Click here to switch to the map view.

The map label for this gene is argD [H]

Identifier: 197119997

GI number: 197119997

Start: 4159721

End: 4160914

Strand: Direct

Name: argD [H]

Synonym: Gbem_3636

Alternate gene names: 197119997

Gene position: 4159721-4160914 (Clockwise)

Preceding gene: 197119996

Following gene: 197119998

Centisome position: 90.13

GC content: 62.56

Gene sequence:

>1194_bases
ATGAATTCAGCAGCATGGATGGAAAAAGCTGACAAATATATCATGAAGACCTACGGCCGCTATCCGCTGGTCCCGGTGAA
GGGCGATGGATGCTACCTGTGGGACGCGGACGGCAAGAAGTACCTGGACTTCCTCGCGGGGGTCGCGGTGAACAACCTGG
GGCACTGCCACCCGAAGGTGACGGCGGCCCTCGCCAAGCAGGCGGCGGAGCTGATCCACTGCTCGAACTACTACCATATC
CCGCAGCAGATCGAACTGGCCGAGCTTCTTTGCGGACTCTCCTTCGCGGACAAGGCGTTCTTCTGCAACTCGGGCGCCGA
GGCTAACGAGGCGGCCATCAAGCTGGCCAGGAAGTACAGCCGCGAGAAGTACGGCGTCGACCGCTACGAAATCATCACCG
CCATCTCCTCCTTCCACGGCCGCACCATGGCCACGGTCTCGGCGACCGGGCAGGAGAAGGTGCAGAAATTCTTCGATCCC
CTGCTGCACGGGTTCCGCCATGTGCCGTTCAATGACGCCAAGGCGCTCAAGGAGGCCATCGGCCCCTGCACCTGCGCCAT
CATGCTGGAGCCGATCCAGGGCGAGGGTGGCGTGGTGGTCCCGGACGCCGCCTACTTCCAAAAGGTGCGCCAGATTTGCG
ACGAGAACAACCTGATCCTCATCTTCGACGAGGTGCAGGTGGGGATGGGCAGGACCGGGAAGATGTTTGCCCACGAGCAC
TTCGGCATCACCCCCGACATCATGACGCTGGCCAAGGCGCTGGCCGGCGGCGCCCCCATCGGGACCATGCTCGCCACCGA
GAAGCTTGCGGCAGCCTTCTCCCCAGGAACCCACGGCTCCACTTTCGGCGGCAACCCGCTGGTCACCGCCGCCGCCGTCG
CCACCATCAGGGCCATGCAGGAAGAAGGGGTCCTGAACCACTGCGAGGAGATCGGCGAGTACCTGATGGGCGAGTTGGAG
GCGCTGAAGCATAAGTTCCCCGGGTTCATCACCGACGTGCGGGGCATCGGCCTCATGATCGGGGTCGAGCTTTCCATCCC
CGGCGGCGACCTGGTGAAGACCGCCCTCTCCCGGGGGCTCCTCTTGAACTGCGCCCAGGAAAAGGTGCTCCGTTTCGTGC
CGCCCTTGATCGTCGGAAAGAAAGAAGTGGACGAGATGCTCAGCATTTTGACCGGAATTCTGCAGGAACTTTAA

Upstream 100 bases:

>100_bases
GGGATGGATGGTACGGCGCCGTCACAGTGAAGAGACAACGCTGCCGACGCCGCCTCTCGAACGTTGAACCCGGAACGTTG
AACGGTTTCTAGGAGATTCT

Downstream 100 bases:

>100_bases
CTGCTCCCTCCCCCTCCCTTGACGGGAGGGGGAAGTTGATATGAGGTGCCGGCTCGGCCGGCACCATTAAAACTAGAAAC
GAGACCACACCACATGAAAA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNSAAWMEKADKYIMKTYGRYPLVPVKGDGCYLWDADGKKYLDFLAGVAVNNLGHCHPKVTAALAKQAAELIHCSNYYHI
PQQIELAELLCGLSFADKAFFCNSGAEANEAAIKLARKYSREKYGVDRYEIITAISSFHGRTMATVSATGQEKVQKFFDP
LLHGFRHVPFNDAKALKEAIGPCTCAIMLEPIQGEGGVVVPDAAYFQKVRQICDENNLILIFDEVQVGMGRTGKMFAHEH
FGITPDIMTLAKALAGGAPIGTMLATEKLAAAFSPGTHGSTFGGNPLVTAAAVATIRAMQEEGVLNHCEEIGEYLMGELE
ALKHKFPGFITDVRGIGLMIGVELSIPGGDLVKTALSRGLLLNCAQEKVLRFVPPLIVGKKEVDEMLSILTGILQEL

Sequences:

>Translated_397_residues
MNSAAWMEKADKYIMKTYGRYPLVPVKGDGCYLWDADGKKYLDFLAGVAVNNLGHCHPKVTAALAKQAAELIHCSNYYHI
PQQIELAELLCGLSFADKAFFCNSGAEANEAAIKLARKYSREKYGVDRYEIITAISSFHGRTMATVSATGQEKVQKFFDP
LLHGFRHVPFNDAKALKEAIGPCTCAIMLEPIQGEGGVVVPDAAYFQKVRQICDENNLILIFDEVQVGMGRTGKMFAHEH
FGITPDIMTLAKALAGGAPIGTMLATEKLAAAFSPGTHGSTFGGNPLVTAAAVATIRAMQEEGVLNHCEEIGEYLMGELE
ALKHKFPGFITDVRGIGLMIGVELSIPGGDLVKTALSRGLLLNCAQEKVLRFVPPLIVGKKEVDEMLSILTGILQEL
>Mature_397_residues
MNSAAWMEKADKYIMKTYGRYPLVPVKGDGCYLWDADGKKYLDFLAGVAVNNLGHCHPKVTAALAKQAAELIHCSNYYHI
PQQIELAELLCGLSFADKAFFCNSGAEANEAAIKLARKYSREKYGVDRYEIITAISSFHGRTMATVSATGQEKVQKFFDP
LLHGFRHVPFNDAKALKEAIGPCTCAIMLEPIQGEGGVVVPDAAYFQKVRQICDENNLILIFDEVQVGMGRTGKMFAHEH
FGITPDIMTLAKALAGGAPIGTMLATEKLAAAFSPGTHGSTFGGNPLVTAAAVATIRAMQEEGVLNHCEEIGEYLMGELE
ALKHKFPGFITDVRGIGLMIGVELSIPGGDLVKTALSRGLLLNCAQEKVLRFVPPLIVGKKEVDEMLSILTGILQEL

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=393, Percent_Identity=36.1323155216285, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI284507298, Length=297, Percent_Identity=36.7003367003367, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI13994255, Length=441, Percent_Identity=28.5714285714286, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=29.2056074766355, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=28.5035629453682, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=28.2710280373832, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=28.9672544080605, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI188536080, Length=426, Percent_Identity=25.1173708920188, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI38679950, Length=426, Percent_Identity=25.1173708920188, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI38679946, Length=426, Percent_Identity=25.1173708920188, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1788044, Length=380, Percent_Identity=43.1578947368421, Blast_Score=338, Evalue=2e-94,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=42.2163588390501, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI145693181, Length=364, Percent_Identity=38.7362637362637, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=33.256351039261, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=35.25, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1786991, Length=404, Percent_Identity=28.2178217821782, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786349, Length=341, Percent_Identity=28.7390029325513, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=404, Percent_Identity=36.1386138613861, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI32564660, Length=438, Percent_Identity=30.365296803653, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI25144274, Length=272, Percent_Identity=36.3970588235294, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=29.4392523364486, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17541228, Length=453, Percent_Identity=25.60706401766, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71981843, Length=179, Percent_Identity=34.6368715083799, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71992985, Length=110, Percent_Identity=37.2727272727273, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323470, Length=405, Percent_Identity=35.3086419753086, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6324432, Length=393, Percent_Identity=36.1323155216285, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6321456, Length=427, Percent_Identity=25.9953161592506, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324386, Length=410, Percent_Identity=23.4146341463415, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357415, Length=388, Percent_Identity=36.5979381443299, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=30.1369863013699, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=30.1401869158879, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21356575, Length=432, Percent_Identity=30.5555555555556, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI281366494, Length=426, Percent_Identity=25.1173708920188, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667139, Length=426, Percent_Identity=25.1173708920188, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667143, Length=426, Percent_Identity=25.1173708920188, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 43025; Mature: 43025

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAAWMEKADKYIMKTYGRYPLVPVKGDGCYLWDADGKKYLDFLAGVAVNNLGHCHPKV
CCCHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHH
TAALAKQAAELIHCSNYYHIPQQIELAELLCGLSFADKAFFCNSGAEANEAAIKLARKYS
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHCCCEEECCCCCHHHHHHHHHHHHH
REKYGVDRYEIITAISSFHGRTMATVSATGQEKVQKFFDPLLHGFRHVPFNDAKALKEAI
HHHHCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GPCTCAIMLEPIQGEGGVVVPDAAYFQKVRQICDENNLILIFDEVQVGMGRTGKMFAHEH
CCEEEEEEEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEECEECCCCCCCCHHHHHC
FGITPDIMTLAKALAGGAPIGTMLATEKLAAAFSPGTHGSTFGGNPLVTAAAVATIRAMQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EEGVLNHCEEIGEYLMGELEALKHKFPGFITDVRGIGLMIGVELSIPGGDLVKTALSRGL
HCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHCCH
LLNCAQEKVLRFVPPLIVGKKEVDEMLSILTGILQEL
HHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNSAAWMEKADKYIMKTYGRYPLVPVKGDGCYLWDADGKKYLDFLAGVAVNNLGHCHPKV
CCCHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHCCCCCCHHH
TAALAKQAAELIHCSNYYHIPQQIELAELLCGLSFADKAFFCNSGAEANEAAIKLARKYS
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHCCCEEECCCCCHHHHHHHHHHHHH
REKYGVDRYEIITAISSFHGRTMATVSATGQEKVQKFFDPLLHGFRHVPFNDAKALKEAI
HHHHCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GPCTCAIMLEPIQGEGGVVVPDAAYFQKVRQICDENNLILIFDEVQVGMGRTGKMFAHEH
CCEEEEEEEEEECCCCCEECCCHHHHHHHHHHHCCCCEEEEEECEECCCCCCCCHHHHHC
FGITPDIMTLAKALAGGAPIGTMLATEKLAAAFSPGTHGSTFGGNPLVTAAAVATIRAMQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EEGVLNHCEEIGEYLMGELEALKHKFPGFITDVRGIGLMIGVELSIPGGDLVKTALSRGL
HCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHCCH
LLNCAQEKVLRFVPPLIVGKKEVDEMLSILTGILQEL
HHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]