Click here to switch to the map view.

The map label for this gene is thyX [H]

Identifier: 220916374

GI number: 220916374

Start: 1422457

End: 1423278

Strand: Reverse

Name: thyX [H]

Synonym: A2cp1_1268

Alternate gene names: 220916374

Gene position: 1423278-1422457 (Counterclockwise)

Preceding gene: 220916377

Following gene: 220916373

Centisome position: 28.3

GC content: 68.13

Gene sequence:

>822_bases
ATGCCGCTCGAGGTCACCCTCATCGACTACGCCCGCGATCCGCTGCAGAAGCTCTACGGCGCGTACCGCACCTGCTACAC
GCCGAAGACGCCGGGCGAGGTCTGGGGCGAGATCCGCGACGGCTCCATCTCCGCGGACCGGATCCGCGACTTCATCGGCG
AGCGCCTCAAGACCGGCCACGCCTCGCCGCTCGAGCAGGTGGTGTTCTGGTTCGGCATCTCCGGCGTCTCGCGTGCGCTC
TCGCACCAGTTCGTCCGGCACCGGATCGGCATCAGCTTCGAGCAGCAGTCGCAGCGCTACGTGAAGTACAAGGAGGAGCG
GCTCGACTACGTCATGCCGAAGACCTGGCAGAAGGTCGCCGGGATGGCGGACGAGTACGACCGGCTCATGCGCGAGATCA
CCCGCGTGTACGAGGACGCGCTCGCGAAGGGCATCCCGGCCGAGGACGCGCGCTTCGTCCTCCCGAACGCCACGCCCACC
AACTTCCAGGTGATGGTGAACTTCACCGAGCTGCTGCACATCGCCGACCTGCGGCTGTGCTGGCGGGCCCAGTGGGAGAT
CCGCCACATGGTCGCGCTCATGCGGCGCGAGGTGATGAAGGCGGTCCCCGAGATCGGCGGCTACCTGCAGCCGAAGTGCG
GCGACAAGCGCATGGGGTACTGCGACGAGCCGGTGAAGGAGTGGGAGGCGTGCCCGCTCGGGAAGGTGCGCCCGCACAAG
GAGCAGCTCCTGCAGGTGTTCCGCGAGTACCGCGCCGGGAACCTGGTTCCGCTGGCGGAGGAGCACATCCGCGCCGTCGA
GGACGCCGGCAACGAGGAGTGA

Upstream 100 bases:

>100_bases
TTGGGAGCGGGCATGCGCCACCCTTAGCACGGGCCGCGGCGCCCCTCCCGCGCTGTCGTGGGTTCGTCGTAAGATGCGCG
CCCTTCCCCGGAGCCGATCC

Downstream 100 bases:

>100_bases
CATCGCGCCGCGTCCGCTTGGGGCCCGGCGCGCGGATGACCGCGGCGCCGCCCCCCGCGCGCGAGCGGCTCCGGTAGAAT
CCGCGCCGGAGCCACCATGA

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MPLEVTLIDYARDPLQKLYGAYRTCYTPKTPGEVWGEIRDGSISADRIRDFIGERLKTGHASPLEQVVFWFGISGVSRAL
SHQFVRHRIGISFEQQSQRYVKYKEERLDYVMPKTWQKVAGMADEYDRLMREITRVYEDALAKGIPAEDARFVLPNATPT
NFQVMVNFTELLHIADLRLCWRAQWEIRHMVALMRREVMKAVPEIGGYLQPKCGDKRMGYCDEPVKEWEACPLGKVRPHK
EQLLQVFREYRAGNLVPLAEEHIRAVEDAGNEE

Sequences:

>Translated_273_residues
MPLEVTLIDYARDPLQKLYGAYRTCYTPKTPGEVWGEIRDGSISADRIRDFIGERLKTGHASPLEQVVFWFGISGVSRAL
SHQFVRHRIGISFEQQSQRYVKYKEERLDYVMPKTWQKVAGMADEYDRLMREITRVYEDALAKGIPAEDARFVLPNATPT
NFQVMVNFTELLHIADLRLCWRAQWEIRHMVALMRREVMKAVPEIGGYLQPKCGDKRMGYCDEPVKEWEACPLGKVRPHK
EQLLQVFREYRAGNLVPLAEEHIRAVEDAGNEE
>Mature_272_residues
PLEVTLIDYARDPLQKLYGAYRTCYTPKTPGEVWGEIRDGSISADRIRDFIGERLKTGHASPLEQVVFWFGISGVSRALS
HQFVRHRIGISFEQQSQRYVKYKEERLDYVMPKTWQKVAGMADEYDRLMREITRVYEDALAKGIPAEDARFVLPNATPTN
FQVMVNFTELLHIADLRLCWRAQWEIRHMVALMRREVMKAVPEIGGYLQPKCGDKRMGYCDEPVKEWEACPLGKVRPHKE
QLLQVFREYRAGNLVPLAEEHIRAVEDAGNEE

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 31690; Mature: 31559

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLEVTLIDYARDPLQKLYGAYRTCYTPKTPGEVWGEIRDGSISADRIRDFIGERLKTGH
CCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
ASPLEQVVFWFGISGVSRALSHQFVRHRIGISFEQQSQRYVKYKEERLDYVMPKTWQKVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHC
GMADEYDRLMREITRVYEDALAKGIPAEDARFVLPNATPTNFQVMVNFTELLHIADLRLC
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHHHHHH
WRAQWEIRHMVALMRREVMKAVPEIGGYLQPKCGDKRMGYCDEPVKEWEACPLGKVRPHK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCH
EQLLQVFREYRAGNLVPLAEEHIRAVEDAGNEE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLEVTLIDYARDPLQKLYGAYRTCYTPKTPGEVWGEIRDGSISADRIRDFIGERLKTGH
CEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
ASPLEQVVFWFGISGVSRALSHQFVRHRIGISFEQQSQRYVKYKEERLDYVMPKTWQKVA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHC
GMADEYDRLMREITRVYEDALAKGIPAEDARFVLPNATPTNFQVMVNFTELLHIADLRLC
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEEHHHHHHHHHHHHHH
WRAQWEIRHMVALMRREVMKAVPEIGGYLQPKCGDKRMGYCDEPVKEWEACPLGKVRPHK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCH
EQLLQVFREYRAGNLVPLAEEHIRAVEDAGNEE
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA