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The map label for this gene is murC

Identifier: 197116890

GI number: 197116890

Start: 594171

End: 595556

Strand: Direct

Name: murC

Synonym: Gbem_0492

Alternate gene names: 197116890

Gene position: 594171-595556 (Clockwise)

Preceding gene: 197116889

Following gene: 197116891

Centisome position: 12.87

GC content: 64.43

Gene sequence:

>1386_bases
GTGTACGGAAAAATAGAGAGAATACATTTCGTCGGCATCGGCGGCATCGGGATGAGCGGCATCGCGGAGGTGCTCCTGAA
CCTGGGGTACAAGGTTTCGGGATCGGACCTGCGTGGCTCGGAGATCACCCAGCGGCTGGAGAGCCTGGGAGGCGAGATCT
TCTTCGGGCACGCCGCCGAGAACGTGGCGAACGCCGACGTGGTGGTCATCTCCAGCGCCGTCCACGACGACAACCCCGAG
GTGGTCGAGGCGCATCTGAGGCTGATACCGGTGATCCCACGTGCCGAGATGCTGGCCGAGCTGATGCGCATGAAGTACGG
CATCGCCGTCGCCGGGACCCACGGCAAGACCACGACCACCTCCATGGTGGCGACCATCCTCTCCAAGGGGGGGATCGACC
CGACCATCGTCATCGGCGGCAGGCTCAACTCGCTTGGCACCAACGCGAGGCTGGGACAGGGACAGTTCCTGGTGGCCGAG
GCGGACGAGTCGGACGGCTCTTTCCTGCTCCTCTCCCCCACCATAGCCGTGGTCACCAACATCGACGCCGACCACCTCGA
CTTCTACAGCGGCATCGAGGAGATCAAGGACACCTTCGTCGAGTTCATCAACAAGATCCCCTTCTACGGGCTTGCCGTAC
TCTGCCTGGACAACGGCAACATAGCCGACGTCCTGCCCCGGGTGAAGAAGCGCTTCACGAGCTACGGCATGTCGGCCCAG
GCGGACTTCAGGGCCACCGACGTGAAGCTCTCTGGGTTCTCGACCAGCTTCGTGGCGCATCACAAAGGGGTGCGGCTGGG
AGAGATCACCTTCTCCATGCCGGGCGCCCACAACGTACTGAACGCGCTGGCCGCGATCGCCGTGGCCATGGAGCTGGACA
TCCCGTTCGAGACCATCCAGGAAGGTTTCGCCGGGTTCGGCGGGGTGGGGCGCCGCTTCCATCTGAAGGGGGAGGCCAAC
GGCATCATGGTGGTGGACGACTACGGGCATCACCCGACCGAGATCAAGGCGACCTTGGGCGCCGCCAAGGCAGGCTTTGC
CGAGAACCGTCTGGTCGTCGTGTTCCAGCCGCACCGCTATTCCAGGACCAAGGAGCTCTTCGAGGAGTTCGTCAAGGCGT
TCCACGACGCCGACGTCCTGATCCTGACCGACATCTATCCGGCGGGGGAGGCCCCCATCGAGGGGGTGACCGCCGAGGCG
CTGGCAAACAGGGTCCGCAGGCACGGCCAGAAGGACGTCACCTGGATCTCCGACCGCGACAAGCTCTGCGAGCACCTGGA
GCGCGTGCTTGCTCCCGGCGACATCCTGCTGACCCTTGGGGCCGGCAACGTCTGGCAGGTGGGAGAGACCATGCTGCTGC
GGTTGAAGGCCGCGAAGGAGAGCTGA

Upstream 100 bases:

>100_bases
AAGTGGCTTTGAGACATTGACGATAGAGCGAGGTTGAGAAGCTAGGGTTTTACTCAATCTTTATCTTTATCTTTATCTGC
GACCGAAGGGAGCACAGAGA

Downstream 100 bases:

>100_bases
GGTTGACACGGGGCGAGCTCGAACAAGCGGTCCAGGGGGTGCGCGGCACGGTCAAGTGGGACGAGCCGATGTGGCAGCAC
ACCTCCCTTAAAGTCGGGGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MYGKIERIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSEITQRLESLGGEIFFGHAAENVANADVVVISSAVHDDNPE
VVEAHLRLIPVIPRAEMLAELMRMKYGIAVAGTHGKTTTTSMVATILSKGGIDPTIVIGGRLNSLGTNARLGQGQFLVAE
ADESDGSFLLLSPTIAVVTNIDADHLDFYSGIEEIKDTFVEFINKIPFYGLAVLCLDNGNIADVLPRVKKRFTSYGMSAQ
ADFRATDVKLSGFSTSFVAHHKGVRLGEITFSMPGAHNVLNALAAIAVAMELDIPFETIQEGFAGFGGVGRRFHLKGEAN
GIMVVDDYGHHPTEIKATLGAAKAGFAENRLVVVFQPHRYSRTKELFEEFVKAFHDADVLILTDIYPAGEAPIEGVTAEA
LANRVRRHGQKDVTWISDRDKLCEHLERVLAPGDILLTLGAGNVWQVGETMLLRLKAAKES

