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The map label for this gene is relA [H]

Identifier: 220904804

GI number: 220904804

Start: 1833949

End: 1836108

Strand: Reverse

Name: relA [H]

Synonym: Ddes_1536

Alternate gene names: 220904804

Gene position: 1836108-1833949 (Counterclockwise)

Preceding gene: 220904806

Following gene: 220904803

Centisome position: 63.9

GC content: 55.37

Gene sequence:

>2160_bases
ATGATTCGTATACAGGAAATTCTCGACAAGGTGTCGGCGCACAATCCCGACGCAGACCTGGAGCTTATCCAGAAAGCTTA
TGTTTACGCCGCCACTGCCCATGCGGGGCAAACCCGCCTGTCGGGCGAGCCGTATCTTTCCCATCCGCTGGCCGTGGCCG
ACACCCTGGCTGAAATGGGTTTTGACGAATCAACGGTGGTCGCCGGGCTTTTGCACGACACCGTAGAAGATACCAAGGCC
ACGCTTGAAGAGCTGGACGAGAATTTCGGCGAGGATGTGGCCGATATTGTTGACGGTGTGACCAAGATCAGCATGATCCC
CTTTGAAAACAAAGAGGAAGCCCAGGCAGAGAACATCCGCAAGATGATCTTGGCCATGAGCCACGACATGCGGGTGCTTA
TGGTCAAACTTGCCGACCGCCTGCACAACATGCGCACCCTGGATTTTCAGAAAGCCCACAAGCAGAAAGGCATTGCCCAG
GAAACAATGGATATATATGCGCCTCTGGCAAACCGCCTGGGCCTGTATATCATGAAGCGCAACCTGGAAGACCTGAGCTT
CAAGTATCTGCGCCCCGACATTTTCAATCAGATAGACCACTGGCTGGACAAGCATCAGGTAGTGGAAAAACAGATTATCG
CCAAGGTGGTGGACCTGATAAAAGACCTTCTTGCCTCCAATGGCATCGAAGGGCAGGTTTACGGCCGCATCAAGCACAAA
TACAGTATCTATAAAAAGATGCAGTCCCAGTCCCTGACACTGGATGAAATGCACGACATCATGGCGTTTCGTGTTCTGGT
CAAGGATATCAGAGACTGTTACGCAGCGCTTGGCCTTGTGCACTCGCAATGGAGGCCCGTACACGGGCGCTTTAAAGACT
ATATCTCCATGCCCAAGACCAATGGCTACCAGAGCCTGCACACCACGGTCATCGGGCCTGAAGGCGAACGCATAGAAATC
CAGATACGCACCGAAGACATGCACCGGCAGGCTGAGCACGGCGTGGCCGCCCACTGGCTTTACAAGGAAAAAGGCCGGGT
TAACAGCAAAGACCTGGAGCAGTTTGGCTGGCTGCGCGAGATTTTTGAGCGCCAGAGCGAAGAAACGGACTCGCGCGAAT
TTATGCATTCGCTCAAGCTGGACCTCTTCAAGGACGAAGTCTACGTCTACACCCCGGCGGGCGATGTCAAGGAACTGCCC
GAAGGGGCCACCCCTCTGGATTTTGCGTTTATCATCCATACCAAGGTGGGGCAGCACTGCACCGGAGCCAAGATCAACGG
TCGGCTCATGCCTTTGAGTACAGAGCTTAAAAACGGTGATATTGTTGAAATTCTTACTGATCCAAGCAGAAAGCCCAACA
GGGACTGGCTCAAAATCGTCAAGACAGCCAGGGCGCGCAGCCGTATTCAGCGCTACCTGCGCACCGAGGAGCGCGCCCAC
GCGGTGAGCCTTGGACGCGATATGCTGGAAAAAGAAGGGCGAAAGGTCAGCCTCAACGTCAACAAGGCCATCAAGGACGG
GCATATGGCCCTGGTGGCCCAGGAAATGAATTTTGAGAGCGTGGACGACCTTGTGGCATCAGTGGGCTATGCCCACACAA
CGCCGCGCAAGGTGCTCAACCGGCTGTACGCCGTGCTGCATCCGGATGCGGTTTCCTCCGCGCCTGAAACGCCCACAGTC
AAAGAAAGCAAAGAGGCCGCCGGCCGTAAAACGGAAGGTGTGGGCATTTCCGGGGTGGACGGTGTGCTCATGCGTTTTGC
CAAGTGCTGCAACCCGGTACCCGGAGATCCTATTATCGGGTACATCAGCCGTGGCCTTGGTGTCAGCGTGCATCGTGCAG
ACTGCCCCAATGTGGCGAATATGGAGCCGGAGCGGCTTATATCCGTGCATTGGGACGGTGCGGAAGAAAAACCTTACGAA
GCCGGTATTTTTATCATTGCCAGAAACGAGCACGGTGTGCTGGCCCTGGTGGCCCAGGTGCTTGCCAAAAACAACGTGAA
CATCACCGGGCTGAATATGGACAACCTTGTGGACGGCCGTGCCAAGCTGCGCTTTACCGTGGAAGTGCGCGACGCCACGC
AGCTCTATCAGCTCATCGAGTCCATCCGTTCTCTGCCGCCCATTCTTGAGGTGGTGCGCGATACAGAAGACGCCCAGTAG

Upstream 100 bases:

>100_bases
CGGCAGGGCTTGCTGCGGAGTCAATAACATTGACAAGGTCGCGCAACTGATAACATAGTCAGGACATCACAAAGATTTTA
CGCCCGGACGGGATTTACGC

Downstream 100 bases:

>100_bases
CGTTTTTCGAGAATACGAGGTTTTGTGCAGACGCAACATGTTTGCATTGCAGTTTTTATATCCTGCCCACGCCATTTGAT
TCCAACGGGCCGAACCTGCT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MIRIQEILDKVSAHNPDADLELIQKAYVYAATAHAGQTRLSGEPYLSHPLAVADTLAEMGFDESTVVAGLLHDTVEDTKA
TLEELDENFGEDVADIVDGVTKISMIPFENKEEAQAENIRKMILAMSHDMRVLMVKLADRLHNMRTLDFQKAHKQKGIAQ
ETMDIYAPLANRLGLYIMKRNLEDLSFKYLRPDIFNQIDHWLDKHQVVEKQIIAKVVDLIKDLLASNGIEGQVYGRIKHK
YSIYKKMQSQSLTLDEMHDIMAFRVLVKDIRDCYAALGLVHSQWRPVHGRFKDYISMPKTNGYQSLHTTVIGPEGERIEI
QIRTEDMHRQAEHGVAAHWLYKEKGRVNSKDLEQFGWLREIFERQSEETDSREFMHSLKLDLFKDEVYVYTPAGDVKELP
EGATPLDFAFIIHTKVGQHCTGAKINGRLMPLSTELKNGDIVEILTDPSRKPNRDWLKIVKTARARSRIQRYLRTEERAH
AVSLGRDMLEKEGRKVSLNVNKAIKDGHMALVAQEMNFESVDDLVASVGYAHTTPRKVLNRLYAVLHPDAVSSAPETPTV
KESKEAAGRKTEGVGISGVDGVLMRFAKCCNPVPGDPIIGYISRGLGVSVHRADCPNVANMEPERLISVHWDGAEEKPYE
AGIFIIARNEHGVLALVAQVLAKNNVNITGLNMDNLVDGRAKLRFTVEVRDATQLYQLIESIRSLPPILEVVRDTEDAQ

Sequences:

