Click here to switch to the map view.

The map label for this gene is gpsA

Identifier: 189026232

GI number: 189026232

Start: 1102100

End: 1103170

Strand: Reverse

Name: gpsA

Synonym: TPASS_1009

Alternate gene names: 189026232

Gene position: 1103170-1102100 (Counterclockwise)

Preceding gene: 189026233

Following gene: 189026231

Centisome position: 96.82

GC content: 52.01

Gene sequence:

>1071_bases
ATGGCTTCGATTGCAATACTCGGTGGAGGGGCATGGGGCACGGCGCTTGCTGCGTCTCTCACCGTAAACGGTCACACCGT
AATGCTGTGGGCCCGTCGTAGGCAGACGTGCGATGCTATCAATGCACGAAACGAAAATGTTCAGTATCTGCCGGGCATTA
CGTTGCCCGCAGCCTTGTGTGCCTCTCCCGATATGGCATATGTCTGTGCCGGCGCGGATCTTATTGTATTAGCGGTTCCT
TCGTGCTATTTGGCTGAAGTAGCTGCGCTTATGAATACCACTCCTCGTTTTCAGAGGTTGCGTACTGCTGCCGTAGGACA
GGAATATCCCCTTATTGGTATTTTGACAAAAGGATTTATTCCGGATCAGGAAGGGATGCCTCATCTAATTACCGATGCGC
TGGGTGCGTTGTTGCCGTCTGGGGCGCACGGGCAGCTCGTGTATATTTCGGGTCCAAGCCATGCACAGGAGGTAGCGCAG
GGAAAGGTGACCGGACTTATTGCAGCGAGCCAAAATCCTATGGCGGCCATTCGGGTGCGGGAATTGCTGCGCTCGAAGAG
GGTGCAGGTGTATTCCAGTCTTGATGTTGTTGGGGTGCAAGTGTGTGCAGCGGTAAAAAACGTGATTGCCATTGCATTTG
GTCTTTTGGATGCGATGGCTGAGCATTCTGAAGCTTTTGGGGACAATACAGAGTCGATGCTGCTCGCAGCGGGCTTGAAT
GAAATTCAAACCATTGGAAAACAGTTGGGTTCTACACATCCTGAAACATTCACATCGCTTGCAGGAATAGGAGATTTGGA
TGTGACGTGTCGCAGCGCGTATGGACGCAACCGACGTTTCGGACGCGACATAGTGCATAAGGGGATCCTTGATTCCTTTT
CTGGAATACAGGATCTCGTGAGTCGTTTGCCCGAAGTAGGGTATCTGGCGGAAGGGGTAGTTGCCTGTATGCATGTGCAG
CGCCTGGCTGAGCGGGATCGGTTGAAGGTTCCAATTTGCGCGGGACTGTACGCTATTTTAAATCGGGAAAAGGGTGCTGA
CACCTTTATGCAAGAGATTCTTGGTTGGTAG

Upstream 100 bases:

>100_bases
CTAAAAAGTTTAGGGTCTGCGGTGCGTGTTCTTTTTCGATACGGTGATCATGTTTCCTCTTGCTGAAGAAAGGTGAGGAT
CAGGGGAGGGGTTAGGAATC

Downstream 100 bases:

>100_bases
CACGGGGGTGTTTTCTTCCGCGCGTCTCTGTGGGGGAAGCGTAAAGAACGAGTCTAGGAGTGGAAGCGAGAACTCTTACC
CAAATGTTATTTTTGGCCCA

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALCASPDMAYVCAGADLIVLAVP
SCYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFIPDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQ
GKVTGLIAASQNPMAAIRVRELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLN
EIQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLVSRLPEVGYLAEGVVACMHVQ
RLAERDRLKVPICAGLYAILNREKGADTFMQEILGW

Sequences:

>Translated_356_residues
MASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALCASPDMAYVCAGADLIVLAVP
SCYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFIPDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQ
GKVTGLIAASQNPMAAIRVRELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLN
EIQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLVSRLPEVGYLAEGVVACMHVQ
RLAERDRLKVPICAGLYAILNREKGADTFMQEILGW
>Mature_355_residues
ASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALCASPDMAYVCAGADLIVLAVPS
CYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFIPDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQG
KVTGLIAASQNPMAAIRVRELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLNE
IQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLVSRLPEVGYLAEGVVACMHVQR
LAERDRLKVPICAGLYAILNREKGADTFMQEILGW

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=304, Percent_Identity=27.6315789473684, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI24307999, Length=353, Percent_Identity=26.0623229461756, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1790037, Length=358, Percent_Identity=33.5195530726257, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32564399, Length=302, Percent_Identity=26.4900662251656, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193210136, Length=302, Percent_Identity=25.4966887417219, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32564403, Length=302, Percent_Identity=25.4966887417219, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320181, Length=349, Percent_Identity=27.5071633237822, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324513, Length=372, Percent_Identity=25.5376344086022, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17136202, Length=303, Percent_Identity=26.4026402640264, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136204, Length=303, Percent_Identity=26.4026402640264, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136200, Length=303, Percent_Identity=26.4026402640264, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362270, Length=303, Percent_Identity=26.0726072607261, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45551945, Length=303, Percent_Identity=26.0726072607261, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648969, Length=258, Percent_Identity=25.968992248062, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_TREPA (O83973)

Other databases:

- EMBL:   AE000520
- PIR:   E71252
- RefSeq:   NP_219446.1
- ProteinModelPortal:   O83973
- SMR:   O83973
- IntAct:   O83973
- GeneID:   2610820
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP1009
- NMPDR:   fig|243276.1.peg.1004
- TIGR:   TP_1009
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- ProtClustDB:   PRK00094
- BioCyc:   TPAL243276:TP_1009-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 37879; Mature: 37748

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 206-206 BINDING 117-117 BINDING 117-117 BINDING 155-155 BINDING 276-276 BINDING 311-311

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALC
CCEEEEEECCHHHHHHHHEEEECCCEEEEEECHHHHHHHHCCCCCCCEECCCCCHHHHHH
ASPDMAYVCAGADLIVLAVPSCYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFI
CCCCCEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCC
PDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQGKVTGLIAASQNPMAAIRVR
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHCCHHEEEEEECCCCHHHHHHH
ELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHH
EIQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLV
HHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SRLPEVGYLAEGVVACMHVQRLAERDRLKVPICAGLYAILNREKGADTFMQEILGW
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
ASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALC
CEEEEEECCHHHHHHHHEEEECCCEEEEEECHHHHHHHHCCCCCCCEECCCCCHHHHHH
ASPDMAYVCAGADLIVLAVPSCYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFI
CCCCCEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCC
PDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQGKVTGLIAASQNPMAAIRVR
CCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHCCHHEEEEEECCCCHHHHHHH
ELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHH
EIQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLV
HHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SRLPEVGYLAEGVVACMHVQRLAERDRLKVPICAGLYAILNREKGADTFMQEILGW
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876