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The map label for this gene is hisI

Identifier: 197117121

GI number: 197117121

Start: 857967

End: 858344

Strand: Direct

Name: hisI

Synonym: Gbem_0726

Alternate gene names: 197117121

Gene position: 857967-858344 (Clockwise)

Preceding gene: 197117120

Following gene: 197117122

Centisome position: 18.59

GC content: 55.56

Gene sequence:

>378_bases
ATGATAAAGATCGATTTCGAAAAGATGGGTGGATTGATCCCGGCAGTTATCCAGGACAACGAGAGCGGGGAAGTATTGAT
GGTTGCGTTCATGGACGAGAAGACCCTGAACCTGACCCTGGAAAGCGGCAAGACCTGGTTCTTCAGCCGCACCAGGAACA
AGTACTGGATGAAAGGGGAGGAATCCGGCAATACGCAGGACGTGGTCGAGGTGCTGACCGACTGCGACGCCGACACCGTC
GTCATCAAGGTGAAGCAAAACGGTCCCGCCGCCTGCCACACCGGCAACCGCAGCTGCTTCTATGTCAGATACGAGAACGG
CGCCTGGGTCGAGCACTCCAACCCGCTCTTCGATCCCAACACCGTCTATAAGAAGTAA

Upstream 100 bases:

>100_bases
TGGTTTTGATGTCTACATAATCGTTGACATAGCTCGCGCCCAAGGTGTATTAAAAGACACTTTTTTATCAATAAATGCTG
CGGAAGGACTGAGAGAAACC

Downstream 100 bases:

>100_bases
GACAAAACCATTGGCAAGGAGGAAATCTGAGAACTTCTGAGAAAGCTTTGGATTTTCTCAAGCCTTTTGCTTGTCTCAGA
TTTCCTCAGAAGTTCTCCTT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MIKIDFEKMGGLIPAVIQDNESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQDVVEVLTDCDADTV
VIKVKQNGPAACHTGNRSCFYVRYENGAWVEHSNPLFDPNTVYKK

Sequences:

>Translated_125_residues
MIKIDFEKMGGLIPAVIQDNESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQDVVEVLTDCDADTV
VIKVKQNGPAACHTGNRSCFYVRYENGAWVEHSNPLFDPNTVYKK
>Mature_125_residues
MIKIDFEKMGGLIPAVIQDNESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQDVVEVLTDCDADTV
VIKVKQNGPAACHTGNRSCFYVRYENGAWVEHSNPLFDPNTVYKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=48.9795918367347, Blast_Score=104, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=36, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_GEOBB (B5EE14)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137548.1
- ProteinModelPortal:   B5EE14
- SMR:   B5EE14
- GeneID:   6783559
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0726
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 14190; Mature: 14190

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKIDFEKMGGLIPAVIQDNESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGE
CEEEEHHHHCCEEEEEEECCCCCCEEEEEEECCCEEEEEEECCCEEEEEECCCEEEEECC
ESGNTQDVVEVLTDCDADTVVIKVKQNGPAACHTGNRSCFYVRYENGAWVEHSNPLFDPN
CCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCEEEEEECCCEEEECCCCCCCCC
TVYKK
CCCCC
>Mature Secondary Structure
MIKIDFEKMGGLIPAVIQDNESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGE
CEEEEHHHHCCEEEEEEECCCCCCEEEEEEECCCEEEEEEECCCEEEEEECCCEEEEECC
ESGNTQDVVEVLTDCDADTVVIKVKQNGPAACHTGNRSCFYVRYENGAWVEHSNPLFDPN
CCCCHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCEEEEEECCCEEEECCCCCCCCC
TVYKK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA