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The map label for this gene is nanM1 [H]

Identifier: 218692468

GI number: 218692468

Start: 4873936

End: 4875054

Strand: Direct

Name: nanM1 [H]

Synonym: ECED1_4916

Alternate gene names: 218692468

Gene position: 4873936-4875054 (Clockwise)

Preceding gene: 218692467

Following gene: 218692469

Centisome position: 93.56

GC content: 39.95

Gene sequence:

>1119_bases
GTGATTACAATGAAAGTGAAAAACTTTATATATCTTCCCTTCTGCTTGTTTATTGGAACGTCGGTAGCCGGAGCTTTACC
GGAAATTCCTGAACCATTTAAATATGGTGTAGGAGGGATCGAGAATGGTAAAATATATATAGGACTGGGAAGTCTGGGAA
ATAACTGGTATATGATAGATACAAACCAGAGTGAAAAAAAATGGACTAAGATAGCACAATGGCCGACAGTTCCCAGAGAG
CAGGCAACAGCTACTATTATTGATGGTAAGATCTATGTATTTGGAGGAATTGGAAAAGATAAAAGTGGAGTCATAACCTT
ACAAAAAGATGTCTATTCCTATGATATTGCTAAAGATAAATGGGAAAAATTGATGACCCGTCCCCCTGTATCTCTTGCCG
GTCATGTTTCTTTTATCCATAATGGTCATGCGGTATCTACTGGTGGTGTAAATGAGAATATTTTTAATGGATACTTTTCA
GATGTCGAGTTATCAAAAGGGAATTCCGCGCTGACAGAGAAAGTCAACAGGGATTATTTTAGTAAACCTGCTGATGATTA
TTTTTTAAATAATCATATAATTTCTTATGACCCGTCAAAAAACCAGTGGAAGAACCTGGGAACGACTCCATTTCCGGGAA
CTGCTGGTTCATCGGTGATTTTTGCAGAACAGCAAATTTATATACTGGGAGGGGAGAGAAAACCGGGGCTTCGTTCTGTT
AGATCCTGGACGGGGGAGCTTTCGCATGATCGAATTAAATGGTCTGAACTTCCACCAGTAGCTTCACCCGAGGGGGTGTC
AGGAGCATATGCCTCTGTTATTGATGGAAATATCTTTCTGGCCGGTGGTGCATATTTCCCGGGGGCGGCAGAAAAGTATA
GCAATGGTGAATACTGGTCTCATAAAGGACTGGATAAAGCCTATTCAAAAGAGATATATCAGCTAATAAAAAATGACTGG
AAAAAAGTTGGTTCTTTGCCGGAAGGACTTGCTTATGGTGTAAGCCTGCCCTGGCAGGGGGGGATGCTCATTCTGGGTGG
GGAGAAAAAAGATGGTAAAGCTGTTTCAGATGTTATTTATCTGAAAAAAAATGACAAACAAATAAAGATTGTTAAATAA

Upstream 100 bases:

>100_bases
TATAGAATATGATTACCTGGATAAACAAGGGGTGTATAAGGGGAAAGATAATAAACATGAAAATAGTTACCGTGTCGGTG
TTCTGATTAATTTTTAAAAG

Downstream 100 bases:

>100_bases
CTGTAATGCAGGTGACTGTATTAGTTGTTCAGTCACCTGAGTTATTTTAATGGGGTTTATAATGAATAAAGATAAATCTT
TAAATGAAATGATGTTAAGC

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase 1; Neu5Ac mutarotase 1; Sialic acid epimerase 1 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MITMKVKNFIYLPFCLFIGTSVAGALPEIPEPFKYGVGGIENGKIYIGLGSLGNNWYMIDTNQSEKKWTKIAQWPTVPRE
QATATIIDGKIYVFGGIGKDKSGVITLQKDVYSYDIAKDKWEKLMTRPPVSLAGHVSFIHNGHAVSTGGVNENIFNGYFS
DVELSKGNSALTEKVNRDYFSKPADDYFLNNHIISYDPSKNQWKNLGTTPFPGTAGSSVIFAEQQIYILGGERKPGLRSV
RSWTGELSHDRIKWSELPPVASPEGVSGAYASVIDGNIFLAGGAYFPGAAEKYSNGEYWSHKGLDKAYSKEIYQLIKNDW
KKVGSLPEGLAYGVSLPWQGGMLILGGEKKDGKAVSDVIYLKKNDKQIKIVK

Sequences:

>Translated_372_residues
MITMKVKNFIYLPFCLFIGTSVAGALPEIPEPFKYGVGGIENGKIYIGLGSLGNNWYMIDTNQSEKKWTKIAQWPTVPRE
QATATIIDGKIYVFGGIGKDKSGVITLQKDVYSYDIAKDKWEKLMTRPPVSLAGHVSFIHNGHAVSTGGVNENIFNGYFS
DVELSKGNSALTEKVNRDYFSKPADDYFLNNHIISYDPSKNQWKNLGTTPFPGTAGSSVIFAEQQIYILGGERKPGLRSV
RSWTGELSHDRIKWSELPPVASPEGVSGAYASVIDGNIFLAGGAYFPGAAEKYSNGEYWSHKGLDKAYSKEIYQLIKNDW
KKVGSLPEGLAYGVSLPWQGGMLILGGEKKDGKAVSDVIYLKKNDKQIKIVK
>Mature_372_residues
MITMKVKNFIYLPFCLFIGTSVAGALPEIPEPFKYGVGGIENGKIYIGLGSLGNNWYMIDTNQSEKKWTKIAQWPTVPRE
QATATIIDGKIYVFGGIGKDKSGVITLQKDVYSYDIAKDKWEKLMTRPPVSLAGHVSFIHNGHAVSTGGVNENIFNGYFS
DVELSKGNSALTEKVNRDYFSKPADDYFLNNHIISYDPSKNQWKNLGTTPFPGTAGSSVIFAEQQIYILGGERKPGLRSV
RSWTGELSHDRIKWSELPPVASPEGVSGAYASVIDGNIFLAGGAYFPGAAEKYSNGEYWSHKGLDKAYSKEIYQLIKNDW
KKVGSLPEGLAYGVSLPWQGGMLILGGEKKDGKAVSDVIYLKKNDKQIKIVK

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats [H]

Homologues:

Organism=Escherichia coli, GI87082419, Length=364, Percent_Identity=44.2307692307692, Blast_Score=343, Evalue=1e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936 [H]

Pfam domain/function: PF01344 Kelch_1 [H]

EC number: NA

Molecular weight: Translated: 40989; Mature: 40989

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITMKVKNFIYLPFCLFIGTSVAGALPEIPEPFKYGVGGIENGKIYIGLGSLGNNWYMID
CEEEEECCEEHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCEEEEE
TNQSEKKWTKIAQWPTVPREQATATIIDGKIYVFGGIGKDKSGVITLQKDVYSYDIAKDK
CCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCCCCEEEEECCCHHHHCHHHH
WEKLMTRPPVSLAGHVSFIHNGHAVSTGGVNENIFNGYFSDVELSKGNSALTEKVNRDYF
HHHHHCCCCCCCEEEEEEEECCEEEECCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHH
SKPADDYFLNNHIISYDPSKNQWKNLGTTPFPGTAGSSVIFAEQQIYILGGERKPGLRSV
CCCCCCEEECCEEEEECCCHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCHHHH
RSWTGELSHDRIKWSELPPVASPEGVSGAYASVIDGNIFLAGGAYFPGAAEKYSNGEYWS
HHHCCCCCCCEEECCCCCCCCCCCCCCCCCCEEECCCEEEECCCCCCCCHHHCCCCCCCC
HKGLDKAYSKEIYQLIKNDWKKVGSLPEGLAYGVSLPWQGGMLILGGEKKDGKAVSDVIY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEEECCCCCCCCEEEEEEE
LKKNDKQIKIVK
EECCCCEEEEEC
>Mature Secondary Structure
MITMKVKNFIYLPFCLFIGTSVAGALPEIPEPFKYGVGGIENGKIYIGLGSLGNNWYMID
CEEEEECCEEHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEEEECCCCCCEEEEE
TNQSEKKWTKIAQWPTVPREQATATIIDGKIYVFGGIGKDKSGVITLQKDVYSYDIAKDK
CCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCCCCEEEEECCCHHHHCHHHH
WEKLMTRPPVSLAGHVSFIHNGHAVSTGGVNENIFNGYFSDVELSKGNSALTEKVNRDYF
HHHHHCCCCCCCEEEEEEEECCEEEECCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHH
SKPADDYFLNNHIISYDPSKNQWKNLGTTPFPGTAGSSVIFAEQQIYILGGERKPGLRSV
CCCCCCEEECCEEEEECCCHHHHHCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCHHHH
RSWTGELSHDRIKWSELPPVASPEGVSGAYASVIDGNIFLAGGAYFPGAAEKYSNGEYWS
HHHCCCCCCCEEECCCCCCCCCCCCCCCCCCEEECCCEEEECCCCCCCCHHHCCCCCCCC
HKGLDKAYSKEIYQLIKNDWKKVGSLPEGLAYGVSLPWQGGMLILGGEKKDGKAVSDVIY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCEEEECCCCCCCCEEEEEEE
LKKNDKQIKIVK
EECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]