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The map label for this gene is citT [C]

Identifier: 218709267

GI number: 218709267

Start: 1372014

End: 1373432

Strand: Direct

Name: citT [C]

Synonym: VS_1274

Alternate gene names: 218709267

Gene position: 1372014-1373432 (Clockwise)

Preceding gene: 218709266

Following gene: 218709268

Centisome position: 41.58

GC content: 44.75

Gene sequence:

>1419_bases
ATGCGCCACTATATTAAATACATTATCCCTATTTTAATTCCTTTCATTATCCTCGTAATGCCGCTATCAGCGTTTCCATT
TGAAGGCCTTACGATTATTCAACAACGCGTTATTGCGATCTTTTTATTGGCGGCATTGTGCTGGGTGTTCGAGCCCATCC
CGATCTACGCGACGTCTGTTGTTATTATCGTTCTGCAATTGTTGATGTTGTCGGATAAAGGGCTGATCTTTTTAAGGTTT
GAGCATGGGCAGGAACATTTTGGTGAGTTGTTAAAATACAGCGATATCATGGCGACATTCGCTAGCCCAATCATCATGCT
GTTTTTGGGCGGTTTTTTCTTAGCGATGGCCGCCACTAAATATCGATTAGACGTAAACTTAGCTCGCGTGTTGTTGAAGC
CATTTGGACAAGACCCAAAGTTTGTGATGCTCGGCTTAATGTTGATCACCGGTATCTTTTCGATGTTTATGTCTAACACG
GCAACAACGGCAATGATGCTATCTATTTTAACGCCGGTACTGGCTGTGTTTGGCCCGAAAGACCCCGGTCGTATAGCGTT
TGCGCTTTGTATCCCTGTTGCCGCTAACATCGGCGGAATTGGTACCCCGATCGGTACCCCCCCGAACGCTATCGCCCTTA
AATATTTAGTTGGCGATAACCTCATTACGTTCGGTGAATGGATGGCGTTTGGTGTGCCGTTTGTCGTTATTATGATGGCG
TTAGCGTGGTTTTTAATAGGCTTTATGTACAAAGCTGACCAAAAGAAAATTGAGCTAAGCATCAAAGGTAAATTCCTTAA
AACTCCCAAAGCCATTGCGGTATACGTCACTTTTGCGCTGACCATCATTCTTTGGTTAATGGGCTCAAGCCATGGCATGA
ACTCTTATACCGTCGCTCTGATTCCTGTCGCTGTGTTCTCACTCACAGGGATCATCAATAAAGAAGACCTGAAAAAGATT
TCTTGGGACGTACTGTGGCTTGTATCAGGTGGTATTGCACTTGGTTTAGCTCTCGATAAAACTGGCTTAGCAAGGCTCGT
GGTACACAGCATTCCGTTTGATGCTTACTCACCATATGTGGTGTTGTTCGGAGCGGCGTTCTTGTGTTTGGTAATGGCAA
ACTTTATGTCTCATACCGCAACGGCTAACTTGTTAATGCCAATTATGGCTGCATTAGGTTCGTCTATGGCTTCACTCACG
CCACTCGGCGGTGAGTTAACGTTAATTCTGGTTGTGACTTTTGCCGCTTCATTAGGTATGTCGCTGCCAATCAGTACGCC
ACCGAATGCGTTGGCTCATGCCACAGGTCATGTGCAAAGTAATCAAATGGCCAGAATCGGTATTATTTTAGGTGTGGTTG
GTGTGCTACTGAGTTTTGTTATGGTGTGGGTGCTACATTCAATTGGTCACATAGGATAA

Upstream 100 bases:

>100_bases
TGAGATAGAGATAAGAGGTCGATAATTCGTTGTCGGATCTAAATTAGAACTTTAAATCTAATTTCTAAGTAGTTGTTATC
TCAGGAAGAGTTTTTGTGCT

Downstream 100 bases:

>100_bases
CGATACGTGTATCAACAAAAGCTAGAAGCACTTATCGATCGTTATTTTAATCAGACAGAGCGTCGGGTGACGTGCCGTGC
CGGTAACACCATTATTGAAC

Product: putative transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MRHYIKYIIPILIPFIILVMPLSAFPFEGLTIIQQRVIAIFLLAALCWVFEPIPIYATSVVIIVLQLLMLSDKGLIFLRF
EHGQEHFGELLKYSDIMATFASPIIMLFLGGFFLAMAATKYRLDVNLARVLLKPFGQDPKFVMLGLMLITGIFSMFMSNT
ATTAMMLSILTPVLAVFGPKDPGRIAFALCIPVAANIGGIGTPIGTPPNAIALKYLVGDNLITFGEWMAFGVPFVVIMMA
LAWFLIGFMYKADQKKIELSIKGKFLKTPKAIAVYVTFALTIILWLMGSSHGMNSYTVALIPVAVFSLTGIINKEDLKKI
SWDVLWLVSGGIALGLALDKTGLARLVVHSIPFDAYSPYVVLFGAAFLCLVMANFMSHTATANLLMPIMAALGSSMASLT
PLGGELTLILVVTFAASLGMSLPISTPPNALAHATGHVQSNQMARIGIILGVVGVLLSFVMVWVLHSIGHIG

Sequences:

>Translated_472_residues
MRHYIKYIIPILIPFIILVMPLSAFPFEGLTIIQQRVIAIFLLAALCWVFEPIPIYATSVVIIVLQLLMLSDKGLIFLRF
EHGQEHFGELLKYSDIMATFASPIIMLFLGGFFLAMAATKYRLDVNLARVLLKPFGQDPKFVMLGLMLITGIFSMFMSNT
ATTAMMLSILTPVLAVFGPKDPGRIAFALCIPVAANIGGIGTPIGTPPNAIALKYLVGDNLITFGEWMAFGVPFVVIMMA
LAWFLIGFMYKADQKKIELSIKGKFLKTPKAIAVYVTFALTIILWLMGSSHGMNSYTVALIPVAVFSLTGIINKEDLKKI
SWDVLWLVSGGIALGLALDKTGLARLVVHSIPFDAYSPYVVLFGAAFLCLVMANFMSHTATANLLMPIMAALGSSMASLT
PLGGELTLILVVTFAASLGMSLPISTPPNALAHATGHVQSNQMARIGIILGVVGVLLSFVMVWVLHSIGHIG
>Mature_472_residues
MRHYIKYIIPILIPFIILVMPLSAFPFEGLTIIQQRVIAIFLLAALCWVFEPIPIYATSVVIIVLQLLMLSDKGLIFLRF
EHGQEHFGELLKYSDIMATFASPIIMLFLGGFFLAMAATKYRLDVNLARVLLKPFGQDPKFVMLGLMLITGIFSMFMSNT
ATTAMMLSILTPVLAVFGPKDPGRIAFALCIPVAANIGGIGTPIGTPPNAIALKYLVGDNLITFGEWMAFGVPFVVIMMA
LAWFLIGFMYKADQKKIELSIKGKFLKTPKAIAVYVTFALTIILWLMGSSHGMNSYTVALIPVAVFSLTGIINKEDLKKI
SWDVLWLVSGGIALGLALDKTGLARLVVHSIPFDAYSPYVVLFGAAFLCLVMANFMSHTATANLLMPIMAALGSSMASLT
PLGGELTLILVVTFAASLGMSLPISTPPNALAHATGHVQSNQMARIGIILGVVGVLLSFVMVWVLHSIGHIG

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI29171306, Length=532, Percent_Identity=25.5639097744361, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI31377715, Length=564, Percent_Identity=21.8085106382979, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI301069349, Length=295, Percent_Identity=25.7627118644068, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI219802232, Length=462, Percent_Identity=24.4588744588745, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI58761541, Length=330, Percent_Identity=22.1212121212121, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI301069353, Length=330, Percent_Identity=22.4242424242424, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI31795546, Length=340, Percent_Identity=25.2941176470588, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923838, Length=331, Percent_Identity=23.5649546827795, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786829, Length=489, Percent_Identity=22.6993865030675, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32565804, Length=427, Percent_Identity=29.2740046838407, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71988385, Length=427, Percent_Identity=29.2740046838407, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71989118, Length=505, Percent_Identity=23.1683168316832, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32564681, Length=441, Percent_Identity=25.3968253968254, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319885, Length=449, Percent_Identity=30.5122494432071, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322263, Length=440, Percent_Identity=29.5454545454545, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324340, Length=446, Percent_Identity=29.8206278026906, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI281366409, Length=507, Percent_Identity=23.4714003944773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737623, Length=507, Percent_Identity=23.4714003944773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666468, Length=507, Percent_Identity=23.4714003944773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551633, Length=507, Percent_Identity=23.4714003944773, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362114, Length=222, Percent_Identity=28.3783783783784, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281362112, Length=222, Percent_Identity=28.3783783783784, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281362116, Length=222, Percent_Identity=28.3783783783784, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 51132; Mature: 51132

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHYIKYIIPILIPFIILVMPLSAFPFEGLTIIQQRVIAIFLLAALCWVFEPIPIYATSV
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VIIVLQLLMLSDKGLIFLRFEHGQEHFGELLKYSDIMATFASPIIMLFLGGFFLAMAATK
HHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRLDVNLARVLLKPFGQDPKFVMLGLMLITGIFSMFMSNTATTAMMLSILTPVLAVFGPK
HEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
DPGRIAFALCIPVAANIGGIGTPIGTPPNAIALKYLVGDNLITFGEWMAFGVPFVVIMMA
CCCCEEHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHH
LAWFLIGFMYKADQKKIELSIKGKFLKTPKAIAVYVTFALTIILWLMGSSHGMNSYTVAL
HHHHHHHHHHHCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
IPVAVFSLTGIINKEDLKKISWDVLWLVSGGIALGLALDKTGLARLVVHSIPFDAYSPYV
HHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHCCCCCCCHHH
VLFGAAFLCLVMANFMSHTATANLLMPIMAALGSSMASLTPLGGELTLILVVTFAASLGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCC
SLPISTPPNALAHATGHVQSNQMARIGIILGVVGVLLSFVMVWVLHSIGHIG
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRHYIKYIIPILIPFIILVMPLSAFPFEGLTIIQQRVIAIFLLAALCWVFEPIPIYATSV
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VIIVLQLLMLSDKGLIFLRFEHGQEHFGELLKYSDIMATFASPIIMLFLGGFFLAMAATK
HHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRLDVNLARVLLKPFGQDPKFVMLGLMLITGIFSMFMSNTATTAMMLSILTPVLAVFGPK
HEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
DPGRIAFALCIPVAANIGGIGTPIGTPPNAIALKYLVGDNLITFGEWMAFGVPFVVIMMA
CCCCEEHHHHHHHHHCCCCCCCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHH
LAWFLIGFMYKADQKKIELSIKGKFLKTPKAIAVYVTFALTIILWLMGSSHGMNSYTVAL
HHHHHHHHHHHCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
IPVAVFSLTGIINKEDLKKISWDVLWLVSGGIALGLALDKTGLARLVVHSIPFDAYSPYV
HHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCEEEEECCHHHHHHHHHHCCCCCCCHHH
VLFGAAFLCLVMANFMSHTATANLLMPIMAALGSSMASLTPLGGELTLILVVTFAASLGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCC
SLPISTPPNALAHATGHVQSNQMARIGIILGVVGVLLSFVMVWVLHSIGHIG
CCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]