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The map label for this gene is pth

Identifier: 189026234

GI number: 189026234

Start: 1103842

End: 1104450

Strand: Reverse

Name: pth

Synonym: TPASS_1011

Alternate gene names: 189026234

Gene position: 1104450-1103842 (Counterclockwise)

Preceding gene: 189026235

Following gene: 189026233

Centisome position: 96.93

GC content: 50.25

Gene sequence:

>609_bases
TTGGGCATACAACTTATAGTGTTTTTAGGAAATCCTGGTGCAGAGTACGAAGAAACGCGGCACAATGCTGCATGGTTGCT
TTTAACGTACCTTTTCCCATCCATCGTGCTTCCTTGGCGATGCGGATGTCGGGGGTCGATTGCGCGTATTGAAGGGTTTG
AAGGGTCAAGCGAAGAAGTTTGGCTTTTGAAACCGCTGACTTATATGAACCGTTCTGGGAAAAGCGTAGGGGCAGCATGT
GCCTTTTTGCAGACGGATGCGAAGCAGCTCTTAGTAGTGCACGATGAATTAGAATTACCGTTCGGTGTGGTGAGTTTAAA
ACAAGGCGGAGGGCTTGGAGGACACAATGGGTTGCGCTCTATCAAGGAAGTGCTTGGTACCGCAGATTTTTGGCGGTTGC
GCATAGGCATCGGGCGTCCACCCAGTGAGAGTGTGAATATAGCGCAGTACGTCCTCTCTGCCTTTTACCCGGCAGAGATG
GCTGCATTCCCAAAGCTGGGGCGTGCCACGCGAGATCTTCTGTGTCAGCTTGTAGTAACAGATCAGGCAGCGACAGTCAC
CTTACTCAGTGCGTGGAGAAAAAAACGGTTGCTGTCTTTATGCGAATAA

Upstream 100 bases:

>100_bases
AAAAAGGCTTTGTTGCGTATCCGTAGCTGTGCCCGTCAACACAGACTGGATTCCTACATAGCGTAGACATCAGAGGCGTA
TGAAATAGGAGCAGGACGCG

Downstream 100 bases:

>100_bases
GGACAGGGTGACTCACCATACGGTGAAGGAAGGGTAAAAAGAGAAAGTGTGGGGAGGACTTGCATAAAGAAAGAATGGTG
GGTACGCTGGCGCGCCACGT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MGIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEVWLLKPLTYMNRSGKSVGAAC
AFLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRSIKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEM
AAFPKLGRATRDLLCQLVVTDQAATVTLLSAWRKKRLLSLCE

Sequences:

>Translated_202_residues
MGIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEVWLLKPLTYMNRSGKSVGAAC
AFLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRSIKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEM
AAFPKLGRATRDLLCQLVVTDQAATVTLLSAWRKKRLLSLCE
>Mature_201_residues
GIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEVWLLKPLTYMNRSGKSVGAACA
FLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRSIKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEMA
AFPKLGRATRDLLCQLVVTDQAATVTLLSAWRKKRLLSLCE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=189, Percent_Identity=32.8042328042328, Blast_Score=84, Evalue=6e-17,
Organism=Escherichia coli, GI1787455, Length=143, Percent_Identity=47.5524475524476, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321983, Length=171, Percent_Identity=31.5789473684211, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_TREPA (O83975)

Other databases:

- EMBL:   AE000520
- PIR:   G71252
- RefSeq:   NP_219448.1
- ProteinModelPortal:   O83975
- SMR:   O83975
- IntAct:   O83975
- GeneID:   2610833
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1011
- NMPDR:   fig|243276.1.peg.1006
- TIGR:   TP_1011
- HOGENOM:   HBG610927
- OMA:   NESGRQV
- ProtClustDB:   PRK05426
- BioCyc:   TPAL243276:TP_1011-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22178; Mature: 22047

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEV
CCEEEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCE
WLLKPLTYMNRSGKSVGAACAFLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRS
EEECCHHHHCCCCCCHHHHHHHHHCCCHHEEEEECCCCCCCCEEEECCCCCCCCHHHHHH
IKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEMAAFPKLGRATRDLLCQLVVT
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCC
DQAATVTLLSAWRKKRLLSLCE
CCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEV
CEEEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCE
WLLKPLTYMNRSGKSVGAACAFLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRS
EEECCHHHHCCCCCCHHHHHHHHHCCCHHEEEEECCCCCCCCEEEECCCCCCCCHHHHHH
IKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEMAAFPKLGRATRDLLCQLVVT
HHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCC
DQAATVTLLSAWRKKRLLSLCE
CCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876