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The map label for this gene is xseA

Identifier: 188586316

GI number: 188586316

Start: 1773930

End: 1775201

Strand: Reverse

Name: xseA

Synonym: Nther_1699

Alternate gene names: 188586316

Gene position: 1775201-1773930 (Counterclockwise)

Preceding gene: 188586317

Following gene: 188586315

Centisome position: 56.08

GC content: 37.03

Gene sequence:

>1272_bases
ATGTCTGAACGAACAGTAACGGTTTCGCAACTAACGAATTATCTTAAAAACCTGTTACTACAAGATCATAATCTTAAAAA
TGTCCTGGTGAGAGGTGAGATTTCTAATTTTAAACACCACTCATCAGGACATATGTATTTTACTTTAAAAGATGAAGGGG
CTAGTCTCCGCTGTGTGATGTTTCGCAACCGCAATTGGAATTTAGATTTTTCTCCCCAAGATGGAATGGACGTTATAGTA
CAAGGTGTTGTAGGAATTTTTGAAAGAGCAGGCTTATATCAACTTTATGTAGAGAAAATGTACTCCCATGGTTTAGGATC
GTTGCATCTTGCCTTTGAGCAATTGAAGGAAAAATTAGCAGAAGAAGGCATATTTAATGAGGAATATAAAAAAACTTTAC
CTCCTTTTCCCAAGAAAATTGCCGTGGTTACTTCGCCGACAGGAGCTGCAGTTAGAGATATGATAGTAACTATAAGTAGA
AGATTTCCTTTAACATCAATACTGTTAATCCCCGTGAGAGTACAGGGTGAATATGCAGCCAGTGAAATAAGAGCAGGAAT
TGATTATGCTAACTCAATTGATGATATAGATGTGATTTTAGTCGGTAGAGGTGGAGGTTCTTTAGAGGAAATTTGGCCCT
TCAATACTGAAGAAGTGGCTAGGGCAATTTTTTCGTCAAAAGCTCCTGTGATTTCATGTGTTGGACACGAAACGGACTTT
ACCATTTCAGATTTTGTGTCAGATTTGAGAGCCCCTACTCCAACTGCAGCAGCAGAATTGGTGGTTCCAGATCAGGTTGA
GCTTAAAAGGCAAGTTAGTGACTACAAACATAGATTGACAAAAGCGTTATACCATAAGTATCGCAATTTAGATCAGAGAG
TAGTAGAGTTACTTGACAGGCCGGTTATGAAAAATCCGTATACATTAATCTCTGAACGAAAAAAAGAATTAGAATATTTA
GATCAGCGATTGTTAAGGGAAGTTTATCATCTCTTTAAACTTAAAAGAAATAAATACTCATCTTTAGTAGAACAGCTGGA
CTCATTGAGCCCTCTAAAAACTTTAGGGCGTGGTTATACTTTTTGCCAGACACATGATGGGGACATAGTCAGGAGTGTAA
CTGACATAGAACAGGAAGATATCCTGAAACTTACGTTTTTTGATGGTTCTGCGAAATGTTTAGTAAAGGAAAAGCAAGAA
CATCATATAAGTGAAGACCATTCAAATTTGAATTCTTTGTGTAATGAGGAGGAAGACTATGACAGACAATAA

Upstream 100 bases:

>100_bases
CTGCCAAAGAAGTTGCTGGATGGATTACACCTGTACCAGGCGGTGTTGGCCCTATGACCATCACAATGCTTTTAAATAAT
ACCATCGAGGCTGCCAGGAG

Downstream 100 bases:

>100_bases
CAAAGAGGAAATCAATCAAAATAATCAAGAAAATGTAGAGTTCGAACATGCTTTAACTGAGCTAGAAAAGGTTGTGCAGG
CACTAGAACGGGGCGAGCTC

Product: exodeoxyribonuclease VII, large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSERTVTVSQLTNYLKNLLLQDHNLKNVLVRGEISNFKHHSSGHMYFTLKDEGASLRCVMFRNRNWNLDFSPQDGMDVIV
QGVVGIFERAGLYQLYVEKMYSHGLGSLHLAFEQLKEKLAEEGIFNEEYKKTLPPFPKKIAVVTSPTGAAVRDMIVTISR
RFPLTSILLIPVRVQGEYAASEIRAGIDYANSIDDIDVILVGRGGGSLEEIWPFNTEEVARAIFSSKAPVISCVGHETDF
TISDFVSDLRAPTPTAAAELVVPDQVELKRQVSDYKHRLTKALYHKYRNLDQRVVELLDRPVMKNPYTLISERKKELEYL
DQRLLREVYHLFKLKRNKYSSLVEQLDSLSPLKTLGRGYTFCQTHDGDIVRSVTDIEQEDILKLTFFDGSAKCLVKEKQE
HHISEDHSNLNSLCNEEEDYDRQ

Sequences:

>Translated_423_residues
MSERTVTVSQLTNYLKNLLLQDHNLKNVLVRGEISNFKHHSSGHMYFTLKDEGASLRCVMFRNRNWNLDFSPQDGMDVIV
QGVVGIFERAGLYQLYVEKMYSHGLGSLHLAFEQLKEKLAEEGIFNEEYKKTLPPFPKKIAVVTSPTGAAVRDMIVTISR
RFPLTSILLIPVRVQGEYAASEIRAGIDYANSIDDIDVILVGRGGGSLEEIWPFNTEEVARAIFSSKAPVISCVGHETDF
TISDFVSDLRAPTPTAAAELVVPDQVELKRQVSDYKHRLTKALYHKYRNLDQRVVELLDRPVMKNPYTLISERKKELEYL
DQRLLREVYHLFKLKRNKYSSLVEQLDSLSPLKTLGRGYTFCQTHDGDIVRSVTDIEQEDILKLTFFDGSAKCLVKEKQE
HHISEDHSNLNSLCNEEEDYDRQ
>Mature_422_residues
SERTVTVSQLTNYLKNLLLQDHNLKNVLVRGEISNFKHHSSGHMYFTLKDEGASLRCVMFRNRNWNLDFSPQDGMDVIVQ
GVVGIFERAGLYQLYVEKMYSHGLGSLHLAFEQLKEKLAEEGIFNEEYKKTLPPFPKKIAVVTSPTGAAVRDMIVTISRR
FPLTSILLIPVRVQGEYAASEIRAGIDYANSIDDIDVILVGRGGGSLEEIWPFNTEEVARAIFSSKAPVISCVGHETDFT
ISDFVSDLRAPTPTAAAELVVPDQVELKRQVSDYKHRLTKALYHKYRNLDQRVVELLDRPVMKNPYTLISERKKELEYLD
QRLLREVYHLFKLKRNKYSSLVEQLDSLSPLKTLGRGYTFCQTHDGDIVRSVTDIEQEDILKLTFFDGSAKCLVKEKQEH
HISEDHSNLNSLCNEEEDYDRQ

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=438, Percent_Identity=38.3561643835616, Blast_Score=308, Evalue=5e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_NATTJ (B2A531)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917861.1
- GeneID:   6317043
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1699
- HOGENOM:   HBG634411
- OMA:   LINWANE
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 48391; Mature: 48260

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERTVTVSQLTNYLKNLLLQDHNLKNVLVRGEISNFKHHSSGHMYFTLKDEGASLRCVM
CCCCEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEE
FRNRNWNLDFSPQDGMDVIVQGVVGIFERAGLYQLYVEKMYSHGLGSLHLAFEQLKEKLA
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EEGIFNEEYKKTLPPFPKKIAVVTSPTGAAVRDMIVTISRRFPLTSILLIPVRVQGEYAA
HCCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHH
SEIRAGIDYANSIDDIDVILVGRGGGSLEEIWPFNTEEVARAIFSSKAPVISCVGHETDF
HHHHHCCCCCCCCCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCC
TISDFVSDLRAPTPTAAAELVVPDQVELKRQVSDYKHRLTKALYHKYRNLDQRVVELLDR
CHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
PVMKNPYTLISERKKELEYLDQRLLREVYHLFKLKRNKYSSLVEQLDSLSPLKTLGRGYT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCE
FCQTHDGDIVRSVTDIEQEDILKLTFFDGSAKCLVKEKQEHHISEDHSNLNSLCNEEEDY
EEECCCCHHHHHHHHCCHHCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
DRQ
CCC
>Mature Secondary Structure 
SERTVTVSQLTNYLKNLLLQDHNLKNVLVRGEISNFKHHSSGHMYFTLKDEGASLRCVM
CCCEEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEEE
FRNRNWNLDFSPQDGMDVIVQGVVGIFERAGLYQLYVEKMYSHGLGSLHLAFEQLKEKLA
EECCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EEGIFNEEYKKTLPPFPKKIAVVTSPTGAAVRDMIVTISRRFPLTSILLIPVRVQGEYAA
HCCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHH
SEIRAGIDYANSIDDIDVILVGRGGGSLEEIWPFNTEEVARAIFSSKAPVISCVGHETDF
HHHHHCCCCCCCCCCEEEEEEECCCCCHHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCC
TISDFVSDLRAPTPTAAAELVVPDQVELKRQVSDYKHRLTKALYHKYRNLDQRVVELLDR
CHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCC
PVMKNPYTLISERKKELEYLDQRLLREVYHLFKLKRNKYSSLVEQLDSLSPLKTLGRGYT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCE
FCQTHDGDIVRSVTDIEQEDILKLTFFDGSAKCLVKEKQEHHISEDHSNLNSLCNEEEDY
EEECCCCHHHHHHHHCCHHCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
DRQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA