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The map label for this gene is nuoN1

Identifier: 189184492

GI number: 189184492

Start: 1616605

End: 1618044

Strand: Reverse

Name: nuoN1

Synonym: OTT_1585

Alternate gene names: 189184492

Gene position: 1618044-1616605 (Counterclockwise)

Preceding gene: 189184493

Following gene: 189184491

Centisome position: 80.54

GC content: 28.33

Gene sequence:

>1440_bases
ATGGAAATGTTATATGGTATTATGCCAGAAATTTCGCTTCTTTTATCAGCTTTGATTTTTCAACTAATTGGAGCATATAG
TAACAATACGCTAACTCATGTCATAGCTAAAATGGCAATTGGTTTTGCCGCTATATTAATAGCTATTTTAGTATTTCATC
CTAGCTGGTTTAATGGTATTTACTGGAATAATACATTTATTGTTAACCAATCTAAAATATACTTAAAAATTATTATTTTA
ATTTTTTATATATTTCTTACTTTAATTTATTCTGGATATATCAAGGTTGCAAACTTAAAAGGCCATAGTGAATATATAGT
ACTAATGCAGCTTGGAGCTTTAGGAGGATTAATATTGGTTTCAGCTAATGATTTTATGGTTATGTACCTTGGTATTGAGA
TGCAAGGAATAATAGGATATATTTTAACGACTTTTAATTATAATAATTCTAGATCATCTGAAGCTGGTTTAAAATATTTT
ATATTAGGAACAGTTTTCTCAGCTATTATGTTGTTTGGTATATCTTTAGTATATGGTACTACTCAAAGCATAAGGTATGA
TATTGCTTTGCATGCATTGCAAAATCCAAGCTCTGATATGGCTGTGCTAGTTGCTGCTATATTAATGATACTTGTAGGAG
TCTTATTTAAATTATCTATTGCGCCGTTTCATATGTGGACACCTGATATTTATGATGGAGCACCTTTAGTAGTAGTTGCG
TTATTTTCTAGCTTGCCTAAAATTAGTGTATTAGCATTGCTTGGAAATTTATTATCTGAATTAAAGTTTGCTAGTGATGC
ATTCTTTTATATAAAAACGATAATAATGGTACTGGCATGTCTATCATTAATTGTTGGTGCATTTGGCGCATTATTACAAC
AATCAATTCAAAGGTTTATTGCCTATAGTGCAATATTAAATTTAGGATATGCTGTACTTGCTTTAGTTGCTAACAGCTCT
AATGTTATTAGAGCAGAAATATCATATTTTTATATTATTATTTATGCTGCTAGTATGTTAGGATTTATTGCGATAATAAT
AAACAATTTTACTAATCGTGCTAATTATTTAAAAATTAGTCATCTTAGTGGATTATCTAATGTAAAAAAATTATCGTCAA
TATTAATAGCAATACAGATGTTCTCATTAGTAGGAATTCCACCTTTTGCAGGGTTTATTAGTAAGTATATTATCTTTACT
AGTATTTTAAAATCTGGTATGTATGAATTAATAATTATGGGAATAGCAGCAGTTGTGATTGGATCATATTGTTATCTTAA
TATTGTTAAAGTAATGTACTTTTTACCTGCTACAGTCAGGTTTCAGAATTCCAGTGTAAATTTTGAGCTAAGCTTAGTAA
GTATAGCTTCAACTATAATTGTTATATCATTAATGATTATATGCATGCTTTTTGGTGAAGGTTTAAACGTTATTGTATAA

Upstream 100 bases:

>100_bases
TATTAAACATTTTATTGATACCAGCTAAGAACTTAAGCAGTTTATTTATTATATAAATTGTAATTGCTGTGTACGTTTAA
TTTTATTTGAAAGAGTTATT

Downstream 100 bases:

>100_bases
TGCTTAGTCAAAATGAGATATGGATTATTTAAGTTTTAGGCTATTGATAGTATGCAAACAGAAGGGTTTAAAGCTATTAA
ACCCTATGGCTTAGTAAAGC

Product: NADH dehydrogenase I chain N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MEMLYGIMPEISLLLSALIFQLIGAYSNNTLTHVIAKMAIGFAAILIAILVFHPSWFNGIYWNNTFIVNQSKIYLKIIIL
IFYIFLTLIYSGYIKVANLKGHSEYIVLMQLGALGGLILVSANDFMVMYLGIEMQGIIGYILTTFNYNNSRSSEAGLKYF
ILGTVFSAIMLFGISLVYGTTQSIRYDIALHALQNPSSDMAVLVAAILMILVGVLFKLSIAPFHMWTPDIYDGAPLVVVA
LFSSLPKISVLALLGNLLSELKFASDAFFYIKTIIMVLACLSLIVGAFGALLQQSIQRFIAYSAILNLGYAVLALVANSS
NVIRAEISYFYIIIYAASMLGFIAIIINNFTNRANYLKISHLSGLSNVKKLSSILIAIQMFSLVGIPPFAGFISKYIIFT
SILKSGMYELIIMGIAAVVIGSYCYLNIVKVMYFLPATVRFQNSSVNFELSLVSIASTIIVISLMIICMLFGEGLNVIV

Sequences:

>Translated_479_residues
MEMLYGIMPEISLLLSALIFQLIGAYSNNTLTHVIAKMAIGFAAILIAILVFHPSWFNGIYWNNTFIVNQSKIYLKIIIL
IFYIFLTLIYSGYIKVANLKGHSEYIVLMQLGALGGLILVSANDFMVMYLGIEMQGIIGYILTTFNYNNSRSSEAGLKYF
ILGTVFSAIMLFGISLVYGTTQSIRYDIALHALQNPSSDMAVLVAAILMILVGVLFKLSIAPFHMWTPDIYDGAPLVVVA
LFSSLPKISVLALLGNLLSELKFASDAFFYIKTIIMVLACLSLIVGAFGALLQQSIQRFIAYSAILNLGYAVLALVANSS
NVIRAEISYFYIIIYAASMLGFIAIIINNFTNRANYLKISHLSGLSNVKKLSSILIAIQMFSLVGIPPFAGFISKYIIFT
SILKSGMYELIIMGIAAVVIGSYCYLNIVKVMYFLPATVRFQNSSVNFELSLVSIASTIIVISLMIICMLFGEGLNVIV
>Mature_479_residues
MEMLYGIMPEISLLLSALIFQLIGAYSNNTLTHVIAKMAIGFAAILIAILVFHPSWFNGIYWNNTFIVNQSKIYLKIIIL
IFYIFLTLIYSGYIKVANLKGHSEYIVLMQLGALGGLILVSANDFMVMYLGIEMQGIIGYILTTFNYNNSRSSEAGLKYF
ILGTVFSAIMLFGISLVYGTTQSIRYDIALHALQNPSSDMAVLVAAILMILVGVLFKLSIAPFHMWTPDIYDGAPLVVVA
LFSSLPKISVLALLGNLLSELKFASDAFFYIKTIIMVLACLSLIVGAFGALLQQSIQRFIAYSAILNLGYAVLALVANSS
NVIRAEISYFYIIIYAASMLGFIAIIINNFTNRANYLKISHLSGLSNVKKLSSILIAIQMFSLVGIPPFAGFISKYIIFT
SILKSGMYELIIMGIAAVVIGSYCYLNIVKVMYFLPATVRFQNSSVNFELSLVSIASTIIVISLMIICMLFGEGLNVIV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=209, Percent_Identity=25.8373205741627, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI145693160, Length=372, Percent_Identity=28.494623655914, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1788831, Length=334, Percent_Identity=27.5449101796407, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788614, Length=321, Percent_Identity=23.6760124610592, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_ORITI (B3CUJ6)

Other databases:

- EMBL:   AP008981
- RefSeq:   YP_001938277.1
- GeneID:   6337894
- GenomeReviews:   AP008981_GR
- KEGG:   ott:OTT_1585
- HOGENOM:   HBG747830
- OMA:   SIGHIGF
- ProtClustDB:   CLSK2325918
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52680; Mature: 52680

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x20f7a1b0)-; HASH(0x245e4d9c)-; HASH(0x2463a6a4)-; HASH(0x22f3dd44)-; HASH(0x2465aab8)-; HASH(0x24651e1c)-; HASH(0x23e4e748)-; HASH(0x246586e0)-; HASH(0x246586c8)-; HASH(0x24374d04)-; HASH(0x20d32e1c)-; HASH(0x245e4f58)-; HASH(0x24651c78)-; HASH(0x245cd218)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMLYGIMPEISLLLSALIFQLIGAYSNNTLTHVIAKMAIGFAAILIAILVFHPSWFNGI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
YWNNTFIVNQSKIYLKIIILIFYIFLTLIYSGYIKVANLKGHSEYIVLMQLGALGGLILV
EECCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCEEEE
SANDFMVMYLGIEMQGIIGYILTTFNYNNSRSSEAGLKYFILGTVFSAIMLFGISLVYGT
ECCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
TQSIRYDIALHALQNPSSDMAVLVAAILMILVGVLFKLSIAPFHMWTPDIYDGAPLVVVA
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHH
LFSSLPKISVLALLGNLLSELKFASDAFFYIKTIIMVLACLSLIVGAFGALLQQSIQRFI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSAILNLGYAVLALVANSSNVIRAEISYFYIIIYAASMLGFIAIIINNFTNRANYLKIS
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
HLSGLSNVKKLSSILIAIQMFSLVGIPPFAGFISKYIIFTSILKSGMYELIIMGIAAVVI
HHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSYCYLNIVKVMYFLPATVRFQNSSVNFELSLVSIASTIIVISLMIICMLFGEGLNVIV
HHHHHHHHHHHHHHCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MEMLYGIMPEISLLLSALIFQLIGAYSNNTLTHVIAKMAIGFAAILIAILVFHPSWFNGI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
YWNNTFIVNQSKIYLKIIILIFYIFLTLIYSGYIKVANLKGHSEYIVLMQLGALGGLILV
EECCEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCEEEE
SANDFMVMYLGIEMQGIIGYILTTFNYNNSRSSEAGLKYFILGTVFSAIMLFGISLVYGT
ECCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
TQSIRYDIALHALQNPSSDMAVLVAAILMILVGVLFKLSIAPFHMWTPDIYDGAPLVVVA
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCHHHHHH
LFSSLPKISVLALLGNLLSELKFASDAFFYIKTIIMVLACLSLIVGAFGALLQQSIQRFI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSAILNLGYAVLALVANSSNVIRAEISYFYIIIYAASMLGFIAIIINNFTNRANYLKIS
HHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
HLSGLSNVKKLSSILIAIQMFSLVGIPPFAGFISKYIIFTSILKSGMYELIIMGIAAVVI
HHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSYCYLNIVKVMYFLPATVRFQNSSVNFELSLVSIASTIIVISLMIICMLFGEGLNVIV
HHHHHHHHHHHHHHCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA