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The map label for this gene is hemE [H]

Identifier: 189183422

GI number: 189183422

Start: 541040

End: 542068

Strand: Direct

Name: hemE [H]

Synonym: OTT_0515

Alternate gene names: 189183422

Gene position: 541040-542068 (Clockwise)

Preceding gene: 189183417

Following gene: 189183423

Centisome position: 26.93

GC content: 27.21

Gene sequence:

>1029_bases
ATGAGTAAAATTATACAAGCTTTTAATAGTTCTAATAGAAATTACACTCCAATATGGTTTATGAGACAAGCAGGTAGGTA
TCTCCCAGAATATCAAATGTTGAGAAAAACAACAAATAGCTTTTTTGAATTATGTTATGATCCAATTAAAGCAGCTGAAG
TTACTTTACAACCAATAGCAAGATTTGACTTTGATGCAGCAATAATATTCTCAGATATTTTAGTACTTCCTGACTCTCTA
GGAATAAATATTAGATTTATTAATAACTTAGGTCCAACAGCAGAAAAAATACCAAATCTACTAGACTTACAAAAATTAAA
AATACAAAATACTAAAATTAGCAAAGTATACGAAGCAATAGATATAGTAAGAAAAAAATTAAATAAACAAAAATCTCTTA
TAGGATTCTGTGGAGGACCATGGACAGTATTAACTTACATTTTAGGATATAACAGTAGAAATACTCCAAAGTTTCAAGAA
ATAAAATCTAATAATAAGCATGAACTTATTTTAGATTCAATCAACATTCTGACAAAGCATACAATAGATCATCTAGAAAA
TCAGATACTGGCAGGAGCTGATATAGTTCAAATATTTGATAGTTGGGCTGGAATTTTACCATATCAAGAGTTTTCTGAAT
ATGTGATTAAACCAACTTCTAATATAGTCAAAACATTGAAAGAAAAATTTCCTCATATAAAGATCATTGGATTTCCAAAA
GGAGCAGGTAAATTATATCACAAATATACTAAGGAAACTAATGTTGATGGAATAAGCTGTGATTATAATTTACCACTAAA
TGAAATGTTAAAATTACAAAAAAATGCTCTTGTTCAAGGAAATCTTAATCCTAATACAATCTTGTCAGAAGATAGCAAAA
TCATTGAAGAATCTGTAATAAAAATTATGGATACTTTATCAAACAATAGATTTATTTTTAATTTAGGTCATGGTATTCTA
CCAGAAACTCCAATAAAAAATGTTGAGTTAATAGTTAAACTAGTAAAAAACTACCATTCAAGTGAGTAA

Upstream 100 bases:

>100_bases
AAATGTGGATAAAAATGTGGATAAAAAATAATCCACTAAAAACTGCTTACATAAACAACTATCAAATAATATTTATATAT
TTAATATTGTTAATTTAGTC

Downstream 100 bases:

>100_bases
CGAAAAAAAGATAGCAATAGTTCTACTAAACCTTGGAGGACCAGATAAAATTGAATCTGTTAAACAGTTTTTGTTTAATT
TGTTTTATGATAAACATATA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSKIIQAFNSSNRNYTPIWFMRQAGRYLPEYQMLRKTTNSFFELCYDPIKAAEVTLQPIARFDFDAAIIFSDILVLPDSL
GINIRFINNLGPTAEKIPNLLDLQKLKIQNTKISKVYEAIDIVRKKLNKQKSLIGFCGGPWTVLTYILGYNSRNTPKFQE
IKSNNKHELILDSINILTKHTIDHLENQILAGADIVQIFDSWAGILPYQEFSEYVIKPTSNIVKTLKEKFPHIKIIGFPK
GAGKLYHKYTKETNVDGISCDYNLPLNEMLKLQKNALVQGNLNPNTILSEDSKIIEESVIKIMDTLSNNRFIFNLGHGIL
PETPIKNVELIVKLVKNYHSSE

Sequences:

>Translated_342_residues
MSKIIQAFNSSNRNYTPIWFMRQAGRYLPEYQMLRKTTNSFFELCYDPIKAAEVTLQPIARFDFDAAIIFSDILVLPDSL
GINIRFINNLGPTAEKIPNLLDLQKLKIQNTKISKVYEAIDIVRKKLNKQKSLIGFCGGPWTVLTYILGYNSRNTPKFQE
IKSNNKHELILDSINILTKHTIDHLENQILAGADIVQIFDSWAGILPYQEFSEYVIKPTSNIVKTLKEKFPHIKIIGFPK
GAGKLYHKYTKETNVDGISCDYNLPLNEMLKLQKNALVQGNLNPNTILSEDSKIIEESVIKIMDTLSNNRFIFNLGHGIL
PETPIKNVELIVKLVKNYHSSE
>Mature_341_residues
SKIIQAFNSSNRNYTPIWFMRQAGRYLPEYQMLRKTTNSFFELCYDPIKAAEVTLQPIARFDFDAAIIFSDILVLPDSLG
INIRFINNLGPTAEKIPNLLDLQKLKIQNTKISKVYEAIDIVRKKLNKQKSLIGFCGGPWTVLTYILGYNSRNTPKFQEI
KSNNKHELILDSINILTKHTIDHLENQILAGADIVQIFDSWAGILPYQEFSEYVIKPTSNIVKTLKEKFPHIKIIGFPKG
AGKLYHKYTKETNVDGISCDYNLPLNEMLKLQKNALVQGNLNPNTILSEDSKIIEESVIKIMDTLSNNRFIFNLGHGILP
ETPIKNVELIVKLVKNYHSSE

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=348, Percent_Identity=30.7471264367816, Blast_Score=188, Evalue=7e-48,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=32.4786324786325, Blast_Score=187, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6320252, Length=334, Percent_Identity=32.6347305389222, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=35.7558139534884, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=35.7558139534884, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39062; Mature: 38931

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS00906 UROD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIIQAFNSSNRNYTPIWFMRQAGRYLPEYQMLRKTTNSFFELCYDPIKAAEVTLQPIA
CHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFDFDAAIIFSDILVLPDSLGINIRFINNLGPTAEKIPNLLDLQKLKIQNTKISKVYEAI
HCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHH
DIVRKKLNKQKSLIGFCGGPWTVLTYILGYNSRNTPKFQEIKSNNKHELILDSINILTKH
HHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEHHHHHHHHHH
TIDHLENQILAGADIVQIFDSWAGILPYQEFSEYVIKPTSNIVKTLKEKFPHIKIIGFPK
HHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCC
GAGKLYHKYTKETNVDGISCDYNLPLNEMLKLQKNALVQGNLNPNTILSEDSKIIEESVI
CCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCEEECCCCCCCEECCHHHHHHHHHH
KIMDTLSNNRFIFNLGHGILPETPIKNVELIVKLVKNYHSSE
HHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKIIQAFNSSNRNYTPIWFMRQAGRYLPEYQMLRKTTNSFFELCYDPIKAAEVTLQPIA
HHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFDFDAAIIFSDILVLPDSLGINIRFINNLGPTAEKIPNLLDLQKLKIQNTKISKVYEAI
HCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHH
DIVRKKLNKQKSLIGFCGGPWTVLTYILGYNSRNTPKFQEIKSNNKHELILDSINILTKH
HHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEHHHHHHHHHH
TIDHLENQILAGADIVQIFDSWAGILPYQEFSEYVIKPTSNIVKTLKEKFPHIKIIGFPK
HHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCC
GAGKLYHKYTKETNVDGISCDYNLPLNEMLKLQKNALVQGNLNPNTILSEDSKIIEESVI
CCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCEEECCCCCCCEECCHHHHHHHHHH
KIMDTLSNNRFIFNLGHGILPETPIKNVELIVKLVKNYHSSE
HHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA