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The map label for this gene is trpF

Identifier: 220904855

GI number: 220904855

Start: 1910093

End: 1910728

Strand: Reverse

Name: trpF

Synonym: Ddes_1589

Alternate gene names: 220904855

Gene position: 1910728-1910093 (Counterclockwise)

Preceding gene: 220904856

Following gene: 220904854

Centisome position: 66.5

GC content: 62.58

Gene sequence:

>636_bases
ATGCTTATTAAGGTTTGCGGCCTCACACGGCAGGCGGATGTGGATCTGGCCGCCTCTTTTGGGGCAAGCATGTGCGGATT
TATTTTTCATCCGGTCAGCCCCCGGTGCGTCAGTCCGGTTCAGGCCGCCTCGCTGGAGAGCGGCAGCATGTTGCGCGTGG
GTGTTTTTGTGGAGCAGGACGCTGAAGAAATATGCCGCATCATGGCCGAGGCGCGGCTGGACATGGCCCAACTGCACGGC
CGGCAGGATGCGGCCTGTGCCAGGGCCGTGGGGGCACAGCGGGTGATCCGTGTCATCTGGCCCGCGCGCTATTGCCACAG
GGCCTTGCTGTATAACGAATTGCAGAATCACGCCGACGCCTGCGCCTGCTACCTGCTGGATGCGGGTCTGGCTGGCGGGG
GCAGTGGCGTGCGTCTTGATTGGGAAGATCTGAACCATCTGCCGTCGCCGCGCCCTTGGCTTCTGGCCGGCGGCCTGAGC
GCAGAAAACGTGGGGCTGGCCCTGAGCAGATGCTCCCCGGATGGAGTGGATTTCAATTCCGGCGTGGAGGATGCGCCGGG
GCAGAAAAATGCGCAAAAGCTGGCGGCCGCCCTCGCGGTAGCCGCAAAACAGAAAGGCAATAGGTACTTGTCATGA

Upstream 100 bases:

>100_bases
ATGGCTGGCGGCACGCCGGGGCTGACGCTGACCCGTCTGCTTGAACAGGCGCAAGCCACCGGTGATGCCGCGTCCTGTAC
GGCAGGGGAGAAAAAAGGCC

Downstream 100 bases:

>100_bases
AGAACAGATATTTTGGTGAATTCGGCGGCTGCTTTGTGCCCGAATTGCTCATGCCGCCGCTTATGGAGGTCGAGGCGGCC
ATGCACGACATTTATCCCAC

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MLIKVCGLTRQADVDLAASFGASMCGFIFHPVSPRCVSPVQAASLESGSMLRVGVFVEQDAEEICRIMAEARLDMAQLHG
RQDAACARAVGAQRVIRVIWPARYCHRALLYNELQNHADACACYLLDAGLAGGGSGVRLDWEDLNHLPSPRPWLLAGGLS
AENVGLALSRCSPDGVDFNSGVEDAPGQKNAQKLAAALAVAAKQKGNRYLS

Sequences:

>Translated_211_residues
MLIKVCGLTRQADVDLAASFGASMCGFIFHPVSPRCVSPVQAASLESGSMLRVGVFVEQDAEEICRIMAEARLDMAQLHG
RQDAACARAVGAQRVIRVIWPARYCHRALLYNELQNHADACACYLLDAGLAGGGSGVRLDWEDLNHLPSPRPWLLAGGLS
AENVGLALSRCSPDGVDFNSGVEDAPGQKNAQKLAAALAVAAKQKGNRYLS
>Mature_211_residues
MLIKVCGLTRQADVDLAASFGASMCGFIFHPVSPRCVSPVQAASLESGSMLRVGVFVEQDAEEICRIMAEARLDMAQLHG
RQDAACARAVGAQRVIRVIWPARYCHRALLYNELQNHADACACYLLDAGLAGGGSGVRLDWEDLNHLPSPRPWLLAGGLS
AENVGLALSRCSPDGVDFNSGVEDAPGQKNAQKLAAALAVAAKQKGNRYLS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=198, Percent_Identity=39.8989898989899, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=29.6803652968037, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_DESDA (B8J162)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002480167.1
- GeneID:   7285287
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1589
- HOGENOM:   HBG554803
- ProtClustDB:   CLSK704643
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22447; Mature: 22447

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKVCGLTRQADVDLAASFGASMCGFIFHPVSPRCVSPVQAASLESGSMLRVGVFVEQD
CEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCHHHHCCCCCCEEEEEEEECCC
AEEICRIMAEARLDMAQLHGRQDAACARAVGAQRVIRVIWPARYCHRALLYNELQNHADA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CACYLLDAGLAGGGSGVRLDWEDLNHLPSPRPWLLAGGLSAENVGLALSRCSPDGVDFNS
HHHHHHHCCCCCCCCCCEEEHHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCC
GVEDAPGQKNAQKLAAALAVAAKQKGNRYLS
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLIKVCGLTRQADVDLAASFGASMCGFIFHPVSPRCVSPVQAASLESGSMLRVGVFVEQD
CEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCHHHHCCCCCCEEEEEEEECCC
AEEICRIMAEARLDMAQLHGRQDAACARAVGAQRVIRVIWPARYCHRALLYNELQNHADA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CACYLLDAGLAGGGSGVRLDWEDLNHLPSPRPWLLAGGLSAENVGLALSRCSPDGVDFNS
HHHHHHHCCCCCCCCCCEEEHHHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCC
GVEDAPGQKNAQKLAAALAVAAKQKGNRYLS
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA