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The map label for this gene is dnaX [H]

Identifier: 189184647

GI number: 189184647

Start: 1759985

End: 1761664

Strand: Reverse

Name: dnaX [H]

Synonym: OTT_1740

Alternate gene names: 189184647

Gene position: 1761664-1759985 (Counterclockwise)

Preceding gene: 189184649

Following gene: 189184646

Centisome position: 87.69

GC content: 31.01

Gene sequence:

>1680_bases
ATGCTAGAAAGGCAAAGTGGCTATGTAGTTTGGGCTAGAAAATATAGACCTAAAACTATGTGTGAGTTGATAGGGCAGGA
AGTATTAACTAAAGTTTTAACTTATAGTATGATTACTGGCTGCTTATCGCAAGCTTATTTGTTGAGTGGTATTCGCGGCG
TTGGAAAAACAACTGCAGCTAGAATCATTGCTACAACAATTAATTGTTTGCAGCCATTAGTAACTTCAAAAACAATATTT
GCTTGTACTAAGTGTAATAGCTGTATAGCTATCGAAAATAATAGCCATCCTGATATTAATGAAATTGATGCAGCTAGTAG
AACTGGAGTAGATGATGTCAGGACAATAATTGATGATAGTGAATATAAGCCATTAATTTCTAAATATAAGATATTTATTA
TTGATGAAGTTCATATGCTCTCTAAGAACGCATTTAATGCATTGTTAAAGCTTCTTGAAGAACCTCCAAGTCACACTATT
TTTATTTTTGCAACAACCGAGATTAATAAAATTCCTTTGACAGTGATTTCTAGATGTCAAAAATTTGACTTAAGACGATT
GGATGTAAATAATATTGTTCAAATTTTGAGTAACATTATAGCTAAGGAAAATGTTAGCGCTACTAAAGAAATATTAGAAT
TTATTGCTGTTAAGGCAGATGGATCCGCAAGGGATGCAATATCATTACTTGAGCAGGCTAAAGCATTAGCCCAAAATATT
GCAGATACTGCAAGTTCTGAGGCAGTAGTGATTAGTTTAAATACTGTCGAACAGATGTGCGGGGTATTAGATTTAGGAAA
ATCAACAGATCTTCTATCAGCAATTGCTGAGAAAAATGCAGAAAAAGGCATTAATATTGTTACAGATTTATATATAAGTG
GAACTGATTTTGTAGTATGCAGTCAAAATATACTAGATCTGATTGGGTATTTAATTAAAGTGAAAACGATAGATGGCTAT
ACTGAATCTATTTATGCGAGTCATAATAATAGATTAAATTCTCTTAGTATGAAATTATCTTTATCGCGATTGACTGTGCT
ATGGCAAATATTTAGTAAATCTATACAAGAGTTAAAGATTAGTCATAACCCAAGGCTTTGTTTTGAGGTTGTTGTTATAA
AAGCTATTTACAGTTTTTCATTACCAACTCCTATAGATGCATTAAGGCAATTAAAGAGTGAATTAACTGATGCTAAAACT
AATGTCGATAATGCCGCTAATTCGCCTGCTGTAGCTGAATCTTTACCGGCCAGCATGGATAAATATGAGCTACAATCTTA
TGAATGCTATTCTGATATAAATAATAAAAAAATGTTGACTAAATCTAATAATAGTAATAATTATTTGACGATTTTAGTAG
ATTTTTTAAAATATCTTAACCAAATTGGAGAGGTTGATCTTTATTATTATCTAATGAACATAGTTTCGGTTATTGATATT
ACTGGATGTAGTGTTTTCTTAGGCAGCAAAGGTAGTAATGCAAAGATGAACAGTCAATTGACAATGCATTTATGTCAATG
GAAGCCTAATAATTGGAATGTCTTAACTGTAGAAAATGATACAAAATTGCCATTAAAAGCAGAGCTCATTCAAATGTTTA
AAGTTTCTAAAGCATGGGATTTAATTACAACTAATTTTAAAGATGTTGAGGTTGTTGATATTATAATGAATAAAAAATAG

Upstream 100 bases:

>100_bases
AAGCAGCTGTAGTAAGTCCTTGGTGGGTTACGCTAGTAGTTTTATCTTAACAATGAGTGTATTTTTACATTCCTTTTTCT
CTTGAAGTTTAATTAGATTA

Downstream 100 bases:

>100_bases
TTAGGCACTCTATGAGAAAATTAAGACAGTTATTAAGACAAGTTGAAGATGCTCAAAAGCAGGTTTCGCAGAAAGAATAT
AGCGGTAGTGCTATGATTGA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MLERQSGYVVWARKYRPKTMCELIGQEVLTKVLTYSMITGCLSQAYLLSGIRGVGKTTAARIIATTINCLQPLVTSKTIF
ACTKCNSCIAIENNSHPDINEIDAASRTGVDDVRTIIDDSEYKPLISKYKIFIIDEVHMLSKNAFNALLKLLEEPPSHTI
FIFATTEINKIPLTVISRCQKFDLRRLDVNNIVQILSNIIAKENVSATKEILEFIAVKADGSARDAISLLEQAKALAQNI
ADTASSEAVVISLNTVEQMCGVLDLGKSTDLLSAIAEKNAEKGINIVTDLYISGTDFVVCSQNILDLIGYLIKVKTIDGY
TESIYASHNNRLNSLSMKLSLSRLTVLWQIFSKSIQELKISHNPRLCFEVVVIKAIYSFSLPTPIDALRQLKSELTDAKT
NVDNAANSPAVAESLPASMDKYELQSYECYSDINNKKMLTKSNNSNNYLTILVDFLKYLNQIGEVDLYYYLMNIVSVIDI
TGCSVFLGSKGSNAKMNSQLTMHLCQWKPNNWNVLTVENDTKLPLKAELIQMFKVSKAWDLITTNFKDVEVVDIIMNKK

Sequences:

>Translated_559_residues
MLERQSGYVVWARKYRPKTMCELIGQEVLTKVLTYSMITGCLSQAYLLSGIRGVGKTTAARIIATTINCLQPLVTSKTIF
ACTKCNSCIAIENNSHPDINEIDAASRTGVDDVRTIIDDSEYKPLISKYKIFIIDEVHMLSKNAFNALLKLLEEPPSHTI
FIFATTEINKIPLTVISRCQKFDLRRLDVNNIVQILSNIIAKENVSATKEILEFIAVKADGSARDAISLLEQAKALAQNI
ADTASSEAVVISLNTVEQMCGVLDLGKSTDLLSAIAEKNAEKGINIVTDLYISGTDFVVCSQNILDLIGYLIKVKTIDGY
TESIYASHNNRLNSLSMKLSLSRLTVLWQIFSKSIQELKISHNPRLCFEVVVIKAIYSFSLPTPIDALRQLKSELTDAKT
NVDNAANSPAVAESLPASMDKYELQSYECYSDINNKKMLTKSNNSNNYLTILVDFLKYLNQIGEVDLYYYLMNIVSVIDI
TGCSVFLGSKGSNAKMNSQLTMHLCQWKPNNWNVLTVENDTKLPLKAELIQMFKVSKAWDLITTNFKDVEVVDIIMNKK
>Mature_559_residues
MLERQSGYVVWARKYRPKTMCELIGQEVLTKVLTYSMITGCLSQAYLLSGIRGVGKTTAARIIATTINCLQPLVTSKTIF
ACTKCNSCIAIENNSHPDINEIDAASRTGVDDVRTIIDDSEYKPLISKYKIFIIDEVHMLSKNAFNALLKLLEEPPSHTI
FIFATTEINKIPLTVISRCQKFDLRRLDVNNIVQILSNIIAKENVSATKEILEFIAVKADGSARDAISLLEQAKALAQNI
ADTASSEAVVISLNTVEQMCGVLDLGKSTDLLSAIAEKNAEKGINIVTDLYISGTDFVVCSQNILDLIGYLIKVKTIDGY
TESIYASHNNRLNSLSMKLSLSRLTVLWQIFSKSIQELKISHNPRLCFEVVVIKAIYSFSLPTPIDALRQLKSELTDAKT
NVDNAANSPAVAESLPASMDKYELQSYECYSDINNKKMLTKSNNSNNYLTILVDFLKYLNQIGEVDLYYYLMNIVSVIDI
TGCSVFLGSKGSNAKMNSQLTMHLCQWKPNNWNVLTVENDTKLPLKAELIQMFKVSKAWDLITTNFKDVEVVDIIMNKK

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=301, Percent_Identity=25.2491694352159, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI31881687, Length=301, Percent_Identity=25.2491694352159, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786676, Length=378, Percent_Identity=34.9206349206349, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71986063, Length=296, Percent_Identity=25.3378378378378, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=263, Percent_Identity=23.9543726235741, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=281, Percent_Identity=27.7580071174377, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=224, Percent_Identity=27.6785714285714, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=247, Percent_Identity=27.1255060728745, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI18859927, Length=252, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62321; Mature: 62321

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERQSGYVVWARKYRPKTMCELIGQEVLTKVLTYSMITGCLSQAYLLSGIRGVGKTTAA
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RIIATTINCLQPLVTSKTIFACTKCNSCIAIENNSHPDINEIDAASRTGVDDVRTIIDDS
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHCCCCCCCHHHHHHHHCCC
EYKPLISKYKIFIIDEVHMLSKNAFNALLKLLEEPPSHTIFIFATTEINKIPLTVISRCQ
CCCCHHHCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHH
KFDLRRLDVNNIVQILSNIIAKENVSATKEILEFIAVKADGSARDAISLLEQAKALAQNI
HCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHH
ADTASSEAVVISLNTVEQMCGVLDLGKSTDLLSAIAEKNAEKGINIVTDLYISGTDFVVC
HHCCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEE
SQNILDLIGYLIKVKTIDGYTESIYASHNNRLNSLSMKLSLSRLTVLWQIFSKSIQELKI
CHHHHHHHHHHHEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SHNPRLCFEVVVIKAIYSFSLPTPIDALRQLKSELTDAKTNVDNAANSPAVAESLPASMD
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCC
KYELQSYECYSDINNKKMLTKSNNSNNYLTILVDFLKYLNQIGEVDLYYYLMNIVSVIDI
HHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TGCSVFLGSKGSNAKMNSQLTMHLCQWKPNNWNVLTVENDTKLPLKAELIQMFKVSKAWD
CCCEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LITTNFKDVEVVDIIMNKK
HHCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MLERQSGYVVWARKYRPKTMCELIGQEVLTKVLTYSMITGCLSQAYLLSGIRGVGKTTAA
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
RIIATTINCLQPLVTSKTIFACTKCNSCIAIENNSHPDINEIDAASRTGVDDVRTIIDDS
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCHHHCCCCCCCHHHHHHHHCCC
EYKPLISKYKIFIIDEVHMLSKNAFNALLKLLEEPPSHTIFIFATTEINKIPLTVISRCQ
CCCCHHHCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHH
KFDLRRLDVNNIVQILSNIIAKENVSATKEILEFIAVKADGSARDAISLLEQAKALAQNI
HCCCHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHH
ADTASSEAVVISLNTVEQMCGVLDLGKSTDLLSAIAEKNAEKGINIVTDLYISGTDFVVC
HHCCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEE
SQNILDLIGYLIKVKTIDGYTESIYASHNNRLNSLSMKLSLSRLTVLWQIFSKSIQELKI
CHHHHHHHHHHHEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SHNPRLCFEVVVIKAIYSFSLPTPIDALRQLKSELTDAKTNVDNAANSPAVAESLPASMD
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCC
KYELQSYECYSDINNKKMLTKSNNSNNYLTILVDFLKYLNQIGEVDLYYYLMNIVSVIDI
HHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TGCSVFLGSKGSNAKMNSQLTMHLCQWKPNNWNVLTVENDTKLPLKAELIQMFKVSKAWD
CCCEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LITTNFKDVEVVDIIMNKK
HHCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]