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The map label for this gene is tenI [H]

Identifier: 197117049

GI number: 197117049

Start: 774714

End: 775370

Strand: Reverse

Name: tenI [H]

Synonym: Gbem_0652

Alternate gene names: 197117049

Gene position: 775370-774714 (Counterclockwise)

Preceding gene: 197117050

Following gene: 197117048

Centisome position: 16.8

GC content: 66.82

Gene sequence:

>657_bases
GTGAAAGAGCTGGAATCCCCCTGGATAGACTTCAACCTCTACCTGATTACCGGCAGGGAGGAGACGCAGGGGCGCCCCCT
CGGGTACGTGGTCGAGGAAGCGCTTAAGGGCGGGGTGCGCGCGGTACAGTACCGCGACAAGGACGCCACCAGCAAGGAAC
TCTACGAGACGGCCCACGAGCTGCGCCGCCTCACCTCGCGCTACGGCGCGAAACTCATCATCAACGACCGCGCCGACATA
GCGCTCGCCGTCGACGCCGACGGCGTGCACATAGGAAGCGCCAGCATGCCCATCTACAAGGTGCGGCGGATCCTGGGAGA
GCGGAAGCTGATCGGGGTCTCCTGCCACAACAAGGCGCAGGCCATCGCAGCCCAGGAGATGGGGGCCGACTTCATCACCT
TCGGCCCGGTCTACTACACCCCCTCCAAGGCCCCCTACGGCGACCCGGTGGGGACCGCAAAGCTTCAGACAGTGGCGGGA
CTTTTGCAGGTCCCGGTCTTCGCGCTCGGGGGGATCAAAAAGGAGAACTGCGCCGAGGCAGCCGGCTGCGGCGTGCGCGG
CGTCGCGCTCATCTCCGCCGTCCTCTCCGCAGCCGACCCGCGCGAGGCGGCGAAGAAGCTCATCGCCCTTCTCCCCCCCC
TGGAGCACGCCGACTGA

Upstream 100 bases:

>100_bases
TGAACTGCGCGGTGCGCGCGGGGAGGCTCGCCTACCTGGCCGGGCGCATCCCGAGGAAGCTCTACGCCAGCGCCTCCTCC
CCCTTGGCGGGGCTCATCGG

Downstream 100 bases:

>100_bases
ACATGACCGGATCCCCCATCCATAGCGAGCTCCGCATCAACTCCTACGGCTCCTACCTGAGAAGGCGCTTTTCCTGCCGC
GTCTCCAAGGTGAACGTGGA

Product: carboxythiazole phosphate tautomerase

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKELESPWIDFNLYLITGREETQGRPLGYVVEEALKGGVRAVQYRDKDATSKELYETAHELRRLTSRYGAKLIINDRADI
ALAVDADGVHIGSASMPIYKVRRILGERKLIGVSCHNKAQAIAAQEMGADFITFGPVYYTPSKAPYGDPVGTAKLQTVAG
LLQVPVFALGGIKKENCAEAAGCGVRGVALISAVLSAADPREAAKKLIALLPPLEHAD

Sequences:

>Translated_218_residues
MKELESPWIDFNLYLITGREETQGRPLGYVVEEALKGGVRAVQYRDKDATSKELYETAHELRRLTSRYGAKLIINDRADI
ALAVDADGVHIGSASMPIYKVRRILGERKLIGVSCHNKAQAIAAQEMGADFITFGPVYYTPSKAPYGDPVGTAKLQTVAG
LLQVPVFALGGIKKENCAEAAGCGVRGVALISAVLSAADPREAAKKLIALLPPLEHAD
>Mature_218_residues
MKELESPWIDFNLYLITGREETQGRPLGYVVEEALKGGVRAVQYRDKDATSKELYETAHELRRLTSRYGAKLIINDRADI
ALAVDADGVHIGSASMPIYKVRRILGERKLIGVSCHNKAQAIAAQEMGADFITFGPVYYTPSKAPYGDPVGTAKLQTVAG
LLQVPVFALGGIKKENCAEAAGCGVRGVALISAVLSAADPREAAKKLIALLPPLEHAD

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

Organism=Escherichia coli, GI1790426, Length=181, Percent_Identity=30.939226519337, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325042, Length=222, Percent_Identity=34.2342342342342, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 23461; Mature: 23461

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELESPWIDFNLYLITGREETQGRPLGYVVEEALKGGVRAVQYRDKDATSKELYETAHE
CCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LRRLTSRYGAKLIINDRADIALAVDADGVHIGSASMPIYKVRRILGERKLIGVSCHNKAQ
HHHHHHHHCCEEEEECCCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCEEEECCCCHHH
AIAAQEMGADFITFGPVYYTPSKAPYGDPVGTAKLQTVAGLLQVPVFALGGIKKENCAEA
HHHHHHHCCCEEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AGCGVRGVALISAVLSAADPREAAKKLIALLPPLEHAD
HCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKELESPWIDFNLYLITGREETQGRPLGYVVEEALKGGVRAVQYRDKDATSKELYETAHE
CCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LRRLTSRYGAKLIINDRADIALAVDADGVHIGSASMPIYKVRRILGERKLIGVSCHNKAQ
HHHHHHHHCCEEEEECCCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCEEEECCCCHHH
AIAAQEMGADFITFGPVYYTPSKAPYGDPVGTAKLQTVAGLLQVPVFALGGIKKENCAEA
HHHHHHHCCCEEEECCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AGCGVRGVALISAVLSAADPREAAKKLIALLPPLEHAD
HCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA