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The map label for this gene is trpC [H]

Identifier: 220904856

GI number: 220904856

Start: 1910718

End: 1911599

Strand: Reverse

Name: trpC [H]

Synonym: Ddes_1590

Alternate gene names: 220904856

Gene position: 1911599-1910718 (Counterclockwise)

Preceding gene: 220904857

Following gene: 220904855

Centisome position: 66.53

GC content: 64.17

Gene sequence:

>882_bases
ATGCTGCTTGAGCGTTTCATCAAGGCCAAGACGGCCGAAGTTGAGGGCCTGCGCCGTCTGGCGGAGCAGGGTAAAATCCC
CGCGCCGCTTGATGTGCCGCGGCCGGAGTTTTCGGCGGCCCTGTGCGGCCGCTCCGTGCCTGCCGTGCGCCTGGGGGAAT
ATTCGCTGGCCGTGGTGGCCGAATACAAGCGGGCCTCGCCTTCGCGCGGGGTCATCTGCGAAAACCTCGGGGTTGAGGAG
GCCGCGCGCCAGTACGCCGCTTCAGGAGCAGGCTGCCTGTCCATCCTGACGGAAGAGACGTATTTTCACGGCGATATAAG
CTACCTGCACAAGGCGGCAGATCCGGCCCTGTACGCGAAGTATCAGCCGCCCCTCTTGCGCAAGGATTTCATTTTTGATC
CGCTTCAGGTGGCAGCCACGGCGGCTACTCCGGCCTCGGCTCTGCTGCTCATCGTGCGGCTCACCCCGGATGCCCGCACA
TTGCGGTCCTTGCGGGAACAGGCCGAAAGCCTCGGGATGCAGGCTGTGGTGGAGGTGTTTGACAAGGAAGACCTGGACCT
TGCCCGGCAGAGCGGGGCGCGCATTATTCAGGTCAATGCGCGGGATCTGGGCAGCCTCGTGATCGACCGCAAGGCCCCCC
TGGACCTTATCCGGGCCTGCCCCCCGCAAAAAGATGAAGTATGGATAGCTGCCAGCGGCATAGACAGCGGAGGGCACTTG
CTGGACTCGGCCCGGGCGGGCTTTGCCGCAGTGCTGGTGGGCAGCGCTCTTATGGCTGGCGGCACGCCGGGGCTGACGCT
GACCCGTCTGCTTGAACAGGCGCAAGCCACCGGTGATGCCGCGTCCTGTACGGCAGGGGAGAAAAAAGGCCATGCTTATT
AA

Upstream 100 bases:

>100_bases
GGGCTGGCGGTGTACCTGCTGGAAGAAAACATGGACATGGCCCTGTGCATGGCGCGCGCGCGCGAAGCCGTAAGCGGAGG
CTTTGGCAGGAAGGTGCTGC

Downstream 100 bases:

>100_bases
GGTTTGCGGCCTCACACGGCAGGCGGATGTGGATCTGGCCGCCTCTTTTGGGGCAAGCATGTGCGGATTTATTTTTCATC
CGGTCAGCCCCCGGTGCGTC

Product: Indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLLERFIKAKTAEVEGLRRLAEQGKIPAPLDVPRPEFSAALCGRSVPAVRLGEYSLAVVAEYKRASPSRGVICENLGVEE
AARQYAASGAGCLSILTEETYFHGDISYLHKAADPALYAKYQPPLLRKDFIFDPLQVAATAATPASALLLIVRLTPDART
LRSLREQAESLGMQAVVEVFDKEDLDLARQSGARIIQVNARDLGSLVIDRKAPLDLIRACPPQKDEVWIAASGIDSGGHL
LDSARAGFAAVLVGSALMAGGTPGLTLTRLLEQAQATGDAASCTAGEKKGHAY

Sequences:

>Translated_293_residues
MLLERFIKAKTAEVEGLRRLAEQGKIPAPLDVPRPEFSAALCGRSVPAVRLGEYSLAVVAEYKRASPSRGVICENLGVEE
AARQYAASGAGCLSILTEETYFHGDISYLHKAADPALYAKYQPPLLRKDFIFDPLQVAATAATPASALLLIVRLTPDART
LRSLREQAESLGMQAVVEVFDKEDLDLARQSGARIIQVNARDLGSLVIDRKAPLDLIRACPPQKDEVWIAASGIDSGGHL
LDSARAGFAAVLVGSALMAGGTPGLTLTRLLEQAQATGDAASCTAGEKKGHAY
>Mature_293_residues
MLLERFIKAKTAEVEGLRRLAEQGKIPAPLDVPRPEFSAALCGRSVPAVRLGEYSLAVVAEYKRASPSRGVICENLGVEE
AARQYAASGAGCLSILTEETYFHGDISYLHKAADPALYAKYQPPLLRKDFIFDPLQVAATAATPASALLLIVRLTPDART
LRSLREQAESLGMQAVVEVFDKEDLDLARQSGARIIQVNARDLGSLVIDRKAPLDLIRACPPQKDEVWIAASGIDSGGHL
LDSARAGFAAVLVGSALMAGGTPGLTLTRLLEQAQATGDAASCTAGEKKGHAY

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=219, Percent_Identity=33.7899543378995, Blast_Score=89, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322638, Length=205, Percent_Identity=38.0487804878049, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 31178; Mature: 31178

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLERFIKAKTAEVEGLRRLAEQGKIPAPLDVPRPEFSAALCGRSVPAVRLGEYSLAVVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCEEEHH
EYKRASPSRGVICENLGVEEAARQYAASGAGCLSILTEETYFHGDISYLHKAADPALYAK
HHHHCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHEECCCHHHHHHHCCCCEEEC
YQPPLLRKDFIFDPLQVAATAATPASALLLIVRLTPDARTLRSLREQAESLGMQAVVEVF
CCCCCCCHHHCCCHHHHHHHCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
DKEDLDLARQSGARIIQVNARDLGSLVIDRKAPLDLIRACPPQKDEVWIAASGIDSGGHL
CCCCHHHHHHCCCEEEEECCHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCHH
LDSARAGFAAVLVGSALMAGGTPGLTLTRLLEQAQATGDAASCTAGEKKGHAY
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MLLERFIKAKTAEVEGLRRLAEQGKIPAPLDVPRPEFSAALCGRSVPAVRLGEYSLAVVA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCEEEHH
EYKRASPSRGVICENLGVEEAARQYAASGAGCLSILTEETYFHGDISYLHKAADPALYAK
HHHHCCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHHHEECCCHHHHHHHCCCCEEEC
YQPPLLRKDFIFDPLQVAATAATPASALLLIVRLTPDARTLRSLREQAESLGMQAVVEVF
CCCCCCCHHHCCCHHHHHHHCCCCHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
DKEDLDLARQSGARIIQVNARDLGSLVIDRKAPLDLIRACPPQKDEVWIAASGIDSGGHL
CCCCHHHHHHCCCEEEEECCHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCCCCHH
LDSARAGFAAVLVGSALMAGGTPGLTLTRLLEQAQATGDAASCTAGEKKGHAY
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA