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The map label for this gene is nuoM [H]

Identifier: 189184493

GI number: 189184493

Start: 1618089

End: 1619588

Strand: Reverse

Name: nuoM [H]

Synonym: OTT_1586

Alternate gene names: 189184493

Gene position: 1619588-1618089 (Counterclockwise)

Preceding gene: 189184494

Following gene: 189184492

Centisome position: 80.62

GC content: 29.13

Gene sequence:

>1500_bases
ATGCCAATAATAGTAACTCAAGATATTCCTATATTATCAGTTTGTATTTCTTTGCCATTAAGTGCATTGATAATTTTGCT
GCTTATGAGATTAAGCAATTATTTTAATAAATTAGTGTATGTTAAATTCATTGCACTATTAAGTTCAGTATTAACATTAC
TTTGTACCATATATTTATTAGTACAATTTGATAATACTGCACATACATATCAGTTTGTTGAATTATATTCAATATTTAAA
TTGATTGGGCTTAATTATCATGTAGGTATTGATGGTATATCTATCTTCTTTATTGCTTTAACAGCTTTACTTACATTATT
ATCTATTGTTATTAGTATTTTTACTGTTCAGAAAAAACTTGAAGATAATTTATTATGTTTTTTATTAATAGAATCATTAG
TTATTGGAGCTTTTAGCTCGATGAATTTATTGCTATTTTTCATGTTTTTTGAAGCATCATTGTTTCCAATATTTTTGTTA
ATAGGAATTTGGGGAAGCAGCAATAGAATCTATGCTGCATTAAAGTTTTTTTTGTATAGTTTTGTTGGATCAGTATTTTT
CTTGGTAGCTATTATATATATACACACATACACTGGTACACTTGAGATTGCAGAGTTATATGATCTTATGCCTAAGTTTG
ATATATCAGTACAAATGCTATTATGGTTAAGTATATTTGTTGCTTTTGCTATTAAAATACCTATGTTGCCTTTGCATAGT
TGGTTGCCTGATGCTCACGTTGAAGCTCCAACCGGAGGCTCTGTAATGCTAGCTGGAATATTACTTAAATTGGGTGGATT
TGGATTATTAAGAATATGTTTGCCTATGTTGCCAGCTGCATCACAAAAATTTAGTAGTATAGCTATGATATTCAGTGTAG
CTGCTATTATTTATTTTTCCATTATAGCTTTTCAACAGATAGATATAAAAAAAGCAATTGCTTATTCTTCAATTGCTCAT
ATGGGGTATGTTACTGTTGGTATTTTTAGCTTGAATACTTATGGAATTCAGGGAGCAATTTTTCAAATGTTAAGTCATGG
ATTGATATCATCAGCTTTATTTATGATTATCGGTATTTTATATGATCGAACTCATACTAGAGAAATAAGGCTTTATGGTG
GTTTAGCTGTTAAAATGAATAAATTAGCTAGTATTTTTATGGCAGCAGTACTTGGGTCAATAGGAGTGCCAGGTACAAGT
GGATTTATTGGTGAATTTTTAGTGTTATTAGGGGCTATTACAGCATCTCCATTAATTGGAAGTTTTGCAATTCTAGGAGT
GTTACTTGGGGCTTTATATATGCTTTCGCTTTATCGGCGTATTATGTTAGGAGAAATTACTAATCAAAGAGTTTATCAGT
TGAATGATATTTCATTAAGTGAAAAGGTAGCTGTGCTACCTTTAATAGTAGCTATGTTTATAATAGGTGTATATCCTAAA
TTTGTATTAAACATTTTATTGATACCAGCTAAGAACTTAAGCAGTTTATTTATTATATAA

Upstream 100 bases:

>100_bases
GCAATCAGGGTATGTATCTTACTATATACTAATAGCACTAGTTAGCATGACTGCATTCTTTACTTTAATTGTTATTAATT
ACTTTATAACTAGTAACTAA

Downstream 100 bases:

>100_bases
ATTGTAATTGCTGTGTACGTTTAATTTTATTTGAAAGAGTTATTATGGAAATGTTATATGGTATTATGCCAGAAATTTCG
CTTCTTTTATCAGCTTTGAT

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MPIIVTQDIPILSVCISLPLSALIILLLMRLSNYFNKLVYVKFIALLSSVLTLLCTIYLLVQFDNTAHTYQFVELYSIFK
LIGLNYHVGIDGISIFFIALTALLTLLSIVISIFTVQKKLEDNLLCFLLIESLVIGAFSSMNLLLFFMFFEASLFPIFLL
IGIWGSSNRIYAALKFFLYSFVGSVFFLVAIIYIHTYTGTLEIAELYDLMPKFDISVQMLLWLSIFVAFAIKIPMLPLHS
WLPDAHVEAPTGGSVMLAGILLKLGGFGLLRICLPMLPAASQKFSSIAMIFSVAAIIYFSIIAFQQIDIKKAIAYSSIAH
MGYVTVGIFSLNTYGIQGAIFQMLSHGLISSALFMIIGILYDRTHTREIRLYGGLAVKMNKLASIFMAAVLGSIGVPGTS
GFIGEFLVLLGAITASPLIGSFAILGVLLGALYMLSLYRRIMLGEITNQRVYQLNDISLSEKVAVLPLIVAMFIIGVYPK
FVLNILLIPAKNLSSLFII

Sequences:

>Translated_499_residues
MPIIVTQDIPILSVCISLPLSALIILLLMRLSNYFNKLVYVKFIALLSSVLTLLCTIYLLVQFDNTAHTYQFVELYSIFK
LIGLNYHVGIDGISIFFIALTALLTLLSIVISIFTVQKKLEDNLLCFLLIESLVIGAFSSMNLLLFFMFFEASLFPIFLL
IGIWGSSNRIYAALKFFLYSFVGSVFFLVAIIYIHTYTGTLEIAELYDLMPKFDISVQMLLWLSIFVAFAIKIPMLPLHS
WLPDAHVEAPTGGSVMLAGILLKLGGFGLLRICLPMLPAASQKFSSIAMIFSVAAIIYFSIIAFQQIDIKKAIAYSSIAH
MGYVTVGIFSLNTYGIQGAIFQMLSHGLISSALFMIIGILYDRTHTREIRLYGGLAVKMNKLASIFMAAVLGSIGVPGTS
GFIGEFLVLLGAITASPLIGSFAILGVLLGALYMLSLYRRIMLGEITNQRVYQLNDISLSEKVAVLPLIVAMFIIGVYPK
FVLNILLIPAKNLSSLFII
>Mature_498_residues
PIIVTQDIPILSVCISLPLSALIILLLMRLSNYFNKLVYVKFIALLSSVLTLLCTIYLLVQFDNTAHTYQFVELYSIFKL
IGLNYHVGIDGISIFFIALTALLTLLSIVISIFTVQKKLEDNLLCFLLIESLVIGAFSSMNLLLFFMFFEASLFPIFLLI
GIWGSSNRIYAALKFFLYSFVGSVFFLVAIIYIHTYTGTLEIAELYDLMPKFDISVQMLLWLSIFVAFAIKIPMLPLHSW
LPDAHVEAPTGGSVMLAGILLKLGGFGLLRICLPMLPAASQKFSSIAMIFSVAAIIYFSIIAFQQIDIKKAIAYSSIAHM
GYVTVGIFSLNTYGIQGAIFQMLSHGLISSALFMIIGILYDRTHTREIRLYGGLAVKMNKLASIFMAAVLGSIGVPGTSG
FIGEFLVLLGAITASPLIGSFAILGVLLGALYMLSLYRRIMLGEITNQRVYQLNDISLSEKVAVLPLIVAMFIIGVYPKF
VLNILLIPAKNLSSLFII

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=335, Percent_Identity=35.8208955223881, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI251831117, Length=338, Percent_Identity=25.7396449704142, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788613, Length=475, Percent_Identity=37.0526315789474, Blast_Score=291, Evalue=9e-80,
Organism=Escherichia coli, GI1788827, Length=281, Percent_Identity=29.1814946619217, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788831, Length=349, Percent_Identity=26.9340974212034, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI145693160, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788829, Length=379, Percent_Identity=27.1767810026385, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788614, Length=477, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55081; Mature: 54949

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIVTQDIPILSVCISLPLSALIILLLMRLSNYFNKLVYVKFIALLSSVLTLLCTIYLL
CCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQFDNTAHTYQFVELYSIFKLIGLNYHVGIDGISIFFIALTALLTLLSIVISIFTVQKKL
HHCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EDNLLCFLLIESLVIGAFSSMNLLLFFMFFEASLFPIFLLIGIWGSSNRIYAALKFFLYS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
FVGSVFFLVAIIYIHTYTGTLEIAELYDLMPKFDISVQMLLWLSIFVAFAIKIPMLPLHS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
WLPDAHVEAPTGGSVMLAGILLKLGGFGLLRICLPMLPAASQKFSSIAMIFSVAAIIYFS
CCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IIAFQQIDIKKAIAYSSIAHMGYVTVGIFSLNTYGIQGAIFQMLSHGLISSALFMIIGIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
YDRTHTREIRLYGGLAVKMNKLASIFMAAVLGSIGVPGTSGFIGEFLVLLGAITASPLIG
HCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SFAILGVLLGALYMLSLYRRIMLGEITNQRVYQLNDISLSEKVAVLPLIVAMFIIGVYPK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
FVLNILLIPAKNLSSLFII
HHHHHHHCCCCCCCCEECC
>Mature Secondary Structure 
PIIVTQDIPILSVCISLPLSALIILLLMRLSNYFNKLVYVKFIALLSSVLTLLCTIYLL
CEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA