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The map label for this gene is hisG-1 [H]

Identifier: 197117122

GI number: 197117122

Start: 858497

End: 859369

Strand: Direct

Name: hisG-1 [H]

Synonym: Gbem_0727

Alternate gene names: 197117122

Gene position: 858497-859369 (Clockwise)

Preceding gene: 197117121

Following gene: 197117123

Centisome position: 18.6

GC content: 61.17

Gene sequence:

>873_bases
ATGGAACAGTTGAAACTCGGCATCCCCAAGGGGAGCCTGGAAAGCGCCACCGTCGATCTCTTCAAAAAAGCCGGCTGGCA
GATATCTATCTCTTCACGCAGCTACTTCCCCACTATCGACGATGAGGAAATCAAGTGCTCGCTGATGCGTCCGCAGGAGA
TGGCGAAGTACGTCGAGCGCGGCACCATCGATGTCGGCATCGCCGGCCGCGACTGGGTGCGGGAGAACCAGTCGGACGTC
CTTGAACTGTGCGAGATGGTGTACTCCAAGGTTTCCCGCCGCCCGGCTCGCTGGGTGCTGGTGGTAAACGGCGACTCCAA
GGTGCAGGGCCCTGAGGACCTGCGCGGCGCGACCATATCGACGGAGCTCGTGGGTTTCACCAAGCGCTACTTCGCCGAGC
GCAACATCCCGGTCAACGTGGAATTTTCCTGGGGCGCCACCGAGGCGAAGGTGGTCGAGGGGCTCTGCGACGCGATCGTT
GAGGTGACAGAGACCGGCTCCACCATCAAGGCCAACGGTCTGCGCATAGTCACCGAACTGATGGAGTCCGTCCCGGTCAT
GGTGGTCAACAAAGCCTCCTGGGAAGATCCCTGGAAGAAGGCGAAGATCCAGCAGATCGCCACCCTGCTCCAGTCTGCGC
TTAGGGCCGAGGGGATGGTTGGCCTGAAGATGAACGCGCCCGGGGCGAAGGTGCCGGCCATCACCGCCATTCTCCCGAGC
CTCAACAACCCGACCGTTTCCAACCTCTACAACTCGGACTGGGTCTCCATCGAGAGCATCATGCCCGAGCAGGAGGTGCG
CCGCATCGTACCCGAACTCCTCAAGCTCGGAGCGGAGGGGATCGTGGAGTACTCCCTCAACAAGATCATCTAG

Upstream 100 bases:

>100_bases
TTTTCTCAAGCCTTTTGCTTGTCTCAGATTTCCTCAGAAGTTCTCCTTGTTAATGGTTCTCGGGTTTTCTGCTTTTATTC
TATTGAATGGAGAGGGCACC

Downstream 100 bases:

>100_bases
TCCGAATCTTAATCTTCTTCAGCTAATAGCTATGGCCGTACACTGACCGGCCTCCCAGAACAGGGAGGCCGGTCTTGTTG
TTTATAGACACCTTTCTTAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MEQLKLGIPKGSLESATVDLFKKAGWQISISSRSYFPTIDDEEIKCSLMRPQEMAKYVERGTIDVGIAGRDWVRENQSDV
LELCEMVYSKVSRRPARWVLVVNGDSKVQGPEDLRGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVEGLCDAIV
EVTETGSTIKANGLRIVTELMESVPVMVVNKASWEDPWKKAKIQQIATLLQSALRAEGMVGLKMNAPGAKVPAITAILPS
LNNPTVSNLYNSDWVSIESIMPEQEVRRIVPELLKLGAEGIVEYSLNKII

Sequences:

>Translated_290_residues
MEQLKLGIPKGSLESATVDLFKKAGWQISISSRSYFPTIDDEEIKCSLMRPQEMAKYVERGTIDVGIAGRDWVRENQSDV
LELCEMVYSKVSRRPARWVLVVNGDSKVQGPEDLRGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVEGLCDAIV
EVTETGSTIKANGLRIVTELMESVPVMVVNKASWEDPWKKAKIQQIATLLQSALRAEGMVGLKMNAPGAKVPAITAILPS
LNNPTVSNLYNSDWVSIESIMPEQEVRRIVPELLKLGAEGIVEYSLNKII
>Mature_290_residues
MEQLKLGIPKGSLESATVDLFKKAGWQISISSRSYFPTIDDEEIKCSLMRPQEMAKYVERGTIDVGIAGRDWVRENQSDV
LELCEMVYSKVSRRPARWVLVVNGDSKVQGPEDLRGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVEGLCDAIV
EVTETGSTIKANGLRIVTELMESVPVMVVNKASWEDPWKKAKIQQIATLLQSALRAEGMVGLKMNAPGAKVPAITAILPS
LNNPTVSNLYNSDWVSIESIMPEQEVRRIVPELLKLGAEGIVEYSLNKII

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=294, Percent_Identity=24.4897959183673, Blast_Score=81, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320896, Length=293, Percent_Identity=26.6211604095563, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32113; Mature: 32113

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLKLGIPKGSLESATVDLFKKAGWQISISSRSYFPTIDDEEIKCSLMRPQEMAKYVER
CCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHC
GTIDVGIAGRDWVRENQSDVLELCEMVYSKVSRRPARWVLVVNGDSKVQGPEDLRGATIS
CCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCEEH
TELVGFTKRYFAERNIPVNVEFSWGATEAKVVEGLCDAIVEVTETGSTIKANGLRIVTEL
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
MESVPVMVVNKASWEDPWKKAKIQQIATLLQSALRAEGMVGLKMNAPGAKVPAITAILPS
HHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCC
LNNPTVSNLYNSDWVSIESIMPEQEVRRIVPELLKLGAEGIVEYSLNKII
CCCCCHHHCCCCCCEEHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCC
>Mature Secondary Structure
MEQLKLGIPKGSLESATVDLFKKAGWQISISSRSYFPTIDDEEIKCSLMRPQEMAKYVER
CCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHHC
GTIDVGIAGRDWVRENQSDVLELCEMVYSKVSRRPARWVLVVNGDSKVQGPEDLRGATIS
CCEEEECCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHCCCEEH
TELVGFTKRYFAERNIPVNVEFSWGATEAKVVEGLCDAIVEVTETGSTIKANGLRIVTEL
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
MESVPVMVVNKASWEDPWKKAKIQQIATLLQSALRAEGMVGLKMNAPGAKVPAITAILPS
HHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCC
LNNPTVSNLYNSDWVSIESIMPEQEVRRIVPELLKLGAEGIVEYSLNKII
CCCCCHHHCCCCCCEEHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA