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The map label for this gene is lpxB [H]

Identifier: 218710305

GI number: 218710305

Start: 2508208

End: 2509404

Strand: Reverse

Name: lpxB [H]

Synonym: VS_2339

Alternate gene names: 218710305

Gene position: 2509404-2508208 (Counterclockwise)

Preceding gene: 218710306

Following gene: 218710304

Centisome position: 76.06

GC content: 43.69

Gene sequence:

>1197_bases
ATGGCACAGCAAGAAGCAGCAACCAATAGCTTGGACTTTGTTTCGAATGAACCTCTGCGTGTAGGTATCGTTGTCGGAGA
ACTCTCTGGTGACACGCTTGGCGAAGGCTTTATTAAAGCGATCAAATCACAATATCCGAATGCTGAGTTCGTGGGTATTG
GCGGACCAAAAATGAAGGCGCTTGGTTGTGAGTCTCTTTTCGAAATGGAAGAGCTTGCCGTGATGGGGCTTGTAGAAGTG
CTTGGTCGTTTACCTCGCTTGCTAAAAGTGAAAGCGGAGCTAGTTAAGTACTTTACTCAAAACCCGCCAGATGTCTTCGT
CGGTATCGATGCGCCAGACTTTAATCTAAGACTTGAATTAGATCTTAAGAACGCGGGCATTAAGACTGTTCATTATGTCA
GCCCTTCAGTCTGGGCATGGCGTCCAAAGCGTATCTTTAAAATCGACAAAGCAACCGATTTGGTACTGGCTTTCTTACCA
TTCGAAAAAGCGTTTTATGATAAATATAACGTTGCTTGTGAATTCGTTGGCCACACGTTGGCTGATACCATTCCACTGGA
GCCGAATAAGAAAGAGGCTCGCGATCTTTTAGGTTTAGATCAAGATAAGCCGTGGTTAGCGGTATTGCCAGGTAGCCGTG
GTGGTGAAATGAGTTTGATTGCTCAACCATTTATCGAAACTTGTCAGCGCATTAAGCAAAAGTACTCTGATATCAATTTT
GTTGTTGCATTGGTTAATGAACAGCGCAAGAAACAGTTTACAGAGATCTGGCAATCGACGGCACCTGAACTTGAATTTAC
CTTGGTAGAAGATACGGCTACCAATGTGATTACTGCTGCTGATTCTGTTTTGTTAGCTTCTGGTACTGTTGCTCTTGAGT
GTATGTTGCTGAAACGCCCAATGGTCGTTGGCTACAAGGTCAACAAGCTCACTGGCTATATCGTTAAGAAATTGTCGATC
ACAGAATTTGTCTCGTTACCGAATATCCTAGCGGGTGAAGAAATCGTAAAAGAACACATTCTTGAGGAGTGTCACCCAGA
TTACCTTTTCCCATCGGTCGATAAGATGCTTTCAACTGACAACGCGCCACTTATTGAACGCTTTACTGAAATGCATCACT
GGATTCGTAAAGATGCTGATAAACAGGCAGCTAACGCAGTTCTGAAATTGATCGGTCGAGAGTGTGTTGAATCATAA

Upstream 100 bases:

>100_bases
TGAGTATGACAATAGTTACCTCGTTAGATTGGTATAACAAAAAGATCGCTACTCGTTAGGCGATCTTTTTTGTTTTAGGC
AAGAAGGGAATTAGAAAACT

Downstream 100 bases:

>100_bases
AGTGCTTCTTTCAAAAGCATTTGCTTAAAAGTTACAAAGAGAATTGTCATGGCAGTAAAAGAGAAAAAAGAATTTCCTCC
TTTTGAGTATCCTCAAGGCT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MAQQEAATNSLDFVSNEPLRVGIVVGELSGDTLGEGFIKAIKSQYPNAEFVGIGGPKMKALGCESLFEMEELAVMGLVEV
LGRLPRLLKVKAELVKYFTQNPPDVFVGIDAPDFNLRLELDLKNAGIKTVHYVSPSVWAWRPKRIFKIDKATDLVLAFLP
FEKAFYDKYNVACEFVGHTLADTIPLEPNKKEARDLLGLDQDKPWLAVLPGSRGGEMSLIAQPFIETCQRIKQKYSDINF
VVALVNEQRKKQFTEIWQSTAPELEFTLVEDTATNVITAADSVLLASGTVALECMLLKRPMVVGYKVNKLTGYIVKKLSI
TEFVSLPNILAGEEIVKEHILEECHPDYLFPSVDKMLSTDNAPLIERFTEMHHWIRKDADKQAANAVLKLIGRECVES

Sequences:

>Translated_398_residues
MAQQEAATNSLDFVSNEPLRVGIVVGELSGDTLGEGFIKAIKSQYPNAEFVGIGGPKMKALGCESLFEMEELAVMGLVEV
LGRLPRLLKVKAELVKYFTQNPPDVFVGIDAPDFNLRLELDLKNAGIKTVHYVSPSVWAWRPKRIFKIDKATDLVLAFLP
FEKAFYDKYNVACEFVGHTLADTIPLEPNKKEARDLLGLDQDKPWLAVLPGSRGGEMSLIAQPFIETCQRIKQKYSDINF
VVALVNEQRKKQFTEIWQSTAPELEFTLVEDTATNVITAADSVLLASGTVALECMLLKRPMVVGYKVNKLTGYIVKKLSI
TEFVSLPNILAGEEIVKEHILEECHPDYLFPSVDKMLSTDNAPLIERFTEMHHWIRKDADKQAANAVLKLIGRECVES
>Mature_397_residues
AQQEAATNSLDFVSNEPLRVGIVVGELSGDTLGEGFIKAIKSQYPNAEFVGIGGPKMKALGCESLFEMEELAVMGLVEVL
GRLPRLLKVKAELVKYFTQNPPDVFVGIDAPDFNLRLELDLKNAGIKTVHYVSPSVWAWRPKRIFKIDKATDLVLAFLPF
EKAFYDKYNVACEFVGHTLADTIPLEPNKKEARDLLGLDQDKPWLAVLPGSRGGEMSLIAQPFIETCQRIKQKYSDINFV
VALVNEQRKKQFTEIWQSTAPELEFTLVEDTATNVITAADSVLLASGTVALECMLLKRPMVVGYKVNKLTGYIVKKLSIT
EFVSLPNILAGEEIVKEHILEECHPDYLFPSVDKMLSTDNAPLIERFTEMHHWIRKDADKQAANAVLKLIGRECVES

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=380, Percent_Identity=55.2631578947368, Blast_Score=434, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 44445; Mature: 44314

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQQEAATNSLDFVSNEPLRVGIVVGELSGDTLGEGFIKAIKSQYPNAEFVGIGGPKMKA
CCCCHHCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHH
LGCESLFEMEELAVMGLVEVLGRLPRLLKVKAELVKYFTQNPPDVFVGIDAPDFNLRLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEE
DLKNAGIKTVHYVSPSVWAWRPKRIFKIDKATDLVLAFLPFEKAFYDKYNVACEFVGHTL
EECCCCCEEEEEECCCCEEECCCCEEEECCHHHHHHEECCHHHHHHHHHHHHHHHHHHHH
ADTIPLEPNKKEARDLLGLDQDKPWLAVLPGSRGGEMSLIAQPFIETCQRIKQKYSDINF
HCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
VVALVNEQRKKQFTEIWQSTAPELEFTLVEDTATNVITAADSVLLASGTVALECMLLKRP
EEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHEECCHHHHHHHHHHCC
MVVGYKVNKLTGYIVKKLSITEFVSLPNILAGEEIVKEHILEECHPDYLFPSVDKMLSTD
EEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCC
NAPLIERFTEMHHWIRKDADKQAANAVLKLIGRECVES
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQQEAATNSLDFVSNEPLRVGIVVGELSGDTLGEGFIKAIKSQYPNAEFVGIGGPKMKA
CCCHHCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHH
LGCESLFEMEELAVMGLVEVLGRLPRLLKVKAELVKYFTQNPPDVFVGIDAPDFNLRLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEE
DLKNAGIKTVHYVSPSVWAWRPKRIFKIDKATDLVLAFLPFEKAFYDKYNVACEFVGHTL
EECCCCCEEEEEECCCCEEECCCCEEEECCHHHHHHEECCHHHHHHHHHHHHHHHHHHHH
ADTIPLEPNKKEARDLLGLDQDKPWLAVLPGSRGGEMSLIAQPFIETCQRIKQKYSDINF
HCCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEE
VVALVNEQRKKQFTEIWQSTAPELEFTLVEDTATNVITAADSVLLASGTVALECMLLKRP
EEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHEECCHHHHHHHHHHCC
MVVGYKVNKLTGYIVKKLSITEFVSLPNILAGEEIVKEHILEECHPDYLFPSVDKMLSTD
EEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCC
NAPLIERFTEMHHWIRKDADKQAANAVLKLIGRECVES
CCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA