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The map label for this gene is pyrC

Identifier: 218905018

GI number: 218905018

Start: 3741582

End: 3742868

Strand: Reverse

Name: pyrC

Synonym: BCAH820_3902

Alternate gene names: 218905018

Gene position: 3742868-3741582 (Counterclockwise)

Preceding gene: 218905019

Following gene: 218905017

Centisome position: 70.58

GC content: 40.17

Gene sequence:

>1287_bases
ATGAATTATTTGTTTAAAAATGGTCGTTATATGAATGAAGAAGGAAAAATCGTAGCAACGGATCTTCTCGTACAAGACGG
TAAAATCGCTAAAGTAGCAGAAAATATTACGGCAGATAATGCTGAAGTGATCGATGTGAACGGAAAGTTAATCGCACCTG
GATTAGTAGATGTACACGTACACCTTCGTGAACCAGGTGGTGAACATAAAGAAACAATTGAAACAGGTACATTAGCAGCG
GCAAAAGGTGGATTCACTACAATTTGCGCAATGCCAAATACACGCCCAGTACCAGATTGCAGAGAACATATGGAAGACTT
GCAAAATCGTATTAAAGAAAAAGCACATGTTAACGTACTACCATATGGAGCAATTACAGTACGTCAAGCCGGTTCTGAAA
TGACAGATTTCGAAACATTAAAAGAGCTTGGAGCATTTGCTTTCACTGATGACGGTGTAGGCGTACAAGATGCTAGCATG
ATGTTAGCTGCTATGAAGCGTGCAGCGAAATTAAATATGGCAGTAGTTGCGCACTGTGAAGAGAATACTCTTATTAATAA
AGGTTGTGTACATGAAGGGAAGTTTTCTGAGAAACACGGATTAAACGGTATCCCATCAGTATGTGAATCTGTACATATTG
CAAGGGATATACTGCTTGCTGAAGCAGCAGATTGTCACTATCACGTATGTCACGTAAGTACGAAAGGCTCTGTACGCGTA
ATTCGTGATGCAAAGCGCGCTGGAATTAAAGTAACAGCAGAGGTAACGCCTCATCACTTAGTGTTATGTGAAGATGATAT
CCCATCAGCTGATCCTAATTTTAAAATGAACCCACCGCTTCGTGGAAAAGAAGACCACGAAGCATTAATTGAAGGTTTAT
TAGATGGAACAATCGATATGATCGCAACTGACCATGCACCGCATACAGCAGAAGAGAAAGCGCAAGGAATTGAAAGAGCA
CCATTCGGGATTACTGGTTTTGAAACTGCATTCCCACTTCTATACACAAACCTTGTGAAAAAAGGAATTATTACACTAGA
GCAGTTAATTCAATTCTTAACAGAAAAGCCAGCTGATACATTCGGCTTAGAAGCAGGTCGCCTGAAAGAAGGTAGAACAG
CTGATATTACAATCATTGATTTAGAACAAGAAGAAGAGATTGACCCAACAACATTCTTATCAAAAGGAAAAAATACACCA
TTCGCAGGTTGGAAATGCCAAGGATGGCCGGTAATGACAATCGTTGGTGGTAAGATCGCATGGCAAAAGGAGAGTGCATT
AGTATGA

Upstream 100 bases:

>100_bases
TGTGAGCGTTCACGCATATTTAAACAAATGGAAAATGGAGTTTACGTAAGAATGGCTGTACTAAAACGCGCCTTACCAAA
TGTATTAGGAGGAATGAAAC

Downstream 100 bases:

>100_bases
AAAGACAACTTATCTTAGAAGATGGAACAGTATTAATTGGAACAGGTTTCGGAGGAGAAATCGAAAAGTCAGGTGAGGTT
GTATTTACAACAGGAATGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTP
FAGWKCQGWPVMTIVGGKIAWQKESALV

Sequences:

>Translated_428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTP
FAGWKCQGWPVMTIVGGKIAWQKESALV
>Mature_428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHEALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTP
FAGWKCQGWPVMTIVGGKIAWQKESALV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=389, Percent_Identity=32.9048843187661, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI4503375, Length=452, Percent_Identity=25.2212389380531, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503051, Length=444, Percent_Identity=24.5495495495495, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI62422571, Length=444, Percent_Identity=24.5495495495495, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI19923821, Length=444, Percent_Identity=25.2252252252252, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786722, Length=446, Percent_Identity=30.2690582959641, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI87082175, Length=435, Percent_Identity=28.735632183908, Blast_Score=141, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI193204318, Length=359, Percent_Identity=32.8690807799443, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=29.2410714285714, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17539558, Length=448, Percent_Identity=26.7857142857143, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=25.7336343115124, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=436, Percent_Identity=25.4587155963303, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24642586, Length=384, Percent_Identity=33.0729166666667, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=26.634382566586, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_BACAA (C3P658)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868124.1
- ProteinModelPortal:   C3P658
- SMR:   C3P658
- EnsemblBacteria:   EBBACT00000129739
- GeneID:   7852509
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4050
- GeneTree:   EBGT00050000001626
- ProtClustDB:   PRK09357
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46657; Mature: 46657

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHV
CCCEECCCCEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHEALIEGLLDGTIDM
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIA
HCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEECCCEEEEEECCEEE
WQKESALV
ECCCCCCC
>Mature Secondary Structure
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHV
CCCEECCCCEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHEALIEGLLDGTIDM
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIA
HCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEECCCEEEEEECCEEE
WQKESALV
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA