Click here to switch to the map view.

The map label for this gene is sppA [H]

Identifier: 220916373

GI number: 220916373

Start: 1419856

End: 1422360

Strand: Reverse

Name: sppA [H]

Synonym: A2cp1_1267

Alternate gene names: 220916373

Gene position: 1422360-1419856 (Counterclockwise)

Preceding gene: 220916374

Following gene: 220916372

Centisome position: 28.28

GC content: 77.96

Gene sequence:

>2505_bases
ATGAAACCCTTCGTGAACCTCGCGGCGCTGGCGCTCGCGCTCGCCGCCCCCGCCGCCGCGCACGCCCAGCTCTCCGCCGT
CACCGACCGCGTGCAGGGCCTGCCCGCGGGCCTGGGGGTGCCCTCGCTCGGCGCGGCCGTCGCGGAGGAGCCCGCCGACC
TGTCCGCGAACCCGGCCGCGATCGGCTTCCTCGGCGGCCTGGGGCTCCAGTACTTCCACGAGTCCGGGCTGCGGCCCGGC
GCGCGGGGCGACGGCCTGTACGCGGGCGACCGCCTCGGCCCGCTCGGCGTGGGGTACTCGGTGGAGTGGCTCCGGCCCGG
CCTCGACGCGGGCGGCGAGCGCTGGCGGCGCAGCCGGCTGGGGCTCACGCTCGGCGACGGCCGCGCGCTCTCGCTGGGCG
TCGCCTGGACCTGGATCGCCTCGCGGAACGACGCGATCGAGCAGGCCGGCGGCTGGGACCTCGGGCTGACGCTGCGGCCC
ACGCGGTGGCTCTCGATCGGCGCCGCCATGCTGGGCCGCGACGCCCGGCTGGGCGGCGCGGACGTGCCGGTCCGCTACGA
CCTCGGGCTCGCGACCCGGCTCTGGCACGACCGGCTCACGCTCTCCGCCGACCTGCTCGCCGACGACGAGGCGCGCGACG
CGTTCCGCTCCGATCACCTCGCGTTCGGCGCCTCGGCCGAGCTGTGGCGCGGGGTGGCGCTCGGCCTCCAGGTGCAGCTC
CCGGTGCGCGACCTCCCCGGCGACGCCGGCGATCCGCTCGGGCTCGTGTCGCTCACCTGGAACGCGCCGCACTCCGGCGT
CACGTTCGCCGGGGCCGGCGTGGGCGGGCGCGGCGGGTGGCTGGGGGGCGTGCGCCTCTCGGAGGAGCGCTACCGCTCCG
GCGGCCCCGCGGTCGTCATGCCCACCGTGGACGTGGATCGCGAGCTCCAGCGCCGGCGCGTGCTCGTGTTCGACGTGGGC
GACCGGGATCCCTACGCCACGCTGGTCACGCGGCTGGAGGCGGCGCGCGACGATCCGGAGGTCGGGGCGCTGCTGGTGCG
CATCGGCGGCCTGTCGCTGGGCGGCGGGCGGGTCGAGGAGCTGCGCGCGCTGCTCGCCGCGGTGCGGGCCCGCAAGCCGG
TGCTCGCGTACCTGGAGGGCGGCGGGACCCGCGAGTACTGGCTCGCCACCGGCGCCACCGCCATCGCGGCGCCGCCCGGC
GCGCCGCTCATCGTGAACGGCATCTCCACCTCCCAGCTCTTCCTGCGCGGCGGGCTGGCGCGGCTCGGGATCGCGTTCGA
CGTGGTGAAGGCCGGCGCGTACAAGAGCGCCGCCGAGCCGCTGGTGCGCGACGCGCCCTCGCCCGAGGCGCGCGAGGCCA
CCGAGGCGGTCCTGGACGACGTGTTCGGGCGCTTCGTGGCCCAGGTCGCCGAGGCGCGGCGGCTGCCCCCCGAGCGCGTG
CGCGCGCTGGTGGACCAGGGGCTCTTCACCGCCGAGGAGGCGAAGGACGCGGGGCTCGTGGACGCGGTGGCCTGGCCCGA
CGAGCTCGAGCGCTGGGGGCGCGCCGTCGCCGGGCGCCGGCTGTTCGAGCGCGGCGCGTACCGGCCCGAGCCGGAGCGGC
TCGCGCAGCGATGGGGCCGGCCCGCGGTGATCCAGGTGGTGCGCGTGGAGGGGATCATCGCCCGCGGGAGGAGCCGTGCC
GACCCGCTCGGCGCGGACGGGGTGGCGGGCGCCGAGACCATCGCCGCCGAGATCCACCGCGCCGCCGACGACGCCGCGGT
CCGGGCCATCGTGCTGCGGATCGAGTCCGGCGGGGGCGATGGGCTGGCCTCCGACCTGATCTGGCGCGAGGCGGTCCGCG
CGCGGCGCAAGGGCAAGCCGGTGATCGCCTCGATGGGCGACCTGGCGGCGAGCGGCGGGTACCTGGTGGCGGTCGGCGCC
GACGCGATCCTCGCCGAGCGCTCCACGCTCACCGGCTCGATCGGCGTGTTCGCGGCGAAGCCCGACCTCTCCGGCCTGCT
CGCGAAGCTGTCGATCCACCCCGAGGCCTACCAGCGCGGCGAGAACGCCCGCCTGGTCTCGGTGCTGAAGCCCTGGACCC
CCGCCGAGCGCGCCGTCCTCGAGAAGCAGGTCGGGGCCTTCTACCGCCAGTTCGTGGCCCGCGTGGCCGAGGGGCGGCGG
CTCACCACGGCGGAGGTCGAGGCAGTCGCCGGCGGTCGGGTCTGGACCGGCCAGCAGGCGCTGGAGCGGCGGCTCGTGGA
TCGCATCGGCACGCTCGCCGACGCCATCCGGCTGGCGCGCGAGCGGATCGGCCTCGCGCCGGACGACGTGGTGGAGGTGC
GGCGGGAGGACGGCGGCGGCGCGCTCGCCCGCGTGGCCGGCCACGCCCTCACGGCGGCGCCCGAGCCGCCGCTCGCCGGG
CTCGCTCGCGCGTTCCCGGAGCTGTCCGCGCTGGCGCTGCTGACCGAGATCGGGCCGGTGCTCGCGATCCCGGAGGAGTG
GGTGGCTCCCGAGGCGGGCCCGTGA

Upstream 100 bases:

>100_bases
GTGACATCGCGCCGCGTCCGCTTGGGGCCCGGCGCGCGGATGACCGCGGCGCCGCCCCCCGCGCGCGAGCGGCTCCGGTA
GAATCCGCGCCGGAGCCACC

Downstream 100 bases:

>100_bases
TCGCGGGACCCTACCGGGCGCGGTCAGGGCTTTCGCTCCAGGATCTTTTTTGCTATGGATTCTCTTGTCTCCCCTCTGCG
AGCGACCTACGTTTCGAGGC

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 834; Mature: 834

Protein sequence:

>834_residues
MKPFVNLAALALALAAPAAAHAQLSAVTDRVQGLPAGLGVPSLGAAVAEEPADLSANPAAIGFLGGLGLQYFHESGLRPG
ARGDGLYAGDRLGPLGVGYSVEWLRPGLDAGGERWRRSRLGLTLGDGRALSLGVAWTWIASRNDAIEQAGGWDLGLTLRP
TRWLSIGAAMLGRDARLGGADVPVRYDLGLATRLWHDRLTLSADLLADDEARDAFRSDHLAFGASAELWRGVALGLQVQL
PVRDLPGDAGDPLGLVSLTWNAPHSGVTFAGAGVGGRGGWLGGVRLSEERYRSGGPAVVMPTVDVDRELQRRRVLVFDVG
DRDPYATLVTRLEAARDDPEVGALLVRIGGLSLGGGRVEELRALLAAVRARKPVLAYLEGGGTREYWLATGATAIAAPPG
APLIVNGISTSQLFLRGGLARLGIAFDVVKAGAYKSAAEPLVRDAPSPEAREATEAVLDDVFGRFVAQVAEARRLPPERV
RALVDQGLFTAEEAKDAGLVDAVAWPDELERWGRAVAGRRLFERGAYRPEPERLAQRWGRPAVIQVVRVEGIIARGRSRA
DPLGADGVAGAETIAAEIHRAADDAAVRAIVLRIESGGGDGLASDLIWREAVRARRKGKPVIASMGDLAASGGYLVAVGA
DAILAERSTLTGSIGVFAAKPDLSGLLAKLSIHPEAYQRGENARLVSVLKPWTPAERAVLEKQVGAFYRQFVARVAEGRR
LTTAEVEAVAGGRVWTGQQALERRLVDRIGTLADAIRLARERIGLAPDDVVEVRREDGGGALARVAGHALTAAPEPPLAG
LARAFPELSALALLTEIGPVLAIPEEWVAPEAGP

Sequences:

>Translated_834_residues
MKPFVNLAALALALAAPAAAHAQLSAVTDRVQGLPAGLGVPSLGAAVAEEPADLSANPAAIGFLGGLGLQYFHESGLRPG
ARGDGLYAGDRLGPLGVGYSVEWLRPGLDAGGERWRRSRLGLTLGDGRALSLGVAWTWIASRNDAIEQAGGWDLGLTLRP
TRWLSIGAAMLGRDARLGGADVPVRYDLGLATRLWHDRLTLSADLLADDEARDAFRSDHLAFGASAELWRGVALGLQVQL
PVRDLPGDAGDPLGLVSLTWNAPHSGVTFAGAGVGGRGGWLGGVRLSEERYRSGGPAVVMPTVDVDRELQRRRVLVFDVG
DRDPYATLVTRLEAARDDPEVGALLVRIGGLSLGGGRVEELRALLAAVRARKPVLAYLEGGGTREYWLATGATAIAAPPG
APLIVNGISTSQLFLRGGLARLGIAFDVVKAGAYKSAAEPLVRDAPSPEAREATEAVLDDVFGRFVAQVAEARRLPPERV
RALVDQGLFTAEEAKDAGLVDAVAWPDELERWGRAVAGRRLFERGAYRPEPERLAQRWGRPAVIQVVRVEGIIARGRSRA
DPLGADGVAGAETIAAEIHRAADDAAVRAIVLRIESGGGDGLASDLIWREAVRARRKGKPVIASMGDLAASGGYLVAVGA
DAILAERSTLTGSIGVFAAKPDLSGLLAKLSIHPEAYQRGENARLVSVLKPWTPAERAVLEKQVGAFYRQFVARVAEGRR
LTTAEVEAVAGGRVWTGQQALERRLVDRIGTLADAIRLARERIGLAPDDVVEVRREDGGGALARVAGHALTAAPEPPLAG
LARAFPELSALALLTEIGPVLAIPEEWVAPEAGP
>Mature_834_residues
MKPFVNLAALALALAAPAAAHAQLSAVTDRVQGLPAGLGVPSLGAAVAEEPADLSANPAAIGFLGGLGLQYFHESGLRPG
ARGDGLYAGDRLGPLGVGYSVEWLRPGLDAGGERWRRSRLGLTLGDGRALSLGVAWTWIASRNDAIEQAGGWDLGLTLRP
TRWLSIGAAMLGRDARLGGADVPVRYDLGLATRLWHDRLTLSADLLADDEARDAFRSDHLAFGASAELWRGVALGLQVQL
PVRDLPGDAGDPLGLVSLTWNAPHSGVTFAGAGVGGRGGWLGGVRLSEERYRSGGPAVVMPTVDVDRELQRRRVLVFDVG
DRDPYATLVTRLEAARDDPEVGALLVRIGGLSLGGGRVEELRALLAAVRARKPVLAYLEGGGTREYWLATGATAIAAPPG
APLIVNGISTSQLFLRGGLARLGIAFDVVKAGAYKSAAEPLVRDAPSPEAREATEAVLDDVFGRFVAQVAEARRLPPERV
RALVDQGLFTAEEAKDAGLVDAVAWPDELERWGRAVAGRRLFERGAYRPEPERLAQRWGRPAVIQVVRVEGIIARGRSRA
DPLGADGVAGAETIAAEIHRAADDAAVRAIVLRIESGGGDGLASDLIWREAVRARRKGKPVIASMGDLAASGGYLVAVGA
DAILAERSTLTGSIGVFAAKPDLSGLLAKLSIHPEAYQRGENARLVSVLKPWTPAERAVLEKQVGAFYRQFVARVAEGRR
LTTAEVEAVAGGRVWTGQQALERRLVDRIGTLADAIRLARERIGLAPDDVVEVRREDGGGALARVAGHALTAAPEPPLAG
LARAFPELSALALLTEIGPVLAIPEEWVAPEAGP

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=454, Percent_Identity=31.4977973568282, Blast_Score=190, Evalue=3e-49,
Organism=Escherichia coli, GI1787527, Length=204, Percent_Identity=31.8627450980392, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 87746; Mature: 87746

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPFVNLAALALALAAPAAAHAQLSAVTDRVQGLPAGLGVPSLGAAVAEEPADLSANPAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCH
IGFLGGLGLQYFHESGLRPGARGDGLYAGDRLGPLGVGYSVEWLRPGLDAGGERWRRSRL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHC
GLTLGDGRALSLGVAWTWIASRNDAIEQAGGWDLGLTLRPTRWLSIGAAMLGRDARLGGA
CEEECCCCEEEEEEEEEEEECCCHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCC
DVPVRYDLGLATRLWHDRLTLSADLLADDEARDAFRSDHLAFGASAELWRGVALGLQVQL
CCCEEECCCHHHHHHHHHHEEEHHHHCCCHHHHHHHHCCEECCCCHHHHHHHEECEEEEE
PVRDLPGDAGDPLGLVSLTWNAPHSGVTFAGAGVGGRGGWLGGVRLSEERYRSGGPAVVM
CHHHCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCCEEECHHHHHCCCCEEEE
PTVDVDRELQRRRVLVFDVGDRDPYATLVTRLEAARDDPEVGALLVRIGGLSLGGGRVEE
ECCCCCHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCHHH
LRALLAAVRARKPVLAYLEGGGTREYWLATGATAIAAPPGAPLIVNGISTSQLFLRGGLA
HHHHHHHHHHCCCEEEEEECCCCEEEEEECCCEEEECCCCCCEEEECCCHHHHHHHCCHH
RLGIAFDVVKAGAYKSAAEPLVRDAPSPEAREATEAVLDDVFGRFVAQVAEARRLPPERV
HHHHHHHHHHHCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RALVDQGLFTAEEAKDAGLVDAVAWPDELERWGRAVAGRRLFERGAYRPEPERLAQRWGR
HHHHHCCCCCHHHHCCCCCEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
PAVIQVVRVEGIIARGRSRADPLGADGVAGAETIAAEIHRAADDAAVRAIVLRIESGGGD
CCEEEEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCC
GLASDLIWREAVRARRKGKPVIASMGDLAASGGYLVAVGADAILAERSTLTGSIGVFAAK
CHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCEEEEECCCHHHHCCCCCCCCCEEEEEC
PDLSGLLAKLSIHPEAYQRGENARLVSVLKPWTPAERAVLEKQVGAFYRQFVARVAEGRR
CCHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTTAEVEAVAGGRVWTGQQALERRLVDRIGTLADAIRLARERIGLAPDDVVEVRREDGGG
EEHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
ALARVAGHALTAAPEPPLAGLARAFPELSALALLTEIGPVLAIPEEWVAPEAGP
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHCCCCCCC
>Mature Secondary Structure
MKPFVNLAALALALAAPAAAHAQLSAVTDRVQGLPAGLGVPSLGAAVAEEPADLSANPAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCH
IGFLGGLGLQYFHESGLRPGARGDGLYAGDRLGPLGVGYSVEWLRPGLDAGGERWRRSRL
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHC
GLTLGDGRALSLGVAWTWIASRNDAIEQAGGWDLGLTLRPTRWLSIGAAMLGRDARLGGA
CEEECCCCEEEEEEEEEEEECCCHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCC
DVPVRYDLGLATRLWHDRLTLSADLLADDEARDAFRSDHLAFGASAELWRGVALGLQVQL
CCCEEECCCHHHHHHHHHHEEEHHHHCCCHHHHHHHHCCEECCCCHHHHHHHEECEEEEE
PVRDLPGDAGDPLGLVSLTWNAPHSGVTFAGAGVGGRGGWLGGVRLSEERYRSGGPAVVM
CHHHCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCCCCEEECHHHHHCCCCEEEE
PTVDVDRELQRRRVLVFDVGDRDPYATLVTRLEAARDDPEVGALLVRIGGLSLGGGRVEE
ECCCCCHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCCCHHH
LRALLAAVRARKPVLAYLEGGGTREYWLATGATAIAAPPGAPLIVNGISTSQLFLRGGLA
HHHHHHHHHHCCCEEEEEECCCCEEEEEECCCEEEECCCCCCEEEECCCHHHHHHHCCHH
RLGIAFDVVKAGAYKSAAEPLVRDAPSPEAREATEAVLDDVFGRFVAQVAEARRLPPERV
HHHHHHHHHHHCCCHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RALVDQGLFTAEEAKDAGLVDAVAWPDELERWGRAVAGRRLFERGAYRPEPERLAQRWGR
HHHHHCCCCCHHHHCCCCCEEHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
PAVIQVVRVEGIIARGRSRADPLGADGVAGAETIAAEIHRAADDAAVRAIVLRIESGGGD
CCEEEEEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEECCCCC
GLASDLIWREAVRARRKGKPVIASMGDLAASGGYLVAVGADAILAERSTLTGSIGVFAAK
CHHHHHHHHHHHHHHHCCCCEEEECHHHHCCCCEEEEECCCHHHHCCCCCCCCCEEEEEC
PDLSGLLAKLSIHPEAYQRGENARLVSVLKPWTPAERAVLEKQVGAFYRQFVARVAEGRR
CCHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
LTTAEVEAVAGGRVWTGQQALERRLVDRIGTLADAIRLARERIGLAPDDVVEVRREDGGG
EEHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
ALARVAGHALTAAPEPPLAGLARAFPELSALALLTEIGPVLAIPEEWVAPEAGP
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]