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The map label for this gene is clpA [H]

Identifier: 189026026

GI number: 189026026

Start: 869812

End: 872241

Strand: Reverse

Name: clpA [H]

Synonym: TPASS_0801

Alternate gene names: 189026026

Gene position: 872241-869812 (Counterclockwise)

Preceding gene: 189026030

Following gene: 189026023

Centisome position: 76.55

GC content: 48.85

Gene sequence:

>2430_bases
ATGAAAATTATCATCAGTGCTTCTGTGCAAATTATTCTTGATCAGGCCTTTGATTTAGCGCGTAAGCGGCGTCACGAGTA
CATCACCGCAGAGCATGTTCTTTTTTCTGCCCTTGCGCATCCTGCTGCGTTGGAAATTATCAATCTCTGTAGCGCGGATA
TCGCGCTCATCCATAGTAATCTGTCAGAGTTTTTAAAAACACAAGTTCCCGTTGACTTAAGTCATACTCCTTCTCAATCA
CTGGGTTTTCAGCATCTGCTTAAGCGTGCAGTCTTGTATTGCGAGGCGAATAAAAAAAGTGCTCTTGAAGTCGGAGATCT
GTTGGTAAGTCTCCTCCAAGCGGAGACAAACTATGCTTCGTACTACATGCGTATGTCGGGTATGAGTACGGCGCGCTTGA
TTGAAGTAATAGCTCGTGTCAATGGCATCCGACACGGGGATAAGAATGTGTCGATGGGGTCGAACGCGCAAGAAAGGTAT
TCAGAGTCAGACGACGTTGGCGAATCTGCAGGGCACGGTCCTCCGCTCGATGGAACAGAGGGGGATGGTAACACAGCGGA
CGTACATGTGCACTATGAACACTGCGCGCATAAACGCACGGATGCAGATACGCATCGGTATACGGTGCTGGAAAAGTATA
CGGTGAATCTCACCGAACGTGCTCGTCGGGGAGAGCTTGCTCCGCTCATTGGGCGTACGCAGGAAATTGAGCGGACGATT
CAGATTTTGTGCCGGAGACAGAAGAATAATCCGGTACATGTGGGTGAAGCTGGTGTGGGAAAGACGGCAATTACTGAGGG
GCTTGCGCAACGTATCGTGCGGTGCGATGTGCCAGAGGCGTTAGAGGGAGTAGAGATTTTTAGCCTTGATATGACAAGCC
TGTTAGCAGGTACAAAGTTTCGAGGGGATTTTGAAGAGCGGCTCAAGCGTCTTGCAGAAGAGTTGGAAAAGAAAACACAA
GCAATTCTTTTTATTGATGAAATTCATACGGTAGTCGGTACTGGCTCAGGCGGTTCGGGTGGTTTGGATGCGTCTAACTT
ACTCAAACCGCTGCTTTCTTCAGGAAAGATTCGCTGTATTGGTTCTACCACGTATGAGGAATACACCAAACATTTTCGCA
AAGATCAGGCGTTAGCACGGCGTTTTCAAAAAATTGATATTGAAGAGCCTTCTGAGGAGGAAACCCTCCGAATTTTGGAA
GGGATTCGCACGCTTTACGAAGACTTTCATGCAGTGCATTACAGTGATGAAGCATTAGCTGCTGCGGTGAGACTTTCGGT
GCAATACATCCAAGGGAGACATCTGCCGGATAAGGCGATTGATATTATCGACGAAGCAGGCGCGTGTGCAAAGCTATCCC
GGGGAAAGCACGGAACAGAGGGAGTGTGTTCAGTAATTGGGGAGTCGGATATAGACGAAATTGTGGCAAAAATTGCGAAA
ATCCCTAAGCAGCGGGTATCTGCAAGTGAAATAGAAAAGTTGCGTAACTTTGAGCGCAGTATTTCAGAAAAAATTTTTGG
ACAAGGCGAGGCAATTGACTTAGTCACTCGTACGCTGAAGCGCGCGCGGGTGGGATTGCGCGTAAAGCATAAACCTATAG
CAAACTTGCTTTTTGTGGGGGCTACCGGTGTGGGAAAAACAGAGCTTGCGCGGACGCTTGCCCAGGAACTAGGGATTGTG
CTGCATCGTTTTGACATGAGTGAGTATCAGGAAAAGCACACGGTGAGTCGGTTGATCGGCTCACCGCCCGGTTATGTTGG
GTTTGAAGAGGGGGGATTGCTCACCGACGCGGTAAGGAAACAACCGCATGCGGTGCTCCTTTTGGACGAAATAGAAAAAG
CTCACCCGGACATTTTTAATGTCCTGCTCCAGGTTATGGATTACGCAACGCTCACTGACAACCAAGGCAGAAAAGCGGAT
TTTCGCAATGTTATTTTGATAATGACAAGTAATGCGGGTGCCCGGAACATGGGTGTTTCTCTCATCGGTTTTCACAAGGG
GCAGGTGGGTACTGCAGTTATCGACGAAGCAGTAGAACGTATTTTCTCTCCAGAATTTCGGAATCGGCTGGACGCAGTTA
TTCGTTTTGATGCGTTGTCCTTGGAAACGATGGAACGCATCGCCCGCAAGGAGCTTGCCCTGGTGTGTGAGCAACTGCAG
AAAAAACACATTCGTTTTGATATTACCGATGATGCACTCGCGTTGCTCGCTGAGCGTAGTCACTCAGGGGGAAGTGGTGC
GCGTAATGTTGCACGCTTGGTAGAGCAAGAAGTTGCAAATGTGCTTGCAGATCTTATGCTTTTTGGAGGAGTCGCTGAGG
GGGATGCGTTGCGGTGCACGGTAAAAGATCGGCATGCTCAATGCAATTTTCTCCGCATCGAGTGCGTGCAGTCTTCGTAT
TCGGGGAGTATCCAAGACGCGCTGGGGTGA

Upstream 100 bases:

>100_bases
TGCAGCCCTGCCTTGTGCAGGGTGTGTCTTGCGATTGCGTTGGGGCATGCTGCAAGAAGCGTACACAGGGGGGCATCCCC
CACGAGGGTATGGAGAGGAA

Downstream 100 bases:

>100_bases
TGATGCGTGGCACGGTAACGGTGTATCCGTGTGGTAGGCAGTGCACGTGCACTGAGTTATTCAAACGCGTTTCTCTCTTA
TCTTCCGCCAAAGCTCTACA

Product: ATP-dependent Clp protease, subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 809; Mature: 809

Protein sequence:

>809_residues
MKIIISASVQIILDQAFDLARKRRHEYITAEHVLFSALAHPAALEIINLCSADIALIHSNLSEFLKTQVPVDLSHTPSQS
LGFQHLLKRAVLYCEANKKSALEVGDLLVSLLQAETNYASYYMRMSGMSTARLIEVIARVNGIRHGDKNVSMGSNAQERY
SESDDVGESAGHGPPLDGTEGDGNTADVHVHYEHCAHKRTDADTHRYTVLEKYTVNLTERARRGELAPLIGRTQEIERTI
QILCRRQKNNPVHVGEAGVGKTAITEGLAQRIVRCDVPEALEGVEIFSLDMTSLLAGTKFRGDFEERLKRLAEELEKKTQ
AILFIDEIHTVVGTGSGGSGGLDASNLLKPLLSSGKIRCIGSTTYEEYTKHFRKDQALARRFQKIDIEEPSEEETLRILE
GIRTLYEDFHAVHYSDEALAAAVRLSVQYIQGRHLPDKAIDIIDEAGACAKLSRGKHGTEGVCSVIGESDIDEIVAKIAK
IPKQRVSASEIEKLRNFERSISEKIFGQGEAIDLVTRTLKRARVGLRVKHKPIANLLFVGATGVGKTELARTLAQELGIV
LHRFDMSEYQEKHTVSRLIGSPPGYVGFEEGGLLTDAVRKQPHAVLLLDEIEKAHPDIFNVLLQVMDYATLTDNQGRKAD
FRNVILIMTSNAGARNMGVSLIGFHKGQVGTAVIDEAVERIFSPEFRNRLDAVIRFDALSLETMERIARKELALVCEQLQ
KKHIRFDITDDALALLAERSHSGGSGARNVARLVEQEVANVLADLMLFGGVAEGDALRCTVKDRHAQCNFLRIECVQSSY
SGSIQDALG

Sequences:

