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The map label for this gene is nanC [H]

Identifier: 218692467

GI number: 218692467

Start: 4873192

End: 4873932

Strand: Direct

Name: nanC [H]

Synonym: ECED1_4915

Alternate gene names: 218692467

Gene position: 4873192-4873932 (Clockwise)

Preceding gene: 218692466

Following gene: 218692468

Centisome position: 93.54

GC content: 36.17

Gene sequence:

>741_bases
GTGATAAATATATTTAATGATGAGGCATTTATGAAAAAATATTATCCACTATTAACTGTAATTCTTCTTGGTTTACCTTT
GTGCTCTCAGGCATTAACTCTTAATCTACGTGGGGGATACAGAAGCGCCAGTCACGCTTATGAAACGTTGATTCAGGTTA
GTCAGGGGTGGAATAATGGTTGGTGGGCAAGTTTTGAGTCAAACACCTGGAATACAATTCACAACAATGAAAATGAATTG
TTTGCACTCAATTATAATAAAATAGATATAAATAAAACATATAAAATAGATGACAAATGGGCTCTAATCCCAGGGATTCA
GACACAATGGATGTCAGCAGGAAGTCAGTATAACCCTTATCTGAAAATTTCGTATCAGGCAACGCCAGATCTTAATCTGG
CCTTACGCTATCGCTATGACTGGAAAGCTTTCCGACAGACGGATTTAGATGGCAACAGGGCGCGTAATGATCAGCATCAG
TTTGATGGTTATGTGACATACAAAATTAATGATTCATGGTTGTTTGCATGGCAGACCACGGTATATACGAAGGTTAATAA
TTTCAAATATGGGAATCATAAAAAAACAGCAACTGAAAATGCATTTGTTCTGCAATATAAAATGTCACCGGTGTTCACCC
CATATATAGAATATGATTACCTGGATAAACAAGGGGTGTATAAGGGGAAAGATAATAAACATGAAAATAGTTACCGTGTC
GGTGTTCTGATTAATTTTTAA

Upstream 100 bases:

>100_bases
TGGTGTATCCGGAAAAAATGGATATCCGATAGAAAAATGGCAAAGCCTGCTTCTGGAATGGCTTGCGGAACATAAGTTTC
ATTGAGAAATCAAATTACAA

Downstream 100 bases:

>100_bases
AAGGTGATTACAATGAAAGTGAAAAACTTTATATATCTTCCCTTCTGCTTGTTTATTGGAACGTCGGTAGCCGGAGCTTT
ACCGGAAATTCCTGAACCAT

Product: putative N-acetylneuraminic acid outer membrane channel protein nanC

Products: NA

Alternate protein names: Porin nanC [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MINIFNDEAFMKKYYPLLTVILLGLPLCSQALTLNLRGGYRSASHAYETLIQVSQGWNNGWWASFESNTWNTIHNNENEL
FALNYNKIDINKTYKIDDKWALIPGIQTQWMSAGSQYNPYLKISYQATPDLNLALRYRYDWKAFRQTDLDGNRARNDQHQ
FDGYVTYKINDSWLFAWQTTVYTKVNNFKYGNHKKTATENAFVLQYKMSPVFTPYIEYDYLDKQGVYKGKDNKHENSYRV
GVLINF

Sequences:

>Translated_246_residues
MINIFNDEAFMKKYYPLLTVILLGLPLCSQALTLNLRGGYRSASHAYETLIQVSQGWNNGWWASFESNTWNTIHNNENEL
FALNYNKIDINKTYKIDDKWALIPGIQTQWMSAGSQYNPYLKISYQATPDLNLALRYRYDWKAFRQTDLDGNRARNDQHQ
FDGYVTYKINDSWLFAWQTTVYTKVNNFKYGNHKKTATENAFVLQYKMSPVFTPYIEYDYLDKQGVYKGKDNKHENSYRV
GVLINF
>Mature_246_residues
MINIFNDEAFMKKYYPLLTVILLGLPLCSQALTLNLRGGYRSASHAYETLIQVSQGWNNGWWASFESNTWNTIHNNENEL
FALNYNKIDINKTYKIDDKWALIPGIQTQWMSAGSQYNPYLKISYQATPDLNLALRYRYDWKAFRQTDLDGNRARNDQHQ
FDGYVTYKINDSWLFAWQTTVYTKVNNFKYGNHKKTATENAFVLQYKMSPVFTPYIEYDYLDKQGVYKGKDNKHENSYRV
GVLINF

Specific function: Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac or sialic acid) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oligogalacturonate-specific porin kdgM (TC 1.B.35) family. NanC subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082420, Length=234, Percent_Identity=61.1111111111111, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1790307, Length=214, Percent_Identity=27.5700934579439, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009331
- InterPro:   IPR001702 [H]

Pfam domain/function: PF06178 KdgM [H]

EC number: NA

Molecular weight: Translated: 28988; Mature: 28988

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIFNDEAFMKKYYPLLTVILLGLPLCSQALTLNLRGGYRSASHAYETLIQVSQGWNNG
CEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
WWASFESNTWNTIHNNENELFALNYNKIDINKTYKIDDKWALIPGIQTQWMSAGSQYNPY
EEEEECCCCCCEEECCCCCEEEEECCEEECCEEEEECCCEEEECCCCHHHHCCCCCCCCE
LKISYQATPDLNLALRYRYDWKAFRQTDLDGNRARNDQHQFDGYVTYKINDSWLFAWQTT
EEEEEECCCCCEEEEEEEECCHHHEECCCCCCCCCCCCHHCCCEEEEEECCCEEEEEEEE
VYTKVNNFKYGNHKKTATENAFVLQYKMSPVFTPYIEYDYLDKQGVYKGKDNKHENSYRV
EEEEECCEECCCCCCCCCCCEEEEEEECCCEEECEEEEECCCCCCCCCCCCCCCCCCEEE
GVLINF
EEEEEC
>Mature Secondary Structure
MINIFNDEAFMKKYYPLLTVILLGLPLCSQALTLNLRGGYRSASHAYETLIQVSQGWNNG
CEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
WWASFESNTWNTIHNNENELFALNYNKIDINKTYKIDDKWALIPGIQTQWMSAGSQYNPY
EEEEECCCCCCEEECCCCCEEEEECCEEECCEEEEECCCEEEECCCCHHHHCCCCCCCCE
LKISYQATPDLNLALRYRYDWKAFRQTDLDGNRARNDQHQFDGYVTYKINDSWLFAWQTT
EEEEEECCCCCEEEEEEEECCHHHEECCCCCCCCCCCCHHCCCEEEEEECCCEEEEEEEE
VYTKVNNFKYGNHKKTATENAFVLQYKMSPVFTPYIEYDYLDKQGVYKGKDNKHENSYRV
EEEEECCEECCCCCCCCCCCEEEEEEECCCEEECEEEEECCCCCCCCCCCCCCCCCCEEE
GVLINF
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]