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The map label for this gene is rnc [H]

Identifier: 194333018

GI number: 194333018

Start: 180749

End: 181582

Strand: Reverse

Name: rnc [H]

Synonym: Paes_0172

Alternate gene names: 194333018

Gene position: 181582-180749 (Counterclockwise)

Preceding gene: 194333019

Following gene: 194333017

Centisome position: 7.23

GC content: 50.24

Gene sequence:

>834_bases
ATGGAGCATTTCTGGCATAAAATCGGCAAAATAGCCTTTAACCGCTCTGAAAGCGTTCCTCAAACAAGCCAAACATCGTC
TGAAGCGAGCACAGGGAATGACGCCCTGTGCAACGCGATAAGAGCATATGTCGAACAACTGATCCGCCAGCCCTGCGCTT
CAGTCGACATCTACAAAACAGCCTTTACCCATCGATCCTTCGTTCACGATCAGCATCAGGGCTCTAGTCCGGCACCCTTT
GATTCCAACCAGCGCCTTGAATTTCTTGGCGATGCCGTGCTCGACCTGATTATCTCCGAACACCTCTATAAGCTCTTCCC
TGAAAGCGATGAAGGTGCGCTCTCGAGCACCAGGTCAAAAATCGTCAACCGCAAGTCGCTGGCTGATTTTGCTCAAGCCA
TAGCCCTTGGCAATCAACTCATCATAGGAGAGTCAGCTGATGAAGAAAAGATCCGCAAGAGCGAAGCGACCATGGCAGAC
GCCTTCGAAGCATTAATCGGAGCTATCTACCTCGATAAAGGGCTTCCTGCCGTGCAGCGTTTCATTGACGATCATGTCAT
GACGATTGTCGATGTGCCGAAACTCGCGACAATCGAGCACAACCATAAAAGCAGACTGATAGAATTCGCTCAGGCAAATC
AGCTTTCCCATCCCCAATACACGATCATCAGGGAAGAAGGGGCGGAACATCAGAAAACCTTTACGGTAGAGGTCTCCTTT
GATGGAAAACCTTTCGGAACAGGAACTGCCGCAAGAAAAAAGGATGCGGAGCAGGCTGCTGCAAGACGGGCACTTCTGCT
CCTTCAAAGCGATAGCGGCAACGATCAAAACTGA

Upstream 100 bases:

>100_bases
AAATCTGGAATACGTGCTGAACAATGGTTTTGGTTTCGGCGGTCATAATGCAACGCTGATTTTCAAAAAAATCTGATCAG
CCTGAAAACACCTCCGGCTC

Downstream 100 bases:

>100_bases
AAACCGCCCAAAAGACTTTTTTTCTTCCCGGTTTGAGCAATTGATGTCGCTCTTCTATATTGAATGTATTAACGCAACAA
GGCACTCACCATCTGTCGTA

Product: Ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEHFWHKIGKIAFNRSESVPQTSQTSSEASTGNDALCNAIRAYVEQLIRQPCASVDIYKTAFTHRSFVHDQHQGSSPAPF
DSNQRLEFLGDAVLDLIISEHLYKLFPESDEGALSSTRSKIVNRKSLADFAQAIALGNQLIIGESADEEKIRKSEATMAD
AFEALIGAIYLDKGLPAVQRFIDDHVMTIVDVPKLATIEHNHKSRLIEFAQANQLSHPQYTIIREEGAEHQKTFTVEVSF
DGKPFGTGTAARKKDAEQAAARRALLLLQSDSGNDQN

Sequences:

>Translated_277_residues
MEHFWHKIGKIAFNRSESVPQTSQTSSEASTGNDALCNAIRAYVEQLIRQPCASVDIYKTAFTHRSFVHDQHQGSSPAPF
DSNQRLEFLGDAVLDLIISEHLYKLFPESDEGALSSTRSKIVNRKSLADFAQAIALGNQLIIGESADEEKIRKSEATMAD
AFEALIGAIYLDKGLPAVQRFIDDHVMTIVDVPKLATIEHNHKSRLIEFAQANQLSHPQYTIIREEGAEHQKTFTVEVSF
DGKPFGTGTAARKKDAEQAAARRALLLLQSDSGNDQN
>Mature_277_residues
MEHFWHKIGKIAFNRSESVPQTSQTSSEASTGNDALCNAIRAYVEQLIRQPCASVDIYKTAFTHRSFVHDQHQGSSPAPF
DSNQRLEFLGDAVLDLIISEHLYKLFPESDEGALSSTRSKIVNRKSLADFAQAIALGNQLIIGESADEEKIRKSEATMAD
AFEALIGAIYLDKGLPAVQRFIDDHVMTIVDVPKLATIEHNHKSRLIEFAQANQLSHPQYTIIREEGAEHQKTFTVEVSF
DGKPFGTGTAARKKDAEQAAARRALLLLQSDSGNDQN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=193, Percent_Identity=31.0880829015544, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI155030234, Length=193, Percent_Identity=31.0880829015544, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1788920, Length=201, Percent_Identity=32.8358208955224, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=201, Percent_Identity=31.8407960199005, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=201, Percent_Identity=31.8407960199005, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137682, Length=216, Percent_Identity=32.8703703703704, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 30667; Mature: 30667

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHFWHKIGKIAFNRSESVPQTSQTSSEASTGNDALCNAIRAYVEQLIRQPCASVDIYKT
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
AFTHRSFVHDQHQGSSPAPFDSNQRLEFLGDAVLDLIISEHLYKLFPESDEGALSSTRSK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IVNRKSLADFAQAIALGNQLIIGESADEEKIRKSEATMADAFEALIGAIYLDKGLPAVQR
HHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
FIDDHVMTIVDVPKLATIEHNHKSRLIEFAQANQLSHPQYTIIREEGAEHQKTFTVEVSF
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEEEE
DGKPFGTGTAARKKDAEQAAARRALLLLQSDSGNDQN
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure
MEHFWHKIGKIAFNRSESVPQTSQTSSEASTGNDALCNAIRAYVEQLIRQPCASVDIYKT
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
AFTHRSFVHDQHQGSSPAPFDSNQRLEFLGDAVLDLIISEHLYKLFPESDEGALSSTRSK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IVNRKSLADFAQAIALGNQLIIGESADEEKIRKSEATMADAFEALIGAIYLDKGLPAVQR
HHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
FIDDHVMTIVDVPKLATIEHNHKSRLIEFAQANQLSHPQYTIIREEGAEHQKTFTVEVSF
HHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEEEEEE
DGKPFGTGTAARKKDAEQAAARRALLLLQSDSGNDQN
CCCCCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]