>Translated_809_residues
MKIIISASVQIILDQAFDLARKRRHEYITAEHVLFSALAHPAALEIINLCSADIALIHSNLSEFLKTQVPVDLSHTPSQS
LGFQHLLKRAVLYCEANKKSALEVGDLLVSLLQAETNYASYYMRMSGMSTARLIEVIARVNGIRHGDKNVSMGSNAQERY
SESDDVGESAGHGPPLDGTEGDGNTADVHVHYEHCAHKRTDADTHRYTVLEKYTVNLTERARRGELAPLIGRTQEIERTI
QILCRRQKNNPVHVGEAGVGKTAITEGLAQRIVRCDVPEALEGVEIFSLDMTSLLAGTKFRGDFEERLKRLAEELEKKTQ
AILFIDEIHTVVGTGSGGSGGLDASNLLKPLLSSGKIRCIGSTTYEEYTKHFRKDQALARRFQKIDIEEPSEEETLRILE
GIRTLYEDFHAVHYSDEALAAAVRLSVQYIQGRHLPDKAIDIIDEAGACAKLSRGKHGTEGVCSVIGESDIDEIVAKIAK
IPKQRVSASEIEKLRNFERSISEKIFGQGEAIDLVTRTLKRARVGLRVKHKPIANLLFVGATGVGKTELARTLAQELGIV
LHRFDMSEYQEKHTVSRLIGSPPGYVGFEEGGLLTDAVRKQPHAVLLLDEIEKAHPDIFNVLLQVMDYATLTDNQGRKAD
FRNVILIMTSNAGARNMGVSLIGFHKGQVGTAVIDEAVERIFSPEFRNRLDAVIRFDALSLETMERIARKELALVCEQLQ
KKHIRFDITDDALALLAERSHSGGSGARNVARLVEQEVANVLADLMLFGGVAEGDALRCTVKDRHAQCNFLRIECVQSSY
SGSIQDALG
>Mature_809_residues
MKIIISASVQIILDQAFDLARKRRHEYITAEHVLFSALAHPAALEIINLCSADIALIHSNLSEFLKTQVPVDLSHTPSQS
LGFQHLLKRAVLYCEANKKSALEVGDLLVSLLQAETNYASYYMRMSGMSTARLIEVIARVNGIRHGDKNVSMGSNAQERY
SESDDVGESAGHGPPLDGTEGDGNTADVHVHYEHCAHKRTDADTHRYTVLEKYTVNLTERARRGELAPLIGRTQEIERTI
QILCRRQKNNPVHVGEAGVGKTAITEGLAQRIVRCDVPEALEGVEIFSLDMTSLLAGTKFRGDFEERLKRLAEELEKKTQ
AILFIDEIHTVVGTGSGGSGGLDASNLLKPLLSSGKIRCIGSTTYEEYTKHFRKDQALARRFQKIDIEEPSEEETLRILE
GIRTLYEDFHAVHYSDEALAAAVRLSVQYIQGRHLPDKAIDIIDEAGACAKLSRGKHGTEGVCSVIGESDIDEIVAKIAK
IPKQRVSASEIEKLRNFERSISEKIFGQGEAIDLVTRTLKRARVGLRVKHKPIANLLFVGATGVGKTELARTLAQELGIV
LHRFDMSEYQEKHTVSRLIGSPPGYVGFEEGGLLTDAVRKQPHAVLLLDEIEKAHPDIFNVLLQVMDYATLTDNQGRKAD
FRNVILIMTSNAGARNMGVSLIGFHKGQVGTAVIDEAVERIFSPEFRNRLDAVIRFDALSLETMERIARKELALVCEQLQ
KKHIRFDITDDALALLAERSHSGGSGARNVARLVEQEVANVLADLMLFGGVAEGDALRCTVKDRHAQCNFLRIECVQSSY
SGSIQDALG

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=324, Percent_Identity=32.4074074074074, Blast_Score=158, Evalue=2e-38,
Organism=Escherichia coli, GI1787109, Length=778, Percent_Identity=46.0154241645244, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=244, Percent_Identity=54.9180327868852, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6320464, Length=326, Percent_Identity=41.1042944785276, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6323002, Length=261, Percent_Identity=47.5095785440613, Blast_Score=239, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 89329; Mature: 89329

