The gene/protein map for NC_010741 is currently unavailable.
Definition Treponema pallidum subsp. pallidum SS14, complete genome.
Accession NC_010741
Length 1,139,457

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The map label for this gene is ndk

Identifier: 189026233

GI number: 189026233

Start: 1103267

End: 1103716

Strand: Reverse

Name: ndk

Synonym: TPASS_1010

Alternate gene names: 189026233

Gene position: 1103716-1103267 (Counterclockwise)

Preceding gene: 189026234

Following gene: 189026232

Centisome position: 96.86

GC content: 51.11

Gene sequence:

>450_bases
ATGGCATTTGAAACAACTTTCGTCATGCTTAAGCCGGGTGTTCTTCAACGTAGACTGGTAGGGGAGGTTTTGAGTCGCTT
CGAGCGCAAAGGGCTCGTGCTGACTGCGCTCAGGCTGTTGTGCGTCGATACAGCTACTGCGGAGTTGCATTACGCGGAGC
ATCGCGAGAAGCCTTTTTATCCTTCGCTTATCGCTTATATTACGAGCGCACCGGTGGTTGCACTCGCATTCAAGGGGGAG
AATGCTATCAGTCTTGTGCGCACGCTTTGTGGCTCTACGCGTGTGGAGCACGCTCAACCGGGAACGATTCGTGGTGATTT
TGCGCTACGCACCACTACTAATATTGTCCATGCTTCTGATTCTCCCGAGAGCGCTGCACGAGAACTAGCGCTCTACTTTT
CTGCGCAAGATTTTGTTGAATGGCGTGACGGGAATTACGATTTTTTCTAA

Upstream 100 bases:

>100_bases
AAGGAAGGGTAAAAAGAGAAAGTGTGGGGAGGACTTGCATAAAGAAAGAATGGTGGGTACGCTGGCGCGCCACGTGTATT
CGCTAGGACGAGGAAATCAT

Downstream 100 bases:

>100_bases
AAAGTTTAGGGTCTGCGGTGCGTGTTCTTTTTCGATACGGTGATCATGTTTCCTCTTGCTGAAGAAAGGTGAGGATCAGG
GGAGGGGTTAGGAATCATGG

Product: nucleoside-diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGE
NAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF

Sequences:

>Translated_149_residues
MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGE
NAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF
>Mature_148_residues
AFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGEN
AISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4826862, Length=142, Percent_Identity=45.7746478873239, Blast_Score=145, Evalue=9e-36,
Organism=Homo sapiens, GI37693993, Length=142, Percent_Identity=48.5915492957746, Blast_Score=143, Evalue=4e-35,
Organism=Homo sapiens, GI66392203, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=9e-33,
Organism=Homo sapiens, GI66392227, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392205, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4505409, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI66392192, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI4557797, Length=138, Percent_Identity=39.8550724637681, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI38045913, Length=138, Percent_Identity=39.8550724637681, Blast_Score=128, Evalue=2e-30,
Organism=Homo sapiens, GI5031951, Length=145, Percent_Identity=35.1724137931034, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788866, Length=134, Percent_Identity=40.2985074626866, Blast_Score=113, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17506807, Length=138, Percent_Identity=41.304347826087, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=34.8484848484849, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=138, Percent_Identity=42.7536231884058, Blast_Score=137, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45549037, Length=145, Percent_Identity=41.3793103448276, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_TREPA (O83974)

Other databases:

- EMBL:   AE000520
- PIR:   F71252
- RefSeq:   NP_219447.1
- ProteinModelPortal:   O83974
- SMR:   O83974
- IntAct:   O83974
- GeneID:   2610832
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1010
- NMPDR:   fig|243276.1.peg.1005
- TIGR:   TP_1010
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   CLSK2300350
- BioCyc:   TPAL243276:TP_1010-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16657; Mature: 16526

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFY
CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PSLIAYITSAPVVALAFKGENAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECEEEECCC
SPESAARELALYFSAQDFVEWRDGNYDFF
CHHHHHHHHHHHHCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFY
CCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PSLIAYITSAPVVALAFKGENAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECEEEECCC
SPESAARELALYFSAQDFVEWRDGNYDFF
CHHHHHHHHHHHHCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876