Definition | Treponema pallidum subsp. pallidum SS14, complete genome. |
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Accession | NC_010741 |
Length | 1,139,457 |
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The map label for this gene is ndk
Identifier: 189026233
GI number: 189026233
Start: 1103267
End: 1103716
Strand: Reverse
Name: ndk
Synonym: TPASS_1010
Alternate gene names: 189026233
Gene position: 1103716-1103267 (Counterclockwise)
Preceding gene: 189026234
Following gene: 189026232
Centisome position: 96.86
GC content: 51.11
Gene sequence:
>450_bases ATGGCATTTGAAACAACTTTCGTCATGCTTAAGCCGGGTGTTCTTCAACGTAGACTGGTAGGGGAGGTTTTGAGTCGCTT CGAGCGCAAAGGGCTCGTGCTGACTGCGCTCAGGCTGTTGTGCGTCGATACAGCTACTGCGGAGTTGCATTACGCGGAGC ATCGCGAGAAGCCTTTTTATCCTTCGCTTATCGCTTATATTACGAGCGCACCGGTGGTTGCACTCGCATTCAAGGGGGAG AATGCTATCAGTCTTGTGCGCACGCTTTGTGGCTCTACGCGTGTGGAGCACGCTCAACCGGGAACGATTCGTGGTGATTT TGCGCTACGCACCACTACTAATATTGTCCATGCTTCTGATTCTCCCGAGAGCGCTGCACGAGAACTAGCGCTCTACTTTT CTGCGCAAGATTTTGTTGAATGGCGTGACGGGAATTACGATTTTTTCTAA
Upstream 100 bases:
>100_bases AAGGAAGGGTAAAAAGAGAAAGTGTGGGGAGGACTTGCATAAAGAAAGAATGGTGGGTACGCTGGCGCGCCACGTGTATT CGCTAGGACGAGGAAATCAT
Downstream 100 bases:
>100_bases AAAGTTTAGGGTCTGCGGTGCGTGTTCTTTTTCGATACGGTGATCATGTTTCCTCTTGCTGAAGAAAGGTGAGGATCAGG GGAGGGGTTAGGAATCATGG
Product: nucleoside-diphosphate kinase
Products: NA
Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase
Number of amino acids: Translated: 149; Mature: 148
Protein sequence:
>149_residues MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGE NAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF
Sequences:
>Translated_149_residues MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGE NAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF >Mature_148_residues AFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGEN AISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF
Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate
COG id: COG0105
COG function: function code F; Nucleoside diphosphate kinase
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the NDK family
Homologues:
Organism=Homo sapiens, GI4826862, Length=142, Percent_Identity=45.7746478873239, Blast_Score=145, Evalue=9e-36, Organism=Homo sapiens, GI37693993, Length=142, Percent_Identity=48.5915492957746, Blast_Score=143, Evalue=4e-35, Organism=Homo sapiens, GI66392203, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=9e-33, Organism=Homo sapiens, GI66392227, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32, Organism=Homo sapiens, GI66392205, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32, Organism=Homo sapiens, GI4505409, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32, Organism=Homo sapiens, GI66392192, Length=146, Percent_Identity=39.041095890411, Blast_Score=135, Evalue=1e-32, Organism=Homo sapiens, GI4557797, Length=138, Percent_Identity=39.8550724637681, Blast_Score=128, Evalue=2e-30, Organism=Homo sapiens, GI38045913, Length=138, Percent_Identity=39.8550724637681, Blast_Score=128, Evalue=2e-30, Organism=Homo sapiens, GI5031951, Length=145, Percent_Identity=35.1724137931034, Blast_Score=80, Evalue=9e-16, Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=1e-12, Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=2e-12, Organism=Escherichia coli, GI1788866, Length=134, Percent_Identity=40.2985074626866, Blast_Score=113, Evalue=7e-27, Organism=Caenorhabditis elegans, GI17506807, Length=138, Percent_Identity=41.304347826087, Blast_Score=129, Evalue=4e-31, Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=34.8484848484849, Blast_Score=67, Evalue=3e-12, Organism=Saccharomyces cerevisiae, GI6322783, Length=138, Percent_Identity=42.7536231884058, Blast_Score=137, Evalue=5e-34, Organism=Drosophila melanogaster, GI45549037, Length=145, Percent_Identity=41.3793103448276, Blast_Score=136, Evalue=4e-33, Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=30.4347826086957, Blast_Score=75, Evalue=2e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NDK_TREPA (O83974)
Other databases:
- EMBL: AE000520 - PIR: F71252 - RefSeq: NP_219447.1 - ProteinModelPortal: O83974 - SMR: O83974 - IntAct: O83974 - GeneID: 2610832 - GenomeReviews: AE000520_GR - KEGG: tpa:TP1010 - NMPDR: fig|243276.1.peg.1005 - TIGR: TP_1010 - HOGENOM: HBG445152 - OMA: ERPFFGA - ProtClustDB: CLSK2300350 - BioCyc: TPAL243276:TP_1010-MONOMER - BRENDA: 2.7.4.6 - GO: GO:0005737 - HAMAP: MF_00451 - InterPro: IPR001564 - InterPro: IPR023005 - Gene3D: G3DSA:3.30.70.141 - PANTHER: PTHR11349 - PRINTS: PR01243 - SMART: SM00562
Pfam domain/function: PF00334 NDK; SSF54919 NDK
EC number: =2.7.4.6
Molecular weight: Translated: 16657; Mature: 16526
Theoretical pI: Translated: 6.94; Mature: 6.94
Prosite motif: PS00469 NDP_KINASES
Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 0.7 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFY CCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC PSLIAYITSAPVVALAFKGENAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASD HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECEEEECCC SPESAARELALYFSAQDFVEWRDGNYDFF CHHHHHHHHHHHHCHHHHHHHCCCCCCCC >Mature Secondary Structure AFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFY CCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC PSLIAYITSAPVVALAFKGENAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASD HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECEEEECCC SPESAARELALYFSAQDFVEWRDGNYDFF CHHHHHHHHHHHHCHHHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9665876