Sequences:

>Translated_461_residues
MYGKIERIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSEITQRLESLGGEIFFGHAAENVANADVVVISSAVHDDNPE
VVEAHLRLIPVIPRAEMLAELMRMKYGIAVAGTHGKTTTTSMVATILSKGGIDPTIVIGGRLNSLGTNARLGQGQFLVAE
ADESDGSFLLLSPTIAVVTNIDADHLDFYSGIEEIKDTFVEFINKIPFYGLAVLCLDNGNIADVLPRVKKRFTSYGMSAQ
ADFRATDVKLSGFSTSFVAHHKGVRLGEITFSMPGAHNVLNALAAIAVAMELDIPFETIQEGFAGFGGVGRRFHLKGEAN
GIMVVDDYGHHPTEIKATLGAAKAGFAENRLVVVFQPHRYSRTKELFEEFVKAFHDADVLILTDIYPAGEAPIEGVTAEA
LANRVRRHGQKDVTWISDRDKLCEHLERVLAPGDILLTLGAGNVWQVGETMLLRLKAAKES
>Mature_461_residues
MYGKIERIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSEITQRLESLGGEIFFGHAAENVANADVVVISSAVHDDNPE
VVEAHLRLIPVIPRAEMLAELMRMKYGIAVAGTHGKTTTTSMVATILSKGGIDPTIVIGGRLNSLGTNARLGQGQFLVAE
ADESDGSFLLLSPTIAVVTNIDADHLDFYSGIEEIKDTFVEFINKIPFYGLAVLCLDNGNIADVLPRVKKRFTSYGMSAQ
ADFRATDVKLSGFSTSFVAHHKGVRLGEITFSMPGAHNVLNALAAIAVAMELDIPFETIQEGFAGFGGVGRRFHLKGEAN
GIMVVDDYGHHPTEIKATLGAAKAGFAENRLVVVFQPHRYSRTKELFEEFVKAFHDADVLILTDIYPAGEAPIEGVTAEA
LANRVRRHGQKDVTWISDRDKLCEHLERVLAPGDILLTLGAGNVWQVGETMLLRLKAAKES

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=458, Percent_Identity=49.1266375545852, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1790680, Length=467, Percent_Identity=28.6937901498929, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_GEOBB (B5EBQ2)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137317.1
- ProteinModelPortal:   B5EBQ2
- SMR:   B5EBQ2
- GeneID:   6783321
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0492
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49752; Mature: 49752

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGKIERIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSEITQRLESLGGEIFFGHAAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCEEEECCCCC
NVANADVVVISSAVHDDNPEVVEAHLRLIPVIPRAEMLAELMRMKYGIAVAGTHGKTTTT
CCCCCCEEEEEECCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHCCEEEECCCCCCHHH
SMVATILSKGGIDPTIVIGGRLNSLGTNARLGQGQFLVAEADESDGSFLLLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEEC
IDADHLDFYSGIEEIKDTFVEFINKIPFYGLAVLCLDNGNIADVLPRVKKRFTSYGMSAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
ADFRATDVKLSGFSTSFVAHHKGVRLGEITFSMPGAHNVLNALAAIAVAMELDIPFETIQ
CCCEEEEEEECCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHH
EGFAGFGGVGRRFHLKGEANGIMVVDDYGHHPTEIKATLGAAKAGFAENRLVVVFQPHRY
HHHCCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
SRTKELFEEFVKAFHDADVLILTDIYPAGEAPIEGVTAEALANRVRRHGQKDVTWISDRD
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCHH
KLCEHLERVLAPGDILLTLGAGNVWQVGETMLLRLKAAKES
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHEEEECCCCC
>Mature Secondary Structure
MYGKIERIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLRGSEITQRLESLGGEIFFGHAAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCEEEECCCCC
NVANADVVVISSAVHDDNPEVVEAHLRLIPVIPRAEMLAELMRMKYGIAVAGTHGKTTTT
CCCCCCEEEEEECCCCCCHHHHHHHHHHEECCCHHHHHHHHHHHHCCEEEECCCCCCHHH
SMVATILSKGGIDPTIVIGGRLNSLGTNARLGQGQFLVAEADESDGSFLLLSPTIAVVTN
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEEC
IDADHLDFYSGIEEIKDTFVEFINKIPFYGLAVLCLDNGNIADVLPRVKKRFTSYGMSAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCC
ADFRATDVKLSGFSTSFVAHHKGVRLGEITFSMPGAHNVLNALAAIAVAMELDIPFETIQ
CCCEEEEEEECCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHH
EGFAGFGGVGRRFHLKGEANGIMVVDDYGHHPTEIKATLGAAKAGFAENRLVVVFQPHRY
HHHCCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
SRTKELFEEFVKAFHDADVLILTDIYPAGEAPIEGVTAEALANRVRRHGQKDVTWISDRD
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCHH
KLCEHLERVLAPGDILLTLGAGNVWQVGETMLLRLKAAKES
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA