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The map label for this gene is tmk [H]

Identifier: 189183417

GI number: 189183417

Start: 531512

End: 532165

Strand: Direct

Name: tmk [H]

Synonym: OTT_0510

Alternate gene names: 189183417

Gene position: 531512-532165 (Clockwise)

Preceding gene: 189183416

Following gene: 189183422

Centisome position: 26.46

GC content: 27.68

Gene sequence:

>654_bases
ATGAGTAATACTACAATAGGAAAATTTATAACTTTTGAAGGAAATGAAGGAAGCGGCAAAACTACTCAAAGCAAACTACT
TTATGAAAAATTATTAGATAATGGTATAAAAGCAGTATGGACTAGAGAAATTGGTGGAACTGATATTGCAGAGTTAATTC
GTGATATAGTTTTATTTAAAGATATGTCTATTACCACAGAATTATTGTTAATAATGGCAGCTAGGTATGAACATATTGAA
AAATTTATTAGGCCAAATTTAAATGAAGGGAAATGGGTAATATGTGATAGATTTATAGATTCTACTTTATGTTACCAATC
TGAAAATAGCGAGGAACAGCAGCTAATACTTGAGCTACACCGTAAATTATTAGACAATTTTTTTCCAGATCTTACTTTAA
TAATTAATGTATCACCAAGTATTGCAATGCAAAGAATAAAGATAAGAGAAATACATAAAAACACAAATCAACTTAATAAG
TTTGATAGTAGAAATCAACAGTTTCATCAAAAAATTACTGATGCATTTATTCAAGTTAGCAAGTTATTTCCGGAACGTAT
AGTACAAATCAATGGTGAGCCAATGATAGAAGATGTTAGTTCAGAAGTTATAAATATCATAAATAATAAAATGAAAGTTA
ATTTACTTAGGTAA

Upstream 100 bases:

>100_bases
ATAGGACATAATTATCAACAACCTTTTCAAAGAACATTATCTAGGCTATATGAAATGAATAGTAATGAATATTTATTTCA
TTCAAAATATCAAGAGGTAT

Downstream 100 bases:

>100_bases
ATCAATTATTTTATGTATTTAGAGCATACTAGACATTTCTCTGCTATTAATTTTTAGTTTATATGTTGGTTCTCTTGTAT
TAATTAATTTAGTGTTAAAA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSNTTIGKFITFEGNEGSGKTTQSKLLYEKLLDNGIKAVWTREIGGTDIAELIRDIVLFKDMSITTELLLIMAARYEHIE
KFIRPNLNEGKWVICDRFIDSTLCYQSENSEEQQLILELHRKLLDNFFPDLTLIINVSPSIAMQRIKIREIHKNTNQLNK
FDSRNQQFHQKITDAFIQVSKLFPERIVQINGEPMIEDVSSEVINIINNKMKVNLLR

Sequences:

>Translated_217_residues
MSNTTIGKFITFEGNEGSGKTTQSKLLYEKLLDNGIKAVWTREIGGTDIAELIRDIVLFKDMSITTELLLIMAARYEHIE
KFIRPNLNEGKWVICDRFIDSTLCYQSENSEEQQLILELHRKLLDNFFPDLTLIINVSPSIAMQRIKIREIHKNTNQLNK
FDSRNQQFHQKITDAFIQVSKLFPERIVQINGEPMIEDVSSEVINIINNKMKVNLLR
>Mature_216_residues
SNTTIGKFITFEGNEGSGKTTQSKLLYEKLLDNGIKAVWTREIGGTDIAELIRDIVLFKDMSITTELLLIMAARYEHIEK
FIRPNLNEGKWVICDRFIDSTLCYQSENSEEQQLILELHRKLLDNFFPDLTLIINVSPSIAMQRIKIREIHKNTNQLNKF
DSRNQQFHQKITDAFIQVSKLFPERIVQINGEPMIEDVSSEVINIINNKMKVNLLR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=181, Percent_Identity=34.8066298342541, Blast_Score=103, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 25172; Mature: 25040

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTTIGKFITFEGNEGSGKTTQSKLLYEKLLDNGIKAVWTREIGGTDIAELIRDIVLFK
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHC
DMSITTELLLIMAARYEHIEKFIRPNLNEGKWVICDRFIDSTLCYQSENSEEQQLILELH
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHH
RKLLDNFFPDLTLIINVSPSIAMQRIKIREIHKNTNQLNKFDSRNQQFHQKITDAFIQVS
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLFPERIVQINGEPMIEDVSSEVINIINNKMKVNLLR
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure 
SNTTIGKFITFEGNEGSGKTTQSKLLYEKLLDNGIKAVWTREIGGTDIAELIRDIVLFK
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHC
DMSITTELLLIMAARYEHIEKFIRPNLNEGKWVICDRFIDSTLCYQSENSEEQQLILELH
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHH
RKLLDNFFPDLTLIINVSPSIAMQRIKIREIHKNTNQLNKFDSRNQQFHQKITDAFIQVS
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLFPERIVQINGEPMIEDVSSEVINIINNKMKVNLLR
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA