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The map label for this gene is fabF [H]

Identifier: 194333019

GI number: 194333019

Start: 181607

End: 182851

Strand: Reverse

Name: fabF [H]

Synonym: Paes_0173

Alternate gene names: 194333019

Gene position: 182851-181607 (Counterclockwise)

Preceding gene: 194333020

Following gene: 194333018

Centisome position: 7.28

GC content: 52.69

Gene sequence:

>1245_bases
ATGAGTCAGGAAAGAAAAAAAATAGTGATTACCGGTGTAGGGCTACTCTCTCCGGTTGGCCTGTCAAAGCAGGAACTCTG
GGAATCCCTGTCCATGGGAAAAAGCGGCGCTGCGCCTATAACCTATTTTGACGCAACAAACTTCGCGACACGCTTTGCCT
GTGAACTGAAAGGGTTCAACGCGACTGATTATATCGACCAGAAATCAGCCGGAAGAATGGACCCCTTCTGCCAGTATGCT
GTTGCCGCTTCCGACCAGGCCCTGAAAGATTCAGGGCTTGATGTATCATCGATCGACAAGGCAAGAATCGGTGTCGTCTA
CGGTTCAGGAACGGGAGGCATGACAACGCATGACCAGCAGATGCGAGTCTATCTCGAACGCGGTCCGAGAAGGATCAGTC
CGTTTTTTATCCCGATGCTTATCCCCGATATTGCCGCTGGTCAGATCGCGATGCGACACGGGCTCATGGGACCGAACTAC
GCGACGGCATCCGCCTGCGCCACCTCGCTCCACGCGATTATGGACGCATGGATGCTTATGCAGATGGGAATGGCCGACTA
CATGGTCTGTGGAGGTTCTGAAGCTGCTATCACGCCGATGAGTGTAGCAGGATTCAACGCCGCACGCGCACTGTCAACAG
CCAATGACAACCCGACAACTGCCTCCCGCCCTTATGACAAGGATCGAGACGGCTTTGTTATGGGAGAAGGTGCCGGTGCA
CTGGTACTGGAAACACTGGAATCAGCGCAGGCACGCGGCGCAACAATTTACGGCGAAATAGCAGGTGTCGGCGCTTCTGC
CGATGCACATCACCTGACAGCACCCCACCCGGAAGGGTTAGGAGCAGTCAACGCGATGAACTGCGCCTTGCAGCAGGCAG
GCATAACGCCCGATAAAATTGATTACATCAATACGCATGGCACTGCGACCCCTCTGGGTGATCTCGCAGAACTGAAAGCC
ATCAAGACCGTCCTCGGAGATCATGCCAAAACAGTCAGCATCAGTTCGACAAAATCAATGACCGGTCACCTGCTTGGTGC
CGCAGGTGTCGTCGAATCGATCATCTGTCTTCTGGCCATGAAAAACCAGATCGTACCGCCGACGATCAACCTCGACAATC
TCGACCCTGAAATCGATGTCGATGTTACTCCGAATACGCCTAAAGAAAAAAATCTGGAATACGTGCTGAACAATGGTTTT
GGTTTCGGCGGTCATAATGCAACGCTGATTTTCAAAAAAATCTGA

Upstream 100 bases:

>100_bases
AGCAACGTTCAGCAGGCAATCGACTACATCGTCAATGCAAAAAAGTAAATAGAGAATTTATTAACAGCATACGGCTGCAG
GCCGGTGTTAACGAAGAATA

Downstream 100 bases:

>100_bases
TCAGCCTGAAAACACCTCCGGCTCATGGAGCATTTCTGGCATAAAATCGGCAAAATAGCCTTTAACCGCTCTGAAAGCGT
TCCTCAAACAAGCCAAACAT

Product: 3-oxoacyl-(acyl-carrier-protein) synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSQERKKIVITGVGLLSPVGLSKQELWESLSMGKSGAAPITYFDATNFATRFACELKGFNATDYIDQKSAGRMDPFCQYA
VAASDQALKDSGLDVSSIDKARIGVVYGSGTGGMTTHDQQMRVYLERGPRRISPFFIPMLIPDIAAGQIAMRHGLMGPNY
ATASACATSLHAIMDAWMLMQMGMADYMVCGGSEAAITPMSVAGFNAARALSTANDNPTTASRPYDKDRDGFVMGEGAGA
LVLETLESAQARGATIYGEIAGVGASADAHHLTAPHPEGLGAVNAMNCALQQAGITPDKIDYINTHGTATPLGDLAELKA
IKTVLGDHAKTVSISSTKSMTGHLLGAAGVVESIICLLAMKNQIVPPTINLDNLDPEIDVDVTPNTPKEKNLEYVLNNGF
GFGGHNATLIFKKI

Sequences:

>Translated_414_residues
MSQERKKIVITGVGLLSPVGLSKQELWESLSMGKSGAAPITYFDATNFATRFACELKGFNATDYIDQKSAGRMDPFCQYA
VAASDQALKDSGLDVSSIDKARIGVVYGSGTGGMTTHDQQMRVYLERGPRRISPFFIPMLIPDIAAGQIAMRHGLMGPNY
ATASACATSLHAIMDAWMLMQMGMADYMVCGGSEAAITPMSVAGFNAARALSTANDNPTTASRPYDKDRDGFVMGEGAGA
LVLETLESAQARGATIYGEIAGVGASADAHHLTAPHPEGLGAVNAMNCALQQAGITPDKIDYINTHGTATPLGDLAELKA
IKTVLGDHAKTVSISSTKSMTGHLLGAAGVVESIICLLAMKNQIVPPTINLDNLDPEIDVDVTPNTPKEKNLEYVLNNGF
GFGGHNATLIFKKI
>Mature_413_residues
SQERKKIVITGVGLLSPVGLSKQELWESLSMGKSGAAPITYFDATNFATRFACELKGFNATDYIDQKSAGRMDPFCQYAV
AASDQALKDSGLDVSSIDKARIGVVYGSGTGGMTTHDQQMRVYLERGPRRISPFFIPMLIPDIAAGQIAMRHGLMGPNYA
TASACATSLHAIMDAWMLMQMGMADYMVCGGSEAAITPMSVAGFNAARALSTANDNPTTASRPYDKDRDGFVMGEGAGAL
VLETLESAQARGATIYGEIAGVGASADAHHLTAPHPEGLGAVNAMNCALQQAGITPDKIDYINTHGTATPLGDLAELKAI
KTVLGDHAKTVSISSTKSMTGHLLGAAGVVESIICLLAMKNQIVPPTINLDNLDPEIDVDVTPNTPKEKNLEYVLNNGFG
FGGHNATLIFKKI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=42.9594272076372, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=49.7005988023952, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=24.113475177305, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=50.6082725060827, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=40.0479616306954, Blast_Score=253, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=34.3825665859564, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=39.7683397683398, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI212642053, Length=375, Percent_Identity=26.4, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=400, Percent_Identity=25.75, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=35.4401805869075, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=42.5837320574163, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI221330659, Length=368, Percent_Identity=25.2717391304348, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920632, Length=368, Percent_Identity=25.2717391304348, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24581345, Length=367, Percent_Identity=23.1607629427793, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43650; Mature: 43519

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQERKKIVITGVGLLSPVGLSKQELWESLSMGKSGAAPITYFDATNFATRFACELKGFN
CCCCCCEEEEEECHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCC
ATDYIDQKSAGRMDPFCQYAVAASDQALKDSGLDVSSIDKARIGVVYGSGTGGMTTHDQQ
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCHHCCCCEEEEEEEECCCCCCCCCHHH
MRVYLERGPRRISPFFIPMLIPDIAAGQIAMRHGLMGPNYATASACATSLHAIMDAWMLM
HHHHHHCCCCCCCCEEHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
QMGMADYMVCGGSEAAITPMSVAGFNAARALSTANDNPTTASRPYDKDRDGFVMGEGAGA
HHCCHHEEEECCCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCH
LVLETLESAQARGATIYGEIAGVGASADAHHLTAPHPEGLGAVNAMNCALQQAGITPDKI
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
DYINTHGTATPLGDLAELKAIKTVLGDHAKTVSISSTKSMTGHLLGAAGVVESIICLLAM
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KNQIVPPTINLDNLDPEIDVDVTPNTPKEKNLEYVLNNGFGFGGHNATLIFKKI
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
SQERKKIVITGVGLLSPVGLSKQELWESLSMGKSGAAPITYFDATNFATRFACELKGFN
CCCCCEEEEEECHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCC
ATDYIDQKSAGRMDPFCQYAVAASDQALKDSGLDVSSIDKARIGVVYGSGTGGMTTHDQQ
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCHHCCCCEEEEEEEECCCCCCCCCHHH
MRVYLERGPRRISPFFIPMLIPDIAAGQIAMRHGLMGPNYATASACATSLHAIMDAWMLM
HHHHHHCCCCCCCCEEHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
QMGMADYMVCGGSEAAITPMSVAGFNAARALSTANDNPTTASRPYDKDRDGFVMGEGAGA
HHCCHHEEEECCCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCH
LVLETLESAQARGATIYGEIAGVGASADAHHLTAPHPEGLGAVNAMNCALQQAGITPDKI
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCE
DYINTHGTATPLGDLAELKAIKTVLGDHAKTVSISSTKSMTGHLLGAAGVVESIICLLAM
EEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KNQIVPPTINLDNLDPEIDVDVTPNTPKEKNLEYVLNNGFGFGGHNATLIFKKI
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]