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The map label for this gene is htrA2 [C]

Identifier: 189026065

GI number: 189026065

Start: 914623

End: 916080

Strand: Reverse

Name: htrA2 [C]

Synonym: TPASS_0841

Alternate gene names: 189026065

Gene position: 916080-914623 (Counterclockwise)

Preceding gene: 189026066

Following gene: 189026063

Centisome position: 80.4

GC content: 52.88

Gene sequence:

>1458_bases
GTGCCCTCTGCAGACACGATGGCTCGGCGCGTTGCCGGAGACAGTGGGAACGCTGGGGGGCGGACATTACTTCCTGTGGG
GGTTTCGCGTGAATCGGTGCAGCTGTTAGAACGGCTGCAAAACGCGAACCGTCAGGTAACTGCCGAAGTGCTGCCTTCAG
TAGTGACGCTGGATGTGGTGGAGACCAGAAAGGTTCGGGTACGTGATCCGTTTGGCGGTTTTCCGTGGTTTTTCTTTCGT
GGTCCTGAAGGTCCGGGTGCGGGGCCTGGCGGTGGTTCTGGAAACAAAGGGGAAGCTGAGGAACGGGAGTACAAAACGGA
GGGACTTGGTTCTGGAGTCATTGTAAAGAAGACAGGGAAGACGCATTACGTGCTTACCAACTATCACGTGGCGGGTAAGG
CTAATGAGATAGAGATTAAACTGCACGATGGCAGAATCGTAAAAGGTAAACTTGTCGGTGGTGACCAGCGCAAGGACATC
GCGCTGGTCTCCTTTGAGGACGCAGACCCAAATATCCGTGTTGCCGTCCTTGGTGACTCGGATGCAGTACGGGTAGGAGA
CATTGTGTTCGCAGTTGGCTCTCCTCTTGGGTACACTTCCACTGTAACGCAGGGGATTATCAGTGCGCTGGGTCGCTTTG
GGGGACCGGGCAACAATATTAATGATTTTATTCAAACAGATGCGGCCATAAACCAGGGCAATTCCGGGGGACCAATGGTC
AATATTTATGGCGAAGTGATTGGGATTAACGCGTGGATTGCCTCCTCAAGTGGGGGATCGCAAGGGATTGGTTTTTCAAT
TCCTATCAATAATGTGAAGTCGGATATCGAATCATTTATCCAGTACGGGCAGGTGAAGTACGGGTGGTTAGGCGTGCAGC
TGGTGGCAACGGATGCGGACACCGTAGCATCGCTTGGTATTGCAAAGGGTACAAAAGGGGTGCTTGCGGCGGAAATTTTC
TTAGGTTCTCCTGCGCACAAGGGGGGACTGAAACCGGGCGATTACTGTGTAAAACTGAACGGAAAAGAAGTAAAGGATGT
AAATCAGTTTGTGCGGGATGTCGGCGCGCTGCGCATTGGGCAAACAGCAGTATTCGATTTAATTCGCGGTGGTGTGCCGA
TGACGCTTTCGGTGCGCATTACGGAGCGTGATGAAAAAATAGTAAATGACTACTCAAAGCTTTGGCCTGGGTTCATCCCA
CTGCCGCTTACGGAGGCCGTGCGTAAACGTTTGGATTTGAAAGCGTCGGTGCGTGGTGTGCTAGTTAGCAACGCGCAGAG
CAAAAGCCCTGCGGCGCTGATGGGATTGAAGTCGGCGGACATAGTAGTGGCGGTCAATGATCAAAGAGTCTCGAGCGTGC
GTGAGTTTTACGCGGTGCTTGCACGTCAGACGAGGGAGGTGTGGTTTGACGTGTTGCGCGATGGGCAAACGCTTTCTACC
GTGCGATTTCGGTTTTAG

Upstream 100 bases:

>100_bases
CTCGTTTGTGTGTGGGGTACATGCGGTATGCCGCAGTTTTTTTACAGCAGCGGCGTTGCTCGTTTTTATCTGCTGCTCTG
GTCATCCAAGTTCTGCGCGT

Downstream 100 bases:

>100_bases
GGGGGATAGTCACGGTCGATCACGTCCTGCGGCGTGTTGTGCGCACCGGGCCGTCTGAGCGCTAAGAGCACATGAGTGCG
GGTTTTCTAAACAAGGTGGC

Product: periplasmic serine protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MPSADTMARRVAGDSGNAGGRTLLPVGVSRESVQLLERLQNANRQVTAEVLPSVVTLDVVETRKVRVRDPFGGFPWFFFR
GPEGPGAGPGGGSGNKGEAEEREYKTEGLGSGVIVKKTGKTHYVLTNYHVAGKANEIEIKLHDGRIVKGKLVGGDQRKDI
ALVSFEDADPNIRVAVLGDSDAVRVGDIVFAVGSPLGYTSTVTQGIISALGRFGGPGNNINDFIQTDAAINQGNSGGPMV
NIYGEVIGINAWIASSSGGSQGIGFSIPINNVKSDIESFIQYGQVKYGWLGVQLVATDADTVASLGIAKGTKGVLAAEIF
LGSPAHKGGLKPGDYCVKLNGKEVKDVNQFVRDVGALRIGQTAVFDLIRGGVPMTLSVRITERDEKIVNDYSKLWPGFIP
LPLTEAVRKRLDLKASVRGVLVSNAQSKSPAALMGLKSADIVVAVNDQRVSSVREFYAVLARQTREVWFDVLRDGQTLST
VRFRF

Sequences:

>Translated_485_residues
MPSADTMARRVAGDSGNAGGRTLLPVGVSRESVQLLERLQNANRQVTAEVLPSVVTLDVVETRKVRVRDPFGGFPWFFFR
GPEGPGAGPGGGSGNKGEAEEREYKTEGLGSGVIVKKTGKTHYVLTNYHVAGKANEIEIKLHDGRIVKGKLVGGDQRKDI
ALVSFEDADPNIRVAVLGDSDAVRVGDIVFAVGSPLGYTSTVTQGIISALGRFGGPGNNINDFIQTDAAINQGNSGGPMV
NIYGEVIGINAWIASSSGGSQGIGFSIPINNVKSDIESFIQYGQVKYGWLGVQLVATDADTVASLGIAKGTKGVLAAEIF
LGSPAHKGGLKPGDYCVKLNGKEVKDVNQFVRDVGALRIGQTAVFDLIRGGVPMTLSVRITERDEKIVNDYSKLWPGFIP
LPLTEAVRKRLDLKASVRGVLVSNAQSKSPAALMGLKSADIVVAVNDQRVSSVREFYAVLARQTREVWFDVLRDGQTLST
VRFRF
>Mature_484_residues
PSADTMARRVAGDSGNAGGRTLLPVGVSRESVQLLERLQNANRQVTAEVLPSVVTLDVVETRKVRVRDPFGGFPWFFFRG
PEGPGAGPGGGSGNKGEAEEREYKTEGLGSGVIVKKTGKTHYVLTNYHVAGKANEIEIKLHDGRIVKGKLVGGDQRKDIA
LVSFEDADPNIRVAVLGDSDAVRVGDIVFAVGSPLGYTSTVTQGIISALGRFGGPGNNINDFIQTDAAINQGNSGGPMVN
IYGEVIGINAWIASSSGGSQGIGFSIPINNVKSDIESFIQYGQVKYGWLGVQLVATDADTVASLGIAKGTKGVLAAEIFL
GSPAHKGGLKPGDYCVKLNGKEVKDVNQFVRDVGALRIGQTAVFDLIRGGVPMTLSVRITERDEKIVNDYSKLWPGFIPL
PLTEAVRKRLDLKASVRGVLVSNAQSKSPAALMGLKSADIVVAVNDQRVSSVREFYAVLARQTREVWFDVLRDGQTLSTV
RFRF

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=258, Percent_Identity=34.8837209302326, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI7019477, Length=272, Percent_Identity=32.7205882352941, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI22129776, Length=258, Percent_Identity=32.5581395348837, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI24308541, Length=257, Percent_Identity=31.1284046692607, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1786356, Length=438, Percent_Identity=34.703196347032, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1789629, Length=372, Percent_Identity=35.752688172043, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1789630, Length=295, Percent_Identity=32.5423728813559, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646839, Length=262, Percent_Identity=35.8778625954198, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51697; Mature: 51565

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSADTMARRVAGDSGNAGGRTLLPVGVSRESVQLLERLQNANRQVTAEVLPSVVTLDVV
CCCHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEHHHCCCEEEEEEE
ETRKVRVRDPFGGFPWFFFRGPEGPGAGPGGGSGNKGEAEEREYKTEGLGSGVIVKKTGK
CCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCC
THYVLTNYHVAGKANEIEIKLHDGRIVKGKLVGGDQRKDIALVSFEDADPNIRVAVLGDS
EEEEEEEEEEECCCCEEEEEEECCEEEEEEEECCCCCCCEEEEEEECCCCCEEEEEECCC
DAVRVGDIVFAVGSPLGYTSTVTQGIISALGRFGGPGNNINDFIQTDAAINQGNSGGPMV
CCEEECEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHCCCCCCCCEE
NIYGEVIGINAWIASSSGGSQGIGFSIPINNVKSDIESFIQYGQVKYGWLGVQLVATDAD
EEEEEEEEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCH
TVASLGIAKGTKGVLAAEIFLGSPAHKGGLKPGDYCVKLNGKEVKDVNQFVRDVGALRIG
HHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCC
QTAVFDLIRGGVPMTLSVRITERDEKIVNDYSKLWPGFIPLPLTEAVRKRLDLKASVRGV
HHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHCEE
LVSNAQSKSPAALMGLKSADIVVAVNDQRVSSVREFYAVLARQTREVWFDVLRDGQTLST
EEECCCCCCCHHHEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VRFRF
EEECC
>Mature Secondary Structure 
PSADTMARRVAGDSGNAGGRTLLPVGVSRESVQLLERLQNANRQVTAEVLPSVVTLDVV
CCHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEHHHCCCEEEEEEE
ETRKVRVRDPFGGFPWFFFRGPEGPGAGPGGGSGNKGEAEEREYKTEGLGSGVIVKKTGK
CCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCC
THYVLTNYHVAGKANEIEIKLHDGRIVKGKLVGGDQRKDIALVSFEDADPNIRVAVLGDS
EEEEEEEEEEECCCCEEEEEEECCEEEEEEEECCCCCCCEEEEEEECCCCCEEEEEECCC
DAVRVGDIVFAVGSPLGYTSTVTQGIISALGRFGGPGNNINDFIQTDAAINQGNSGGPMV
CCEEECEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHCCCCCCCCEE
NIYGEVIGINAWIASSSGGSQGIGFSIPINNVKSDIESFIQYGQVKYGWLGVQLVATDAD
EEEEEEEEEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCCEEEEEEEEEEEEECCH
TVASLGIAKGTKGVLAAEIFLGSPAHKGGLKPGDYCVKLNGKEVKDVNQFVRDVGALRIG
HHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCC
QTAVFDLIRGGVPMTLSVRITERDEKIVNDYSKLWPGFIPLPLTEAVRKRLDLKASVRGV
HHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHCEE
LVSNAQSKSPAALMGLKSADIVVAVNDQRVSSVREFYAVLARQTREVWFDVLRDGQTLST
EEECCCCCCCHHHEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VRFRF
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]