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIISASVQIILDQAFDLARKRRHEYITAEHVLFSALAHPAALEIINLCSADIALIHSN
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LSEFLKTQVPVDLSHTPSQSLGFQHLLKRAVLYCEANKKSALEVGDLLVSLLQAETNYAS
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCHHH
YYMRMSGMSTARLIEVIARVNGIRHGDKNVSMGSNAQERYSESDDVGESAGHGPPLDGTE
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
GDGNTADVHVHYEHCAHKRTDADTHRYTVLEKYTVNLTERARRGELAPLIGRTQEIERTI
CCCCEEEEEEEHHHHCCCCCCCCCHHEEEHHHHEECHHHHHHCCCCCHHHCCHHHHHHHH
QILCRRQKNNPVHVGEAGVGKTAITEGLAQRIVRCDVPEALEGVEIFSLDMTSLLAGTKF
HHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHCCCEEEEECHHHHHHCCCC
RGDFEERLKRLAEELEKKTQAILFIDEIHTVVGTGSGGSGGLDASNLLKPLLSSGKIRCI
CCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEE
GSTTYEEYTKHFRKDQALARRFQKIDIEEPSEEETLRILEGIRTLYEDFHAVHYSDEALA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAVRLSVQYIQGRHLPDKAIDIIDEAGACAKLSRGKHGTEGVCSVIGESDIDEIVAKIAK
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHH
IPKQRVSASEIEKLRNFERSISEKIFGQGEAIDLVTRTLKRARVGLRVKHKPIANLLFVG
CCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEECCCHHHEEEEC
ATGVGKTELARTLAQELGIVLHRFDMSEYQEKHTVSRLIGSPPGYVGFEEGGLLTDAVRK
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHC
QPHAVLLLDEIEKAHPDIFNVLLQVMDYATLTDNQGRKADFRNVILIMTSNAGARNMGVS
CCCEEEEHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
LIGFHKGQVGTAVIDEAVERIFSPEFRNRLDAVIRFDALSLETMERIARKELALVCEQLQ
EEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKHIRFDITDDALALLAERSHSGGSGARNVARLVEQEVANVLADLMLFGGVAEGDALRCT
HCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VKDRHAQCNFLRIECVQSSYSGSIQDALG
EECCCCCCCEEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MKIIISASVQIILDQAFDLARKRRHEYITAEHVLFSALAHPAALEIINLCSADIALIHSN
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
LSEFLKTQVPVDLSHTPSQSLGFQHLLKRAVLYCEANKKSALEVGDLLVSLLQAETNYAS
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCHHH
YYMRMSGMSTARLIEVIARVNGIRHGDKNVSMGSNAQERYSESDDVGESAGHGPPLDGTE
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
GDGNTADVHVHYEHCAHKRTDADTHRYTVLEKYTVNLTERARRGELAPLIGRTQEIERTI
CCCCEEEEEEEHHHHCCCCCCCCCHHEEEHHHHEECHHHHHHCCCCCHHHCCHHHHHHHH
QILCRRQKNNPVHVGEAGVGKTAITEGLAQRIVRCDVPEALEGVEIFSLDMTSLLAGTKF
HHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHCCCEEEEECHHHHHHCCCC
RGDFEERLKRLAEELEKKTQAILFIDEIHTVVGTGSGGSGGLDASNLLKPLLSSGKIRCI
CCCHHHHHHHHHHHHHHHHHHEEEHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEE
GSTTYEEYTKHFRKDQALARRFQKIDIEEPSEEETLRILEGIRTLYEDFHAVHYSDEALA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AAVRLSVQYIQGRHLPDKAIDIIDEAGACAKLSRGKHGTEGVCSVIGESDIDEIVAKIAK
HHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHH
IPKQRVSASEIEKLRNFERSISEKIFGQGEAIDLVTRTLKRARVGLRVKHKPIANLLFVG
CCHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEECCCHHHEEEEC
ATGVGKTELARTLAQELGIVLHRFDMSEYQEKHTVSRLIGSPPGYVGFEEGGLLTDAVRK
CCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHC
QPHAVLLLDEIEKAHPDIFNVLLQVMDYATLTDNQGRKADFRNVILIMTSNAGARNMGVS
CCCEEEEHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEE
LIGFHKGQVGTAVIDEAVERIFSPEFRNRLDAVIRFDALSLETMERIARKELALVCEQLQ
EEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKHIRFDITDDALALLAERSHSGGSGARNVARLVEQEVANVLADLMLFGGVAEGDALRCT
HCCCEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
VKDRHAQCNFLRIECVQSSYSGSIQDALG
EECCCCCCCEEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]