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The map label for this gene is slyD [H]

Identifier: 220904860

GI number: 220904860

Start: 1917382

End: 1917804

Strand: Reverse

Name: slyD [H]

Synonym: Ddes_1594

Alternate gene names: 220904860

Gene position: 1917804-1917382 (Counterclockwise)

Preceding gene: 220904871

Following gene: 220904859

Centisome position: 66.74

GC content: 60.28

Gene sequence:

>423_bases
ATGCCCATCAAAAAAGGCGACACAGTGCGCGCGCACTATACGGGAACCCTGGATGACGGCACGGTGTTCGACTCTTCGCG
TGAGCGCGATCCCCTTGAGTTCGTCATGGGCCAGGGCATGCTCATCCCCGGTTTCGAGGCCGCGGTTGACGGCCGTGAGG
CCGGAGAAAGCGTTACCGTAACCATTCCTCCGGCCGAAGCCTATGGCGAAACCGATCCGGAACTGGTCTTTACCGTGGCC
CGCGCCCAGGTGCCGGACCACATTCCCCTCAACGTGGGCGTGCCGTTGCAGCTTTCCAACGAGCAGGGCCAGATGGACGT
GACCATCACCGAAGTGACCGCTGATGAAGTGACCCTTGACGCCAACCATCCGCTGGCTGGCAAGGCTCTCACCTTTGAAA
TAGAGATTGTCAGCGTCAACTAG

Upstream 100 bases:

>100_bases
TTCACTGCGGGCGTTTTTTGCGCTTGTGCCGCAGGGGCGCGAGCATTGCACCACGCGGCAGGGCGCCCGCCCAAACGTCC
GCAAGACCCCTGGAGTATTT

Downstream 100 bases:

>100_bases
CAGACGCCGGGCCGGCGGGCAGATGTCTGCCGGCCTTTTTCAGGGCTTTCCGGCATGTGGCGGCACGGGCCGCCCGGACG
CCGCCGGCAGCAAGCGTTTT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Metallochaperone slyD [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MPIKKGDTVRAHYTGTLDDGTVFDSSRERDPLEFVMGQGMLIPGFEAAVDGREAGESVTVTIPPAEAYGETDPELVFTVA
RAQVPDHIPLNVGVPLQLSNEQGQMDVTITEVTADEVTLDANHPLAGKALTFEIEIVSVN

Sequences:

>Translated_140_residues
MPIKKGDTVRAHYTGTLDDGTVFDSSRERDPLEFVMGQGMLIPGFEAAVDGREAGESVTVTIPPAEAYGETDPELVFTVA
RAQVPDHIPLNVGVPLQLSNEQGQMDVTITEVTADEVTLDANHPLAGKALTFEIEIVSVN
>Mature_139_residues
PIKKGDTVRAHYTGTLDDGTVFDSSRERDPLEFVMGQGMLIPGFEAAVDGREAGESVTVTIPPAEAYGETDPELVFTVAR
AQVPDHIPLNVGVPLQLSNEQGQMDVTITEVTADEVTLDANHPLAGKALTFEIEIVSVN

Specific function: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789748, Length=139, Percent_Identity=35.2517985611511, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI1786211, Length=140, Percent_Identity=30.7142857142857, Blast_Score=75, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=68, Percent_Identity=48.5294117647059, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 14992; Mature: 14861

Theoretical pI: Translated: 3.96; Mature: 3.96

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKKGDTVRAHYTGTLDDGTVFDSSRERDPLEFVMGQGMLIPGFEAAVDGREAGESVTV
CCCCCCCEEEEEEEEECCCCEEECCCCCCCCHHHHHCCCEECCCHHHCCCCCCCCCEEEE
TIPPAEAYGETDPELVFTVARAQVPDHIPLNVGVPLQLSNEQGQMDVTITEVTADEVTLD
EECCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCEEEEE
ANHPLAGKALTFEIEIVSVN
CCCCCCCCEEEEEEEEEEEC
>Mature Secondary Structure 
PIKKGDTVRAHYTGTLDDGTVFDSSRERDPLEFVMGQGMLIPGFEAAVDGREAGESVTV
CCCCCCEEEEEEEEECCCCEEECCCCCCCCHHHHHCCCEECCCHHHCCCCCCCCCEEEE
TIPPAEAYGETDPELVFTVARAQVPDHIPLNVGVPLQLSNEQGQMDVTITEVTADEVTLD
EECCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCEEEEE
ANHPLAGKALTFEIEIVSVN
CCCCCCCCEEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]