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The map label for this gene is proA [H]

Identifier: 194736743

GI number: 194736743

Start: 377635

End: 378885

Strand: Direct

Name: proA [H]

Synonym: SeSA_A0372

Alternate gene names: 194736743

Gene position: 377635-378885 (Clockwise)

Preceding gene: 194737323

Following gene: 194737537

Centisome position: 8.02

GC content: 56.27

Gene sequence:

>1251_bases
ATGCTGGAACAAATGGGCATTGCTGCTAAAGCGGCGTCGTATAAGCTGGCGCTGCTCTCCAGCTGCGAAAAAAATCGCGT
GCTGGAAAAAATAGCCGATGAACTGGAAGCGCAAATGGAAAGTATCCTCAGCGCGAACGTACAAGATGTTGAGCAGGCGC
GAGCCAACGGCCTGAGCGAAGCGATGCTGGACCGCCTGGCGCTGACCCCTGCGCGTCTGAAAGCGATTGCTGACGATGTG
CGCCAGGTCTGTAATCTCGCCGACCCGGTCGGGCAGGTGATCGACGGCGGTCTGCTGGACAGCGGCCTGCGTCTGGAGCG
CCGCCGCGTGCCGTTGGGCGTGGTTGGCGTTATCTATGAGGCGCGTCCGAACGTTACCGTTGATGTGGCTTCTTTGTGTC
TGAAAACCGGTAATGCGGTGATTCTACGCGGTGGGAAAGAGACGCATCGCACGAATGCCGCAACCGTTCGTGTCATTCAG
AAGGCGCTGAAAGCTTGCGGTTTACCGGAGGCAGCGGTTCAGGCGATTGATAATCCGGATCGTTCGCTGGTCAATGAAAT
GCTGCGTATGGATAAGTACATCGATATGCTGATCCCGCGCGGCGGCGCAGGCTTGCATAAACTGTGCCGCGAGCAATCCA
CAATCCCAGTGATTACCGGCGGGATTGGCGTGTGCCATATTTTTGTTGATAGCAGCGCAGACATCGCCCCGGCGCTGAAG
ATTATCGTCAACGCCAAAACCCAGCGCCCGAGCACCTGTAACACGGTGGAAACCTTGCTGGTGCATCAGGACATCGCAGA
ACGCTTTTTGCCTGTGCTGAGCAAGCAGATGGCGGAGAGCGGCGTAACGTTGCATGGGGATGAAACCGTCATGCAGGCAC
TGCATGGCCCTGCCAAACTGGTGCCGCTGAAACCGGAAGAGCTGGATAACGAGTTTCTGTCTCTGGATCTGAACGTTGTG
GTGGTCGAAAATATGGATGGCGCTATCGCCCACATTCGCGAACATGGTACTCAGCACTCCGATGCGATTTTGACGAGTGA
TATGCATAATGCTGCGCGTTTCGTGAACGAAGTGGATTCCGCTGCGGTTTATGTCAACGCCTCTACCCGTTTTACCGATG
GCGGGCAGTTTGGGCTTGGCGCAGAAGTGGCGGTCAGCACGCAGAAATTACATGCCCGCGGTCCGATGGGGCTTGAAGCG
CTTACCACCTATAAGTGGATCGGCTTTGGCGATGGTACGATTCGTGCGTAA

Upstream 100 bases:

>100_bases
CCGGCCACCACTCTCAACAAATCGATGCGATTCTGGGCTATGAATATGGCCCGGTCGCTGTTCATCGTGATGACATGATT
ACTCGATAAGGAACAGGCAT

Downstream 100 bases:

>100_bases
TTAATGTCGAGCGGTGCAAAAATAGCCGGTTGAGTAGCAAGGCTATTGACGCACCGCCCGGTTAGTTTTAACCTTCTATC
CCGTGATTCACCCGCGTGAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLEQMGIAAKAASYKLALLSSCEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSEAMLDRLALTPARLKAIADDV
RQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYEARPNVTVDVASLCLKTGNAVILRGGKETHRTNAATVRVIQ
KALKACGLPEAAVQAIDNPDRSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALK
IIVNAKTQRPSTCNTVETLLVHQDIAERFLPVLSKQMAESGVTLHGDETVMQALHGPAKLVPLKPEELDNEFLSLDLNVV
VVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEA
LTTYKWIGFGDGTIRA

Sequences:

>Translated_416_residues
MLEQMGIAAKAASYKLALLSSCEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSEAMLDRLALTPARLKAIADDV
RQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYEARPNVTVDVASLCLKTGNAVILRGGKETHRTNAATVRVIQ
KALKACGLPEAAVQAIDNPDRSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALK
IIVNAKTQRPSTCNTVETLLVHQDIAERFLPVLSKQMAESGVTLHGDETVMQALHGPAKLVPLKPEELDNEFLSLDLNVV
VVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEA
LTTYKWIGFGDGTIRA
>Mature_416_residues
MLEQMGIAAKAASYKLALLSSCEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSEAMLDRLALTPARLKAIADDV
RQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYEARPNVTVDVASLCLKTGNAVILRGGKETHRTNAATVRVIQ
KALKACGLPEAAVQAIDNPDRSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALK
IIVNAKTQRPSTCNTVETLLVHQDIAERFLPVLSKQMAESGVTLHGDETVMQALHGPAKLVPLKPEELDNEFLSLDLNVV
VVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEA
LTTYKWIGFGDGTIRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=37.3170731707317, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=37.3170731707317, Blast_Score=264, Evalue=1e-70,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=85.6115107913669, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=36.144578313253, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=36.144578313253, Blast_Score=261, Evalue=5e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=430, Percent_Identity=36.7441860465116, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI21357643, Length=409, Percent_Identity=36.1858190709046, Blast_Score=265, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44670; Mature: 44670

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQMGIAAKAASYKLALLSSCEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSE
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
AMLDRLALTPARLKAIADDVRQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEEE
ARPNVTVDVASLCLKTGNAVILRGGKETHRTNAATVRVIQKALKACGLPEAAVQAIDNPD
CCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
RSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCEEEEEEECCCCCHHHHHH
IIVNAKTQRPSTCNTVETLLVHQDIAERFLPVLSKQMAESGVTLHGDETVMQALHGPAKL
HHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCEE
VPLKPEELDNEFLSLDLNVVVVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDS
ECCCHHHHCCHHEEEEEEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
AAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDGTIRA
EEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHEEEEEECCCCCCC
>Mature Secondary Structure
MLEQMGIAAKAASYKLALLSSCEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSE
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHH
AMLDRLALTPARLKAIADDVRQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEEE
ARPNVTVDVASLCLKTGNAVILRGGKETHRTNAATVRVIQKALKACGLPEAAVQAIDNPD
CCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
RSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCEEEEEEECCCCCHHHHHH
IIVNAKTQRPSTCNTVETLLVHQDIAERFLPVLSKQMAESGVTLHGDETVMQALHGPAKL
HHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHCCCCEE
VPLKPEELDNEFLSLDLNVVVVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDS
ECCCHHHHCCHHEEEEEEEEEEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
AAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDGTIRA
EEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA