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The map label for this gene is gcvPB

Identifier: 194333017

GI number: 194333017

Start: 179181

End: 180644

Strand: Reverse

Name: gcvPB

Synonym: Paes_0171

Alternate gene names: 194333017

Gene position: 180644-179181 (Counterclockwise)

Preceding gene: 194333018

Following gene: 194333016

Centisome position: 7.19

GC content: 53.14

Gene sequence:

>1464_bases
ATGAAAGAAACCCTTATTTTCGATCTCTCCCGGAAAGGGAGACAGGGACACCGTATCGCAAGCCTCGACATCGAGCCGCA
ACCGGCAATAAACCTGATCCCGGAAAAATTTCTGAGAACCGAACCCGCCGATCTGCCGGAAGTTCCTGAAAGCGAAGTTG
TCCGACACTTCATCAGACTTTCAAATCTGAATCATCATGTCGATAAAGACATGTACCCCCTCGGAAGCTGTACCATGAAG
TACAATCCGAAAATCAACGACCAGACAGCAGATATCGCCGGGTTCACGTCGATACATCCCCTTCAGCCGGCAGAAACCGC
TCAGGGCACCCTGCAGCTCATGTACGAACTTGGTGAGATGCTGCGCGAAATCGCGGGAATGGCAGCCATCACCCTTCAAC
CCGCAGCCGGTGCGCACGGTGAACTGACCGGCATTCTGATGATCCGCAAATACCATGACTCAAGAGCCTCCAAACGCACT
AAGCTGCTGGTGGTTGATTCCGCGCACGGAACCAACCCGGCATCGGCCGCCCTTGTCGGCTACGACATCCTGTCGGTCAA
AAGCAATGCCGAAGGAAGAACGGATATCGAAGATCTGAAAGCGAAGCTTGACGAGAACGTCGCAGCGCTGATGCTGACCA
ACCCCAACACCATAGGGCTCTTCGAAAAAGACATCAAAGAAATTGAACAGCTGGTTCATGACAACGGCAGCCTTCTCTAT
ATGGACGGCGCCAACATGAACGCACTGATGGGCATCACCCGACCCGGCGACATGGGCTTCGACATCGTGCACTACAATCT
GCACAAAACCTTCTCTGCACCTCATGGAGGCGGCGGTCCAGGCAGCGGTCCGGTCGGCGTATGCGACAAGCTGAAACCCT
ATCTGCCGGTTCCGGTCATTGAAAAACATGATGACGGCAATACAAGCCGCTACACACTGACAACAGACCGTCCGCTGAGT
ATCGGACGCATGATGAATTTCTATGGGAATTTCAGTGTCATGGTCAGAGCCTACACCTATATCCGTATGCTTGGAGCCGA
AGGGATCAGAAGAGTATCGGAAAACGCAATAATCAATGCCAATTACCTGCTCAGCAAGCTGATCGACCGCTATGACCTGC
CCTACCCGAAACCAGTCATGCATGAATTCTGTCTCTCCGGGGACCGCCAGAAAAAACAGCACAACGTCAGAACGCTCGAT
ATCGCAAAACGCCTTCTCGATCTCGGATTCCATGCCCCGACCATCTACTTCCCGCTCATCGTCAGCGAAGCCCTGATGAT
CGAACCTACGGAAACGGAAACCAGGGAAACACTCGACAGGTTTGCCGAAGCAATGCTGCAGATCGCCGATGAAACCGAAA
ACAGTCCTGAAACGGTGCAGAACGCACCCCAGTTCACGCCTGTCAAACGACTTGACGAAGCGCAGGCATCGCGAAAACTC
AACATATGCTGTCCAGGCTGCTGA

Upstream 100 bases:

>100_bases
CGCCCAAAAGACTTTTTTTCTTCCCGGTTTGAGCAATTGATGTCGCTCTTCTATATTGAATGTATTAACGCAACAAGGCA
CTCACCATCTGTCGTAACGA

Downstream 100 bases:

>100_bases
AGGACGTGCTGAGTTCGAAGTGCTGAGTTAAAAATCTCAGCACTCAGCACTCAGGACTCAGGACTCAGAACAATTGCCCC
CCTCCTTTCAAGGTTTAACC

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKETLIFDLSRKGRQGHRIASLDIEPQPAINLIPEKFLRTEPADLPEVPESEVVRHFIRLSNLNHHVDKDMYPLGSCTMK
YNPKINDQTADIAGFTSIHPLQPAETAQGTLQLMYELGEMLREIAGMAAITLQPAAGAHGELTGILMIRKYHDSRASKRT
KLLVVDSAHGTNPASAALVGYDILSVKSNAEGRTDIEDLKAKLDENVAALMLTNPNTIGLFEKDIKEIEQLVHDNGSLLY
MDGANMNALMGITRPGDMGFDIVHYNLHKTFSAPHGGGGPGSGPVGVCDKLKPYLPVPVIEKHDDGNTSRYTLTTDRPLS
IGRMMNFYGNFSVMVRAYTYIRMLGAEGIRRVSENAIINANYLLSKLIDRYDLPYPKPVMHEFCLSGDRQKKQHNVRTLD
IAKRLLDLGFHAPTIYFPLIVSEALMIEPTETETRETLDRFAEAMLQIADETENSPETVQNAPQFTPVKRLDEAQASRKL
NICCPGC

Sequences:

>Translated_487_residues
MKETLIFDLSRKGRQGHRIASLDIEPQPAINLIPEKFLRTEPADLPEVPESEVVRHFIRLSNLNHHVDKDMYPLGSCTMK
YNPKINDQTADIAGFTSIHPLQPAETAQGTLQLMYELGEMLREIAGMAAITLQPAAGAHGELTGILMIRKYHDSRASKRT
KLLVVDSAHGTNPASAALVGYDILSVKSNAEGRTDIEDLKAKLDENVAALMLTNPNTIGLFEKDIKEIEQLVHDNGSLLY
MDGANMNALMGITRPGDMGFDIVHYNLHKTFSAPHGGGGPGSGPVGVCDKLKPYLPVPVIEKHDDGNTSRYTLTTDRPLS
IGRMMNFYGNFSVMVRAYTYIRMLGAEGIRRVSENAIINANYLLSKLIDRYDLPYPKPVMHEFCLSGDRQKKQHNVRTLD
IAKRLLDLGFHAPTIYFPLIVSEALMIEPTETETRETLDRFAEAMLQIADETENSPETVQNAPQFTPVKRLDEAQASRKL
NICCPGC
>Mature_487_residues
MKETLIFDLSRKGRQGHRIASLDIEPQPAINLIPEKFLRTEPADLPEVPESEVVRHFIRLSNLNHHVDKDMYPLGSCTMK
YNPKINDQTADIAGFTSIHPLQPAETAQGTLQLMYELGEMLREIAGMAAITLQPAAGAHGELTGILMIRKYHDSRASKRT
KLLVVDSAHGTNPASAALVGYDILSVKSNAEGRTDIEDLKAKLDENVAALMLTNPNTIGLFEKDIKEIEQLVHDNGSLLY
MDGANMNALMGITRPGDMGFDIVHYNLHKTFSAPHGGGGPGSGPVGVCDKLKPYLPVPVIEKHDDGNTSRYTLTTDRPLS
IGRMMNFYGNFSVMVRAYTYIRMLGAEGIRRVSENAIINANYLLSKLIDRYDLPYPKPVMHEFCLSGDRQKKQHNVRTLD
IAKRLLDLGFHAPTIYFPLIVSEALMIEPTETETRETLDRFAEAMLQIADETENSPETVQNAPQFTPVKRLDEAQASRKL
NICCPGC

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=446, Percent_Identity=40.8071748878924, Blast_Score=285, Evalue=9e-77,
Organism=Escherichia coli, GI1789269, Length=435, Percent_Identity=40.6896551724138, Blast_Score=281, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI17535605, Length=414, Percent_Identity=41.5458937198068, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI32564013, Length=369, Percent_Identity=42.2764227642276, Blast_Score=247, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6323843, Length=443, Percent_Identity=41.3092550790068, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24645648, Length=430, Percent_Identity=42.093023255814, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_PROA2 (B4S3N4)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002014877.1
- ProteinModelPortal:   B4S3N4
- SMR:   B4S3N4
- GeneID:   6460428
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0171
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 54094; Mature: 54094

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETLIFDLSRKGRQGHRIASLDIEPQPAINLIPEKFLRTEPADLPEVPESEVVRHFIRL
CCCCEEEECCCCCCCCCEEEEECCCCCCCHHHCHHHHHCCCCCCCCCCCHHHHHHHHHHH
SNLNHHVDKDMYPLGSCTMKYNPKINDQTADIAGFTSIHPLQPAETAQGTLQLMYELGEM
HCCCHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LREIAGMAAITLQPAAGAHGELTGILMIRKYHDSRASKRTKLLVVDSAHGTNPASAALVG
HHHHHCCEEEEEECCCCCCCCEEEEEEEEEHHHHHCCCCEEEEEEECCCCCCCHHHHEEE
YDILSVKSNAEGRTDIEDLKAKLDENVAALMLTNPNTIGLFEKDIKEIEQLVHDNGSLLY
HEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEE
MDGANMNALMGITRPGDMGFDIVHYNLHKTFSAPHGGGGPGSGPVGVCDKLKPYLPVPVI
ECCCCCCEEEEECCCCCCCEEEEEEEEEHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCE
EKHDDGNTSRYTLTTDRPLSIGRMMNFYGNFSVMVRAYTYIRMLGAEGIRRVSENAIINA
ECCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEH
NYLLSKLIDRYDLPYPKPVMHEFCLSGDRQKKQHNVRTLDIAKRLLDLGFHAPTIYFPLI
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
VSEALMIEPTETETRETLDRFAEAMLQIADETENSPETVQNAPQFTPVKRLDEAQASRKL
HCCHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHCEE
NICCPGC
CEECCCC
>Mature Secondary Structure
MKETLIFDLSRKGRQGHRIASLDIEPQPAINLIPEKFLRTEPADLPEVPESEVVRHFIRL
CCCCEEEECCCCCCCCCEEEEECCCCCCCHHHCHHHHHCCCCCCCCCCCHHHHHHHHHHH
SNLNHHVDKDMYPLGSCTMKYNPKINDQTADIAGFTSIHPLQPAETAQGTLQLMYELGEM
HCCCHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
LREIAGMAAITLQPAAGAHGELTGILMIRKYHDSRASKRTKLLVVDSAHGTNPASAALVG
HHHHHCCEEEEEECCCCCCCCEEEEEEEEEHHHHHCCCCEEEEEEECCCCCCCHHHHEEE
YDILSVKSNAEGRTDIEDLKAKLDENVAALMLTNPNTIGLFEKDIKEIEQLVHDNGSLLY
HEEEEECCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEE
MDGANMNALMGITRPGDMGFDIVHYNLHKTFSAPHGGGGPGSGPVGVCDKLKPYLPVPVI
ECCCCCCEEEEECCCCCCCEEEEEEEEEHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCE
EKHDDGNTSRYTLTTDRPLSIGRMMNFYGNFSVMVRAYTYIRMLGAEGIRRVSENAIINA
ECCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEH
NYLLSKLIDRYDLPYPKPVMHEFCLSGDRQKKQHNVRTLDIAKRLLDLGFHAPTIYFPLI
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHH
VSEALMIEPTETETRETLDRFAEAMLQIADETENSPETVQNAPQFTPVKRLDEAQASRKL
HCCHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHCEE
NICCPGC
CEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA