Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 218708409

GI number: 218708409

Start: 368894

End: 369910

Strand: Reverse

Name: pdxA [H]

Synonym: VS_0371

Alternate gene names: 218708409

Gene position: 369910-368894 (Counterclockwise)

Preceding gene: 218708410

Following gene: 218708408

Centisome position: 11.21

GC content: 45.53

Gene sequence:

>1017_bases
TTGTTGAAGTGGTCGAGGATGACCAAGATGACAACTAGACGCCTTGTCATTACAGCAGGTGAACCGGCGGGAATTGGGCC
AGATTTAACTCTCGCATTATCCCAAGAAAGCTGGCCACATCAGCTCGTGGTTTGTGCGGATAAAAGCCTATTAGCAGAGC
GAGCTGAAATGTTAGGGATTGAGGTTGAGCTGTTGGATTACGACTCAACCGCGCCCAAGCAACCTCAACGCTCTGGAACA
TTGGTTGTGAAACACGTTCCACTAGCTGAAGTCGCCGTTGCAGGCCAACTCAACGAGGCTAACGGTCATTACGTATTAAA
TACTTTAGAAACCGCAGCAATTGGCTGTATGAATGATGAATTTGATGCTATTGTCACCGGCCCTGTTCACAAGGGTGTAA
TTAACCGAGCTGGCGTTGCTTTTAGTGGCCATACCGAGTTCTTTGCAGAGAAATCCAATACTCCACTTGTCGTGATGATG
TTGGCAACAGAAGGGCTGCGTGTTGCTCTAGTAACAACGCACATCCCGCTAGCATATGTATCTCAAGCAGTGACCGAAGA
CAGATTAGAGCAAATCATTGCTATTCTGCATAAAGACTTGGTTGAAAAATTTGCTATTGAGAAACCAACTATCTACGTGT
GTGGTTTGAATCCACATGCTGGTGAAGATGGTTGTTTGGGTCGTGAAGAGATAGAAACTATCACCCCTACGCTAGAAAAA
ATTCGCCAGAAAGATGGTATTAATTTAGTTGGCCCATTGCCAGCAGACACCATCTTTAATGAAAAATATTTGCAAGATGC
AGATGCTGTTTTAGGTATGTATCACGACCAAGTACTCCCGGTATTGAAATACAAAGGGTTTGGTCGCTCAGTGAACATCA
CGCTTGGCTTACCGTTTATTCGCACATCAGTCGATCACGGTACCGCCTTAGACTTGGCAGGGAAAGGCCAAGCCGATACA
GGGAGCTTTAGAACAGCGCTCACGCACGCCATTGAATTAGTAGAGAAAAAACAATGA

Upstream 100 bases:

>100_bases
ACCGATTCAGCATTGAAAAACAAAGCTTATCAAATTCTATTTAACCGTAAGTTCAACGAAGAAGTCGGTGCTTGGCTGCA
AGAAGTAAGAGCTAGCGCCT

Downstream 100 bases:

>100_bases
GAAATGATGTCCACTTAGGGCACAAAGCGCGTAAACGTTTTGGTCAAAACTTCCTTAACGACCCATACATTATTGATGGA
ATCGTATCGAGTATTAACCC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLKWSRMTKMTTRRLVITAGEPAGIGPDLTLALSQESWPHQLVVCADKSLLAERAEMLGIEVELLDYDSTAPKQPQRSGT
LVVKHVPLAEVAVAGQLNEANGHYVLNTLETAAIGCMNDEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEKSNTPLVVMM
LATEGLRVALVTTHIPLAYVSQAVTEDRLEQIIAILHKDLVEKFAIEKPTIYVCGLNPHAGEDGCLGREEIETITPTLEK
IRQKDGINLVGPLPADTIFNEKYLQDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGKGQADT
GSFRTALTHAIELVEKKQ

Sequences:

>Translated_338_residues
MLKWSRMTKMTTRRLVITAGEPAGIGPDLTLALSQESWPHQLVVCADKSLLAERAEMLGIEVELLDYDSTAPKQPQRSGT
LVVKHVPLAEVAVAGQLNEANGHYVLNTLETAAIGCMNDEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEKSNTPLVVMM
LATEGLRVALVTTHIPLAYVSQAVTEDRLEQIIAILHKDLVEKFAIEKPTIYVCGLNPHAGEDGCLGREEIETITPTLEK
IRQKDGINLVGPLPADTIFNEKYLQDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGKGQADT
GSFRTALTHAIELVEKKQ
>Mature_338_residues
MLKWSRMTKMTTRRLVITAGEPAGIGPDLTLALSQESWPHQLVVCADKSLLAERAEMLGIEVELLDYDSTAPKQPQRSGT
LVVKHVPLAEVAVAGQLNEANGHYVLNTLETAAIGCMNDEFDAIVTGPVHKGVINRAGVAFSGHTEFFAEKSNTPLVVMM
LATEGLRVALVTTHIPLAYVSQAVTEDRLEQIIAILHKDLVEKFAIEKPTIYVCGLNPHAGEDGCLGREEIETITPTLEK
IRQKDGINLVGPLPADTIFNEKYLQDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALDLAGKGQADT
GSFRTALTHAIELVEKKQ

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=327, Percent_Identity=62.0795107033639, Blast_Score=408, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 36724; Mature: 36724

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKWSRMTKMTTRRLVITAGEPAGIGPDLTLALSQESWPHQLVVCADKSLLAERAEMLGI
CCCHHHHHHHCEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHCE
EVELLDYDSTAPKQPQRSGTLVVKHVPLAEVAVAGQLNEANGHYVLNTLETAAIGCMNDE
EEEEEECCCCCCCCCCCCCCEEEEECCHHHHHEECCCCCCCCCEEEEEHHHHHEECCCCC
FDAIVTGPVHKGVINRAGVAFSGHTEFFAEKSNTPLVVMMLATEGLRVALVTTHIPLAYV
CCEEEECCHHHHHHHHCCEEECCCHHEEECCCCCCEEEEEEECCCEEEEEEEECCCHHHH
SQAVTEDRLEQIIAILHKDLVEKFAIEKPTIYVCGLNPHAGEDGCLGREEIETITPTLEK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
IRQKDGINLVGPLPADTIFNEKYLQDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFI
HHHHCCCEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHH
RTSVDHGTALDLAGKGQADTGSFRTALTHAIELVEKKQ
EECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKWSRMTKMTTRRLVITAGEPAGIGPDLTLALSQESWPHQLVVCADKSLLAERAEMLGI
CCCHHHHHHHCEEEEEEECCCCCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHCE
EVELLDYDSTAPKQPQRSGTLVVKHVPLAEVAVAGQLNEANGHYVLNTLETAAIGCMNDE
EEEEEECCCCCCCCCCCCCCEEEEECCHHHHHEECCCCCCCCCEEEEEHHHHHEECCCCC
FDAIVTGPVHKGVINRAGVAFSGHTEFFAEKSNTPLVVMMLATEGLRVALVTTHIPLAYV
CCEEEECCHHHHHHHHCCEEECCCHHEEECCCCCCEEEEEEECCCEEEEEEEECCCHHHH
SQAVTEDRLEQIIAILHKDLVEKFAIEKPTIYVCGLNPHAGEDGCLGREEIETITPTLEK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
IRQKDGINLVGPLPADTIFNEKYLQDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFI
HHHHCCCEEECCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHH
RTSVDHGTALDLAGKGQADTGSFRTALTHAIELVEKKQ
EECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]