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The map label for this gene is acdA [H]

Identifier: 197116941

GI number: 197116941

Start: 656156

End: 657301

Strand: Reverse

Name: acdA [H]

Synonym: Gbem_0543

Alternate gene names: 197116941

Gene position: 657301-656156 (Counterclockwise)

Preceding gene: 197116942

Following gene: 197116940

Centisome position: 14.24

GC content: 62.22

Gene sequence:

>1146_bases
ATGGAAGCGATCTTCAACGAGGAGCAGAGGAACTTCAAGCAGATGGCGATCGAGTTCGCCCGGCGCGAACTGAACCAGGG
CGCCAAGGAACGCGAGAGAAAAGGCGAGTTCTCCCAGCGCGGTTGGGAAAAATGCGCCGAGTTCGGCATCCCGGGCATCA
CCATGCCCGAGAAGTACGGAGGGCTCGGGCTCGACACCATGACCTCCATCGCCACCATGGAGGGGCTCGGCTACGCCTGC
CTCGACAGCGGCCTGCTTTTCTCCCTGAACTCCCATGTCTGGACCTGCGAGTCCCCCATCAACCGTTTCGGCAGCGAGGA
GCAAAAAAAGCGCTATCTCCCCGGGCTCATCGCCGGCAGCCTCCGAGGCGGGCACGCCATGACGGAGCCCGATGCCGGCT
CCGACGCCTTCAGCATGAGGTGCCGGGCGGAAAAGCGGGGGGACAGGTACATCCTGAACGGCTCCAAGACCTTCATCACC
AACGCCCCCATCGCCGACCTGTTGCTGGTGTTCGCTGTGACCTGCAAGGAAAAGGGGTTCGCCGGGGTTTCCGCCTTCAT
CGTGGAAAGAGGGTTTCCCGGGTTTTCCACGGGGCAACCGCTGGAAACCATGGGCCTTAGGACCTGCCCTTTGGGCGAAG
TGTTCCTGGAGGAGTGCGAGGTTCCCGAGGAGAACCGTCTGGGGCAGGAAGGAAGCGGCGCCGCGATCTTCAACTCCGAG
ATGGAATGGGAGCGGAGCTGCCTTTTCGCCGCGCACCTGGGGGCGATGGACAAGATCCTGGAGGATTGCGTGGCCTACGC
CAAGGAGCGGCAGCAGTTCGGCAAGGCGATAGGCAAATGCCAGTCCATCTCGCACAAGATCTCCGACATGAAGGTCCGCA
TCGAACTCTCCCGGCTGATGCTGCACCAAGTGGCGACGCTCAAGGGACAGGGGAAACGGGCGCCGCTGGAATCGGCGATG
GCGAAGCTCTTCATCAGCGAAAGCTACGTGCAAAACTGCACCGATGCGCTGCAAATCCATGGGGCCTACGGCTACAGCGC
GGAGTACGACTTCGAGCGGAACCTCCGTGACGCCATCGCCGGGAAGATCTACTCCGGCACCTCCGAGATCCAGCGCAACA
TCATCGCCACCTTCCTGGGGCTCTAG

Upstream 100 bases:

>100_bases
GAAGTGCGAGGCGGGGTTTCCTCCCTATTACGGGCTGACCTCGCTTTTACTCACCGTGTGATTCCAGATCCCGGCCGAAC
CGGCCGTACGAGGCCCGCCC

Downstream 100 bases:

>100_bases
CGGAGGGGGCCCAGCGAGGCATCCATGTACCTACTGCAACGATTACTCACCCGAAGCGCCACCTCCTTCCCCGACAAAAC
CGCGGTCTCCTTCCGCAACG

Product: short-chain acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MEAIFNEEQRNFKQMAIEFARRELNQGAKERERKGEFSQRGWEKCAEFGIPGITMPEKYGGLGLDTMTSIATMEGLGYAC
LDSGLLFSLNSHVWTCESPINRFGSEEQKKRYLPGLIAGSLRGGHAMTEPDAGSDAFSMRCRAEKRGDRYILNGSKTFIT
NAPIADLLLVFAVTCKEKGFAGVSAFIVERGFPGFSTGQPLETMGLRTCPLGEVFLEECEVPEENRLGQEGSGAAIFNSE
MEWERSCLFAAHLGAMDKILEDCVAYAKERQQFGKAIGKCQSISHKISDMKVRIELSRLMLHQVATLKGQGKRAPLESAM
AKLFISESYVQNCTDALQIHGAYGYSAEYDFERNLRDAIAGKIYSGTSEIQRNIIATFLGL

Sequences:

>Translated_381_residues
MEAIFNEEQRNFKQMAIEFARRELNQGAKERERKGEFSQRGWEKCAEFGIPGITMPEKYGGLGLDTMTSIATMEGLGYAC
LDSGLLFSLNSHVWTCESPINRFGSEEQKKRYLPGLIAGSLRGGHAMTEPDAGSDAFSMRCRAEKRGDRYILNGSKTFIT
NAPIADLLLVFAVTCKEKGFAGVSAFIVERGFPGFSTGQPLETMGLRTCPLGEVFLEECEVPEENRLGQEGSGAAIFNSE
MEWERSCLFAAHLGAMDKILEDCVAYAKERQQFGKAIGKCQSISHKISDMKVRIELSRLMLHQVATLKGQGKRAPLESAM
AKLFISESYVQNCTDALQIHGAYGYSAEYDFERNLRDAIAGKIYSGTSEIQRNIIATFLGL
>Mature_381_residues
MEAIFNEEQRNFKQMAIEFARRELNQGAKERERKGEFSQRGWEKCAEFGIPGITMPEKYGGLGLDTMTSIATMEGLGYAC
LDSGLLFSLNSHVWTCESPINRFGSEEQKKRYLPGLIAGSLRGGHAMTEPDAGSDAFSMRCRAEKRGDRYILNGSKTFIT
NAPIADLLLVFAVTCKEKGFAGVSAFIVERGFPGFSTGQPLETMGLRTCPLGEVFLEECEVPEENRLGQEGSGAAIFNSE
MEWERSCLFAAHLGAMDKILEDCVAYAKERQQFGKAIGKCQSISHKISDMKVRIELSRLMLHQVATLKGQGKRAPLESAM
AKLFISESYVQNCTDALQIHGAYGYSAEYDFERNLRDAIAGKIYSGTSEIQRNIIATFLGL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=37.6, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=38.150289017341, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=34.5744680851064, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=34.5844504021448, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=33.0687830687831, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=34.1269841269841, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=34.1269841269841, Blast_Score=205, Evalue=7e-53,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=32.8, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI21361497, Length=363, Percent_Identity=34.7107438016529, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI76496475, Length=389, Percent_Identity=33.4190231362468, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4557235, Length=389, Percent_Identity=33.4190231362468, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4503943, Length=304, Percent_Identity=34.2105263157895, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI7669494, Length=293, Percent_Identity=34.1296928327645, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI48976061, Length=337, Percent_Identity=29.080118694362, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI211971008, Length=337, Percent_Identity=29.080118694362, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI38505218, Length=371, Percent_Identity=25.0673854447439, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1786223, Length=342, Percent_Identity=27.7777777777778, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081958, Length=343, Percent_Identity=30.9037900874636, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082384, Length=292, Percent_Identity=27.7397260273973, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=37.6657824933687, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=32.8042328042328, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=30.7692307692308, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=31.6622691292876, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=29.2553191489362, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=29.2349726775956, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=363, Percent_Identity=31.9559228650138, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71990804, Length=298, Percent_Identity=32.8859060402685, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=27.4666666666667, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982178, Length=270, Percent_Identity=31.1111111111111, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=26.2032085561497, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=310, Percent_Identity=30.9677419354839, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17534353, Length=384, Percent_Identity=26.5625, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=32.3651452282158, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=29.7413793103448, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=25.6944444444444, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=36.5591397849462, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=36.6492146596859, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=33.8624338624339, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=32.258064516129, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI281363737, Length=340, Percent_Identity=35.5882352941176, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=32.0855614973262, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920834, Length=384, Percent_Identity=29.9479166666667, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42185; Mature: 42185

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAIFNEEQRNFKQMAIEFARRELNQGAKERERKGEFSQRGWEKCAEFGIPGITMPEKYG
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHC
GLGLDTMTSIATMEGLGYACLDSGLLFSLNSHVWTCESPINRFGSEEQKKRYLPGLIAGS
CCCHHHHHHHHHHHCCCHHHHCCCCEEEECCCEEECCCHHHHCCCHHHHHHHCCHHHHCC
LRGGHAMTEPDAGSDAFSMRCRAEKRGDRYILNGSKTFITNAPIADLLLVFAVTCKEKGF
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEECCCHHHHHHHHHHHHHCCCC
AGVSAFIVERGFPGFSTGQPLETMGLRTCPLGEVFLEECEVPEENRLGQEGSGAAIFNSE
CHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCEEECCC
MEWERSCLFAAHLGAMDKILEDCVAYAKERQQFGKAIGKCQSISHKISDMKVRIELSRLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHH
LHQVATLKGQGKRAPLESAMAKLFISESYVQNCTDALQIHGAYGYSAEYDFERNLRDAIA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
GKIYSGTSEIQRNIIATFLGL
HHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEAIFNEEQRNFKQMAIEFARRELNQGAKERERKGEFSQRGWEKCAEFGIPGITMPEKYG
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHC
GLGLDTMTSIATMEGLGYACLDSGLLFSLNSHVWTCESPINRFGSEEQKKRYLPGLIAGS
CCCHHHHHHHHHHHCCCHHHHCCCCEEEECCCEEECCCHHHHCCCHHHHHHHCCHHHHCC
LRGGHAMTEPDAGSDAFSMRCRAEKRGDRYILNGSKTFITNAPIADLLLVFAVTCKEKGF
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEECCCHHHHHHHHHHHHHCCCC
AGVSAFIVERGFPGFSTGQPLETMGLRTCPLGEVFLEECEVPEENRLGQEGSGAAIFNSE
CHHHHHHHHCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCHHHCCCCCCCCCEEECCC
MEWERSCLFAAHLGAMDKILEDCVAYAKERQQFGKAIGKCQSISHKISDMKVRIELSRLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHH
LHQVATLKGQGKRAPLESAMAKLFISESYVQNCTDALQIHGAYGYSAEYDFERNLRDAIA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
GKIYSGTSEIQRNIIATFLGL
HHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]