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The map label for this gene is lpxA

Identifier: 218710306

GI number: 218710306

Start: 2509534

End: 2510322

Strand: Reverse

Name: lpxA

Synonym: VS_2340

Alternate gene names: 218710306

Gene position: 2510322-2509534 (Counterclockwise)

Preceding gene: 218710307

Following gene: 218710305

Centisome position: 76.09

GC content: 45.12

Gene sequence:

>789_bases
ATGATTCATGAAACAGCGAAAATTCACCCGGCAGCAGTAATCGAAGGTGATGTAACTATCGGTGCTAACGTGACGGTTGG
TCCTTTCACTTACATTGCTGGTAACGTGACAATTGGTGACGACACTGAAGTGATGTCGCATGTTGTGATCAAAGGTCACA
CGACAATTGGTAAGCAAAACCGAATCTTCCCACACGCAGTGATTGGAGAAGAAAACCAAGATAAGAAATACGGTGGTGAA
GATACGACTGTTGTGATCGGTGACCGTAATGTGATTCGTGAAGCAGTTCAGATCCACCGTGGTACAACTCAAGACAAAGC
GACCACTGTGATTGGCGATGACAACTTACTTTGTGTAAATGCTCACGTAGCGCACGATGTTATTGTTGGTAACCATACTC
ACATTGGTAACAATGCTATTCTTGGTGGCCACGTGACGGTTGGCGATTACGCCGGTGTAATGGCATTGTCTGCGATTCAC
CCGTTCTGTTCAATTGGCGCTTATGCGTACATTGGCGGTTGTTCTGCGGTTGTTCAAGATGTACTTCCTTACGTACTTGC
CCAAGGTAACCACGCAGCGCCATTTGGTTTGAACCTAGTGGGTTTGAAGCGTAACGGATTTGAAAAACCAGAAATTCGAG
CATTACAGAAAGCGTACAAAGAGTTATACCGTTCAGGCAAAACACTTGAAGAAGCGAAAGCCGCTTTAGTTGAAATGGCG
AAAGAGTTTGCTTCGGTAACTCCTATGTTAGAAATGCTAGAGAGCTCTGAGCGCGGTATTATTCGTTAA

Upstream 100 bases:

>100_bases
AAAGAACGTCGTGGCATTGCATCGTTCAACGGTGTAGCGAAAGTTGACGGCGTAGTTGTATGTTCAGCTGAACTTAAATG
TGCTCGTAGAGAGTTTTAAT

Downstream 100 bases:

>100_bases
TACTTGATGTGGTTATGTACCAATCAATATGAGTATGACAATAGTTACCTCGTTAGATTGGTATAACAAAAAGATCGCTA
CTCGTTAGGCGATCTTTTTT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIHETAKIHPAAVIEGDVTIGANVTVGPFTYIAGNVTIGDDTEVMSHVVIKGHTTIGKQNRIFPHAVIGEENQDKKYGGE
DTTVVIGDRNVIREAVQIHRGTTQDKATTVIGDDNLLCVNAHVAHDVIVGNHTHIGNNAILGGHVTVGDYAGVMALSAIH
PFCSIGAYAYIGGCSAVVQDVLPYVLAQGNHAAPFGLNLVGLKRNGFEKPEIRALQKAYKELYRSGKTLEEAKAALVEMA
KEFASVTPMLEMLESSERGIIR

Sequences:

>Translated_262_residues
MIHETAKIHPAAVIEGDVTIGANVTVGPFTYIAGNVTIGDDTEVMSHVVIKGHTTIGKQNRIFPHAVIGEENQDKKYGGE
DTTVVIGDRNVIREAVQIHRGTTQDKATTVIGDDNLLCVNAHVAHDVIVGNHTHIGNNAILGGHVTVGDYAGVMALSAIH
PFCSIGAYAYIGGCSAVVQDVLPYVLAQGNHAAPFGLNLVGLKRNGFEKPEIRALQKAYKELYRSGKTLEEAKAALVEMA
KEFASVTPMLEMLESSERGIIR
>Mature_262_residues
MIHETAKIHPAAVIEGDVTIGANVTVGPFTYIAGNVTIGDDTEVMSHVVIKGHTTIGKQNRIFPHAVIGEENQDKKYGGE
DTTVVIGDRNVIREAVQIHRGTTQDKATTVIGDDNLLCVNAHVAHDVIVGNHTHIGNNAILGGHVTVGDYAGVMALSAIH
PFCSIGAYAYIGGCSAVVQDVLPYVLAQGNHAAPFGLNLVGLKRNGFEKPEIRALQKAYKELYRSGKTLEEAKAALVEMA
KEFASVTPMLEMLESSERGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=52.6717557251908, Blast_Score=285, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_VIBSL (B7VIQ6)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002417927.1
- ProteinModelPortal:   B7VIQ6
- SMR:   B7VIQ6
- GeneID:   7161881
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2340
- HOGENOM:   HBG659295
- OMA:   SSTRGIT
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28000; Mature: 28000

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHETAKIHPAAVIEGDVTIGANVTVGPFTYIAGNVTIGDDTEVMSHVVIKGHTTIGKQN
CCCCCCCCCCEEEEECCEEECCCEEECCCEEEEEEEEECCCHHHHHHEEEECCCCCCCCC
RIFPHAVIGEENQDKKYGGEDTTVVIGDRNVIREAVQIHRGTTQDKATTVIGDDNLLCVN
CCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEE
AHVAHDVIVGNHTHIGNNAILGGHVTVGDYAGVMALSAIHPFCSIGAYAYIGGCSAVVQD
CCEEEEEEECCCEECCCCEEEECEEEECHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHH
VLPYVLAQGNHAAPFGLNLVGLKRNGFEKPEIRALQKAYKELYRSGKTLEEAKAALVEMA
HHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KEFASVTPMLEMLESSERGIIR
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIHETAKIHPAAVIEGDVTIGANVTVGPFTYIAGNVTIGDDTEVMSHVVIKGHTTIGKQN
CCCCCCCCCCEEEEECCEEECCCEEECCCEEEEEEEEECCCHHHHHHEEEECCCCCCCCC
RIFPHAVIGEENQDKKYGGEDTTVVIGDRNVIREAVQIHRGTTQDKATTVIGDDNLLCVN
CCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEE
AHVAHDVIVGNHTHIGNNAILGGHVTVGDYAGVMALSAIHPFCSIGAYAYIGGCSAVVQD
CCEEEEEEECCCEECCCCEEEECEEEECHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHH
VLPYVLAQGNHAAPFGLNLVGLKRNGFEKPEIRALQKAYKELYRSGKTLEEAKAALVEMA
HHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KEFASVTPMLEMLESSERGIIR
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA