Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 209695052

GI number: 209695052

Start: 1658502

End: 1659512

Strand: Direct

Name: pyrD

Synonym: VSAL_I1549

Alternate gene names: 209695052

Gene position: 1658502-1659512 (Clockwise)

Preceding gene: 209695051

Following gene: 209695053

Centisome position: 49.88

GC content: 39.66

Gene sequence:

>1011_bases
ATGTTATATCGCATCGCCAGAGCTGGCATTTTCAAACTTGATGCTGAAAAAGCACATGACTTAGCAATTCAAAACTTCAA
GCGCTTTAATGGCACACCTCTTGATATCTTCTATCGTCAAAAATTAGTGTCTAAACCTGTAGAGGTAATGGGCATTCAAT
TTAAAAACCCTATCGGTCTTGCGGCCGGTCTTGAGAAAAACGGTGAGTGCATTGAAGCATTTGGCGCAATGGGTTTTGGA
TTCATTGAAGTGGGTACAGTAACTCCTCGTCCTCAAGCGGGCAATGATAAACCACGTCTTTTCCGTCTTATTGAAGCTGA
GGGTATAATCAATCGCATGGGTTTTAATAACCTAGGTGTTGATAATCTCGTCGAGAACGTAAAGAAAGCAAAATACGATG
GCGTGATTGGCATTAATATTGGTAAAAATAAAGATACGCCAATCGAGAAGGGCACTGAAGATTACTTAATCTGTATGGAG
AAGGTATATCAATACGCAGGTTATATTGCGATTAATATCTCATCACCAAATACTCCAGGACTTCGAACGCTTCAATATGG
TGAAGCACTGGATGATCTTCTTTCTCAACTGAAAGAGAAGCAGAAAGAGTTAGCTGAAAAATACGGTAAGTATGTTCCAA
TCGCATTAAAAATTGCCCCAGACCTTGATGATAATGAATTATCTCAGATTGCCGATTCTTTAATGAAATATAAGATTGAT
GGTGTCATTGCAACAAACACGACATTAGATCGTTCTATGGTTGAAGGAATGAAGCACGCAGAGGAGATGGGGGGACTAAG
TGGTCGTCCTATACAAACTCGCAGTACTGAAGTCGTTCGTCGATTAAAAGAATTATTAGGCGACAGTTTACCTATTATTG
GTGTTGGTGGTGTTGACTCTTATGTTGCAGCAAAAGAGAAGATGGTTGCGGGTGCCGATCTTGTACAGGTATATTCGGGT
TTTATCTATAAAGGTCCGAATCTGATCCGTGATATTGTAAATAATATCTAA

Upstream 100 bases:

>100_bases
AATAAATAATGACAAATTAAGTGCGATTAAGTTTGAATTGTTAATTAAATCAGTGAATAATGACTCCCCGTTTACACGGG
ACTTATTTTTTGGAGTTACA

Downstream 100 bases:

>100_bases
AATATAGGGCTTCGAAAGTTGCTTACATATGATTAACACTAAAGGGGAGATGAAGATTTCCCCTTTTTTTATTCCTAACC
TCTTGTAAAATTAACAGTTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQKLVSKPVEVMGIQFKNPIGLAAGLEKNGECIEAFGAMGFG
FIEVGTVTPRPQAGNDKPRLFRLIEAEGIINRMGFNNLGVDNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICME
KVYQYAGYIAINISSPNTPGLRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPIALKIAPDLDDNELSQIADSLMKYKID
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPIQTRSTEVVRRLKELLGDSLPIIGVGGVDSYVAAKEKMVAGADLVQVYSG
FIYKGPNLIRDIVNNI

Sequences:

>Translated_336_residues
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQKLVSKPVEVMGIQFKNPIGLAAGLEKNGECIEAFGAMGFG
FIEVGTVTPRPQAGNDKPRLFRLIEAEGIINRMGFNNLGVDNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICME
KVYQYAGYIAINISSPNTPGLRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPIALKIAPDLDDNELSQIADSLMKYKID
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPIQTRSTEVVRRLKELLGDSLPIIGVGGVDSYVAAKEKMVAGADLVQVYSG
FIYKGPNLIRDIVNNI
>Mature_336_residues
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQKLVSKPVEVMGIQFKNPIGLAAGLEKNGECIEAFGAMGFG
FIEVGTVTPRPQAGNDKPRLFRLIEAEGIINRMGFNNLGVDNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICME
KVYQYAGYIAINISSPNTPGLRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPIALKIAPDLDDNELSQIADSLMKYKID
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPIQTRSTEVVRRLKELLGDSLPIIGVGGVDSYVAAKEKMVAGADLVQVYSG
FIYKGPNLIRDIVNNI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=328, Percent_Identity=40.8536585365854, Blast_Score=223, Evalue=1e-58,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=69.3452380952381, Blast_Score=501, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17509475, Length=322, Percent_Identity=42.2360248447205, Blast_Score=231, Evalue=3e-61,
Organism=Drosophila melanogaster, GI281361352, Length=328, Percent_Identity=42.6829268292683, Blast_Score=244, Evalue=4e-65,
Organism=Drosophila melanogaster, GI17137316, Length=328, Percent_Identity=42.6829268292683, Blast_Score=244, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_ALISL (B6ELD1)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262981.1
- GeneID:   6988588
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1549
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   PRK05286
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37026; Mature: 37026

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQKLVSKPVEVMGIQFKNPIGL
CCEEECCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHEEEEECCCCCC
AAGLEKNGECIEAFGAMGFGFIEVGTVTPRPQAGNDKPRLFRLIEAEGIINRMGFNNLGV
CCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
DNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICMEKVYQYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPIALKIAPDLDDNELSQIADSLMKYKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPIQTRSTEVVRRLKELLGDSLPIIGVGGVDS
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMVAGADLVQVYSGFIYKGPNLIRDIVNNI
HHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MLYRIARAGIFKLDAEKAHDLAIQNFKRFNGTPLDIFYRQKLVSKPVEVMGIQFKNPIGL
CCEEECCCCEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHEEEEECCCCCC
AAGLEKNGECIEAFGAMGFGFIEVGTVTPRPQAGNDKPRLFRLIEAEGIINRMGFNNLGV
CCCCCCCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
DNLVENVKKAKYDGVIGINIGKNKDTPIEKGTEDYLICMEKVYQYAGYIAINISSPNTPG
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCCCC
LRTLQYGEALDDLLSQLKEKQKELAEKYGKYVPIALKIAPDLDDNELSQIADSLMKYKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHC
GVIATNTTLDRSMVEGMKHAEEMGGLSGRPIQTRSTEVVRRLKELLGDSLPIIGVGGVDS
EEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCHH
YVAAKEKMVAGADLVQVYSGFIYKGPNLIRDIVNNI
HHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA