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The map label for this gene is envZ [H]

Identifier: 209693816

GI number: 209693816

Start: 244329

End: 245636

Strand: Reverse

Name: envZ [H]

Synonym: VSAL_I0203

Alternate gene names: 209693816

Gene position: 245636-244329 (Counterclockwise)

Preceding gene: 209693817

Following gene: 209693814

Centisome position: 7.39

GC content: 43.12

Gene sequence:

>1308_bases
ATGAAAAGTACCTTCGCCAGAACACTGTTACTCCTCGCATCACTCCTAATCGCCAGTCAAATATTCTCTTATCTTGCCGT
CTTTAACTATGCACTTTTGCCTAGCTTGCAACAGTTCAACCGCATTTTGGCTTATGAAGTACGCTTAATGCTGGCAGAAG
ACGTGACACTTAAAAATGGAACAAATATCCAACTAGGCCAACCTTTACGTCGTCAGTTATTAGAGCAATTAGGCGTAAGT
ATCCATGATGAACATGATCCTGAGATGAGAGAGTTTTATCAAGCAAGTCCGGTTGAATTTTTAAGTGAAGAGATGAGTCG
AGAGTTAGAGTCACCAACCGAAGTGCGCTTGATTTTAGGAGCCGACAGTTATGTTCTGTGGATGAAAACAGAAGCGATGC
CAGAGTTTTATATGCGGATCCCGCTTTCTGAGCTACAAGAAGAAGACTTTGCCCCCTTATTTAGAAACAGTTTATTTATC
GCTTTATTAGTGATCCTTGGTGGGTGGGCATTTATACGTATTCAGAATCGGCCATTGATGGCACTGCAAACCGCCGCGAG
AAAAGTGGGCAAGGGTGAAATCCCAGAACCACTTCCAGAGAAAGGCGCGTCAGAAATTCAAGCAGTAACTCGTGCCTTTA
ATCAGATGGCGAAAGGAATTCAGCAACTAGAGCAAGATAGAGCATTACTAATGGCAGGGGTGAGTCATGATATTCGTACC
CCATTAACTCGCATTCGTTTAGCAACAGAAATGATGTCACCGCAAGACGATTATCTCGCAGAAAGTATGATTAAAGACAC
GGAAGAGTGTAATGAGATCATCGGTCAGTTTATGGATTATCTCAAACCAGTAGCAAAACAAGATTTCATTGATGTAGACA
TCAACACCATCGTTAACGAAGTGATTTTAGCTGAAGGCGGTTATGAGCGAGAGATCAAGACTAACTTGGCTAATATCCCT
CAATCTGTGCATGGTAATGCGATTGCGATTAAACGGGTGATCACTAATTTAGTCGTTAATGCGATCCGTTATGGTGGTGA
TTGGATTGCAGTATCGACTCGCGTTTCTGCCGATCATAAAACCGCATGGATTATTATTGAAGATAATGGCCCAGGGATTG
ATGAGGCTCAATTAGAATCGGTGTTTGAACCTTTTACCCGTGGAGATACGGCGCGAGGAAGTGAAGGCACAGGTTTGGGT
CTTGCGATAGTTAAACGTATTGTGGGTCAGCATCAAGGTGAAGTGAGTTTAGCGAATCGCCGAGAAGGTGGCTTGAAAGT
TCAGGTTAAGTTACCGTTAGGGAGATAA

Upstream 100 bases:

>100_bases
AAATTCACACCAGCCATACTCGCTCTTATAGTTTCTAGCTAGCTAGCGCAGCGTATAGTCTCTAACCCTCTTCAAATTCA
TCACCAAACAGAGAATACCC

Downstream 100 bases:

>100_bases
ATCGAGGTTTCAGGAAAAGAACTAGAAACTATACGCTAGCGCTAACTAGACCGCTTCGCTTCTATAAGAGCAAAAGCGAG
GATTCAGGTCTCAGGTTTCA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKSTFARTLLLLASLLIASQIFSYLAVFNYALLPSLQQFNRILAYEVRLMLAEDVTLKNGTNIQLGQPLRRQLLEQLGVS
IHDEHDPEMREFYQASPVEFLSEEMSRELESPTEVRLILGADSYVLWMKTEAMPEFYMRIPLSELQEEDFAPLFRNSLFI
ALLVILGGWAFIRIQNRPLMALQTAARKVGKGEIPEPLPEKGASEIQAVTRAFNQMAKGIQQLEQDRALLMAGVSHDIRT
PLTRIRLATEMMSPQDDYLAESMIKDTEECNEIIGQFMDYLKPVAKQDFIDVDINTIVNEVILAEGGYEREIKTNLANIP
QSVHGNAIAIKRVITNLVVNAIRYGGDWIAVSTRVSADHKTAWIIIEDNGPGIDEAQLESVFEPFTRGDTARGSEGTGLG
LAIVKRIVGQHQGEVSLANRREGGLKVQVKLPLGR

Sequences:

>Translated_435_residues
MKSTFARTLLLLASLLIASQIFSYLAVFNYALLPSLQQFNRILAYEVRLMLAEDVTLKNGTNIQLGQPLRRQLLEQLGVS
IHDEHDPEMREFYQASPVEFLSEEMSRELESPTEVRLILGADSYVLWMKTEAMPEFYMRIPLSELQEEDFAPLFRNSLFI
ALLVILGGWAFIRIQNRPLMALQTAARKVGKGEIPEPLPEKGASEIQAVTRAFNQMAKGIQQLEQDRALLMAGVSHDIRT
PLTRIRLATEMMSPQDDYLAESMIKDTEECNEIIGQFMDYLKPVAKQDFIDVDINTIVNEVILAEGGYEREIKTNLANIP
QSVHGNAIAIKRVITNLVVNAIRYGGDWIAVSTRVSADHKTAWIIIEDNGPGIDEAQLESVFEPFTRGDTARGSEGTGLG
LAIVKRIVGQHQGEVSLANRREGGLKVQVKLPLGR
>Mature_435_residues
MKSTFARTLLLLASLLIASQIFSYLAVFNYALLPSLQQFNRILAYEVRLMLAEDVTLKNGTNIQLGQPLRRQLLEQLGVS
IHDEHDPEMREFYQASPVEFLSEEMSRELESPTEVRLILGADSYVLWMKTEAMPEFYMRIPLSELQEEDFAPLFRNSLFI
ALLVILGGWAFIRIQNRPLMALQTAARKVGKGEIPEPLPEKGASEIQAVTRAFNQMAKGIQQLEQDRALLMAGVSHDIRT
PLTRIRLATEMMSPQDDYLAESMIKDTEECNEIIGQFMDYLKPVAKQDFIDVDINTIVNEVILAEGGYEREIKTNLANIP
QSVHGNAIAIKRVITNLVVNAIRYGGDWIAVSTRVSADHKTAWIIIEDNGPGIDEAQLESVFEPFTRGDTARGSEGTGLG
LAIVKRIVGQHQGEVSLANRREGGLKVQVKLPLGR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=432, Percent_Identity=52.0833333333333, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=31.2267657992565, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1787894, Length=293, Percent_Identity=29.0102389078498, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790551, Length=298, Percent_Identity=28.1879194630872, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=31.4814814814815, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=28.8372093023256, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.8388278388278, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=25.8928571428571, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=27.0833333333333, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=28.75, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786600, Length=245, Percent_Identity=29.3877551020408, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=22.7118644067797, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=284, Percent_Identity=27.112676056338, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=291, Percent_Identity=24.0549828178694, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=292, Percent_Identity=25.6849315068493, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789403, Length=288, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=282, Percent_Identity=24.822695035461, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=23.2142857142857, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48721; Mature: 48721

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTFARTLLLLASLLIASQIFSYLAVFNYALLPSLQQFNRILAYEVRLMLAEDVTLKNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCC
TNIQLGQPLRRQLLEQLGVSIHDEHDPEMREFYQASPVEFLSEEMSRELESPTEVRLILG
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEE
ADSYVLWMKTEAMPEFYMRIPLSELQEEDFAPLFRNSLFIALLVILGGWAFIRIQNRPLM
CCCEEEEEEHHCCHHHHHCCCHHHHCHHCCHHHHHHHHHHHHHHHHCCEEEEEECCCCHH
ALQTAARKVGKGEIPEPLPEKGASEIQAVTRAFNQMAKGIQQLEQDRALLMAGVSHDIRT
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
PLTRIRLATEMMSPQDDYLAESMIKDTEECNEIIGQFMDYLKPVAKQDFIDVDINTIVNE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHH
VILAEGGYEREIKTNLANIPQSVHGNAIAIKRVITNLVVNAIRYGGDWIAVSTRVSADHK
HHHCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
TAWIIIEDNGPGIDEAQLESVFEPFTRGDTARGSEGTGLGLAIVKRIVGQHQGEVSLANR
EEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCC
REGGLKVQVKLPLGR
CCCCEEEEEECCCCC
>Mature Secondary Structure
MKSTFARTLLLLASLLIASQIFSYLAVFNYALLPSLQQFNRILAYEVRLMLAEDVTLKNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCC
TNIQLGQPLRRQLLEQLGVSIHDEHDPEMREFYQASPVEFLSEEMSRELESPTEVRLILG
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEE
ADSYVLWMKTEAMPEFYMRIPLSELQEEDFAPLFRNSLFIALLVILGGWAFIRIQNRPLM
CCCEEEEEEHHCCHHHHHCCCHHHHCHHCCHHHHHHHHHHHHHHHHCCEEEEEECCCCHH
ALQTAARKVGKGEIPEPLPEKGASEIQAVTRAFNQMAKGIQQLEQDRALLMAGVSHDIRT
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
PLTRIRLATEMMSPQDDYLAESMIKDTEECNEIIGQFMDYLKPVAKQDFIDVDINTIVNE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHH
VILAEGGYEREIKTNLANIPQSVHGNAIAIKRVITNLVVNAIRYGGDWIAVSTRVSADHK
HHHCCCCCCHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
TAWIIIEDNGPGIDEAQLESVFEPFTRGDTARGSEGTGLGLAIVKRIVGQHQGEVSLANR
EEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCC
REGGLKVQVKLPLGR
CCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]