>Translated_719_residues
MIRIQEILDKVSAHNPDADLELIQKAYVYAATAHAGQTRLSGEPYLSHPLAVADTLAEMGFDESTVVAGLLHDTVEDTKA
TLEELDENFGEDVADIVDGVTKISMIPFENKEEAQAENIRKMILAMSHDMRVLMVKLADRLHNMRTLDFQKAHKQKGIAQ
ETMDIYAPLANRLGLYIMKRNLEDLSFKYLRPDIFNQIDHWLDKHQVVEKQIIAKVVDLIKDLLASNGIEGQVYGRIKHK
YSIYKKMQSQSLTLDEMHDIMAFRVLVKDIRDCYAALGLVHSQWRPVHGRFKDYISMPKTNGYQSLHTTVIGPEGERIEI
QIRTEDMHRQAEHGVAAHWLYKEKGRVNSKDLEQFGWLREIFERQSEETDSREFMHSLKLDLFKDEVYVYTPAGDVKELP
EGATPLDFAFIIHTKVGQHCTGAKINGRLMPLSTELKNGDIVEILTDPSRKPNRDWLKIVKTARARSRIQRYLRTEERAH
AVSLGRDMLEKEGRKVSLNVNKAIKDGHMALVAQEMNFESVDDLVASVGYAHTTPRKVLNRLYAVLHPDAVSSAPETPTV
KESKEAAGRKTEGVGISGVDGVLMRFAKCCNPVPGDPIIGYISRGLGVSVHRADCPNVANMEPERLISVHWDGAEEKPYE
AGIFIIARNEHGVLALVAQVLAKNNVNITGLNMDNLVDGRAKLRFTVEVRDATQLYQLIESIRSLPPILEVVRDTEDAQ
>Mature_719_residues
MIRIQEILDKVSAHNPDADLELIQKAYVYAATAHAGQTRLSGEPYLSHPLAVADTLAEMGFDESTVVAGLLHDTVEDTKA
TLEELDENFGEDVADIVDGVTKISMIPFENKEEAQAENIRKMILAMSHDMRVLMVKLADRLHNMRTLDFQKAHKQKGIAQ
ETMDIYAPLANRLGLYIMKRNLEDLSFKYLRPDIFNQIDHWLDKHQVVEKQIIAKVVDLIKDLLASNGIEGQVYGRIKHK
YSIYKKMQSQSLTLDEMHDIMAFRVLVKDIRDCYAALGLVHSQWRPVHGRFKDYISMPKTNGYQSLHTTVIGPEGERIEI
QIRTEDMHRQAEHGVAAHWLYKEKGRVNSKDLEQFGWLREIFERQSEETDSREFMHSLKLDLFKDEVYVYTPAGDVKELP
EGATPLDFAFIIHTKVGQHCTGAKINGRLMPLSTELKNGDIVEILTDPSRKPNRDWLKIVKTARARSRIQRYLRTEERAH
AVSLGRDMLEKEGRKVSLNVNKAIKDGHMALVAQEMNFESVDDLVASVGYAHTTPRKVLNRLYAVLHPDAVSSAPETPTV
KESKEAAGRKTEGVGISGVDGVLMRFAKCCNPVPGDPIIGYISRGLGVSVHRADCPNVANMEPERLISVHWDGAEEKPYE
AGIFIIARNEHGVLALVAQVLAKNNVNITGLNMDNLVDGRAKLRFTVEVRDATQLYQLIESIRSLPPILEVVRDTEDAQ

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=124, Percent_Identity=38.7096774193548, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1790082, Length=709, Percent_Identity=41.3258110014104, Blast_Score=553, Evalue=1e-159,
Organism=Escherichia coli, GI1789147, Length=693, Percent_Identity=34.1991341991342, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=35.8208955223881, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650996, Length=149, Percent_Identity=33.5570469798658, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 81128; Mature: 81128

