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The map label for this gene is map

Identifier: 189026066

GI number: 189026066

Start: 916392

End: 917159

Strand: Reverse

Name: map

Synonym: TPASS_0842

Alternate gene names: 189026066

Gene position: 917159-916392 (Counterclockwise)

Preceding gene: 189026067

Following gene: 189026065

Centisome position: 80.49

GC content: 55.08

Gene sequence:

>768_bases
ATGATCCGCATTAAAACACCAGAACAAATCGACGGTATCCGTGCCTCTTGCAAGGCATTGGCGCGCCTTTTCGACGTTCT
TATTCCGCTTGTCAAACCGGGCGTTCAAACCCAGGAGCTTGATGCGTTTTGCCAACGCTTCATCCGCTCAGTCGGTGGTG
TTCCTGCCTGGTTCTCGGAAGGTTTTCCTGCCGCTGCTTGCATTTCAATCAACGAAGAGGTCATCCATGGTTTACCTTCA
GCGCGTGTGATTCAGGACGGGGATCTTGTTTCCCTTGATGTTGGTATCAACCTCAATGGATACATTTCTGACGCGTGTCG
TACTGTTCCTGTCGGTGGAGTTGCACACGAGCGACTAGAACTTTTGCGTGTAACCACTGAGTGCCTCCGTGCGGGCATTA
AAGCGTGCCGTGCCGGAGCGCGCGTGCGCGCTGTTTCTCGCGCTGTATACGCTGTTGCAGCACGGCACCGCTTTGGCGTG
GTGTACGAATATTGCGGACATGGCGTGGGGCTTGCCGTGCATGAGGAGCCGAACATCCCCAATGTGCCTGGCTTGGAAGG
GCCTAATCCACGTTTTTTGCCCGGTATGGTAGTCGCGATAGAACCCATGTTGACGCTTGGCACAGACGAGGTGCGCACCA
GTGCAGATGGCTGGACGGTGGTAACGGCAGACGGATCGTGTGCCTGCCATGTGGAGCACACTGTGGCAGTTTTTGCAGAC
CACACGGAGGTTTTAACAGAACCTACGGAAGTAGAGCGTACCGGCTAG

Upstream 100 bases:

>100_bases
GGAGTACCGTGGTCCTGGGGGACCTCCGAAGGGCTGGAGGTCCCCCTGCAGCTAGTGAACGGACAGAGGAGGGACGCTTG
AGCAGGAAGGAAAGGACCTC

Downstream 100 bases:

>100_bases
TCAGCTATCTTAAGTGTGCGCGGTGTGCTGATAGTACATGCAGGGAGCAGTTTGTGCACGGTAGGCAGCGTGTAAGTGTA
CGTGGCGGGCACAGGTGAAG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIRIKTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSEGFPAAACISINEEVIHGLPS
ARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLELLRVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGV
VYEYCGHGVGLAVHEEPNIPNVPGLEGPNPRFLPGMVVAIEPMLTLGTDEVRTSADGWTVVTADGSCACHVEHTVAVFAD
HTEVLTEPTEVERTG

Sequences:

>Translated_255_residues
MIRIKTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSEGFPAAACISINEEVIHGLPS
ARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLELLRVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGV
VYEYCGHGVGLAVHEEPNIPNVPGLEGPNPRFLPGMVVAIEPMLTLGTDEVRTSADGWTVVTADGSCACHVEHTVAVFAD
HTEVLTEPTEVERTG
>Mature_255_residues
MIRIKTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSEGFPAAACISINEEVIHGLPS
ARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLELLRVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGV
VYEYCGHGVGLAVHEEPNIPNVPGLEGPNPRFLPGMVVAIEPMLTLGTDEVRTSADGWTVVTADGSCACHVEHTVAVFAD
HTEVLTEPTEVERTG

Specific function: Removes the amino-terminal methionine from nascent proteins

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family

Homologues:

Organism=Homo sapiens, GI164420681, Length=254, Percent_Identity=33.8582677165354, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI40385867, Length=250, Percent_Identity=32.4, Blast_Score=141, Evalue=5e-34,
Organism=Escherichia coli, GI1786364, Length=248, Percent_Identity=38.7096774193548, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1788728, Length=218, Percent_Identity=27.9816513761468, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71996291, Length=250, Percent_Identity=31.2, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323273, Length=247, Percent_Identity=35.6275303643725, Blast_Score=155, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24583427, Length=248, Percent_Identity=33.0645161290323, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21355531, Length=250, Percent_Identity=32.8, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AMPM_TREPA (O83814)

Other databases:

- EMBL:   AE000520
- PIR:   B71273
- RefSeq:   NP_219278.1
- ProteinModelPortal:   O83814
- SMR:   O83814
- IntAct:   O83814
- MEROPS:   M24.001
- GeneID:   2611002
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0842
- NMPDR:   fig|243276.1.peg.837
- TIGR:   TP_0842
- HOGENOM:   HBG299384
- OMA:   KHRGPKL
- ProtClustDB:   CLSK218891
- BioCyc:   TPAL243276:TP_0842-MONOMER
- BRENDA:   3.4.11.18
- GO:   GO:0006508
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- Gene3D:   G3DSA:3.90.230.10
- PANTHER:   PTHR10804:SF13
- PANTHER:   PTHR10804
- PRINTS:   PR00599
- TIGRFAMs:   TIGR00500

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.18

Molecular weight: Translated: 27317; Mature: 27317

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00680 MAP_1

Important sites: BINDING 76-76 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIKTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSE
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHC
GFPAAACISINEEVIHGLPSARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLE
CCCCEEEEECCHHHHHCCCCCEEEECCCEEEEEECCCCCCCHHHHHHCCCCCCHHHHHHH
LLRVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGVVYEYCGHGVGLAVHEEPNIP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
NVPGLEGPNPRFLPGMVVAIEPMLTLGTDEVRTSADGWTVVTADGSCACHVEHTVAVFAD
CCCCCCCCCCCCCCCEEEEECHHHHCCCHHHCCCCCCEEEEEECCCEEEEEEEEEEEEEC
HTEVLTEPTEVERTG
CHHHHCCCCCCCCCC
>Mature Secondary Structure
MIRIKTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSE
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHC
GFPAAACISINEEVIHGLPSARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLE
CCCCEEEEECCHHHHHCCCCCEEEECCCEEEEEECCCCCCCHHHHHHCCCCCCHHHHHHH
LLRVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGVVYEYCGHGVGLAVHEEPNIP
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
NVPGLEGPNPRFLPGMVVAIEPMLTLGTDEVRTSADGWTVVTADGSCACHVEHTVAVFAD
CCCCCCCCCCCCCCCEEEEECHHHHCCCHHHCCCCCCEEEEEECCCEEEEEEEEEEEEEC
HTEVLTEPTEVERTG
CHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876