGCCGGTACCTCCGCTCGCTCCAGACCGGCAAG
GTCCAGACCTACCTGTACGGCGCGCTCGGGGGCGCGCTGGTGGTGGTCCTGCTCAACTTCCTCATCTCGTAG

Upstream 100 bases:

>100_bases
CGCGGCCGAGGCGGCGGTGGGCCTCGCCATCGTCCTGGCCATCTTCCAGACGTTCAAGACCATCGACGTCCGCGCCGCGG
ACCTGATGCGGGAGTAGCCG

Downstream 100 bases:

>100_bases
CAACCGGGAGAGCGCGTCATGTTCACGCCAGGAAACGTCCTCAGCTGGGCCACCTTCTTCCCGGTCATCGGGTCGGCGCT
CATCGTCGTCCTGCTGGCCG

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 823; Mature: 823

Protein sequence:

>823_residues
MHETAHELGRIAVTNVGYLWLIPLFPLIGATINALIGWKLQQLFGRKIVHRIAVTAMFAAFGVALVAFSQMLRLPSEERF
LQDTLWNLMTAGRLTVDFGFALDPLSMMMVLVITGIGSLIHVFSIGYMHDEPSYWRFFSYLNLFVFAMLLLVMGDNFAVM
FFGWEGVGLASYLLISFWYTDPEKAKAGMKAFVANRFGDFGFLAGLFLLFWALGGAWTPRTGSGLRNNDYQPIAELNATA
AAATPAQAHALAPAVHDVKVGPTMNFRELRDQVVIDSTGVKEHLAGSSIWGVSLLTLVCILLFVGAMGKSAQIPLYVWLP
DAMAGPTPVSALIHAATMVTAGVYMVARLNFLFALSPSAMGWVALIGAATAIFAASIGFFQYDIKKVLAYSTVSQLGFMF
IGVGVGAYWAGAYHLLTHAFFKATLFLGSGSVILGCHHEQDMRKMGGLKKHMPITRWTYLAACWAIAGFPWMNGFYSKDE
ILYKAFTSGHLALFGVPTPWLGPAIFLVGIVAATGTSFYMFRSYYMTFTGEYRGNAGHHDEHNEDPHAAGAAAMSHLSVS
VHASDGAVHADGHAHGHAAPAHGHAVHAPAAAAATAHAPAHDDHGHHGGTPHESPWTVTLVLSLLALGSFLTLFLGIPMA
WTGKAPILEHWLAPALTAQEGVPFQHLSHSTEYMFQAIGVLAGAVGWFFAMVLFKDAKSEVPARLRDRFLGVWTVVYNKY
YVDELYAVAVLKPSMKVAQAASWFDSNVIDRLVLLAGTVTRVVANLDGAIDKYLVDGAVNAVASVTQECGRYLRSLQTGK
VQTYLYGALGGALVVVLLNFLIS

Sequences:

>Translated_823_residues
MHETAHELGRIAVTNVGYLWLIPLFPLIGATINALIGWKLQQLFGRKIVHRIAVTAMFAAFGVALVAFSQMLRLPSEERF
LQDTLWNLMTAGRLTVDFGFALDPLSMMMVLVITGIGSLIHVFSIGYMHDEPSYWRFFSYLNLFVFAMLLLVMGDNFAVM
FFGWEGVGLASYLLISFWYTDPEKAKAGMKAFVANRFGDFGFLAGLFLLFWALGGAWTPRTGSGLRNNDYQPIAELNATA
AAATPAQAHALAPAVHDVKVGPTMNFRELRDQVVIDSTGVKEHLAGSSIWGVSLLTLVCILLFVGAMGKSAQIPLYVWLP
DAMAGPTPVSALIHAATMVTAGVYMVARLNFLFALSPSAMGWVALIGAATAIFAASIGFFQYDIKKVLAYSTVSQLGFMF
IGVGVGAYWAGAYHLLTHAFFKATLFLGSGSVILGCHHEQDMRKMGGLKKHMPITRWTYLAACWAIAGFPWMNGFYSKDE
ILYKAFTSGHLALFGVPTPWLGPAIFLVGIVAATGTSFYMFRSYYMTFTGEYRGNAGHHDEHNEDPHAAGAAAMSHLSVS
VHASDGAVHADGHAHGHAAPAHGHAVHAPAAAAATAHAPAHDDHGHHGGTPHESPWTVTLVLSLLALGSFLTLFLGIPMA
WTGKAPILEHWLAPALTAQEGVPFQHLSHSTEYMFQAIGVLAGAVGWFFAMVLFKDAKSEVPARLRDRFLGVWTVVYNKY
YVDELYAVAVLKPSMKVAQAASWFDSNVIDRLVLLAGTVTRVVANLDGAIDKYLVDGAVNAVASVTQECGRYLRSLQTGK
VQTYLYGALGGALVVVLLNFLIS
>Mature_823_residues
MHETAHELGRIAVTNVGYLWLIPLFPLIGATINALIGWKLQQLFGRKIVHRIAVTAMFAAFGVALVAFSQMLRLPSEERF
LQDTLWNLMTAGRLTVDFGFALDPLSMMMVLVITGIGSLIHVFSIGYMHDEPSYWRFFSYLNLFVFAMLLLVMGDNFAVM
FFGWEGVGLASYLLISFWYTDPEKAKAGMKAFVANRFGDFGFLAGLFLLFWALGGAWTPRTGSGLRNNDYQPIAELNATA
AAATPAQAHALAPAVHDVKVGPTMNFRELRDQVVIDSTGVKEHLAGSSIWGVSLLTLVCILLFVGAMGKSAQIPLYVWLP
DAMAGPTPVSALIHAATMVTAGVYMVARLNFLFALSPSAMGWVALIGAATAIFAASIGFFQYDIKKVLAYSTVSQLGFMF
IGVGVGAYWAGAYHLLTHAFFKATLFLGSGSVILGCHHEQDMRKMGGLKKHMPITRWTYLAACWAIAGFPWMNGFYSKDE
ILYKAFTSGHLALFGVPTPWLGPAIFLVGIVAATGTSFYMFRSYYMTFTGEYRGNAGHHDEHNEDPHAAGAAAMSHLSVS
VHASDGAVHADGHAHGHAAPAHGHAVHAPAAAAATAHAPAHDDHGHHGGTPHESPWTVTLVLSLLALGSFLTLFLGIPMA
WTGKAPILEHWLAPALTAQEGVPFQHLSHSTEYMFQAIGVLAGAVGWFFAMVLFKDAKSEVPARLRDRFLGVWTVVYNKY
YVDELYAVAVLKPSMKVAQAASWFDSNVIDRLVLLAGTVTRVVANLDGAIDKYLVDGAVNAVASVTQECGRYLRSLQTGK
VQTYLYGALGGALVVVLLNFLIS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=236, Percent_Identity=42.7966101694915, Blast_Score=177, Evalue=3e-44,
Organism=Escherichia coli, GI1788614, Length=460, Percent_Identity=42.6086956521739, Blast_Score=338, Evalue=8e-94,
Organism=Escherichia coli, GI1788829, Length=188, Percent_Identity=35.6382978723404, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1788827, Length=270, Percent_Identity=32.962962962963, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1788831, Length=219, Percent_Identity=29.6803652968037, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI2367154, Length=251, Percent_Identity=30.2788844621514, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788613, Length=486, Percent_Identity=24.6913580246914, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 89151; Mature: 89151

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHETAHELGRIAVTNVGYLWLIPLFPLIGATINALIGWKLQQLFGRKIVHRIAVTAMFAA
CCCCHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGVALVAFSQMLRLPSEERFLQDTLWNLMTAGRLTVDFGFALDPLSMMMVLVITGIGSLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
HVFSIGYMHDEPSYWRFFSYLNLFVFAMLLLVMGDNFAVMFFGWEGVGLASYLLISFWYT
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCC
DPEKAKAGMKAFVANRFGDFGFLAGLFLLFWALGGAWTPRTGSGLRNNDYQPIAELNATA
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCHH
AAATPAQAHALAPAVHDVKVGPTMNFRELRDQVVIDSTGVKEHLAGSSIWGVSLLTLVCI
HCCCCHHHHHHCCCHHCEECCCCCCHHHHHHHEEECCCCCHHHHCCCCHHHHHHHHHHHH
LLFVGAMGKSAQIPLYVWLPDAMAGPTPVSALIHAATMVTAGVYMVARLNFLFALSPSAM
HHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHH
GWVALIGAATAIFAASIGFFQYDIKKVLAYSTVSQLGFMFIGVGVGAYWAGAYHLLTHAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKATLFLGSGSVILGCHHEQDMRKMGGLKKHMPITRWTYLAACWAIAGFPWMNGFYSKDE
HHHHHEECCCCEEEEECCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHH
ILYKAFTSGHLALFGVPTPWLGPAIFLVGIVAATGTSFYMFRSYYMTFTGEYRGNAGHHD
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCCC
EHNEDPHAAGAAAMSHLSVSVHASDGAVHADGHAHGHAAPAHGHAVHAPAAAAATAHAPA
CCCCCCCHHHHHHHHHCEEEEEECCCCEECCCCCCCCCCCCCCCEECCCHHHHHHCCCCC
HDDHGHHGGTPHESPWTVTLVLSLLALGSFLTLFLGIPMAWTGKAPILEHWLAPALTAQE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
GVPFQHLSHSTEYMFQAIGVLAGAVGWFFAMVLFKDAKSEVPARLRDRFLGVWTVVYNKY
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YVDELYAVAVLKPSMKVAQAASWFDSNVIDRLVLLAGTVTRVVANLDGAIDKYLVDGAVN
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVASVTQECGRYLRSLQTGKVQTYLYGALGGALVVVLLNFLIS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHETAHELGRIAVTNVGYLWLIPLFPLIGATINALIGWKLQQLFGRKIVHRIAVTAMFAA
CCCCHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGVALVAFSQMLRLPSEERFLQDTLWNLMTAGRLTVDFGFALDPLSMMMVLVITGIGSLI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
HVFSIGYMHDEPSYWRFFSYLNLFVFAMLLLVMGDNFAVMFFGWEGVGLASYLLISFWYT
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCC
DPEKAKAGMKAFVANRFGDFGFLAGLFLLFWALGGAWTPRTGSGLRNNDYQPIAELNATA
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCHH
AAATPAQAHALAPAVHDVKVGPTMNFRELRDQVVIDSTGVKEHLAGSSIWGVSLLTLVCI
HCCCCHHHHHHCCCHHCEECCCCCCHHHHHHHEEECCCCCHHHHCCCCHHHHHHHHHHHH
LLFVGAMGKSAQIPLYVWLPDAMAGPTPVSALIHAATMVTAGVYMVARLNFLFALSPSAM
HHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHH
GWVALIGAATAIFAASIGFFQYDIKKVLAYSTVSQLGFMFIGVGVGAYWAGAYHLLTHAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKATLFLGSGSVILGCHHEQDMRKMGGLKKHMPITRWTYLAACWAIAGFPWMNGFYSKDE
HHHHHEECCCCEEEEECCHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHH
ILYKAFTSGHLALFGVPTPWLGPAIFLVGIVAATGTSFYMFRSYYMTFTGEYRGNAGHHD
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCCC
EHNEDPHAAGAAAMSHLSVSVHASDGAVHADGHAHGHAAPAHGHAVHAPAAAAATAHAPA
CCCCCCCHHHHHHHHHCEEEEEECCCCEECCCCCCCCCCCCCCCEECCCHHHHHHCCCCC
HDDHGHHGGTPHESPWTVTLVLSLLALGSFLTLFLGIPMAWTGKAPILEHWLAPALTAQE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
GVPFQHLSHSTEYMFQAIGVLAGAVGWFFAMVLFKDAKSEVPARLRDRFLGVWTVVYNKY
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YVDELYAVAVLKPSMKVAQAASWFDSNVIDRLVLLAGTVTRVVANLDGAIDKYLVDGAVN
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVASVTQECGRYLRSLQTGKVQTYLYGALGGALVVVLLNFLIS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]