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The map label for this gene is treR [H]

Identifier: 218710343

GI number: 218710343

Start: 2548123

End: 2549067

Strand: Reverse

Name: treR [H]

Synonym: VS_2379

Alternate gene names: 218710343

Gene position: 2549067-2548123 (Counterclockwise)

Preceding gene: 218710344

Following gene: 218710342

Centisome position: 77.26

GC content: 45.71

Gene sequence:

>945_bases
ATGAGCAAAAAACTCACTATTCTCGATATTGCTAAGCTGTCCGGTGTTGGTAAGTCTACCGTATCTCGTGTTCTGACCAA
TGATCCCAAAGTAAAACCTGAAACCCGTGAAAGGGTGGAAAGAGTCATTCAAGAATCTGGGTACACGCCTTCGAAGTCTG
CGCAGTCGATGCGTGGTGGCAGTCAAAAAGTCATCGGTGTCATCATCTCTCGTCTGGATTCCCCCTCTGAAAACAAAGCG
GTAAGTACGATGCTGGCCGAATTGTATCGAGCGGATTACGATGTCGTGATCATGGAAAGTCAGCTTGATAGAGAAAAAGC
CAATGAGCATCTGCAGGTTCTCAAGCGTCGCAATGTAGATGGCATCATTGTGTTTGGCTTTACTGACTGTGATATTCCTG
CCATTGAAGCTTGGGAACACAAAGCGGTGGTGATTGCTCTGGATACCGAGAACGTGACGTCGATTAACTATGATAACCAA
CAGGTGATCAATAGTGCGTTAACGCATCTAGCAGAGCAGGGAATCTCTGAGGTTGGTTTCATTGGCGTCGATCCTAGCGA
TAAATCAACAGGTGAACTGCGTCTTAAGGCCTATCTCGAGTGGTGTGAAAGCGCTGGAGTGATTGCCAATTATCGTACTG
GTCAACTTCATCATGAAAGTGCTTATCAGCTGGTGGATGAGGTACTGACTCCTACAACTCAAGCACTTGTTTGTGCCAGT
GACACATTGGCTCTTGGTGTAATCAAACGTCTGCAAGAACTACAACGTGAAGATGTGGTGGTGACCGGTGTTGGTGGCAA
TGATCTTCTCTCTTTCTTGTTCCCGCGAGTATTTAGTATTGATCCTGGGTATCAATCTGCGGGTAAGTTGGCCGCTAATT
TATTGATCTCTCAGCTTTTAGGTAATGCAGAGATCTCTCATCACACTCAATCACCTATTCTATAA

Upstream 100 bases:

>100_bases
CCGAAAGTAGGTCATAGTTATCGACTAGGATTTACAAACAGTTAAGTGAGGGAGTTCGCCCTCACTTTTTCTTTCTCTTC
CCTTTAACGTCAGACTTTTT

Downstream 100 bases:

>100_bases
TCCACTCAATCAAGCGAAATTCAACCGCTTAGATTAAAATTAGAGTGTGATCTCTTTCAATTAATGGGACTGTTCCCATT
TTAATTTATCATTCACGTGG

Product: trehalose repressor

Products: NA

Alternate protein names: Trehalose operon repressor [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSKKLTILDIAKLSGVGKSTVSRVLTNDPKVKPETRERVERVIQESGYTPSKSAQSMRGGSQKVIGVIISRLDSPSENKA
VSTMLAELYRADYDVVIMESQLDREKANEHLQVLKRRNVDGIIVFGFTDCDIPAIEAWEHKAVVIALDTENVTSINYDNQ
QVINSALTHLAEQGISEVGFIGVDPSDKSTGELRLKAYLEWCESAGVIANYRTGQLHHESAYQLVDEVLTPTTQALVCAS
DTLALGVIKRLQELQREDVVVTGVGGNDLLSFLFPRVFSIDPGYQSAGKLAANLLISQLLGNAEISHHTQSPIL

Sequences:

>Translated_314_residues
MSKKLTILDIAKLSGVGKSTVSRVLTNDPKVKPETRERVERVIQESGYTPSKSAQSMRGGSQKVIGVIISRLDSPSENKA
VSTMLAELYRADYDVVIMESQLDREKANEHLQVLKRRNVDGIIVFGFTDCDIPAIEAWEHKAVVIALDTENVTSINYDNQ
QVINSALTHLAEQGISEVGFIGVDPSDKSTGELRLKAYLEWCESAGVIANYRTGQLHHESAYQLVDEVLTPTTQALVCAS
DTLALGVIKRLQELQREDVVVTGVGGNDLLSFLFPRVFSIDPGYQSAGKLAANLLISQLLGNAEISHHTQSPIL
>Mature_313_residues
SKKLTILDIAKLSGVGKSTVSRVLTNDPKVKPETRERVERVIQESGYTPSKSAQSMRGGSQKVIGVIISRLDSPSENKAV
STMLAELYRADYDVVIMESQLDREKANEHLQVLKRRNVDGIIVFGFTDCDIPAIEAWEHKAVVIALDTENVTSINYDNQQ
VINSALTHLAEQGISEVGFIGVDPSDKSTGELRLKAYLEWCESAGVIANYRTGQLHHESAYQLVDEVLTPTTQALVCASD
TLALGVIKRLQELQREDVVVTGVGGNDLLSFLFPRVFSIDPGYQSAGKLAANLLISQLLGNAEISHHTQSPIL

Specific function: Repressor of the treBC operon. Binds trehalose 6- phosphate as an inducer [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790689, Length=304, Percent_Identity=45.0657894736842, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1790194, Length=310, Percent_Identity=27.741935483871, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1787906, Length=267, Percent_Identity=26.2172284644195, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790369, Length=314, Percent_Identity=24.5222929936306, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787948, Length=318, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786540, Length=316, Percent_Identity=27.2151898734177, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786268, Length=284, Percent_Identity=28.169014084507, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790715, Length=335, Percent_Identity=23.8805970149254, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994940, Length=331, Percent_Identity=21.7522658610272, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787580, Length=329, Percent_Identity=26.1398176291793, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789068, Length=262, Percent_Identity=25.9541984732824, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789202, Length=290, Percent_Identity=23.7931034482759, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=25.625, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761
- InterPro:   IPR012771 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 34358; Mature: 34227

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLTILDIAKLSGVGKSTVSRVLTNDPKVKPETRERVERVIQESGYTPSKSAQSMRGG
CCCCEEEEEHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCC
SQKVIGVIISRLDSPSENKAVSTMLAELYRADYDVVIMESQLDREKANEHLQVLKRRNVD
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHCHHHHHHHHHHHHHCCCC
GIIVFGFTDCDIPAIEAWEHKAVVIALDTENVTSINYDNQQVINSALTHLAEQGISEVGF
EEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHCHHHCCE
IGVDPSDKSTGELRLKAYLEWCESAGVIANYRTGQLHHESAYQLVDEVLTPTTQALVCAS
EECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHEEECC
DTLALGVIKRLQELQREDVVVTGVGGNDLLSFLFPRVFSIDPGYQSAGKLAANLLISQLL
HHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
GNAEISHHTQSPIL
CCCHHCCCCCCCCC
>Mature Secondary Structure 
SKKLTILDIAKLSGVGKSTVSRVLTNDPKVKPETRERVERVIQESGYTPSKSAQSMRGG
CCCEEEEEHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCC
SQKVIGVIISRLDSPSENKAVSTMLAELYRADYDVVIMESQLDREKANEHLQVLKRRNVD
CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCHHCHHHHHHHHHHHHHCCCC
GIIVFGFTDCDIPAIEAWEHKAVVIALDTENVTSINYDNQQVINSALTHLAEQGISEVGF
EEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHCHHHCCE
IGVDPSDKSTGELRLKAYLEWCESAGVIANYRTGQLHHESAYQLVDEVLTPTTQALVCAS
EECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCHHHEEECC
DTLALGVIKRLQELQREDVVVTGVGGNDLLSFLFPRVFSIDPGYQSAGKLAANLLISQLL
HHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
GNAEISHHTQSPIL
CCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9148912; 7610040; 9278503; 7608078; 9865945 [H]