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIQEILDKVSAHNPDADLELIQKAYVYAATAHAGQTRLSGEPYLSHPLAVADTLAEMG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
FDESTVVAGLLHDTVEDTKATLEELDENFGEDVADIVDGVTKISMIPFENKEEAQAENIR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHH
KMILAMSHDMRVLMVKLADRLHNMRTLDFQKAHKQKGIAQETMDIYAPLANRLGLYIMKR
HHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
NLEDLSFKYLRPDIFNQIDHWLDKHQVVEKQIIAKVVDLIKDLLASNGIEGQVYGRIKHK
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
YSIYKKMQSQSLTLDEMHDIMAFRVLVKDIRDCYAALGLVHSQWRPVHGRFKDYISMPKT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
NGYQSLHTTVIGPEGERIEIQIRTEDMHRQAEHGVAAHWLYKEKGRVNSKDLEQFGWLRE
CCCCHHEEEEECCCCCEEEEEEECHHHHHHHHCCCHHEEEEHHCCCCCHHHHHHHHHHHH
IFERQSEETDSREFMHSLKLDLFKDEVYVYTPAGDVKELPEGATPLDFAFIIHTKVGQHC
HHHHHCCCCHHHHHHHHHHHHEEECCEEEECCCCCHHHCCCCCCCCEEEEEEEHHCCCCC
TGAKINGRLMPLSTELKNGDIVEILTDPSRKPNRDWLKIVKTARARSRIQRYLRTEERAH
CCCEECCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSLGRDMLEKEGRKVSLNVNKAIKDGHMALVAQEMNFESVDDLVASVGYAHTTPRKVLN
HHHHHHHHHHHCCCEEEEEHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHH
RLYAVLHPDAVSSAPETPTVKESKEAAGRKTEGVGISGVDGVLMRFAKCCNPVPGDPIIG
HHHHHHCCHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHH
YISRGLGVSVHRADCPNVANMEPERLISVHWDGAEEKPYEAGIFIIARNEHGVLALVAQV
HHHCCCCCEEECCCCCCCCCCCHHHEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHH
LAKNNVNITGLNMDNLVDGRAKLRFTVEVRDATQLYQLIESIRSLPPILEVVRDTEDAQ
HHCCCCCEEECCHHHHCCCCEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MIRIQEILDKVSAHNPDADLELIQKAYVYAATAHAGQTRLSGEPYLSHPLAVADTLAEMG
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
FDESTVVAGLLHDTVEDTKATLEELDENFGEDVADIVDGVTKISMIPFENKEEAQAENIR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCCCHHHHHHHHH
KMILAMSHDMRVLMVKLADRLHNMRTLDFQKAHKQKGIAQETMDIYAPLANRLGLYIMKR
HHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
NLEDLSFKYLRPDIFNQIDHWLDKHQVVEKQIIAKVVDLIKDLLASNGIEGQVYGRIKHK
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHH
YSIYKKMQSQSLTLDEMHDIMAFRVLVKDIRDCYAALGLVHSQWRPVHGRFKDYISMPKT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
NGYQSLHTTVIGPEGERIEIQIRTEDMHRQAEHGVAAHWLYKEKGRVNSKDLEQFGWLRE
CCCCHHEEEEECCCCCEEEEEEECHHHHHHHHCCCHHEEEEHHCCCCCHHHHHHHHHHHH
IFERQSEETDSREFMHSLKLDLFKDEVYVYTPAGDVKELPEGATPLDFAFIIHTKVGQHC
HHHHHCCCCHHHHHHHHHHHHEEECCEEEECCCCCHHHCCCCCCCCEEEEEEEHHCCCCC
TGAKINGRLMPLSTELKNGDIVEILTDPSRKPNRDWLKIVKTARARSRIQRYLRTEERAH
CCCEECCEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSLGRDMLEKEGRKVSLNVNKAIKDGHMALVAQEMNFESVDDLVASVGYAHTTPRKVLN
HHHHHHHHHHHCCCEEEEEHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHH
RLYAVLHPDAVSSAPETPTVKESKEAAGRKTEGVGISGVDGVLMRFAKCCNPVPGDPIIG
HHHHHHCCHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHH
YISRGLGVSVHRADCPNVANMEPERLISVHWDGAEEKPYEAGIFIIARNEHGVLALVAQV
HHHCCCCCEEECCCCCCCCCCCHHHEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHH
LAKNNVNITGLNMDNLVDGRAKLRFTVEVRDATQLYQLIESIRSLPPILEVVRDTEDAQ
HHCCCCCEEECCHHHHCCCCEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA